Transcriptional repression of E2F gene by proteasome inhibitors in human osteosarcoma cells. - Full text - MIT Libraries
JH Lim, YC Chang, YB Park, JW Park, TK Kwon - Biochem Biophys Res Commun, 2004 - ncbi.nlm.nih.gov
Biochem Biophys Res Commun. 2004 Jun 11;318(4):868-72. ... Interestingly, the expression
levels of E2F1 and E2F2 are down-regulated by proteasome inhibitors. ...
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Identification of positively and negatively acting elements regulating expression of the E2F2 gene … - Full text - MIT Libraries
R Sears, K Ohtani, JR Nevins - Mol. Cell. Biol, 1997 - mcb.asm.org
... factors initially identified as oncogenic pro- teins including Fos, Jun, and Myc.
The experiments we present here demonstrate that the E2F2 gene is subject to ...
Cited by 86 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

B7-1 beyond the immune system - Full text - MIT Libraries
JC Invest - J. Clin. Invest, 2004 - jci.org
... syndrome Jochen Reiser, Gero von Gersdorff, Martin Loos, Jun Oh, Katsuhiko ... Diabetes
and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice ...
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Coordinated regulation of life and death by RB - Full text - MIT Libraries
BN Chau, JYJ Wang - Nature Reviews Cancer, 2003 - nature.com
... E2f3-knockout mice, this study showed that E2f1, but not E2f2 or E2f3 ... Rb protein
down-regulates the stress-activated signals through inhibiting c-Jun N-terminal ...
Cited by 39 - Web Search - nature.com - radiationbiology.dk - ncbi.nlm.nih.gov - all 5 versions »

Tumor Necrosis Factor–Mediated E2F1 Suppression in Endothelial Cells - Full text - MIT Libraries
R Kishore, C Luedemann, E Bord, D Goukassian, DW … - Circulation Research, 2003 - circres.ahajournals.org
... whole-cell extracts that were immunoprecipitated with antibodies to E2F1, E2F2,
E2F4, and ... kinase reactions using GST-E2F1, GST-DP1, or GST-c-jun as substrates ...
Cited by 3 - Web Search - ahavj.ahajournals.org - dx.doi.org - ncbi.nlm.nih.gov - all 10 versions »

Pocket protein-independent repression of urokinase-type plasminogen activator and plasminogen … - Full text - MIT Libraries
M Koziczak, W Krek, Y Nagamine - Mol. Cell. Biol, 2000 - mcb.asm.org
... We found that overexpression of E2F1, E2F2, and E2F3 can repress transcription of
the uPA ... CAT (53) was provided by K. D. Robertson, and pRSV-c-Jun was provided ...
Cited by 17 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Chromosomal imbalances in choroid plexus tumors - Full text - MIT Libraries
CH Rickert, OD Wiestler, W Paulus - Am J Pathol, 2002 - ajp.amjpathol.org
Page 1. Chromosomal Imbalances in Choroid Plexus Tumors Christian H. Rickert,*
Otmar D. Wiestler, † and Werner Paulus* From the ...
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A role for a bent DNA structure in E2F-mediated transcription activation - Full text - MIT Libraries
WD Cress, JR Nevins - Mol. Cell. Biol, 1996 - mcb.asm.org
... Other mammalian transcription factors have been found to bend DNA, including Fos
and Jun (15, 30), NF- B (44), Myc- Max (9), and Oct-1 (51). ... CMV-E2F2 ...
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A new liver metastatic and peritoneal dissemination model established from the same human pancreatic …
H Nomura, H Nishimori, T Yasoshima, F Hata, H … - Clinical & Experimental Metastasis, 2002 - springerlink.com
... Futoshi Nakajima 1 , Toshio Honma 1 , Jun Araya 1 , Kenjiro Kamiguchi 2 ... 0,30 Rad51
D13804 Tumor Suppressor Genes/Apoptosis A060 0,30 E2F2 L22846 Regulatory ...
Cited by 3 - Web Search - kluweronline.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

The paradox of E2F1: oncogene and tumor suppressor gene - Full text - MIT Libraries
DG Johnson, T Smithville - Mol Carcinog, 2000 - doi.wiley.com
... E2F2, E2F3, and E2F4, as well as DP1, each have been shown to behave as ... coactivator
for p53 or through the p53-independent activation of c-jun N-terminal kinase ...
Cited by 19 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Unbiased analysis of RB-mediated transcriptional repression identifies novel targets and … - Full text - MIT Libraries
MP Markey, SP Angus, MW Strobeck, SL Williams, RW … - Cancer Res, 2002 - cancerres.aacrjournals.org
... of PCNA, DHFR, and cyclin A. Together, these results indicate that E2F2 targets
are not ... histones H1 and H3) and the growth factor-inducible genes c-Jun and EGR ...
Cited by 19 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

Interaction of E2F/Rb family members with factor binding to co-repressor element on B-myb and E2F1 …
Y Nakajima - Kokubyo Gakkai Zasshi, 1998 - ncbi.nlm.nih.gov
1998 Jun;65(2):172-88 ... The CHR-mutated promoter is activated by the E2F family of
proteins (E2F1, E2F2, E2F3, and E2F4) but unable to be repressed by any of the ...
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Characterization of transcriptional regulation during negative selection in vivo - Full text - MIT Libraries
D DeRyckere, DL Mann, J DeGregori - J Immunol, 2003 - jimmunol.org
... using thymocytes isolated from mice in which the c-jun gene carried ... CA) and
gene-specific TaqMan probes that hybridize to E2F2 (5'-CTGGATACCCTCCAGCACGTTGGTG ...
Cited by 7 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis-and G - Full text - MIT Libraries
J De GREGORI, T KOWALIK, JR NEVINS - Molecular AND Cellular Biology, 1995 - mcb.asm.org
... levels are low in REF52 cells, we do observe an increase in the E2F2 mRNA at 18 ... the
precise targets for control by proteins such as c-Myc and Fos/Jun, to name ...
Cited by 374 - Web Search - biologie.uni-muenchen.de - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Resistance to Fulminant Hepatitis and Carcinogenesis Conferred by Overexpression of Retinoblastoma … - Full text - MIT Libraries
R Previously - Hepatology, 2001 - doi.wiley.com
... anti-Bax antibody, anti-Bad antibody, anti-Bid antibody, anti-ICE p10 an- tibody,
anti-CPP32 antibody, anti-E2F1, anti-E2F2, anti-E2F3, anti- E2F4, anti-E2F5 ...
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E2F1 and c-Myc in cell growth and death
I Matsumura, H Tanaka, Y Kanakura - Cell Cycle, 2003 - landesbioscience.com
... pression of either c-Myc, E2F1, cyclin D1, cyclin D3 or c-Jun enhances apoptosis ...
15-17 One group, including E2F1, E2F2 and E2F3, shows the similar expres- sion ...
Cited by 7 - Web Search - landesbioscience.com - ncbi.nlm.nih.gov - landesbioscience.com - all 6 versions » - Get it from MIT Libraries

Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb - Full text - MIT Libraries
C Neuveut, KG Low, F Maldarelli, I Schmitt, F … - Mol Cell Biol, 1998 - mcb.asm.org
... Like other oncoproteins, such as Myc, Jun, and Fos, Tax is a transcriptional activator. ...
In T cells, a Tax-associated increase in steady-state E2F2 protein was ...
Cited by 63 - Web Search - pubmedcentral.nih.gov - retrovirus.info - ncifcrf.gov - all 7 versions »

The role of the transcription factor DP in apoptosis
MR Hitchens, PD Robbins - Apoptosis, 2003 - kluweronline.com
... DNA and induce transcrip- tion in vitro, yet only exogenous E2F2 functions in vivo ...
with the appearance of ubiquinated cytoplasmic proteins such as c-jun and p21 ...
Cited by 7 - Web Search - springerlink.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Ab initio identification of putative human transcription factor binding sites by comparative … - Full text - MIT Libraries
D Cora, C Herrmann, C Dieterich, F Di Cunto, P … - BMC Bioinformatics, 2005 - biomedcentral.com
... From the TRANSFAC database we identified 8 such targets, 6 of which are included
in the PAM1 version of the CORG database: CAV1, MYC, DHFR, E2F2, RBL1 and CDC6 ...
Cached - Web Search - dx.doi.org - pubmedcentral.nih.gov - arxiv.org - all 8 versions »

Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by … - Full text - MIT Libraries
Y ZHU, K Jin, XO Mao, DA Greenberg - The FASEB Journal, 2003 - fasebj.org
... VEGF increased nuclear expression of E2F1, E2F2 and E2F3 but not E2F4. ... M., Levin,
ER (1998) Extracellular signal-regulated protein kinase/Jun kinase cross-talk ...
Cited by 17 - Web Search - dx.doi.org - fasebj.org - ncbi.nlm.nih.gov - all 5 versions »

CDC37 Ab-1
S As, C Localization - biocarta.com
... 90, PAb), cdk7 (MO-1.1), cdk8 (PAb), PCNA (PC10), BrdU, Topoisomerase II α
(JH2.7), E2F1 (2xMAbs), E2F2 (2xMAbs), E2F3 ... Genes Dev 1996 Jun 15;10(12):1491-1502. ...
View as HTML - Web Search

A microarray analysis of genes involved in relating egg production to nutritional intake in … - Full text - MIT Libraries
J Terashima, M Bownes - Cell Death and Differentiation, 2005 - nature.com
... 13, 14 bsk encodes c-jun N terminal kinase (JNK), 14 which induces apoptosis in
the ... 33 The Drosophila E2F includes E2F and E2F transcription factor 2 (E2f2). ...
Web Search - nature.com - ncbi.nlm.nih.gov

The Regulation of Normal Melanocyte Proliferation - Full text - MIT Libraries
R Halaban - Pigment Cell Research, 2000 - dx.doi.org
... PI3K triggers JNK/SAPK and the positive phosphorylation of c-Jun and ATF2 transcription
factors ... c-MYC, c-MYB, B-MYB, as well as E2F1 and E2F2, that participate ...
Cited by 59 - Web Search - blackwell-synergy.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

The Accumulation of an E2F-p130 Transcriptional Repressor Distinguishes aG - Full text - MIT Libraries
EJ SMITH, G LEONE, J De GREGORI, L JAKOI, JR … - Molecular AND Cellular Biology, 1996 - mcb.asm.org
... Although the Rb protein may interact preferentially with the E2F1, E2F2, and E2F3
proteins, it is also clear that unlike p130 and p107, Rb can be found to ...
Cited by 106 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Transcription factors
V GUASCONI, Y Hakima, A Slimane - caroll.vjf.cnrs.fr
... E2F2 and 3 are highly homologous to E2F1, and show similar DNA-binding and
transactivation ... Angel P, Karin M. The role of Jun, Fos and the AP-1 complex in cell ...
Cached - Web Search

PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells - Full text - MIT Libraries
A Ryo, YC Liou, G Wulf, M Nakamura, SW Lee, KP Lu - Mol Cell Biol, 2002 - mcb.asm.org
... shown to elevate cyclin D1 gene expression by activating the c-jun/AP-1 ... Furthermore,
two other E2F proteins, E2F2 and E2F3, also potently activated the PIN1 ...
Cited by 17 - Web Search - pubmedcentral.nih.gov - research.bidmc.harvard.edu - dx.doi.org - all 7 versions »

CELL CYCLE DYSREGULATION BY HTLV-I: ROLE OF THE TAX ONCOPROTEIN
C Neuveut, KT Jeang - Frontiers in Bioscience, 2002 - bioscience.org
... upregulates the expression of IL2, IL2-receptor, c-fos, c-Jun, erg-1 ... which was
accompanied by concomitant increases in hyperphosphorylated pRb and E2F2-function ...
Cited by 10 - Cached - Web Search - xylian.igh.cnrs.fr - bioscience.org - ncbi.nlm.nih.gov - all 7 versions » - Get it from MIT Libraries

Down-regulation of Myc as a Potential Target for Growth Arrest Induced by Human Polynucleotide … - Full text - MIT Libraries
D Sarkar, M Leszczyniecka, D Kang, IV Lebedeva, K … - J Biol Chem, 2003 - jbc.org
... progression, from complexes with Rb and together with the direct induction of E2F2
by Myc ... a 500-bp fragment from human GADD34, full-length human c-jun, and full ...
Cited by 6 - Web Search - jbc.org - ncbi.nlm.nih.gov

Ras-Raf-Arf Signaling Critically Depends on the Dmp1 Transcription Factor - Full text - MIT Libraries
R Sreeramaneni, A Chaudhry, M McMahon, CJ Sherr, K … - Mol Cell Biol, 2005 - mcb.asm.org
... A Ras V12 -responsive element was mapped to the 5' leader sequence of the murine
Dmp1 promoter, where endogenous Fos and Jun family proteins bind. ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

Regulation of epidermal apoptosis and DNA repair by E 2 F 1 in response to ultraviolet B radiation - Full text - MIT Libraries
TR Berton, DL Mitchell, R Guo, DG Johnson - Oncogene, 2005 - nature.com
... induce apoptosis, while other studies suggest that E2F3, and perhaps E2F2, can also ...
kinases (ERKs), p38 kinases and the stress-activated c-Jun N-terminal ...
Web Search - nature.com - ncbi.nlm.nih.gov

Cell-cycle regulation of T-cell responses- novel approaches to the control of alloimmunity - Full text - MIT Libraries
AD Wells - Immunological Reviews, 2003 - blackwell-synergy.com
... in the activation and/or synthesis of the promitogenic Ets-1, Fos, Jun, nuclear
factor ... The E2F gene family consists of six members: E2F1, E2F2, E2F3, E2F4, E2F5 ...
Web Search - ncbi.nlm.nih.gov

Candidate nsSNPs That Can Affect the Functions and Interactions of Cell Cycle Proteins - Full text - MIT Libraries
S Savas, MF Ahmad, M Shariff, DY Kim, H Ozcelik - risk - doi.wiley.com
... CDK3, CDK4, CDK5, CDK6, CDK7, CDK9, CDKN1C, CDKN3, E2F4, E2F6, JUN, MDM2, NFKBIA ...
cdkn1b: P46414, cdkn2a: P51480, chek1: O35280, e2f1: Q61501, e2f2: P56931, e2f3 ...
Web Search - ijmm.org - ncbi.nlm.nih.gov

Rb/E2F: A two-edged sword in the melanocytic system
R Halaban - Cancer and Metastasis Reviews, 2005 - springerlink.com
... of antibodies to E2F2 or E2F4, demonstrating suppression of free E2F2 and E2F4 DNA ...
that upregulated cyclin D and E2F1 transcription (CREB, TCF, c-Jun, Ets and ...
Web Search - ingentaconnect.com

Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that …
Q Chen, D Liang, LD Fromm, PA Overbeek - jbc.org
... Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP
induced stimulation in vivo and CBP binding in vitro. ... E2F2. Invest. ...
Web Search - jbc.org

MIF-deficiency is Associated with Altered Cell Growth and Reduced Susceptibility to Ras-mediated … - Full text - MIT Libraries
O Petrenko, G Fingerle-Rowson, T Peng, RA Mitchell … - J. Biol. Chem, 2004 - jbc.org
... transcription factor E2F1, while higher levels of c -Jun and c-Myc were found in
the ... 16 Page 17. E2F1-, E2F2-, and E2F3-dependent transactivation. ...
Web Search - jbc.org

Identification of the polycomb group protein SU (Z) 12 as a potential molecular target for human … - Full text - MIT Libraries
A Kirmizis, SM Bartley, PJ Farnham - Mol. Cancer Ther, 2003 - intl-mct.aacrjournals.org
... Although we have shown that the Myc, cyclin D1, jun, and PPAR promoters ... of positively
and negatively acting elements regulating expression of the E2F2 gene in ...
Cited by 13 - Web Search - mcardle.oncology.wisc.edu - genomics.ucdavis.edu - ncbi.nlm.nih.gov - all 7 versions »

Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer - Full text - MIT Libraries
A Ryo, YC Liou, KP Lu, G Wulf - J Cell Sci, 2003 - jcs.biologists.org
... The AP-1 complex, which includes transcription factors such as Jun, Fos and FosB,
regulates a wide range of cellular processes, including cell proliferation ...
Cited by 12 - Web Search - dx.doi.org - jcs.biologists.org - ncbi.nlm.nih.gov

Identification of Target Genes of Oncogenic Transcription Factors - Full text - MIT Libraries
KE Boyd, PJ Farnham - Proceedings of The Society for Experimental Biology and …, 1999 - ebmonline.org
... E2F1, E2F2, and E2F3 have nuclear localization signals and are predominantly nuclear
at ... noted that an AP1 site (a binding site for Fos/Jun heterodimers) was ...
Cited by 14 - Web Search - ebmonline.org - ncbi.nlm.nih.gov

Andrew D. Wells - Full text - MIT Libraries
AD Wells - Immunological Reviews, 2003 - ingentaconnect.com
... for cell-cycle progression are not expressed in resting T cells, like the cyclins
mentioned above and critical transcription factors such as Fos, Jun, and Myc ...
Web Search

HLXB9 activates IL6 in Hodgkin lymphoma cell lines and is regulated by PI3K signalling involving E2F …
S Nagel, M Scherr, H Quentmeier, M Kaufmann, M … - Leukemia, 2005 - nature.com
... Recently, E2F2 and E2F3 were shown to bind the polycomb protein YY1 via another ...
Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells ...
Web Search - nature.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Role of APC and DNA mismatch repair genes in the development of colorectal cancers - Full text - MIT Libraries
S Narayan, D Roy - Molecular Cancer, 2003 - dx.doi.org
... degrading metalloproteinase, matrysin [50], the AP-1 transcription factors c-jun
and fra-1 ... The E2F1, E2F2 and E2F3 proteins can be grouped in one subgroup since ...
Cited by 9 - Web Search - pubmedcentral.nih.gov - molecular-cancer.com - carcinogenesis.com - all 11 versions »

p53 and E2F-1 Cooperate to Mediate Apoptosis - Full text - MIT Libraries
X Wu, AJ Levine - Proceedings of the National Academy of Sciences - pnas.org
... Cell Growth Differ Home page HI Saavedra, L. Wu, A. de Bruin, C. Timmers, TJ Rosol,
M. Weinstein, ML Robinson, and G. Leone Specificity of E2F1, E2F2, and E2F3 ...
Cited by 386 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu - all 5 versions »

RiboQuant™
I Manual - bdbiosciences.ca
... mCYC-1 Mouse Cyclin 45620P 46 mCYC-2 Mouse Cyclin 45621P 46 Proto-Oncogene
Multi-Probe Template Sets mFos/Jun Mouse Fos/Jun 45357P 47 mMyc Mouse Myc 45356P ...
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RB Reversibly Inhibits DNA Replication via Two Temporally Distinct Mechanisms - Full text - MIT Libraries
SP Angus, CN Mayhew, DA Solomon, WA Braden, MP … - Mol. Cell Biol, 2004 - pubmedcentral.nih.gov
... by GFP fluorescence. A2-4 cells were infected with either GFP- or E2F2-encoding
adenovirus as previously described (43). Rat-1 cells ...
Cited by 2 - Web Search - mdc-berlin.de - dx.doi.org - intl-mcb.asm.org - all 6 versions »

Identification of Target Genes of Oncogenic Transcription Factors (44425)
KE Boyd, PJ Farnham - ingentaconnect.com
... To date six different mammalian E2Fs (E2F1, E2F2, E2F3, E2F4, E2F5, and E2F6) have
been cloned; each of them can heterodimerize with either DP1 or DP2. ...
Web Search - genomics.ucdavis.edu - mcardle.oncology.wisc.edu

Recent acquisitions on functional properties of the p14/p19ARF tumor suppressor protein and its …
R Summary - john-libbey-eurotext.fr
... E2F1 (et aussi E2F2 et 3) activent le promoteur d'ARF [21, 43 ... de dimères (homo- ou
hétéro-) des protéines proto-oncogéniques Fos et Jun qui reconnaissent ...
Cached - Web Search - john-libbey-eurotext.fr

Donnees recentes sur les fonctions du gene suppresseur de tumeur p14/p19ARF et son importance en …
R Summary, R Girot, P Begue, F Galacteros, M Aiach - john-libbey-eurotext.fr
... E2F1 (et aussi E2F2 et 3) activent le promoteur d'ARF [21, 43 ... de dimères (homo- ou
hétéro-) des protéines proto-oncogéniques Fos et Jun qui reconnaissent ...
Cached - Web Search - john-libbey-eurotext.fr

Reovirus-induced alterations in gene expression related to cell cycle regulation - Full text - MIT Libraries
GJ Poggioli, RL DeBiasi, R Bickel, R Jotte, A … - J. Virol, 2002 - jvi.asm.org
... activates the cellular transcription factors NF- B (4, 13) and c-Jun (P. Clarke ... cdc25C,
p21 WAF1/CIP1 , c-myc, B-myb, p107, E2F1, E2F2, dihydrofolate reductase ...
Cited by 9 - Web Search - pubmedcentral.nih.gov - jvi.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Involvement of an SCFSlmb complex in timely elimination of E 2 F upon initiation of DNA replication … - Full text - MIT Libraries
JK Heriche, D Ang, E Bier, P O'Farrell - BMC Genetics, 2003 - biomedcentral.com
... active alkaline phosphatase (lane 4) but not when the phosphatase is inhibited by
sodium vanadate (lane 5). Similar results were obtained with E2F2, the other ...
Cited by 3 - Cached - Web Search - dx.doi.org - pubmedcentral.nih.gov - citebase.eprints.org - all 7 versions »

EGFR family signaling and its association with breast cancer development and resistance to … - Full text - MIT Libraries
PM NAVOLANIC, LS STEELMAN, JA McCUBREY - INTERNATIONAL JOURNAL OF ONCOLOGY, 2003 - 147.52.72.117
... ERK family isoforms are members of the MAPK family of kinases that also includes
members of the p38 MAPK and c-Jun N-terminal kinase (JNK) families (37,38). ...
Cited by 14 - View as HTML - Web Search - virology.med.uoc.gr - ncbi.nlm.nih.gov