High-resolution mapping of a 130-kb core region of the MYCN amplicon in neuroblastomas - Full text - MIT Libraries
JL Reiter, GM Brodeur - Genomics, 1996 - ingentaconnect.com
... amplified in neuroblastomas probably contains little more than the MYCN gene ... The
exact price (including tax) will be displayed in your shopping cart before you ...
Cited by 18 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

HETEROGENEITY OF MYCN AMPLIFICATION IN A CHILD WITH STROMA-RICH NEUROBLASTOMA(GANGLIONEUROBLASTOMA)
AN Lorenzana, M Zielenska, P Thorner, B Gerrie, S … - Pediatric Pathology & Laboratory Medicine, 1997 - ingentaconnect.com
... determining MYCN amplification. ... The full text article is available for purchase.
$29.98. The exact price (including tax) will be displayed in your shopping cart ...
Cited by 7 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

MYCN-related suppression of functional CD44 expression enhances tumorigenic properties of human … - Full text - MIT Libraries
N Gross, K Balmas Bourloud, CB Brognara - Experimental Cell Research, 2000 - ingentaconnect.com
... the suppression of in vivo cell growth, therefore linking the MYCN-related lack ... exact
price (including tax) will be displayed in your shopping cart before you ...
Cited by 7 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

MYCN AMPLIFICATION IN MEDULLOBLASTOMA
V Jay, P Marrano, M Zielenska - Pediatric Pathology & Laboratory Medicine, 1998 - ingentaconnect.com
... two cases are of great interest, especially as they show MYCN amplification in ... exact
price (including tax) will be displayed in your shopping cart before you ...
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Evidence that the MYCN oncogene regulates MRP gene expression in neuroblastoma - Full text - MIT Libraries
MD Norris, SB Bordow, PS Haber, GM Marshall, M … - Eur J Cancer, 1997 - ingentaconnect.com
... Evidence that the MYCN oncogene regulates MRP gene expression in neuroblastoma.
Authors: Norris MD; Bordow SB; Haber PS 1 ; Marshall ...
Cited by 19 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Analysis of candidate gene co-amplification with MYCN in neuroblastoma - Full text - MIT Libraries
RE George, R Kenyon, AG McGuckin, N Kohl, P Kogner … - Eur J Cancer, 1997 - ingentaconnect.com
... Analysis of candidate gene co-amplification with MYCN in neuroblastoma. ... This implies
that several other genes may be present on the MYCN amplicon. ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Neuroblastoma cells can actively eliminate supernumerary MYCN gene copies by micronucleus formation … - Full text - MIT Libraries
IM Ambros, S Rumpler, A Luegmayr, CM Hattinger, S … - Eur J Cancer, 1997 - ingentaconnect.com
... Neuroblastoma cells can actively eliminate supernumerary MYCN gene copies
by micronucleus formation-sign of tumour cell revertance? ...
Cited by 11 - Web Search - ncbi.nlm.nih.gov

The requirement for evasion of programmed cell death in neuroblastomas with MYCN amplification - Full text - MIT Libraries
MD Hogarty - Cancer Letters, 2003 - ingentaconnect.com
... The requirement for evasion of programmed cell death in neuroblastomas with MYCN
amplification. Author: Hogarty MD 1. Source: Cancer Letters, 18 July 2003, vol. ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov

Activity of a 40 kDa RNA-binding protein correlates with MYCN and c-fos mRNA stability in human … - Full text - MIT Libraries
D Chagnovich, SL Cohn - Eur. J. Cancer, 1997 - ingentaconnect.com
... Activity of a 40kDa RNA-binding protein correlates with MYCN and c-fos mRNA stability
in human neuroblastoma. Authors: Chagnovich D.; Cohn SL 1. ...
Cited by 5 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

MYCN in neuronal tumours - Full text - MIT Libraries
M Schwab - Cancer Lett, 2004 - ingentaconnect.com
... MYCN in neuronal tumours. Author: Schwab M. 1. ... MYCN is a member of the MYC family
of oncogenes that encode nuclear proteins serving as transcription factors. ...
Cited by 5 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

