AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t (8; 21) myeloid … - Full text - MIT Libraries
T Pabst, BU Mueller, N Harakawa, C Schoch, T … - Nat Med, 2001 - nature.com
... luciferase vector ptk81-luc 44 ) and 20 ng of expression vector (human CEBPA or
RUNX1–CBF2T1 in the pcDNA3neo vector (InVitrogen, San Diego, California). ...
Cited by 89 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2
J Snaddon, ML Smith, M Neat, M Cambal-Parrales, A … - Genes Chromosomes Cancer, 2003 - doi.wiley.com
... Recent studies, however, have de- scribed both the down-regulation of C/EBP by the
RUNX1-CBFA2T1 fusion protein and CEBPA mutations in patients with AML FAB ...
Cited by 15 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Development of a human acute myeloid leukaemia screening panel and consequent identification of …
ML Smith, R Arch, LL Smith, N Bainton, M Neat, C … - ingentaconnect.com
... Fig 2. Occurrence of mutation in relation to cytogenetic risk group: the six genes
(FLT3, KIT, PTPN11, CEBPA, RUNX1 and NRAS) evaluated are detailed on the y ...
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Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in … - Full text - MIT Libraries
T Pabst, BU Mueller, P Zhang, HS Radomska, S … - Nat Genet, 2001 - nature.com
... of RUNX1 (previously AML1) in 8 of 160 leukemia patients 22 . We identified five
patients with an N-terminal truncation of the full-length, 42-kD CEBPA form ...
Cited by 137 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Further evidence that germline CEBPA mutations cause dominant inheritance of acute myeloid leukaemia …
GS Sellick, HE Spendlove, D Catovsky, K Pritchard- … - Leukemia, 2005 - nature.com
... Loci other than 21q22.12 (RUNX1) and 16q21–23.2 cause familial AML ... 6. Leroy H, Roumier
C, Huyghe P, Biggio V, Fenaux P, Preudhomme C. CEBPA point mutations in ...
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The leukemic fusion gene AML 1-MDS 1-EVI 1 suppresses CEBPA in acute myeloid leukemia by activation … - Full text - MIT Libraries
D Helbling, BU Mueller, NA Timchenko, A Hagemeijer … - Proceedings of the National Academy of Sciences - pnas.org
... Chromosomal abnormalities affecting AML1B/RUNX1, one of the two subunits of the
transcription factor CBF, have been shown to suppress CEBPA transcription (32). ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

… Leukemia with Deletion 9q within a Noncomplex Karyotype Is Associated with CEBPA Loss-of-Function …
W Van Doorn-Khosrovani… - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
... by other mechanisms in these AML subtypes: in t(8;21)- and in inv(16)/t(16;16)-
positive AML, CEBPA expression is down-regulated by the RUNX1–CBFA2T1 and the ...
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[CITATION] Disruption of C/EBP {alpha} Function in Acute Myeloid Leukemia
S Froehling, H Doehner
... of RUNX1 (ie, the RUNX1 protein produced by the remaining normal gene is not sufficient
for normal function of the protein). The heterozygous CEBPA mutation in ...
Web Search - content.nejm.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

[CITATION] Disruption of C/EBPa Function in Acute Myeloid Leukemia
S Froehling, H Doehner
Web Search

… calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with … - Full text - MIT Libraries
D Helbling, BU Mueller, NA Timchenko, J Schardt, M … - Blood, 2005 - bloodjournal.org
... the t(8;21) rearrangement the N-terminal of AML1/RUNX1 is fused ... ETO fusion suppresses
the transcription factor CCAAT/enhancer-binding protein (CEBPA) and that ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

… of CEBPA Mutations in Acute Myeloid Leukemia: Most Patients with CEBPA Mutations Have Biallelic … - Full text - MIT Libraries
LI Lin, CY Chen, DT Lin, W Tsay, JL Tang, YC Yeh, … - Clinical Cancer Research, 2005 - clincancerres.aacrjournals.org
... Runx1, c-Myb, and C/EBP couple differentiation to proliferation or growth ...
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein- ( ...
Web Search - clincancerres.aacrjournals.org - ijp-online.com - ncbi.nlm.nih.gov

[CITATION] Mutation of CEBPAin Familial Acute Myeloid Leukemia - Full text - MIT Libraries
ML Smith, JD Cavenagh, TA Lister, J Fitzgibbon - N Engl J Med, 2004
... been identified both in RUNX1 and in CEBPA, the gene that encodes CCAAT enhancer
binding protein a (C/EBPa) in sporadic, nonfamilial AML. 2,3 ...
Web Search - dx.doi.org - ncbi.nlm.nih.gov

Epigenetic regulation of tumor suppressors in t (8: 21)-containing AML - Full text - MIT Libraries
G Yang, W Khalaf, L van de Locht, JH Jansen, BA … - Annals of Hematology, 2004 - springerlink.com
... 1). RUNX1-MTG8 repression of NF1 stimulates RAS- dependent signaling to stimulate ...
W, Tenen DG (2001) Dominant-negative mutations of CEBPA, encoding CCAAT ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Research Paper Development of a human acute myeloid leukaemia screening panel and consequent … - Full text - MIT Libraries
ML Smith, R Arch, LL Smith, N Bainton, M Neat, C … - British Journal of Haematology, 2005 - blackwell-synergy.com
... Nine (5%) mutations were found in the transcription factor RUNX1. As with CEBPA,
the majority of mutations occurred in patients with normal cytogenetics (six ...
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A leukemogenic twist for GATA 1 - Full text - MIT Libraries
AT Look - Nature Genetics, 2002 - nature.com
... The resultant RUNX1 fusion proteins contribute to either myeloid or lymphoid ... previously
identified in acute myeloid leukemias involving CEBPA, which encodes ...
Cited by 2 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Development of a human acute myeloid leukaemia screening panel and consequent identification of … - Full text - MIT Libraries
ML Smith, R Arch, LL Smith, N Bainton, M Neat, C … - British Journal of Haematology, 2005 - ncbi.nlm.nih.gov
... Analysis was performed on six genes known to be mutated in AML (RUNX1, FLT3, KIT,
CEBPA, PTPN11 and NRAS) and an additional two candidate genes (CCND3 and FES ...
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A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid … - Full text - MIT Libraries
TJ Ley, PJ Minx, MJ Walter, RE Ries, H Sun, M … - Proc Natl Acad Sci US A, 2003 - pubmedcentral.nih.gov
... one M2 patient each. No priority 1 changes were found in the genes encoding
CBFB, AML-1/RUNX1, CEBPA, HRAS, KRAS, or SPI1/PU.1. ...
Cited by 10 - Web Search - dx.doi.org - pnas.org - ncbi.nlm.nih.gov - all 6 versions »

Drug therapy for acute myeloid leukemia - Full text - MIT Libraries
MS Tallman, DG Gilliland, JM Rowe - Blood, 2005 - bloodjournal.org
... differentiation and are potential targets for therapy are listed in Table 3 and
may involve the hematopoietic transcription factors RUNX1, GATA-1, CEBPA, and PU ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Gene Expression Profiling and Microarrays Gene expression profiling of leukemic cell lines reveals …
A Andersson, P Eden, D Lindgren, J Nilsson, C … - Leukemia, 2005 - nature.com
... with RUNX1/CBFA2T1 failed to segregate with the two RUNX1/CBFA2T1-positive cell ...
Comparing AML and ALL, we identified CEBPA, a myeloid transcription factor of ...
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SHORT REPORT Absence of SCL mutations in myeloid malignancies - Full text - MIT Libraries
E Delabesse, J Li, S Schnittger, W Hiddemann, AR … - British Journal of Haematology, 2003 - blackwell-synergy.com
... RUNX1 is essential for murine definitive haematopoiesis and mutations in its ... CEBPA
plays a central role in granulocyte differentiation and acquired mutations ...
Web Search - ncbi.nlm.nih.gov

Absence of SCL mutations in myeloid malignancies - Full text - MIT Libraries
G Munich - British Journal of Haematology, 2003 - ingentaconnect.com
... RUNX1 is essential for murine definitive haematopoiesis and mutations in its ... CEBPA
plays a central role in granulocyte differentiation and acquired mutations ...
Web Search

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the … - Full text - MIT Libraries
Y Yuan, L Zhou, T Miyamoto, H Iwasaki, N Harakawa, … - Mol. Cell. Biol, 2004 - dx.doi.org
... A. Benner, S. Kreitmeier, K. Tobis, H. Dohner, and K. Dohner CEBPA Mutations in ...
Postlethwait, MR Vitas, AM Baas, PS Crosier, and KE Crosier Runx1 is required ...
Cited by 81 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Disruption of differentiation in human cancer: AML shows the way - Full text - MIT Libraries
DG Tenen - Nature Reviews Cancer, 2003 - nature.com
... 15. Huang, G. et al. Dimerization with PEBP2 protects RUNX1/AML1 from
ubiquitin-proteasome-mediated degradation. EMBO J. 20, 723-733 (2001). ...
Cited by 66 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Transcriptional Repression of the Neurofibromatosis-1 Tumor Suppressor by the t (8; 21) Fusion …
G Yang, W Khalaf, L van de Locht, JH Jansen, M Gao … - mcb.asm.org
... those observed previously for p14 ARF or CEBPA (39, 52). Given the multitude of
data indicating that NF1 is a direct transcriptional target of RUNX1-MTG8 (Fig. ...
Web Search - mcb.asm.org

