Myc inhibits CCAAT/enhancer-binding protein a-gene expression in HIB-1B hibernoma cells through …
EJ Biochem - Eur. J. Biochem, 1995 - blackwell-synergy.com
... transcription machinery. Keywords: CCAAT/enhancer-binding protein a (CEBPa) ;
c-myc ; transcription factor ; HIB-1B ; initiator. ...
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Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia …
C Preudhomme, C Sagot, N Boissel, JM Cayuela, I … - BLOOD, 2002 - bloodjournal.org
... In this process, the negative regulation of c-Myc by C/EBP is a ... 6-8 In addition,
several silent CEBPA polymorphisms have been described, especially a frequent ...
Cited by 36 - Web Search - Get it from MIT Libraries

Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2
J Snaddon, ML Smith, M Neat, M Cambal-Parrales, A … - Genes Chromosomes Cancer, 2003 - doi.wiley.com
... genes such as MYC (Johansen et al., 2001) and RAS (Behre et al., 2002). These closely
coupled inter- actions may be disrupted not only by CEBPA mu- tation but ...
Cited by 15 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Loss of C/EBP {alpha} and Favorable Prognosis of Acute Myeloid Leukemias: A Biological Paradox - Full text - MIT Libraries
D Perrotti, G Marcucci, MA Caligiuri - Journal of Clinical Oncology, 2004 - dx.doi.org
... of c-Myc, an important step required for granulocytic differentiation [9,10]. Two
different groups of investigators have initially reported CEBPA mutations in ...
Cited by 2 - Web Search - jco.org - jco.org - ncbi.nlm.nih.gov - all 5 versions »

C/EBP< img border='0' src='/__chars/alpha/black/med/base/glyph. gif' align='bottom' alt='alpha'/> … - Full text - MIT Libraries
C Nerlov - Nature Reviews Cancer, 2004 - nature.com
... factors eIF-4E and eIF-2 in response to growth induction by c-myc. ... Dominant-negative
mutations of CEBPA, encoding CCAAT/enhancer binding protein- (C/EBP ), in ...
Cited by 4 - Web Search - nature.com - peo.cshl.org - ncbi.nlm.nih.gov

Loss of C/EBP and Favorable Prognosis of Acute Myeloid Leukemias: A Biological Paradox
AML Preudhomme… - Journal of Clinical Oncology, 2004 - jco.org
... 2548-2557, 2003 9. Johansen LM, Iwama A, Lodie TA, et al: c-Myc is a ... Pabst T, Mueller
BU, Zhang P, et al: Dominant-negative mutations of CEBPA, encoding CCAAT ...
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Aberrant regulation of translation initiation in tumorigenesis
M Stoneley, AE Willis - Curr Mol Med, 2003 - ingentaconnect.com
... the stimulation of this pathway with no alteration in c-myc mRNA levels ... chronic
myelogenous leukaemia partly through suppressing the translation of CEBPA mRNA. ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU. 1 - Full text - MIT Libraries
F Rosenbauer, K Wagner, JL Kutok, H Iwasaki, MM Le … - Nature Genetics, 2004 - nature.com
... Dominant negative mutations of CEBPA, encoding CCAAT/Enhancer Binding Protein-
(C/EBP ... PubMed | ChemPort |; Marcu, KB, Bossone, SA & Patel, AJ myc function and ...
Cited by 13 - Web Search - nature.com - ncbi.nlm.nih.gov - origin.www.nature.com

Gene regulation in rodent hepatocytes during development, differentiation and disease
KG XANTHOPOULOS, J MIRKOVITCH - European Journal of Biochemistry, 1993 - blackwell-synergy.com
... These include the hepato- cyte nuclear factors HNF-1, HNF-3 and HNF-4 as well
as certain members of the CEBP family (CEBPa and CEBPP) and DBP. ...
Cited by 34 - Web Search - ejbiochem.org - content.febsjournal.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid … - Full text - MIT Libraries
TJ Ley, PJ Minx, MJ Walter, RE Ries, H Sun, M … - Proc Natl Acad Sci US A, 2003 - pubmedcentral.nih.gov
... receptor tyrosine kinases (ie, FLT3 and c-KIT), targets of MAP kinases (NRAS, HRAS,
and KRAS), transcription factors (c-MYC, SPI1/PU.1, and CEBPA), and genes ...
Cited by 10 - Web Search - dx.doi.org - pnas.org - ncbi.nlm.nih.gov - all 6 versions »

AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t (8; 21) myeloid … - Full text - MIT Libraries
T Pabst, BU Mueller, N Harakawa, C Schoch, T … - Nat Med, 2001 - nature.com
... Several reports have described factors that repress CEBPA promoter activity,
such as SP1 (ref. 39), AP2A (ref. 40) or MYC (ref. 41). ...
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CIEBPP (NF-M) IS ESSENTIAL FOR THJ3 GROWTH ARREST-SPECIFIC TRANSCRIPTIONAL INDUCTION OF P20K
KIM SELENA - collectionscanada.ca
Page 1. CIEBPP (NF-M) IS ESSENTIAL FOR THJ3 GROWTH ARREST-SPECIFIC
TRANSCRIPTIONAL INDUCTION OF P20K SELENA KIM: A thesis submitted ...
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Holy BCR-ABL Fusion Protein! Is It Really Chronic Myelogenous Leukemia?
B Training - lfc.edu
... RNA binding protein that regulates transcription, including the transcription of
CEBPA RNA (14 ... two categories: those that drive apoptosis, such as c-myc and p53 ...
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BCR/ABL, mRNA translation and apoptosis - Full text - MIT Libraries
D Perrotti, F Turturro, P Neviani - Cell Death and Differentiation, 2005 - nature.com
... For example, hnRNP E2 and La regulate the translation of cebpa and mdm2 mRNA ... 99,
100 hnRNP K enhances c-myc transcription upon binding to a cis element in the c ...
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Evidence for allelic evolution of C/EBPalpha mutations in acute myeloid leukaemia - Full text - MIT Libraries
J Tiesmeier, A Czwalinna, C Muller-Tidow, J … - British Journal of Haematology, 2003 - blackwell-synergy.com
... TA, Sasaki, K., Felsher, DW, Golub, TR & Tenen, DG (2001) c-myc is a ... G., Hiddemann,
W. & Tenen, DG (2001) Dominant-negative mutations of CEBPA, encoding CCAAT ...
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The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of … - Full text - MIT Libraries
F D'Alo, LM Johansen, EA Nelson, HS Radomska, EK … - Blood, 2003 - bloodjournal.org
... on the c-Myc promoter, 20 the reduction of endogenous c-Myc may be ... Dominant negative
mutations of CEBPA, encoding CCAAT/Enhancer Binding Protein- (C/EBP ), in ...
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The emergence of aC/EBP mutation in the clonal evolution of MDS towards secondary AML
A Kaeferstein, U Krug, J Tiesmeier, M Aivado, M … - Leukemia, 2003 - nature.com
... 21 C-myc was recently identified as a crucial C/EBP target gene in myeloid
differentiation which is negatively regulated by the formation of a C/EBP /E2F-DP1 ...
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Molecular heterogeneity and prognostic biomarkers in adults with acute myeloid leukemia and normal …
G Marcucci, K Mrozek, CD Bloomfield - Current Opinion in Hematology, 2005 - co-hematology.com
... a recurring involvement of chromosome 21 and amplification of the MYC oncogene in ...
BU, Zhang P, et al.: Dominant-negative mutations of CEBPA, encoding CCAAT ...
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Gene Expression Profiling and Microarrays Gene expression profiling of leukemic cell lines reveals …
A Andersson, P Eden, D Lindgren, J Nilsson, C … - Leukemia, 2005 - nature.com
... pink), TRA@/MYC (dark green), P190 BCR/ABL1 (light blue), IGH@/MYC (yellow), TCF3 ...
Comparing AML and ALL, we identified CEBPA, a myeloid transcription factor of ...
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Signal Transducers and Activators of Transcription 3 Augments the Transcriptional Activity of CCAAT/ … - Full text - MIT Libraries
A Numata, K Shimoda, K Kamezaki, T Haro, H … - J Biol Chem, 2005 - jbc.org
... E) or by G-CSF stimulation with 4-HT or vehicle in 32Dcl3/DNStat3/CEBPA cells (B ...
that repress C/EBP promoter activity, such as SP1 (27), AP2A (28), or MYC (29). ...
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Disruption of differentiation in human cancer: AML shows the way - Full text - MIT Libraries
DG Tenen - Nature Reviews Cancer, 2003 - nature.com
1. Nichols, J. & Nimer, SD Transcription factors, translocations, and leukemia.
Blood 80, 2953-2963 (1992). | PubMed | ISI | ChemPort |. 2. ...
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Chromosome localization analysis of genes strongly expressed in human visceral adipose tissue
YS Yang, HD Song, WJ Shi, RM Hu, ZG Han, JL Chen - Endocrine, 2002 - journals.humanapress.com
... CCAAT/ enhancer-binding protein alpha (CEBPA) (#349) gene was mapped to 19q13.12.
Discussion ... 369 S100 calcium-binding protein A8 n 374 c-myc-binding protein y ...
Cited by 4 - Web Search - biomed.humanapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Transforming Growth Factor f5 Modulates Growth and Differentiation of Fetal Hepatocytes in Primary …
A SANCHEZ, AM ALVAREZ, M BENITO, I FABRECAT - doi.wiley.com
... albumin, AFP, haptoglobin, fibronec- tin, and 18s ribosomal cDNA) or by random priming
reaction (c-myc, v-fos, H-ras, HNFla, HNFlP, CEBPa, CEBPP, and CEBPG). ...
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Progress in Hematology
S Koschmieder, F Rosenbauer, U Steidl, BM Owens, … - Int J Hematol, 2005 - cardenjennings.metapress.com
... CEBPA [16,25,86] Hematopoietic cells (HSCs, CMPs, Lack of granulocytes, Same as ...
monocytes), impaired monocytes, increased HSC self-renewal G-CSFR, E2F, c-myc ...
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CCAAT/Enhancer Binding Protein Homologous Protein (DDIT3) Induces Osteoblastic Cell Differentiation - Full text - MIT Libraries
RC Pereira, AM Delany, E Canalis, CT Farmington, C … - Endocrinology, 2004 - endo.endojournals.org
... fragment containing the coding region of the murine Chop/Ddit3 gene, with myc cDNA
sequences ... Chop/Ddit3 cDNA (provided by D. Ron), a 1.8-kb rat Cebpa cDNA, 1.5 ...
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Loss of C/EBP {alpha} cell cycle control increases myeloid progenitor proliferation and transforms … - Full text - MIT Libraries
BT Porse, D Bryder, K Theilgaard-Moench, MS … - J Exp Med, 2005 - jem.org
... 2003. Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2. Genes
Chromosomes Cancer. ... 2001. c-Myc is a critical target for C/EBP in granulopoiesis. ...
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Down-Regulation and Growth Inhibitory Role of C/EBP {alpha} in Breast Cancer - Full text - MIT Libraries
S Gery, S Tanosaki, S Bose, N Bose, J Vadgama, HP … - Clinical Cancer Research, 2005 - clincancerres.aacrjournals.org
... Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-
(C/EBP ), in acute myeloid ... c-Myc is a critical target for c/EBP in granulopoiesis ...
Web Search - clincancerres.aacrjournals.org - ncbi.nlm.nih.gov

The effects of Bcr-Abl on C/EBP transcription-factor regulation and neutrophilic differentiation are … - Full text - MIT Libraries
C Schuster, K Forster, H Dierks, A Elsaesser, G … - Blood, 2003 - bloodjournal.org
... This could be correlated to a defect in c-Myc down-regulation. ... 23. Bcr-Abl
reversibly blocks c-Myc down-regulation upon G-CSF stimulation. ...
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Genomic approaches for reconstructing gene networks
NH Lee - Pharmacogenomics, 2005 - futuremedicine.com
... The general study design involved the perturbation of mammalian or yeast cells by
either knockout (MYC, tup1) or ectopic overexpression (MYC, mad) of a tran ...
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Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT … - Full text - MIT Libraries
DE Zhang, P Zhang, ND Wang, CJ Hetherington, GJ … - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... page, J Clin Oncol Home page S. Frohling, RF Schlenk, I. Stolze, J. Bihlmayr, A.
Benner, S. Kreitmeier, K. Tobis, H. Dohner, and K. Dohner CEBPA Mutations in ...
Cited by 353 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

G ENETIC P ROFILE OF A CUTE M YELOID L EUKEMIA - Full text - MIT Libraries
C Mecucci, R Rosati, R La Starza - Reviews in Clinical & Experimental Hematology, 2002 - blackwell-synergy.com
... T) with complex karyotype and dmin, molecular investigation identified
overrepresentation of 9p and 11q23 regions but not amplification of C-MYC or MLL ... ...
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Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic … - Full text - MIT Libraries
C Muller-Tidow, B Steffen, T Cauvet, L Tickenbrock … - Mol. Cell. Biol, 2004 - pubmedcentral.nih.gov
... of plakoglobin by AML fusion proteins led to downstream signaling and transactivation
of TCF- and LEF-dependent promoters, including the c-myc promoter, which ...
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AML 1-ETO downregulates the granulocytic differentiation factor C/EBP< img border='0' src='/__chars/ … - Full text - MIT Libraries
T Pabst, BU Mueller, N Harakawa, C Schoch, T … - Nature Medicine, 2001 - nature.com
... Dominant negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-
(C/EBP ), in ... Bister, K. & Klempnauer, KH A novel function for Myc: inhibition of ...
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Transcriptional Repression of the Neurofibromatosis-1 Tumor Suppressor by the t (8; 21) Fusion …
G Yang, W Khalaf, L van de Locht, JH Jansen, M Gao … - mcb.asm.org
... GAPDH and c-Myc were used as controls. ... Although we did not focus on C/EBP , mutations
in CEBPA are associated with the M2 subgroup of AML (49, 53). ...
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A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... 2 MINI20 B Muscle initiator sequence-20 MUSCLE INI B Muscle initiator NF1 Q6 Nuclear
factor 1 NFAT Q6 Nuclear factor of activated T-cells NMYC 01 N-Myc OCT1 02 ...
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CCAAT/enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia - Full text - MIT Libraries
BT Truong, YJ Lee, TA Lodie, DJ Park, D Perrotti, … - Blood, 2003 - bloodjournal.org
... These results in RA-sensitive and RA-resistant leukemias show that expression of
retroviruses containing CEBPA or CEBPE cDNAs can suppress the leukemic ...
Cited by 17 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Novel transcription factors in human CD34 antigen-positive hematopoietic cells - Full text - MIT Libraries
I Gomes, TT Sharma, S Edassery, N Fulton, BG Mar, … - Blood, 2002 - bloodjournal.org
... 3 29.5 H PC Hs.7647 MAZ MYC-associated zinc finger protein (purine-binding
transcription factor) 16p11.2 27.3 H W Hs.29417 ZF HCF ...
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Effect of transcription-factor concentrations on leukemic stem cells - Full text - MIT Libraries
F Rosenbauer, S Koschmieder, U Steidl, DG Tenen - Blood, 2005 - bloodjournal.org
... Additional secondary mutations, such as c-myc overexpression because of genomic ...
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein ...
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Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific … - Full text - MIT Libraries
M Mizuki, J Schwable, C Steur, C Choudhary, S … - Blood, 2003 - bloodjournal.org
... has direct antiproliferative effects by inhibition of cdk2 and cdk4 function, 44 ,
45 repression of E2F transcription factors, 46 and down-regulation of c-myc. ...
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Cytogenetics in Acute Myeloid Leukemia - Full text - MIT Libraries
C Schoch, T Haferlach - Current Science, 2002 - current-reports.com
Cited by 8 - Web Search - current-reports.com - biomedcentral.com - ncbi.nlm.nih.gov

Development of a murine hematopoietic progenitor complementary DNA microarray using a subtracted … - Full text - MIT Libraries
X Ma, T Husain, H Peng, S Lin, O Mironenko, N Maun … - Blood, 2002 - bloodjournal.org
... Transcription factors/DNA binding proteins Cbfb Core binding factor — 0.9 0.2
Cebpa-rs1 Transcription regulator related to C/ebp 0.9 0.3 — ...
Cited by 6 - Web Search - info.med.yale.edu - dx.doi.org - ncbi.nlm.nih.gov - all 8 versions »

Interfering with Cancer: A Brief Outline of Advances in RNA Interference in Oncology - Full text - MIT Libraries
PD Rye, T Stigbrand, ASA Axis Shield, N Oslo, PD … - Tumor Biology, 2004 - content.karger.com
... T, Mueller BU, Zhang P, et al: Dominant negative mutations of CEBPA, encoding CCAAT ...
M, De- veraux QL, Quon KC: Synthetic lethal target- ing of MYC by activation ...
Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

Large-scale transcriptional profiling of murine mammary development.
SR Master, LA Chodosh - Breast Disease, 2004 - iospress.metapress.com
... For example, many adipocyte markers, including Cebpa, Ap2, Fsp27, Adrb3, Lep, and ...
by up- regulationof transducersof proliferativesignals (egc- myc) along with ...
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Research Paper
R Papoian, A Scherer, M Saulnier, F Staedtler, A … - springerlink.com
Page 1. : Research Paper VeloceGenomics: An Accelerated in Vivo Drug Discovery
Approach to Rapidly Predict the Biologic, Drug-Like ...
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Predicting the effect of transcription therapy in hematologic malignancies
A Melnick - Leukemia, 2005 - nature.com
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Please read our explanation of accessible NPG websites. ...
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Validating computer programs for functional genomics in gene regulatory regions
L Florea, M Li, C Riemer, B Giardine, W Miller, R … - Current Genomics, 2000 - ingentaconnect.com
... (CEBPA) promoter ... Additional elements of the murine promoter are the Myc/Max binding
site overlapping the USF binding site, and a cis-acting element with binding ...
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Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a … - Full text - MIT Libraries
S Koschmieder, B Goettgens, P Zhang, J Iwasaki- … - Blood, 2005 - bloodjournal.org
... AAG AAG TCG GTG GAC; CEBPA reverse, 5'-CTT TAT CTC GGC TCT TGC GC; CEBPA probe,
5 ... of DNA break repair, as described in a similar inducible model of myc-induced T ...
Cited by 3 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

EFFECTIVE USE OF WEB-BASED PUBLIC GENOMIC DATABANKS FOR AUTOMATIC AND UPDATED PERSONAL ANNOTATIONS …
M Masseroli, A Stella, GE Carrara, M Mazzarani, M … - bioinformatics.polimi.it
... I CCAAT/enhancer binding protein (C/EBP), alpha CEBPA X I CCAAT/enhancer binding
protein (C/EBP), beta CEBPB X X ... I N-myc downstream regulated gene 1 1 NDRG X ...
Web Search - medinfopoli.polimi.it - bioinformatics.polimi.it - medinfopoli.polimi.it

A Novel Temporal Expression Pattern of Three C/EBP Family Members in Differ entia ti ng My el om … - Full text - MIT Libraries
IO SubmittedApnl - Blood, 1992 - bloodjournal.org
... Fig lB, bottom panel). Protein Page 3. ClEBP EXPRESSION IN MYELOID CELLS
1727 A CEBPa 4- I "d. I 68 kd 42kd 42kd Fig 1. Expression ...
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Characterization of three transcriptional repressor sites within the 3′ untranslated region of the …
P Conception, AE SIMAR-BLANCHET, RO Hyo-Sung, LE … - Eur. J. Biochem, 1998 - blackwell-synergy.com
... In this study, we inhibited by anti-CEBPA. However, the interaction of C/EBPA ... 28,
965 974. nuclear protein named SILBF [12], a c-myc oncogene proximal ...
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