Faculty of 1000 = Biology | Invariant visual representation by single neurons in the human = brain.

From: Subject: Faculty of 1000 Biology | Invariant visual representation by single neurons in the human brain. Date: Mon, 27 Jun 2005 13:23:28 -0400 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C57B1B.677E96D0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2180 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C57B1B.677E96D0 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.facultyof1000.com/article/15973409 Faculty of 1000 = Biology | Invariant visual representation by single neurons in the human = brain.

Welcome=20 Massachusetts Institute of=20 Technology

27-Jun-2005

Must Read=20

F1000 Factor = 6.4

Invariant = visual=20 representation by single neurons in the human=20 brain.
Quiroga RQ,=20 Reddy L, Kreiman G, Koch C, Fried I
Nature = 2005 Jun=20 23 435(7045):1102-1107 [abstract on PubMed] [related ar= ticles]=20 [order article] =

Selected by=20 | Mayank Mehta

/ Aina Puce

Evaluated=20 24 Jun 2005
Relevant Sections =

Faculty Comments

Faculty=20 Member	Comments
Mayank = Mehta Brown = University,=20 United States of = America NEUROSCIENCE New=20 Finding	The paper shows that = neurons in the=20 hippocampus and related areas in humans respond = to=20 abstract visual information in a selective = fashion.=20 Using microwires, Quiroga et al. recorded the = activity=20 of neurons from several parts of the medial = temporal=20 lobe, including the hippocampus, of epileptic = patients.=20 The hippocampus is usually associated with = learning,=20 memory and spatial representation. The authors = show that=20 neurons in the human hippocampus respond = robustly to a=20 select subset of images of famous places as well = as=20 faces in a sensory-cortical fashion. Further, = these=20 neurons seemed to encode information in a highly = invariant or abstract fashion in that they = responded=20 robustly to the same face when presented in a = variety of=20 ways, including caricature and semantic = representation.=20 Such selective, yet invariant, representation of = abstract information in the human hippocampus = raises=20 interesting questions about the nature of neural = information processing in the hippocampus.=20 Evaluated=20 24 Jun 2005 cite=20 this evaluation
Aina = Puce University of West=20 Virginia, United States of=20 America NEUROSCIENCE = Hypothesis New = Finding =20 Controversial	This fascinating study = investigated=20 abstract representation in the brains of 8 = patients=20 being investigated for potential seizure = surgery. The=20 investigators found that individual neurons in = the=20 medial temporal lobe responded selectively to = the=20 identity of famous individuals, for example = Halle Berry=20 or Jennifer Anniston, and also to other = categories of=20 object, including famous buildings, in a series = of=20 recording sessions where the responsivity of = neurons to=20 multiple visual categories were = investigated. These=20 intriguing results challenge current ideas and = models of=20 object and face recognition that posit that the = output=20 of multiple neurons typically would code the = identity of=20 an individual person or specific object. = Evaluated=20 24 Jun 2005 cite=20 this=20 = evaluation

Faculty Comments

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How to cite the Faculty of = 1000=20 evaluation(s) for this paper

1) To cite = all the=20 evaluations for this article:

Faculty of 1000: evaluations for = Quiroga RQ=20 et al Nature 2005 Jun 23 435 (7045) :1102-1107=20 = http://www.f1000biology.com/article/15973409/evaluation

2) To cite = an=20 evaluation by a specific Faculty member:

Mayank Mehta: Faculty of 1000,=20 24 Jun 2005=20 = http://www.f1000biology.com/article/15973409/evaluation

Aina=20 Puce: Faculty of 1000, 24 Jun 2005=20 = http://www.f1000biology.com/article/15973409/evaluation

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_udl.hostname!=3D"") = s+=3D"&utmhn=3D"+escape(_udl.hostname); if (!page || page=3D=3D"") s+=3D"&utmr=3D"+_ur; s+=3D"&utmp=3D"+pg; if (_userv=3D=3D0 || _userv=3D=3D2) { var i=3Dnew Image(1,1); i.src=3D_ugifpath+"?"+"utmwv=3D"+_uwv+s; i.onload=3Dfunction() {_uVoid();} } if (_userv=3D=3D1 || _userv=3D=3D2) { var i2=3Dnew Image(1,1); = i2.src=3D_ugifpath2+"?"+"utmwv=3D"+_uwv+s+"&utmac=3D"+_uacct+"&utmcc=3D"+= _uGCS(); i2.onload=3Dfunction() { _uVoid(); } } return; } function _uVoid() { return; } function _uCInfo() { if (!_ucto || _ucto=3D=3D"") { _ucto=3D"15768000"; } var c=3D"",t=3D"-",t2=3D"-",o=3D0,cs=3D0,cn=3D0;i=3D0; var s=3D_udl.search; var z=3D_uGC(s,"__utmz=3D","&"); var x=3Dnew Date(_udt.getTime()+(_ucto*1000)); var dc=3D_ubd.cookie; x=3D" expires=3D"+x.toGMTString()+";"; if (z!=3D"-") { _ubd.cookie=3D"__utmz=3D"+unescape(z)+"; = path=3D/;"+x+_udo; return ""; } z=3Ddc.indexOf("__utmz=3D"+_udh); if (z>-1) { z=3D_uGC(dc,"__utmz=3D"+_udh,";"); } else { z=3D"-"; } 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if = (z!=3D"-" && _ufno=3D=3D1) return ""; } if (c=3D=3D"-" || c=3D=3D"") { if (z=3D=3D"-" && _ufns=3D=3D1) { = c=3D"utmccn=3D(direct)|utmcsr=3D(direct)|utmcmd=3D(none)"; } if (c=3D=3D"-" || c=3D=3D"") return ""; } if (z!=3D"-") { i=3Dz.indexOf("."); if (i>-1) i=3Dz.indexOf(".",i+1); if (i>-1) i=3Dz.indexOf(".",i+1); if (i>-1) i=3Dz.indexOf(".",i+1); t=3Dz.substring(i+1,z.length); if (t.toLowerCase()=3D=3Dc.toLowerCase()) cs=3D1; t=3Dz.substring(0,i); if ((i=3Dt.lastIndexOf(".")) > -1) { t=3Dt.substring(i+1,t.length); cn=3D(t*1); } } if (cs=3D=3D0 || _ufns=3D=3D1) { t=3D_uGC(dc,"__utma=3D"+_udh,";"); if ((i=3Dt.lastIndexOf(".")) > 9) { _uns=3Dt.substring(i+1,t.length); _uns=3D(_uns*1); } cn++; if (_uns=3D=3D0) _uns=3D1; _ubd.cookie=3D"__utmz=3D"+_udh+"."+_ust+"."+_uns+"."+cn+"."+c+"; = path=3D/; "+x+_udo; } if (cs=3D=3D0 || _ufns=3D=3D1) return "&utmcn=3D1"; else return "&utmcr=3D1"; } function _uRef() { if (_ur=3D=3D"0" || _ur=3D=3D"" || _ur=3D=3D"-") return ""; var i=3D0,h,k,n; if ((i=3D_ur.indexOf("://"))<0) return ""; h=3D_ur.substring(i+3,_ur.length); if (h.indexOf("/") > -1) { k=3Dh.substring(h.indexOf("/"),h.length); if (k.indexOf("?") > -1) k=3Dk.substring(0,k.indexOf("?")); h=3Dh.substring(0,h.indexOf("/")); } h=3Dh.toLowerCase(); n=3Dh; if ((i=3Dn.indexOf(":")) > -1) n=3Dn.substring(0,i); for (var ii=3D0;ii<_uRno.length;ii++) { if ((i=3Dn.indexOf(_uRno[ii].toLowerCase())) > -1 && = n.length=3D=3D(i+_uRno[ii].length)) { _ufno=3D1; break; } } if (h.indexOf("www.")=3D=3D0) h=3Dh.substring(4,h.length); return = "utmccn=3D(referral)|utmcsr=3D"+_uEC(h)+"|"+"utmcct=3D"+_uEC(k)+"|utmcmd=3D= referral"; } function _uOrg(t) { if (_ur=3D=3D"0" || _ur=3D=3D"" || _ur=3D=3D"-") return ""; var i=3D0,h,k; if ((i=3D_ur.indexOf("://")) < 0) return ""; h=3D_ur.substring(i+3,_ur.length); if (h.indexOf("/") > -1) { h=3Dh.substring(0,h.indexOf("/")); } for (var ii=3D0;ii<_uOsr.length;ii++) { if (h.indexOf(_uOsr[ii]) > -1) { if ((i=3D_ur.indexOf("?"+_uOkw[ii]+"=3D")) > -1 || = (i=3D_ur.indexOf("&"+_uOkw[ii]+"=3D")) > -1) { k=3D_ur.substring(i+_uOkw[ii].length+2,_ur.length); if ((i=3Dk.indexOf("&")) > -1) k=3Dk.substring(0,i); for (var yy=3D0;yy<_uOno.length;yy++) { if (_uOno[yy].toLowerCase()=3D=3Dk.toLowerCase()) { _ufno=3D1; = break; } } if (t) return _uEC(k); else return = "utmccn=3D(organic)|utmcsr=3D"+_uEC(_uOsr[ii])+"|"+"utmctr=3D"+_uEC(k)+"|= utmcmd=3Dorganic"; } } } return ""; } function _uBInfo(page) { var sr=3D"-",sc=3D"-",ul=3D"-",fl=3D"-",je=3D1; var n=3Dnavigator; if (self.screen) { sr=3Dscreen.width+"x"+screen.height; sc=3Dscreen.colorDepth+"-bit"; } else if (self.java) { var j=3Djava.awt.Toolkit.getDefaultToolkit(); var s=3Dj.getScreenSize(); sr=3Ds.width+"x"+s.height; } if (_ujv=3D=3D"-" && (!page || page=3D=3D"")) { for (var i=3D5;i>=3D0;i--) { var t=3D""; _ubd.write(t); if (_ujv!=3D"-") break; } } if (n.language) { ul=3Dn.language.toLowerCase(); } else if (n.browserLanguage) { ul=3Dn.browserLanguage.toLowerCase(); } je=3Dn.javaEnabled()?1:0; if (_uflash) fl=3D_uFlash(); return = "&utmsr=3D"+sr+"&utmsc=3D"+sc+"&utmul=3D"+ul+"&utmje=3D"+je+"&utmjv=3D"+_= ujv+"&utmfl=3D"+fl; } function __utmSetTrans() { var e; if (_ubd.getElementById) e=3D_ubd.getElementById("utmtrans"); else if (_ubd.utmform && _ubd.utmform.utmtrans) = e=3D_ubd.utmform.utmtrans; if (!e) return; var l=3De.value.split("UTM:"); var i,i2,c; if (_userv=3D=3D0 || _userv=3D=3D2) i=3Dnew Array(); if (_userv=3D=3D1 || _userv=3D=3D2) { i2=3Dnew Array(); c=3D_uGCS(); } for (var ii=3D0;ii=3D2;ii--) { try { var fl=3Deval("new = ActiveXObject('ShockwaveFlash.ShockwaveFlash."+ii+"');"); if (fl) { f=3Dii + '.0'; break; } } catch(e) {} } } return f; } function __utmLinker(l) { var p,a=3D"-",b=3D"-",c=3D"-",z=3D"-",v=3D"-"; var dc=3D_ubd.cookie; if (l && l!=3D"") { if (dc) { a=3D_uGC(dc,"__utma=3D"+_udh,";"); b=3D_uGC(dc,"__utmb=3D"+_udh,";"); c=3D_uGC(dc,"__utmc=3D"+_udh,";"); z=3D_uGC(dc,"__utmz=3D"+_udh,";"); v=3D_uGC(dc,"__utmv=3D"+_udh,";"); = p=3D"__utma=3D"+a+"&__utmb=3D"+b+"&__utmc=3D"+c+"&__utmz=3D"+escape(z)+"&= __utmv=3D"+escape(v); } if (p) { if (l.indexOf("?")<=3D-1) { document.location=3Dl+"?"+p; } else { document.location=3Dl+"&"+p; } } else { document.location=3Dl; } } } function __utmLinkPost(f) { var p,a=3D"-",b=3D"-",c=3D"-",z=3D"-",v=3D"-"; var dc=3D_ubd.cookie; if (!f || !f.action) return; if (dc) { a=3D_uGC(dc,"__utma=3D"+_udh,";"); b=3D_uGC(dc,"__utmb=3D"+_udh,";"); c=3D_uGC(dc,"__utmc=3D"+_udh,";"); z=3D_uGC(dc,"__utmz=3D"+_udh,";"); v=3D_uGC(dc,"__utmv=3D"+_udh,";"); = p=3D"__utma=3D"+a+"&__utmb=3D"+b+"&__utmc=3D"+c+"&__utmz=3D"+escape(z)+"&= __utmv=3D"+escape(v); } if (p) { if (f.action.indexOf("?")<=3D-1) f.action+=3D"?"+p; else f.action+=3D"&"+p; } return; } function __utmSetVar(v) { if (!v || v=3D=3D"") return; var r=3DMath.round(Math.random() * 2147483647); _ubd.cookie=3D"__utmv=3D"+_udh+"."+escape(v)+"; path=3D/; = expires=3DSun, 18 Jan 2038 00:00:00 GMT;"+_udo; var s=3D"&utmt=3Dvar&utmn=3D"+r; if (_userv=3D=3D0 || _userv=3D=3D2) { var i=3Dnew Image(1,1); i.src=3D_ugifpath+"?"+"utmwv=3D"+_uwv+s; i.onload=3Dfunction() { _uVoid(); } } if (_userv=3D=3D1 || _userv=3D=3D2) { var i2=3Dnew Image(1,1); = i2.src=3D_ugifpath2+"?"+"utmwv=3D"+_uwv+s+"&utmac=3D"+_uacct+"&utmcc=3D"+= _uGCS(); i2.onload=3Dfunction() { _uVoid(); } } } function _uGCS() { var t,c=3D"",dc=3D_ubd.cookie; if ((t=3D_uGC(dc,"__utma=3D"+_udh,";"))!=3D"-") = c+=3Descape("__utma=3D"+t+";+"); if ((t=3D_uGC(dc,"__utmb=3D"+_udh,";"))!=3D"-") = c+=3Descape("__utmb=3D"+t+";+"); if ((t=3D_uGC(dc,"__utmc=3D"+_udh,";"))!=3D"-") = c+=3Descape("__utmc=3D"+t+";+"); if ((t=3D_uGC(dc,"__utmz=3D"+_udh,";"))!=3D"-") = c+=3Descape("__utmz=3D"+t+";+"); if ((t=3D_uGC(dc,"__utmv=3D"+_udh,";"))!=3D"-") = c+=3Descape("__utmv=3D"+t+";"); if (c.charAt(c.length-1)=3D=3D"+") c=3Dc.substring(0,c.length-1); return c; } function _uGC(l,n,s) { if (!l || l=3D=3D"" || !n || n=3D=3D"" || !s || s=3D=3D"") return "-"; var i,i2,i3,c=3D"-"; i=3Dl.indexOf(n); i3=3Dn.indexOf("=3D")+1; if (i > -1) { i2=3Dl.indexOf(s,i); if (i2 < 0) { i2=3Dl.length; } c=3Dl.substring((i+i3),i2); } return c; } function _uDomain() { if (!_udn || _udn=3D=3D"" || _udn=3D=3D"none") { _udn=3D""; return 1; } if (_udn=3D=3D"auto") { var d=3D_ubd.domain; if (d.substring(0,4)=3D=3D"www.") { d=3Dd.substring(4,d.length); } _udn=3Dd; } if (_uhash=3D=3D"off") return 1; return _uHash(_udn); } function _uHash(d) { if (!d || d=3D=3D"") return 1; var h=3D0,g=3D0; for (var i=3Dd.length-1;i>=3D0;i--) { var c=3DparseInt(d.charCodeAt(i)); h=3D((h << 6) & 0xfffffff) + c + (c << 14); if ((g=3Dh & 0xfe00000)!=3D0) h=3D(h ^ (g >> 21)); } return h; } function _uFixA(c,s,t) { if (!c || c=3D=3D"" || !s || s=3D=3D"" || !t || t=3D=3D"") return "-"; var a=3D_uGC(c,"__utma=3D"+_udh,s); var lt=3D0,i=3D0; if ((i=3Da.lastIndexOf(".")) > 9) { _uns=3Da.substring(i+1,a.length); _uns=3D(_uns*1)+1; a=3Da.substring(0,i); if ((i=3Da.lastIndexOf(".")) > 7) { lt=3Da.substring(i+1,a.length); a=3Da.substring(0,i); } if ((i=3Da.lastIndexOf(".")) > 5) { a=3Da.substring(0,i); } a+=3D"."+lt+"."+t+"."+_uns; } return a; } function _uTrim(s) { if (!s || s=3D=3D"") return ""; while ((s.charAt(0)=3D=3D' ') || (s.charAt(0)=3D=3D'\n') || = (s.charAt(0,1)=3D=3D'\r')) s=3Ds.substring(1,s.length); while ((s.charAt(s.length-1)=3D=3D' ') || = (s.charAt(s.length-1)=3D=3D'\n') || (s.charAt(s.length-1)=3D=3D'\r')) = s=3Ds.substring(0,s.length-1); return s; } function _uEC(s) { var n=3D""; if (!s || s=3D=3D"") return ""; for (var i=3D0;i0) r=3Da.substring(i+1,i2); else return = ""; =20 if ((i=3Da.indexOf(".",i2+1))>0) t=3Da.substring(i2+1,i); else return = ""; =20 var c=3Dnew = Array('A','B','C','D','E','F','G','H','J','K','L','M','N','P','R','S','T'= ,'U','V','W','X','Y','Z','1','2','3','4','5','6','7','8','9'); return = c[r>>28&m]+c[r>>23&m]+c[r>>18&m]+c[r>>13&m]+"-"+c[r>>8&m]+c[r>>3&m]+c[((r= &7)<<2)+(t>>30&3)]+c[t>>25&m]+c[t>>20&m]+"-"+c[t>>15&m]+c[t>>10&m]+c[t>>5= &m]+c[t&m]; } ------=_NextPart_000_0000_01C57B1B.677E96D0--