Faculty of 1000 Biology | Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex.

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Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex.
Tropea D, Kreiman G, Lyckman A, Mukherjee S, Yu H, Horng S, Sur M
Nat Neurosci 2006 May 9(5):660-8 [abstract on PubMed] [citations on Google Scholar] [related articles] [full text] [order article]

Selected by | Kathleen Rockland
Evaluated 12 May 2006

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Kathleen Rockland
RIKEN Brain Science Institute, Japan
NEUROSCIENCE

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The authors creatively use DNA microarray analysis to screen for changes in gene expression in young mice under conditions of dark rearing or monocular deprivation (see also Majdan and Shatz {1}). The new technology provides interesting confirmation of findings from previous work, as well as evidence that expression of a binding protein of the insulin-like growth factor-1 has an unexpected role in ocular dominance plasticity. The ability to examine large-scale changes in gene expression affords a fascinating window on the coordination of sets of molecules and pathways, and a novel means of investigating the interactions of gene expression and sensory-driven experience. {1} Majdan & Shatz, Nat Neurosci 2006, 9:650-9 [PMID:16582906].

Competing interests: None declared
Evaluated 12 May 2006

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