ORIGINAL PAPER ES02. 01 Transcriptional regulation of haematopoiesis - Full text - MIT Libraries
B Goettgens - Vox Sanguinis, 2004 - blackwell-synergy.com
... The knock-out phenotypes for runx1 and cbf are very similar, consistent with the ...
G, Hiddemann W, Tenen DG: Dominant-negative mutations of CEBPA, encoding CCAAT ...
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Transcriptional regulation of haematopoiesis - Full text - MIT Libraries
B Goettgens - Vox Sanguinis, 2004 - ingentaconnect.com
... The knock-out phenotypes for runx1 and cbfβ are very similar, consistent with ... G,
Hiddemann W, Tenen DG: Dominant-negative muta- tions of CEBPA, encoding CCAAT ...
Web Search

Absence of somatic mutations within the Runt domain of AML2/RUNX3 in acute myeloid leukaemia
EP Sequence - Leukemia, 2003 - nature.com
... of RUNX2/AML3 is restricted to osteochon- drogenic tissue, RUNX1/AML1 and ...
Dominant-negative mutations of CEBPA, encoding CCAAT/ enhancer binding protein-alpha ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping … - Full text - MIT Libraries
A Puig-Kroger, T Sanchez-Elsner, N Ruiz, EJ Andreu … - Blood, 2003 - bloodjournal.org
... The CD11a promoter directs CD11a/CD18 integrin expression, and its activity in lymphoid
cells depends on a functional RUNX1/AML-1–binding site (AML-110 ...
Cited by 1 - Web Search - weizmann.ac.il - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related … - Full text - MIT Libraries
H Harada, Y Harada, H Tanaka, A Kimura, T Inaba - Blood, 2003 - bloodjournal.org
... A good example is AML1/RUNX1/CBFA2, which encodes a component of the ... Mutations of
the CEBPA gene, which encodes the transcription factor CCAAT/enhancer binding ...
Cited by 15 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

research paper Novel loss-of-function mutations of the haematopoiesis-related transcription factor, …
M Nakao, S Horiike, Y Fukushima-Nakase, M … - blackwell-synergy.com
... AML1/RUNX1, which encodes a transcription factor essential for definitive
haematopoiesis, is a frequent target of leukaemia-associated chromosome translocations ...
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Novel loss-of-function mutations of the haematopoiesis-related transcription factor, acute myeloid … - Full text - MIT Libraries
M Nakao, S Horiike, Y Fukushima-Nakase, M … - Br J Haematol, 2004 - ingentaconnect.com
... Acute myeloid leukaemia 1 (AML1; also known as runt-related transcription factor
1: RUNX1) was first cloned from the chromosome 21 breakpoint for the ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related …
SS Heading, H Harada, Y Harada, H Tanaka, A Kimura … - bloodjournal.org
... A good example is AML1/RUNX1/CBFA2, which encodes a component of the AML1-core ...
monoallelic at the somatic level. Mutations of the CEBPA gene, which encodes the ...
Web Search

Progress in Hematology
S Koschmieder, F Rosenbauer, U Steidl, BM Owens, … - Int J Hematol, 2005 - cardenjennings.metapress.com
... hypomorphic mice CEBPA [16,25,86] Hematopoietic cells (HSCs, CMPs, Lack of
granulocytes, Same as for knock-out plus M-CSFR, GM-CSFR, GMPs ...
Web Search

Genomic approaches for reconstructing gene networks
NH Lee - Pharmacogenomics, 2005 - futuremedicine.com
Page 1. 10.1517/14622416.6.3.245 © 2005 Future Medicine Ltd ISSN 1462-2416
Pharmacogenomics (2005) 6(3), 245-258 245 R EVIEW For ...
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Loss of C/EBP {alpha} cell cycle control increases myeloid progenitor proliferation and transforms … - Full text - MIT Libraries
BT Porse, D Bryder, K Theilgaard-Moench, MS … - J Exp Med, 2005 - jem.org
... generally required for definitive hematopoiesis, including AML1/Runx1 and GATA ... our
observations strongly support the etiological relevance of cebpa mutations in ...
Cited by 1 - Web Search - jem.org

G ENETIC P ROFILE OF A CUTE M YELOID L EUKEMIA - Full text - MIT Libraries
C Mecucci, R Rosati, R La Starza - Reviews in Clinical & Experimental Hematology, 2002 - blackwell-synergy.com
... CEBPA. ... The CEBPA gene is translated into two proteins, a 42-kDa full-length form
and a 30-kDa form lacking the N-terminal first transactivation domain (123). ...
Cited by 4 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

G ENETICS OF M YELOID L EUKEMIAS - Full text - MIT Libraries
LM Kelly, DG Gilliland - Annual Review of Genomics and Human Genetics, 2002 - genom.annualreviews.org
... CBF is a heterodimeric transcription factor composed of a DNA-binding component,
AML1 (also known by the HUGO designation RUNX1, CBFA2, and PEBP2A), and the ...
Cited by 35 - Web Search - 128.194.251.107 - fluid.annualreviews.org - ncbi.nlm.nih.gov - all 5 versions »

Molecular cytogenetics in haematological malignancy: current technology and future prospects
LKSW Horsley - Chromosoma - springerlink.com
... found in a high proportion of patients, and confirmed to involve MLL and RUNX1
amplification ... be the case in one patient who was homo- zygous for a CEBPA mutation ...
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Pathogenesis of acute myeloid leukaemia and inv (16)(p 13; q 22): a paradigm for understanding … - Full text - MIT Libraries
JT Reilly - British Journal of Haematology, 2005 - blackwell-synergy.com
... is a family of heterodimeric transcription factors containing a common subunit
(CBF ) and one of three CBF subunits, CBF 1, AML1 (also known as RUNX1 or CBF 2 ...
Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7
SE Langabeer, RE Gale, SJ Rollinson, GJ Morgan, DC … - Genes Chromosomes Cancer, 2002 - doi.wiley.com
... INTRODUCTION The AML1 (CBFA2/RUNX1) gene is a member of the runt family of genes
that is involved in the transcriptional regulation of normal hemopoiesis and ...
Cited by 18 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

AML1 interconnected pathways of leukemogenesis
J Michaud, HS Scott, R Escher - Cancer Invest, 2003 - taylorandfrancis.metapress.com
... AML1, also called CBFa2, PEBPa2 or RUNX1, is thus implicated in a great number of
acute leukemias via a variety of pathogenic mechanisms and seems to act ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Phosphorylation of C/EBP {alpha} inhibits granulopoiesis - Full text - MIT Libraries
SE Ross, HS Radomska, B Wu, P Zhang, JN Winnay, L … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... For instance, AML is frequently caused by a translocation that gives rise to
a fusion protein of RUNX1 and CBF2T1 (also known as AML-ETO). ...
Cited by 7 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Molecular Mechanisms of Myelodysplastic Syndrome - Full text - MIT Libraries
H Hirai - Japanese Journal of Clinical Oncology, 2003 - jjco.oupjournals.org
... AML1 gene The AML1 (Runx1) gene encoding the heterodimeric transcription factor ...
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein ...
Cited by 5 - Web Search - jjco.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Molecular pathogenesis of MDS
H Hirai - Int J Hematol, 2002 - haem.nus.edu.sg
... The AML1 (Runx1) gene encoding the heterodimeric transcription factor, which binds
to DNA through the Runt domain, is frequently involved in chromosomal ...
Cited by 3 - View as HTML - Web Search - ishapd.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Gene expression profiling of pediatric acute myelogenous leukemia - Full text - MIT Libraries
ME Ross, R Mahfouz, M Onciu, HC Liu, X Zhou, G … - Blood, 2004 - bloodjournal.org
Institution: Google Indexer Sign In as Individual. Blood, 1 December 2004,
Vol. 104, No. 12, pp. 3679-3687. Prepublished online as ...
Cited by 8 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov

Novel transcription factors in human CD34 antigen-positive hematopoietic cells - Full text - MIT Libraries
I Gomes, TT Sharma, S Edassery, N Fulton, BG Mar, … - Blood, 2002 - bloodjournal.org
... 13.7 I W Hs.129914 RUNX1 Runt-related transcription factor 1 (acute myeloid
leukemia 1; aml1 oncogene) 21q22.3 13.6 I W Hs.247433 ...
Cited by 3 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »