Myc requires distinct E2F activities to induce S phase and apoptosis - Full text - MIT Libraries
G Leone, R Sears, E Huang, R Rempel, F Nuckolls, … - Mol. Cell, 2001 - sethfield.ucsd.edu
... and the E2F3 promoters has provided evidence that the induction of E2F2 and E2F3
by Myc could be direct, E2F2 and E2F3 but Not E2F1 or E2F4 Are Required ...
Cited by 62 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Identification of positively and negatively acting elements regulating expression of the E2F2 gene … - Full text - MIT Libraries
R Sears, K Ohtani, JR Nevins - Mol. Cell. Biol, 1997 - mcb.asm.org
... We thus conclude that the E-box sites play a significant role in the cell cycle
regulation of the E2F2 promoter and that Myc can activate the E2F2 promoter ...
Cited by 86 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss - Full text - MIT Libraries
TA Baudino, KH Maclean, J Brennan, E Parganas, C … - Mol. Cell, 2003 - uiowa.edu
... suggest that E2f1 activity selectively triggers apoptosis, whereas E2f2 and E2f3 ...
proapoptotic and/or cell cycle-promoting effects of Myc overexpression were ...
Cited by 12 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

… 2 kinase activity, E 2 F-dependent transcription and cell growth by Myc are genetically separable … - Full text - MIT Libraries
R Beier, A Burgin, A Kiermaier, M Fero, H Karsunky … - The EMBO Journal, 2000 - embojournal.npgjournals.com
... Alternatively, Myc has been shown to activate the promoter of the E2F2 gene, and
constitutive expression of Myc upregulates expression of E2F2 protein (Sears ...
Cited by 36 - Web Search - emboj.org - imt.uni-marburg.de - nature.com - all 9 versions »

… are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor …
E Santoni-Rugiu, MR Jensen, SS Thorgeirsson - Cancer Res, 1998 - cancerres.aacrjournals.org
... cyclin D1 mRNA and protein in c-myc/TGF-alpha and c-myc HCCs associated ... regulation,
particularly in the HCCs, of pRb-free E2F1-DP1 and E2F2-DP1 transcription ...
Cited by 52 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization - Full text - MIT Libraries
F Zindy, CM Eischen, DH Randle, T Kamijo, JL … - Genes Dev, 1998 - genesdev.org
... can act like myc in triggering apoptosis in an ARF-dependent manner (see de Stanchina
et al. 1998 ). Among its many effects, E1A releases E2F1, E2F2, and E2F3 ...
Cited by 436 - Web Search - genesdev.org - 138.5.102.101 - pubmedcentral.nih.gov - all 8 versions »

Rabbit Anti-Myc Antibody Quantity
T antibody recognizes recombinant human Myc - amprox.com
... The ability of Myc to induce S phase is impaired in the absence of either
E2F2 or E2F3 but not E2F1 or E2F4. In contrast, the ability ...
View as HTML - Web Search - amprox.com

Rabbit Anti-Myc Antibody Quantity
P IDENTITY - amprox.com
... The ability of Myc to induce S phase is impaired in the absence of either
E2F2 or E2F3 but not E2F1 or E2F4. In contrast, the ability ...
View as HTML - Web Search

… profiling of the Sonic hedgehog response: A critical role for N-myc in proliferation of neuronal … - Full text - MIT Libraries
TG Oliver, LL Grasfeder, AL Carroll, C Kaiser, CL … - Development, 2004 - dx.doi.org
... Retroviral transduction of N-myc into GCPs induces expression of cyclin
D1, E2F1, and E2F2, and promotes proliferation. Moreover ...
Cited by 28 - Web Search - pnas.org - med.stanford.edu - pharmacology.mc.duke.edu - all 8 versions »

Control of cell proliferation by Myc
C Bouchard, P Staller, M Eilers - trends in CELL BIOLOGY (Vol. 8), 1998 - biologie.uni-osnabrueck.de
... compete for the same binding site on Cdk2 complexes – several proteins (including
Cdc25A and E2F2, encoded by another potential tar- get gene of Myc 32 ) are ...
Cited by 97 - View as HTML - Web Search - imt.uni-marburg.de - ingentaconnect.com - all 6 versions »

Direct recruitment of N-myc to target gene promoters - Full text - MIT Libraries
SM Mac, CA D'Cunha, PJ Farnham - Molecular Carcinogenesis, 2000 - doi.wiley.com
... 24]. Because we found that one gene that was regulated by N-myc was E2F2,
we expanded our studies to include other E2Fs. RT-PCR ...
Cited by 11 - Web Search - mcardle.oncology.wisc.edu - genomecenter.ucdavis.edu - ncbi.nlm.nih.gov - all 8 versions »

Contributions of Myc to tumorigenesis
W Lutz, J Leon, M Eilers - Biochim. Biophys. Acta, 2002 - centros.unican.es
... Potential candi- dates are the E2F2 and E2F3 genes [42]; thus, in Myc expressing
cells, the amount of E2F proteins may exceed the amount of pocket proteins ...
Cited by 30 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human … - Full text - MIT Libraries
E Yeh, M Cunningham, H Arnold, D Chasse, T … - Nature Cell Biology, 2004 - nature.com
... of positively and negatively acting elements regulating expression of the E2F2 gene
in ... Papas, TS & Lautenberger, JA Sequence curiosity in v-myc oncogenes. ...
Cited by 21 - Web Search - pharmacology.mc.duke.edu - pharmacology.cwru.edu - pharmacology.case.edu - all 7 versions »

E2F1 and c-Myc in cell growth and death
I Matsumura, H Tanaka, Y Kanakura - Cell Cycle, 2003 - landesbioscience.com
... E2F1 directly induces the expression of c-myc. 123 Conversely, c-Myc induces
the expression of E2F1, E2F2 and E2F3. 50,124,125 In ...
Cited by 7 - Web Search - landesbioscience.com - ncbi.nlm.nih.gov - landesbioscience.com - all 6 versions » - Get it from MIT Libraries

E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress … - Full text - MIT Libraries
JW Zhu, SJ Field, L Gore, M Thompson, H Yang, Y … - Mol. Cell. Biol, 2001 - mcb.asm.org
... FIG. 6. Loss of E2F1 and E2F2 does not affect the regulation of at least
some Myc-and E2F-dependent target genes. (A) Lymphocytes ...
Cited by 22 - Web Search - pubmedcentral.nih.gov - sethfield.ucsd.edu - dx.doi.org - all 6 versions »

Coordinated regulation of life and death by RB - Full text - MIT Libraries
BN Chau, JYJ Wang - Nature Reviews Cancer, 2003 - nature.com
... mouse embryonic fibroblasts from E2f1-, E2f2- and E2f3-knockout mice, this study
showed that E2f1, but not E2f2 or E2f3, was required for Myc-induced apoptosis ...
Cited by 39 - Web Search - nature.com - radiationbiology.dk - ncbi.nlm.nih.gov - all 5 versions »

Complex transcriptional regulatory mechanisms control expression of the E2F3 locus - Full text - MIT Libraries
MR Adams, R Sears, F Nuckolls, G Leone, JR Nevins - Mol. Cell. Biol, 2000 - mcb.asm.org
... Moreover, our recent experiments have demonstrated a role for both E2F1 and E2F2
in enabling Myc function since mouse embryo fibroblasts that carry either an ...
Cited by 29 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Down-regulation of Myc as a Potential Target for Growth Arrest Induced by Human Polynucleotide … - Full text - MIT Libraries
D Sarkar, M Leszczyniecka, D Kang, IV Lebedeva, K … - J Biol Chem, 2003 - jbc.org
... regulate a battery of genes necessary for cell cycle progression, from complexes
with Rb and together with the direct induction of E2F2 by Myc, may further ...
Cited by 6 - Web Search - jbc.org - ncbi.nlm.nih.gov

Myc and the cell cycle
B Amati, K Alevizopoulos, J Vlach, B Amati - Front Biosci, 1998 - bioscience.org
... 250 MYC AND THE CELL CYCLE Bruno Amati, Konstantinos Alevizopoulos and Jaromir Vlach ...
TABLE OF CONTENTS 1. Abstract 2. Introduction 2.1. The Myc protein 2.2. ...
Cited by 120 - View as HTML - Web Search - xylian.igh.cnrs.fr - bioscience.mirror.ac.cn - ncbi.nlm.nih.gov - all 8 versions » - Get it from MIT Libraries

Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb - Full text - MIT Libraries
HI Saavedra, L Wu, A de Bruin, C Timmers, TJ Rosol … - Cell Growth Differ, 2002 - cgd.aacrjournals.org
... but not E2F2–5, can induce apoptosis in serum-starved rat fibroblasts and with recent
findings linking E2F1, but not E2F2 or E2F3, in Myc-induced apoptosis ...
Cited by 10 - Web Search - cgd.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

c-Myc regulates cyclin D-Cdk4 and-Cdk6 activity but affects cell cycle progression at multiple … - Full text - MIT Libraries
MK Mateyak, AJ Obaya, JM Sedivy - Mol. Cell. Biol, 1999 - mcb.asm.org
... c-Myc Regulates Cyclin D-Cdk4 and -Cdk6 Activity but Affects Cell Cycle Progression
at Multiple Independent Points. ... How does c-myc affect growth rate? ...
Cited by 87 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Regulation of N-myc expression in development and disease - Full text - MIT Libraries
V Strieder, W Lutz - Cancer Lett, 2002 - imt.uni-marburg.de
... fibroblasts c-myc expression occurs before the activation of the proliferation
stimulating E2F-family members E2F1, E2F2 and E2F3, and indeed Myc appears to ...
Cited by 12 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

ARF differentially modulates apoptosis induced by E2F1 and Myc - Full text - MIT Libraries
JL Russell, JT Powers, RJ Rounbehler, PM Rogers, … - Mol. Cell. Biol, 2002 - mcb.asm.org
... to Myc. This suggests that ARF may specifically repress E2F1 activity. Two recent
reports suggest that ARF physically interacts with E2F1, as well as with E2F2 ...
Cited by 35 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Mnt–Max to Myc–Max complex switching regulates cell cycle entry - Full text - MIT Libraries
W Walker, ZQ Zhou, S Ota, A Wynshaw-Boris, PJ … - J Cell Biol, 2005 - jcb.org
... that acute Mnt deletion rescues, at least partially, the severe down-regulation
of Myc targets such as Cyclin D2 and E2F2 caused by acute c-Myc deletion in ...
Web Search - jcb.org - ncbi.nlm.nih.gov

… to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 … - Full text - MIT Libraries
GA McArthur, KP Foley, ML Fero, CR Walkley, AJ … - Mol Cell Biol, 2002 - mcb.asm.org
... Myc is generally considered to be upstream of E2F1, E2F2, and E2F3 and to
drive cell cycle progression and cell growth (18, 20, 35). ...
Cited by 14 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Inactivation of E2f1 enhances tumorigenesis in a Myc transgenic model - Full text - MIT Libraries
RJ Rounbehler, PM Rogers, CJ Conti, DG Johnson - Cancer Res, 2002 - cancerres.aacrjournals.org
... It has also been reported that overexpression of Myc can stimulate the
expression of E2F1, as well as E2F2 and E2F3 (31, 32, 33) . ...
Cited by 9 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - peo.cshl.org

Down-regulation of c-myc and Cyclin D 1 genes by antisense oligodeoxy nucleotides inhibits the … - Full text - MIT Libraries
MM Simile, MR De Miglio, MR Muroni, M Frau, G … - Carcinogenesis, 2003 - carcin.oupjournals.org
... CYCLIN A, CYCLIN D1 and CYCLIN E, DNA synthesis genes (DNA polymerase , dihydropholate
reductase), transcriptional factors, including c-MYC, E2F1 and E2F2 (1,37 ...
Cited by 2 - Web Search - carcin.oxfordjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 8 versions »

Defective Gene Expression, S Phase Progression, and Maturation during Hematopoiesis in E2F1/E2F2 … - Full text - MIT Libraries
FX Li, JW Zhu, CJ Hogan, J DeGregori - Mol Cell Biol, 2003 - mcb.asm.org
... of inappropriate translocations involving the Ig-T-cell receptor loci and oncogenes
such as Myc, which could contribute to lymphomagenesis in E2F2 mutant mice. ...
Cited by 6 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

… stimulation of glioblastoma cell cycle progression through G (1) is c-Myc dependent and independent … - Full text - MIT Libraries
KA Walter, MA Hossain, C Luddy, N Goel, TE Reznik, … - Mol Cell Biol, 2002 - mcb.asm.org
... in U2OS sarcoma cells (45). c-Myc can directly promote transcription of
the E2F2 protein (47, 48). Similarly, SF/HGF activated E2F1 ...
Cited by 7 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ijp-online.com - all 7 versions »

Myc Antagonizes Ras-mediated Growth Arrest in Leukemia Cells through the Inhibition of the Ras-ERK-p … - Full text - MIT Libraries
JP Vaque, J Navascues, Y Shiio, M Laiho, N Ajenjo, … - J Biol Chem, 2005 - jbc.org
... In addition, we also found that c-Myc antagonized Ras- but not E2F2-mediated induction
of the cyclin E promoter (not shown), ruling out an unspecific ...
Cited by 2 - Web Search - grupos.unican.es - jbc.org - ncbi.nlm.nih.gov

[CITATION] TRANSCRIPTIONAL REGULATION AND TRANSFORMATION BY MYC PROTEINS - Full text - MIT Libraries
S Adhikary, M Eilers - Nature Reviews Molecular Cell Biology, 2005
Web Search

Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p …
U de Cantabria, S Santander, I de Investigaciones … - grupos.unican.es
... shown). In addition, we also found that c-Myc antagonized Ras- but not
E2F2-mediated induction of cyclin E promoter (not shown), ruling ...
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Dissection of transcriptional programmes in response to serum and c-Myc in a human B-cell line - Full text - MIT Libraries
I Schlosser, M Hoelzel, R Hoffmann, H Burtscher, F … - Oncogene, 2005 - nature.com
... shock 70 gene HSPA4, ABL1, adenosine kinase ADK, transcription factor E2F2 and
eukaryotic ... a strong suppression by serum but also a moderate suppression by Myc. ...
Web Search - nature.com - ncbi.nlm.nih.gov

… Virus Zta Transactivation Domain That Is Regulated by the Cell Cycle Control Factors c-Myc and E2F1 - Full text - MIT Libraries
Z Lin, Q Yin, E Flemington - J Virol, 2004 - jvi.asm.org
... E2F4 and E2F5 cannot (5, 6). Although not as potent as E2F1, E2F2 and E2F3 ... These
data suggest a possible connection between the ability of c-Myc and E2F1 to ...
Web Search - pubmedcentral.nih.gov - jvi.asm.org - ncbi.nlm.nih.gov

The Tip60 HAT-Complex is Recruited to Chromatin by the Transcription Factors E2F and Myc
S Taubert - ethesis.unifr.ch
... to Chromatin by the Transcription Factors E2F and Myc INAUGURAL-DISSERTATION ...
3.3. The Myc/Max/Mad Network of Transcription Factors.....43 ...
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Identification and Characterization of E 2 F 7, a Novel Mammalian E 2 F Family Member Capable of … - Full text - MIT Libraries
A de Bruin, B Maiti, L Jakoi, C Timmers, R Buerki, … - J Biol Chem, 2003 - jbc.org
... MEFs were transiently transfected with 2 µg of pr-E2F2 along with increasing amounts
of pCDNA3-Myc-E2F7 or corresponding doses of the pcDNA3 control vector ...
Cited by 20 - Web Search - dx.doi.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

Pharmacological Regulation of c-myc Gene Expression in Human Breast Cancer Cells
ZK Melkoumian, JS Strobl, M Mawhinney, M Miller, W … - kitkat.wvu.edu
Page 1. Pharmacological Regulation of c-myc Gene Expression in Human Breast Cancer
Cells ... Key words: c-myc, Quinidine, Differentiation, Cell Cycle, Breast Cancer ...
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[BOOK] The transcriptional function of the c-Myc oncoprotein and its regulation by the ubiquitin/proteasome …
N von der Lehr - 2003 - diss-epsilon.slu.se
... c-Myc Oncoprotein and its Regulation ... The transcriptional function of the c-Myc
oncoprotein and its regulation by the ubiquitin/proteasome pathway. ...
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Interaction of YY 1 with E 2 Fs, mediated by RYBP, provides a mechanism for specificity of E 2 F … - Full text - MIT Libraries
S Schlisio, T Halperin, M Vidal, JR Nevins - The EMBO Journal, 2002 - embojournal.npgjournals.com
... Moreover, both E2F2 and E2F3 are required for Myc to induce S phase, whereas E2F1
activity is not required for Myc-induced S phase but is required for Myc ...
Cited by 27 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 7 versions »

Signaling Networks That Link Cell Proliferation and Cell Fate - Full text - MIT Libraries
RC Sears, JR Nevins - J Biol Chem, 2002 - jbc.org
... Ectopic Myc expression in quiescent fibroblasts induces E2F1, E2F2, and E2F3 mRNA
accumulation in the absence of G 1 Cdk activity and G 1 to S phase progression ...
Cited by 67 - Web Search - jbc.org - biotech.korea.ac.kr - ncbi.nlm.nih.gov

Characterization of transcriptional regulation during negative selection in vivo - Full text - MIT Libraries
D DeRyckere, DL Mann, J DeGregori - J Immunol, 2003 - jimmunol.org
... LY294002 (3 µM) and SB203580 (20 µM) did not have a significant effect on the
transcriptional regulation of Egr2, ID3, MyD118, nur77, E2F2, c-myc, NF- B2, c ...
Cited by 7 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Regulation of endogenous E2F1 stability by the retinoblastoma family proteins - Full text - MIT Libraries
F Martelli, DM Livingston - Cell, 1999 - pnas.org
... in late S, cyclin A/cdk2 binds to E2F1 (as well as to E2F2 and E2F3 ... pRbG4-His6-myc-
Ub (44) was a gift of R. Kopito (Stanford University, Stanford, CA), and ...
Cited by 17 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

T HE M YC/M AX/M AD N ETWORK AND THE T RANSCRIPTIONAL C ONTROL OF C ELL B EHAVIOR - Full text - MIT Libraries
C Grandori, SM Cowley, LP James, RN Eisenman - Annual Review of Cell and Developmental Biology, 2000 - cellbio.annualreviews.org
... Max forms heterodimers with members of the Myc and Mad protein families as
well as with the Mnt (or Rox) and Mga proteins. ... Myc, Section: ...
Cited by 259 - Web Search - rkblab.biochem.uci.edu - issoonline.com - ncbi.nlm.nih.gov - all 9 versions »

The Rb/E 2 F pathway and cancer - Full text - MIT Libraries
JR Nevins - Human Molecular Genetics, 2001 - hmg.oupjournals.org
... Finally, additional work has demonstrated a role for Myc in controlling the activation
of the E2F1, E2F2 and E2F3 genes (49,50) and recent evidence ...
Cited by 128 - Web Search - uni-greifswald.de - med.umich.edu - bio.kaist.ac.kr - all 9 versions »

Oncogenes Induce and Activate Endogenous p 73 Protein - Full text - MIT Libraries
A Zaika, M Irwin, C Sansome, UM Moll - J Biol Chem, 2001 - jbc.org
... E2F1 (as well as E2F2 and E2F3a) is induced by c-Myc via a group of E-box elements
in its promoter conferring positive Myc responsiveness. ...
Cited by 55 - Web Search - jbc.org - path.sunysb.edu - ncbi.nlm.nih.gov - all 6 versions »

E 2 F 1 selects tumour cells for both life and death - Full text - MIT Libraries
AH Wyllie - The Journal of Pathology, 2002 - doi.wiley.com
... proteins ORC1 and MCM2- 7). Others include the genes encoding E2F1 and E2F2 themselves,
suggesting ... a decade ago [11] when it was shown that c-myc, an oncogene ...
Cited by 7 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The p 53 Tumor Suppressor Inhibits Transcription of the TATA-less Mouse DP 1 Promoter - Full text - MIT Libraries
RV Gopalkrishnan, EWF Lam, C Kedinger - J Biol Chem, 1998 - intl.jbc.org
... E2F/DP significantly contributes to the transcriptional control of cell cycle
regulators such as the cyclins A, D, and E, E2F1, E2F2, and c-Myc (15-17). ...
Cited by 14 - Web Search - jbc.org - ncbi.nlm.nih.gov

CpG methylation as a mechanism for the regulation of E2F activity - Full text - MIT Libraries
MR Campanero, MI Armstrong, EK Flemington - Am J Physiol Renal Physiol, 2004 - dx.doi.org
... In contrast, methylation of the E2F elements derived from the c-myc and c-myb promoters
minimally affects the binding of E2F2, E2F3, E2F4, and E2F5 but ...
Cited by 26 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Inhibition of cell growth by TGF beta 1 is associated with inhibition of B-myb and cyclin A in both …
DJ Satterwhite, ME Aakre, AE Gorska, HL Moses - Cell Growth Differ, 1994 - cgd.aacrjournals.org
... quiescent MK and Mv1Lu cells and that transcriptional suppression of c-myc by TGF ...
cyclins D1 and D2 and the transcription factors E2F1 and E2F2 were unaffected ...
Cited by 25 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Functional antagonism between E 2 F family members - Full text - MIT Libraries
MV Frolov, DS Huen, O Stevaux, D Dimova, K … - Genes & Development, 2001 - genesdev.org
... proteins was monitored by Western blotting using an anti-myc antibody. ... cross-linking,
proteins were immunoprecipitated with anti-dE2F2 ( -E2F2 IP), with anti ...
Cited by 28 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »