PPARa-dependent modulation of hepatic CYP1A by clofibric acid in rats - Full text - MIT Libraries
Z Shaban, S El-Shazly, M Ishizuka, K Kimura, A … - Arch Toxicol, 2004 - springerlink.com
... (MA, USA). Polyclonal antibodies, goat anti-rat AhR and human AhR, PPARa and b-actin
were purchased from Santa Cruz Biotechnol- ogy (Santa Cruz, CA, USA). ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - csa.com

AhR and PPAR a: antagonistic effects on CYP 2 B and CYP 3 A, and additive inhibitory effects on CYP …
Z Shaban, M Soliman, S El-Shazly, K El-Bohi, A … - Xenobiotica, 2005 - taylorandfrancis.metapress.com
... AhR and PPARa: antagonistic effects on CYP2B and CYP3A, and additive inhibitory
effects on CYP2C11 Z. SHABAN 1 , M. SOLIMAN 2 , S. EL-SHAZLY 3 , K. EL-BOHI 1 , ...
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Receptor-Mediated Hepatocarcinogenesis: Role of Hepatocyte Proliferation and Apoptosis - Full text - MIT Libraries
JD Oliver, RA Roberts - Pharmacology and Toxicology, 2002 - ingentaconnect.com
... AhR, the dioxin receptor, CAR, the phenobarbital receptor, and PPARa, the peroxisome
proliferator-activated receptor, have ligand- dependent transcriptional ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov

IN VITRO INDUCTION OF CYTOCHROME P450 ENZYMES IN HEPATOCYTES ISOLATED FROM THE REGENERATING RAT … - Full text - MIT Libraries
V Tamasi, Z Riedl, O Dobozy, A Falus, L Vereczkey, … - Pol. J. Pharmacol, 2004 - if-pan.krakow.pl
... PPARa and CAR activities are completely abolished by the proliferative response
of ... fact that retinoblastoma protein (pRb), a coactivator of AhR also fluctuates ...
Cited by 1 - View as HTML - Web Search - rabbit.if-pan.krakow.pl - if-pan.krakow.pl - ncbi.nlm.nih.gov - all 6 versions »

1. THE PROMISE OF GENOMICS IN CANCER RESEARCH
V Ling, L Hood - taylorandfrancis.metapress.com
Page 1. DRUG METABOLISM REVIEW Vol. 36, Supplement 1, pp. 1–345, 2004 ABSTRACTS
1. THE PROMISE OF GENOMICS IN CANCER RESEARCH Victor ...
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GEArray Q Series Human Cancer Drug Resistance & Metabolism Gene Array: AR-SAHS-019
FG Grouping - eurogentec.com
... AR, ESR1 (ER-alpha), ESR2 (ER-beta-cx), PPARA, PPARD, PPARG, PPARGC1, RARA, RARB,
RARG, RXRA, RXRB, RXRG, SRD5A2. Transcription Factors: AHR, AP1S1, ELK1, FOS ...
View as HTML - Web Search - eurogentec.be

GEArray Q Series Mouse Cancer Drug Resistance & Metabolism Gene Array: AR-SAMM-019
FG Grouping - eurogentec.com
... Hormone Receptors: Ar, Esr1, Esr2, Igf2r, Ppara, Ppard, Pparg, Ppargc1, Rara, Rarb,
Rxra, Rxrb, Rxrg, Srd5a2. Transcription Factors: Ahr, Ap1s1, Ap1s2, Elk1 ...
View as HTML - Web Search - eurogentec.be

Hepatic Gene Expression in Protoporphyic Fech Mice Is Associated with Cholestatic Injury but Not a … - Full text - MIT Libraries
R Davies, A Schuurman, CR Barker, B Clothier, T … - American Journal of Pathology, 2005 - ajp.amjpathol.org
... 11 -OH steroid dehydrogenase Hsd11b1 0.38 0.048 0.34 0.011 Nuclear receptors AHR
Ahr 1.35 1.27 HNF-1 Tcf1 1.23 1.02 ... RXR Rxra 0.9 1.08 PPAR Ppara ND 0.45 ...
Web Search - ajp.amjpathol.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Identification of two Nereis virens (Annelida: Polychaeta) cytochromes P450 and induction by …
KF Rewitz, C Kjellerup, A Joergensen, C Petersen, … - Comp. Biochem. Physiol. C, 2004 - diggy.ruc.dk
... they lack the specific high-affinity binding of the prototypical AhR ligands, 2 ...
Furthermore, treatment with DMSO increased the PPARa mRNA and protein levels and ...
Cited by 1 - View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Regulation of cytochrome P450 (CYP) genes by nuclear receptors - Full text - MIT Libraries
P Honkakoski, M Negishi - Biochem. J, 2000 - biochemj.org
... CYP mRNAs is suppressed by chemicals that can activate AhR or NRs ... nuclear receptors
CAR (constitutively active receptor), PXR (pregnane X receptor) and PPARa. ...
Cited by 109 - Cached - Web Search - cmbi.kun.nl - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Promoter activity and regulation of the corneal CYP 4 B 1 gene by hypoxia - Full text - MIT Libraries
V Mastyugin, A Mezentsev, WX Zhang, S Ashkar, MW … - Journal of Cellular Biochemistry, 2004 - doi.wiley.com
Page 1. Journal of Cellular Biochemistry 91:1218–1238 (2004) Promoter Activity
and Regulation of the Corneal CYP4B1 Gene by Hypoxia ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Rodent Toxicity and Nongenotoxic Carcinogenesis: Knowledge-Based Human Risk Assessment Based on …
RA Roberts, JI Goodman, HG Shertzer, TP Dalton, WH … - Toxicology Mechanisms and Methods, 2003 - dx.doi.org
... Similarly, dioxins act through another nuclear receptor, AhR. ... 1999). In addition,
the AHR has been shown to associate with NF-κB (Tian et al. ...
Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - csa.com

O-1 Detection and incidence of muscular adverse reactions: a prospective analysis from laboratory …
A Pharmacovigilance, F Saint-Denis - ingentaconnect.com
Page 1. O-1 Detection and incidence of muscular adverse reactions: a
prospective analysis from laboratory signals H. Bagheri a , A ...
Web Search - pharmacol-fr.org

ISSX
AAAN AN, IMI MEETING - issx.org
... Upon ligand-activation, PPARa and PPARg regulate gene transcription by dimerizing
with the Retinoid X Receptor (RXR) and binding to PPAR response elements ...
View as HTML - Web Search - issx.org - issx.org

Role of drug metabolism in drug discovery and development
GN Kumar, S Surapaneni - Medicinal Research Reviews, 2001 - doi.wiley.com
... mediated by aryl hydrocarbon receptor (AhR), although AhR-independent pathways ... X
receptor), and CYP4A induction by clo®brate (PPARa, peroxisome proliferator ...
Cited by 12 - Web Search - pubs3.acs.org - doi.wiley.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Evidence for the involvement of the fatty acid and peroxisomal β-oxidation pathways in the …
FI Ikegwuonu, CR Jefcoate - Molecular and Cellular Biochemistry, 1999 - springerlink.com
... activation of peroxisomal β-oxidation enzymes is mediated by the PPARa [49, 50]. ...
β-oxidation by TCDD and BA and the aryl hydrocarbon receptor (AhR) which is ...
Cited by 5 - Web Search - kluweronline.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

6. Control genico de la expresion del citocromo P-450 en el higado
RJ ATIENZA - ranf.com
... asociado con la respuesta induc- tiva de los genes CYP que se descubrió fue el receptor
de hidrocarburos aromáticos policíclicos, AhR (Aryl hydrocarbon ...
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Pathophysiological factors affecting CAR gene expression
JM Pascussi, Z Dvorak, S Gerbal-Chaloin, E Assenat … - DRUG METABOLISM REVIEWS, 2003 - taylorandfrancis.metapress.com
... reported that glucocorticoids directly activate the transcription of the PPARa gene
in ... been proposed for TNFa and LPS-mediated suppression of AhR-induced mice ...
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2 Abstracts
DIL INJURY, X AGENTS - DRUG METABOLISM REVIEWS, 2003 - taylorandfrancis.metapress.com
Page 1. ©2003 Marcel Dekker, Inc. All rights reserved. This material may
not be used or reproduced in any form without the express ...
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[BOOK] Mechanistic Toxicology
RA Barrios, U Boelsterli - 2003 - print.google.com
... 253 13. 1 . 1 . AHR-rnediated toxicity of polychlorinated dibenzodioxins, dibenzofurans,
and biphenyls 254 13.2. ... 263 13.3. 1 . PPARa-dependent toxicity 264 ...
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Genetic variability and evolution of two pharmacologically important classes of genes
MS Pungliya, BA Salisbury, K Nandabalan, JC … - Pharmacogenomics, 2004 - extenza-eps.com
... HUGO symbols Description AHR Aryl hydrocarbon receptor AR Androgen receptor ... cell
nuclear antigen PGR Progesterone receptor PPARA Peroxisome proliferative ...
Web Search - dx.doi.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions » - Get it from MIT Libraries

Large-scale collection and characterization of promoters of human and mouse genes - Full text - MIT Libraries
Y Suzuki, R Yamashita, M Shirota, Y Sakakibara, J … - Silico Biol, 2004 - iospress.metapress.com
... V$AFP1 Q6 AFP1 1 0.947 35 25 0 V$AHR 01 AhR 1 0.958 2 0 0 ... V$POU1F1 Q6 POU1F1 0.985
0.979 329 202 10 V$PPARA 01 PPARalpha/RXR-alpha 0.899 0.863 6 4 0 ...
Cited by 2 - Web Search - bioinfo.de - bioinfo.de - ncbi.nlm.nih.gov

4. Induction and inhibition of cytochrome P-450
O PELKONEN - ranf.com
... share ligands and thiazines, etc. target genes CYP4A Fibrates PPARa low
PPAR a levels in humans Page 12. tance may have affinity ...
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Xenobiotic Receptors in Fishes: Structural and Functional Diversity and Evolutionary Insights
ME Hahn, RR Merson, SI Karchner, ME Hahn, WHO … - whoi.edu
... includes the aryl hydrocarbon receptor (AHR), through which dioxins and
dioxin-like compounds cause ... AHR: aryl hydrocarbon (Ah) receptor AHRE ...
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Repression of CAR-Mediated Transactivation of CYP 2 B Genes by the Orphan Nuclear Receptor, Short …
Y Bae, JK Kemper, B Kemper - DNA and Cell Biology, 2004 - dx.doi.org
... SHP is also known to interactwith PPARa, TR, RXR, HNF- 4, ERa, and ERb in two ...
heterodimersas was shown for RAR/RXR (Seol et al., 1996) and AhR/Arnt (Klinge et ...
Cited by 4 - Web Search - liebertonline.com - liebertonline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Effects of environmental antiandrogens on reproductive development in experimental animals - Full text - MIT Libraries
LE Gray, J Ostby, J Furr, CJ Wolf, C Lambright, L … - Human Reproduction Update, 2001 - humupd.oupjournals.org
... but the mechanism of action likely involves interaction with a hormone-like nuclear
transcription factor, the hormone-like receptor AhR, rather than AR. ...
Cited by 59 - Web Search - ingentaconnect.com - oup.co.uk - ncbi.nlm.nih.gov - all 7 versions »

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... AAGTT not AAGT PPARA 01 PPAR/RXR heterodimers Core should be AAAGGT not
AAAG VMYB 02 v-Myb Core should be AACGG not AACG MYT1 01 ...
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Abstracts 101
BY LAPACHENOLE - taylorandfrancis.metapress.com
Page 1. ©2003 Marcel Dekker, Inc. All rights reserved. This material may
not be used or reproduced in any form without the express ...
Web Search - silver.he.net

Where is toxicology headed in the future
FP Guengerich - Drug Metab. Rev, 2004 - taylorandfrancis.metapress.com
... have simple and reasonably good ways to characterize molecules as AhR or PPAR ... of
novel peroxisome pro- liferator-activated receptor alpha (PPARa) target genes ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Justus-Liebig-Universitaet Giessen
DBB im Entwicklungsprozess - wiwi.uni-giessen.de
Page 1. Justus-Liebig-Universität Gießen Fachbereich Wirtschaftswissen
schaften Afrika - Der verlorene Kontinent? Die Bedeutung ...
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Research Article Carboxypeptidase E and thrombospondin-1 are differently expressed in subcutaneous …
JM Ramis, NLW Franssen-van Hal, E Kramer, I Llado, … - springerlink.com
Page 1. Research Article Carboxypeptidase E and thrombospondin-1 are differently
expressed in subcutaneous and visceral fat of obese subjects ...
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[BOOK] Bile Acids: From Genomics to Disease and Therapy
G Paumgartner, U Leuschner, D Keppler - 2003 - print.google.com
Page 1. Bile Acids: From Genomics to Disease and Therapy Page 2. • e ii iigu [uJ
vj•y4 Bile Acids: From Genomics to Disease and Therapy Edited by ...
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[BOOK] Handbook of Chemical Reactor Design, Optimization, and Scaleup
B Nauman, EB Nauman - 2001 - print.google.com
Page 1. CHEMICAL REACTOR DESIGN, OPTIMIZATION, AND SCALEUP iiii i[iiuirniuiiii
87ET-C7X-X9WP Page 2. CHEMICAL REACTOR DESIGN, OPTIMIZATION, AND SCALEUP ...
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[BOOK] Molecular Toxicology
N Plant - 2003 - print.google.com
... 70 5.3.2 Arsenic 71 5.4 Receptor-dependent toxicity 72 5.4.1 Aryl hydrocarbon receptor
(AhR) 72 5.4.2 N-methyl-D-aspartate receptor (NMDA) 74 5.5 Neurotoxicity ...
Cited by 1 - Web Search - Get it from MIT Libraries - Library Search

HSP90 FACTS & LITERATURE
HS PROTEIN - cgr.harvard.edu
... PPARa, along with XAP2 (Sumanasekera et al., 2003). ® Dioxin receptor (=AhR) (Denis
et al., 1988; Perdew, 1988), required for ligand regulation and DNA ...
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Methods of in vitro toxicology - Full text - MIT Libraries
G Eisenbrand, B Pool-Zobel, V Baker, M Balls, BJ … - Food and Chemical Toxicology, 2002 - ilsi.org
Page 1. Methods of in vitro toxicology G. Eisenbrand a , B. Pool-Zobel b ,
V. Baker c , M. Balls d , BJ Blaauboer e , A. Boobis f , ...
Cited by 21 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Distinguishing Adverse from Non-Adverse Effects in Drug Development
Toxicologic Pathology, 2002 - dx.doi.org
Page 1. T OXICOLOGIC P ATHOLOGY , vol 30, no 1, pp 41 – 53, 2002 Copyright
C 2002 by the Society of Toxicologic Pathology Distinguishing ...
Cited by 5 - ingentaconnect.com - ncbi.nlm.nih.gov - csa.com - Get it from MIT Libraries

Hepatic Temporal Gene Expression Profiling in Helicobacter hepaticus-Infected A/JCr Mice
S BOUTIN, A ROGERS, Z SHEN, R FRY, J LOVE, P … - Toxicologic Pathology, 2004 - dx.doi.org
Page 1. Toxicologic Pathology, 32:678–693, 2004 Copyright C by the Society
of Toxicologic Pathology ISSN: 0192-6233 print / 1533 ...
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Thursday, 8 thJuly
TAPANLM MODEL, OF HUMAN, G REGULATION - mdo2004.de
... Drug responsive nuclear receptors such as PPARa and PXR also exhibit species ... We produced
nrf2::ahr (dioxin receptor) double knockout mouse and proved unique ...
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TranSignal TM Protein/DNA Arrays
CS Version - panomics.com
Page 1. TranSignal TM Protein/DNA Arrays (Column Separation Version) Cat. #
MA1210, MA1211, MA1212l, MA1213 & MA1214, MA1215 Product ...
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Structural basis for preferential binding of non-ortho-substituted polychlorinated biphenyls by the …
JL Pellequer, WC Shu-wen, Y Keum, AE Karu, QX Li, … - doi.wiley.com
Page 1. JOURNAL OF MOLECULAR RECOGNITION J. Mol. Recognit. in press Published online
in Wiley InterScience (www.interscience.wiley.com). DOI:10.1002/jmr.740 ...
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