… antigen, the target of cytotoxic natural human IgM: correlation to MYCN amplification and effects … - Full text - MIT Libraries
K David, A Ehrhardt, MW Ollert, R Erttmann, R … - Eur. J. Cancer, 1997 - ingentaconnect.com
... Expression of a 260kDa Neuroblastoma Surface Antigen, the Target of Cytotoxic Natural
Human IgM: Correlation to MYCN Amplification and Effects of Retinoic Acid. ...
Cited by 6 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Concomitant Amplif ication and Expression of PAX7-FKHR and MYCN in a Human Rhabdomyosarcoma Cell … - Full text - MIT Libraries
E Frascella, E Lenzini, BW Schafer, L Brecevic, E … - Cancer Genet Cytogenet, 2000 - ingentaconnect.com
... Concomitant Amplif ication and Expression of PAX7-FKHR and MYCN in a Human
Rhabdomyosarcoma Cell Line Carrying a Cryptic t(1;13)(p36;q14). ...
Cited by 4 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

The MYCN oncoprotein as a drug development target - Full text - MIT Libraries
X Lu, A Pearson, J Lunec - Cancer Lett, 2003 - ingentaconnect.com
... The MYCN oncoprotein as a drug development target. Authors: Lu X.; Pearson A.; Lunec
J. 1. Source: Cancer Letters, 18 July 2003, vol. 197, no. 1, pp. 125-130(6) ...
Cited by 2 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Clinical relevance of CD44 cell surface expression and MYCN gene amplification in neuroblastoma - Full text - MIT Libraries
V Combaret, N Gross, C Lasset, D Frappaz, C … - Eur J Cancer, 1997 - ingentaconnect.com
... Clinical relevance of CD44 cell surface expression and MYCN gene amplification
in neuroblastoma. Authors: Combaret V.; Gross N.; Lasset ...
Cited by 5 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Correlation of MYCN amplification, Trk-A and CD44 expression with clinical stage in 250 patients … - Full text - MIT Libraries
K Kramer, NK Cheung, WL Gerald, M LaQuaglia, BH … - Eur J Cancer, 1997 - ingentaconnect.com
... Correlation of MYCN amplification, Trk-A and CD44 expression with clinical
stage in 250 patients with neuroblastoma. Authors: Kramer ...
Cited by 3 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

MYCN gain and MYCN amplification in a stage 4s neuroblastoma - Full text - MIT Libraries
R Noguera, A Canete, A Pellin, A Ruiz, M Tasso, S … - Cancer Genet Cytogenet, 2003 - ingentaconnect.com
... MYCN gain and MYCN amplification in a stage 4S neuroblastoma. Authors: Noguera
R. 1 ; Canete A.; Pelln A.; Ruiz A.; Tasso M.; Navarro ...
Cited by 2 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

DAP-5 is involved in MycN/IFNgamma-induced apoptosis in human neuroblastoma cells - Full text - MIT Libraries
I Wittke, B Madge, R Wiedemeyer, A Kimchi, M … - Cancer Lett, 2001 - ingentaconnect.com
... DAP-5 is involved in MycN/IFN -induced apoptosis in human neuroblastoma cells. Authors:
Wittke I.; Madge B.; Wiedemeyer R.; Kimchi A.; Schwab M. 1. ...
Cited by 4 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Genes co-amplified with MYCN in neuroblastoma: silent passengers or co-determinants of phenotype? - Full text - MIT Libraries
D Scott, J Elsden, A Pearson, J Lunec - Cancer Lett, 2003 - ingentaconnect.com
... Genes co-amplified with MYCN in neuroblastoma: silent passengers or co-determinants
of phenotype? Authors: Scott D.; Elsden J.; Pearson A.; Lunec J. 1. ...
Cited by 3 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

HuD, a neuronal-specific RNA-binding protein, is a potential regulator of MYCN expression in human … - Full text - MIT Libraries
RA Ross, DL Lazarova, GT Manley, PS Smitt, BA … - European Journal of Cancer, 1997 - ingentaconnect.com
... HuD, a neuronal-specific RNA-binding protein, is a potential regulator of
MYCN expression in human neuroblastoma cells. Authors: Ross ...
Cited by 2 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Molecular cytogenetic characterization of two non-MYCN amplified neuroblastoma cell lines with … - Full text - MIT Libraries
CM McConville, S Dyer, SA Rees, ME Luttikhuis, DJ … - Cancer Genet Cytogenet, 2001 - ingentaconnect.com
... Molecular cytogenetic characterization of two non-MYCN amplified neuroblastoma
cell lines with complex t(11;17). Authors: McConville ...
Cited by 1 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Molecular genetic analysis of MYCN and DDX1 co-amplification in pediatric solid tumours - Full text - MIT Libraries
A Pandita, P Thorner, R Godbout, M Zielenska, J … - Cancer Genetics and Cytogenetics, 1996 - ingentaconnect.com
... Molecular genetic analysis of MYCN and DDX1 co-amplification in pediatric
solid tumours. Authors: Pandita A.; Thorner P.; Godbout ...
Web Search

Disseminated alveolar rhabdomyosarcoma with MYCN amplified HSR - Full text - MIT Libraries
M Jeison, I Skuratovsky, S Avigad, C Mor, R … - Cancer Genetics and Cytogenetics, 1996 - ingentaconnect.com
... Disseminated alveolar rhabdomyosarcoma with MYCN amplified HSR. ... Southern blot
hydribization of the tumor at diagnosis revealed >50 copies of MYCN. ...
Web Search

Assignment of human MYCN proto-oncogene to chromosome band 12q24 in higher primates - Full text - MIT Libraries
KH Ramesh, S Gupta, RS Verma - Gene, 1996 - ingentaconnect.com
... Assignment of human MYCN proto-oncogene to chromosome band 12q24 in higher
primates. Authors: Ramesh KH; Gupta S.; Verma RS 1. Source ...
Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

In vivo elimination of acentric double minutes containing amplified MYCN from neuroblastoma tumor … - Full text - MIT Libraries
A Valent, J Benard, B Clausse, M Barrois, D … - Am J Pathol, 2001 - ajp.amjpathol.org
... In Vivo Elimination of Acentric Double Minutes Containing Amplified MYCN from
Neuroblastoma Tumor Cells Through the Formation of Micronuclei. ...
Cited by 9 - Web Search - ajp.amjpathol.org - ncbi.nlm.nih.gov

The current contribution of molecular factors to risk estimation in neuroblastoma patients - Full text - MIT Libraries
F Berthold, K Sahin, B Hero, H Christiansen, M … - Eur J Cancer, 1997 - ingentaconnect.com
... The second step investigated whether molecular characteristics (MYCN, LOH 1p, del
1p, CD44, N-ras, NGF-R, bcl-2, APO-1 (CD95)) contributed additional ...
Cited by 26 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Loss of chromosome 1p may have a prognostic value in localised neuroblastoma: results of the French … - Full text - MIT Libraries
H Rubie, O Delattre, O Hartmann, V Combaret, J … - Eur J Cancer, 1997 - ingentaconnect.com
... In addition to the assessment of a new chemotherapy regimen in unresectable
neuroblastoma, we evaluated the prognostic significance of MYCN amplification and ...
Cited by 12 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

The neuroblastoma amplified gene, NAG: genomic structure and characterisation of the 7.3 kb …
DK Scott, JR Board, X Lu, ADJ Pearson, RM Kenyon, … - 2003 - ingentaconnect.com
... full text options. Abstract: Amplification of the MYCN oncogene in
neuroblastoma is associated with poor prognosis. The amplified ...
Cited by 4 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

The prognostic value of MDR1 gene expression in primary untreated neuroblastoma - Full text - MIT Libraries
M Haber, SB Bordow, PS Haber, GM Marshall, BW … - Eur J Cancer, 1997 - ingentaconnect.com
... malignancy, we examined the relationship between MDR1 expression and patient outcome
in subsets of 60 primary untreated neuroblastomas for which MYCN gene copy ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov

Chromosome 1p in Neuroblastoma: Suppressors and Prognosis - Full text - MIT Libraries
H Caron, P van Sluis, J de Kraker, J Bokkerink, M … - European Journal of Cancer, 1997 - ingentaconnect.com
... We evaluated the most frequent genetic abnormalities (MYCN amplification, LOH 1p,
4p, 11q, 14q, additional 17q) occurring in neuroblastoma for their prognostic ...
Web Search - ingentaconnect.com

Oncogene amplification in solid tumors - Full text - MIT Libraries
M Schwab - Semin Cancer Biol, 1999 - ingentaconnect.com
... MYCN has been the first oncogene found amplified in direct preparations of solid ...
exact price (including tax) will be displayed in your shopping cart before you ...
Cited by 60 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Detection of gene amplification in pediatric solid tumors using a simplified comparative genomic … - Full text - MIT Libraries
BG Beatty, PT Thorner, M Zielenska, J Bayani, A … - Cancer Genetics and Cytogenetics, 1995 - ingentaconnect.com
... A retinoblastoma (RB) cell line and 5 pediatric solid tumors known to contain an
amplification of the MYCN gene were used to test the consistency, specificity ...
Web Search

Patterns of oncogene activation in human neuroblastoma - Full text - MIT Libraries
R Corvi, M Schwab - Cancer Genetics and Cytogenetics, 1996 - ingentaconnect.com
... studies suggest that a multiplicity of genomic alterations contributes to the
development and progression of the tumour.Amplification of the MYCN proto-oncogene ...
Web Search - ingentaconnect.com

Interleukin-1 beta converting enzyme (ICE) is preferentially expressed in neuroblastomas with … - Full text - MIT Libraries
H Ikeda, Y Nakamura, T Hiwasa, S Sakiyama, K Kuida … - Eur J Cancer, 1997 - ingentaconnect.com
... ICE mRNA was expressed in 27 of 47 (57%) tumours without MYCN amplification, but
it was not detected in any tumours with MYCN amplification (P<0.01). ...
Cited by 7 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Yaf2 inhibits Myc biological function - Full text - MIT Libraries
B Madge, C Geisen, T Moroy, M Schwab - Cancer Letters, 2003 - ingentaconnect.com
... Abstract: The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC)
family, including MYC, MYCN and MYCL, encode nuclear proteins that act as ...
Cited by 1 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Telomerase activity in neuroblastoma: is it a prognostic indicator of clinical behaviour - Full text - MIT Libraries
E Hiyama, K Hiyama, K Ohtsu, H Yamaoka, T Ichikawa … - Eur J Cancer, 1997 - ingentaconnect.com
... To evaluate the correlation between telomerase activity and other biological
characteristics reported as prognostic markers (MYCN gene amplification, loss of ...
Cited by 26 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Application of Comparative Genomic Hybridization, Spectral Karyotyping, and Microarray Analysis in …
A Pandita, M Zielenska, P Thorner, J Bayani, R … - Neoplasia, 1999 - ingentaconnect.com
... was present in 6/12 alveolar tumors, and in each case, MYCN was amplified ... The exact
price (including tax) will be displayed in your shopping cart before you ...
Cited by 32 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genetic parameters of neuroblastomas - Full text - MIT Libraries
F Westermann, M Schwab - Cancer Lett, 2002 - ingentaconnect.com
... the cytogenetic and molecular level non-random genetic changes have been identified,
including ploidy changes, amplification of the oncogene MYCN, deletions of ...
Cited by 24 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Evolving significance of prognostic markers associated with new treatment strategies in … - Full text - MIT Libraries
J Mora, NKV Cheung, W Gerald - Cancer Lett, 2003 - ingentaconnect.com
... Among the biologic and clinical features analyzed including age, stage, histology,
ploidy, MYCN, and 1p36, 1p22, 11q, 14q, 9p and 19q loss of heterozygosity ...
Cited by 7 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Synergy between 5'and 3'flanking regions of the human tyrosine hydroxylase gene ensures specific, … - Full text - MIT Libraries
M Gardaneh, J Gilbert, M Haber, MD Norris, SL Cohn … - Neurosci Lett, 2000 - ingentaconnect.com
... We also show that TH mRNA expression level is closely linked to the expression level
of the proto-oncogene, MYCN in neuroblastoma tumor cell lines. ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov

Restriction fragment length polymorphism analysis reveals different allele frequency and a linkage … - Full text - MIT Libraries
P Perri, A Pession, K Mazzocco, P Scaruffi, P … - Eur J Cancer, 1997 - ingentaconnect.com
... full text options. Abstract: Deletion of chromosome 1p and MYCN amplification have
been reported as frequent abnormalities in human neuroblastoma. ...
Cited by 3 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Characterization of the gene expression profile of neuroblastoma cell line IMR-5 using serial … - Full text - MIT Libraries
M FISCHER, F BERTHOLD - Cancer Lett, 2003 - ingentaconnect.com
... The serial analysis of gene expression (SAGE) technique was used to generate a database
of the most abundant transcripts of the MYCN-amplified neuroblastoma ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

Expression of Apo-3 and Apo-3L in primitive neuroectodermal tumours of the central and peripheral … - Full text - MIT Libraries
A Eggert, MA Grotzer, TJ Zuzak, N Ikegaki, H Zhao, … - Eur J Cancer, 2002 - ingentaconnect.com
... We compared the level of expression with the well-established prognostic factors
age, stage, histology, MYCN-amplification and TrkA expression, as well as ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Genes Involved in Metastatic Dissemination and in Response to Chemotherapy in the Neuroblastoma IGR- … - Full text - MIT Libraries
J Da Silva, N Duarte, E Ferrandis, J Benard - European Journal of Cancer, 1997 - ingentaconnect.com
... Briefly, when the MYCN amplified neuroblastoma IGR-N-91 cell line was subcutaneously
xenografted into nude mice, malignant neuroblasts dissemination was ...
Web Search - ingentaconnect.com

der (11) t (11; 17): a distinct cytogenetic pathway of advanced stage neuroblastoma (NBL)–detected … - Full text - MIT Libraries
B Stark, M Jeison, L Glaser-Gabay, MJ Bar-Am I, S … - Cancer Letters, 2003 - ingentaconnect.com
... No MYCN amplification or 1p deletion (except one patient with 1p imbalance) were
found, while 3p deletion, and complex karyotypes were common. ...
Web Search - ncbi.nlm.nih.gov

Role of neurotrophins and their receptors in human neuroblastomas: a primary culture study - Full text - MIT Libraries
A Nakagawara, GM Brodeur - Eur J Cancer, 1997 - ingentaconnect.com
... Interestingly, a stage 4 tumour with MYCN amplification which expressed high level
of neuronal trk-A was dependent on nerve growth factor (NGF) for both ...
Cited by 17 - Web Search - ncbi.nlm.nih.gov

Coexpression of mRNA for the full-length neurotrophin receptor trk-C and trk-A in favourable … - Full text - MIT Libraries
T Svensson, M Ryden, FH Schilling, C Dominici, R … - Eur J Cancer, 1997 - ingentaconnect.com
... We conclude that favourable neuroblastoma may express the full-length trk-C receptor
while unfavourable tumours, especially those with MYCN amplification, seem ...
Cited by 10 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Pediatric neuroblastomas: genetic and epigenetic'Danse Macabre'
MM van Noesel, R Versteeg - 2004 - ingentaconnect.com
... Structural genetic defects such as amplification of MYCN, gain of chromosome 17q
and LOH of 1p and several other chromosomal regions have proven to be valuable ...
Cited by 10 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Expression and function of Trk-C in favourable human neuroblastomas - Full text - MIT Libraries
DJ Yamashiro, XG Liu, CP Lee, A Nakagawara, N … - Eur J Cancer, 1997 - ingentaconnect.com
... express the neurotrophin receptors trk-A and trk-B. Favourable outcome is associated
with expression of trk-A, while unfavourable, MYCN amplified tumours ...
Cited by 9 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Combined 24-color karyotyping and comparative genomic hybridization analysis indicates predominant … - Full text - MIT Libraries
G Schleiermacher, I Janoueix-Lerosey, V Combaret, … - Cancer Genet Cytogenet, 2003 - ingentaconnect.com
... Neuroblastoma is characterized by several distinct genetic alterations including
MYCN amplification, chromosome 1p deletion and gain of chromosome 17. ...
Cited by 9 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

10 years' neuroblastoma screening in Europe: preliminary results of a clinical and biological review … - Full text - MIT Libraries
R Erttmann, T Tafese, F Berthold, R Kerbl, J Mann, … - European Journal of Cancer, 1998 - ingentaconnect.com
... patients had localised NB and 17% were diagnosed with generalised NB (stage 4, 10%;
stage 4s, 7%). Unfavourable biological markers (MYCN amplification, loss of ...
Cited by 9 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »