Fluorescence in situ hybridization analysis of chromosome 1p36 deletion in human MYCN amplified …
H Komuro, MB Valentine, ST Rowe, VJ Kidd, S Makino … - J. Pediatr. Surg, 1998 - ncbi.nlm.nih.gov
... was performed to detect chromosome 1p36 abnormalities in 42 MYCN-amplified
neuroblastomas. Four different probes from the 1p36 region, the E2F2, NPPA, D1S160 ...
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EXPRESSION OF P27 KIP1 IS PROGNOSTIC AND INDEPENDENT OF MYCN AMPLIFICATION IN HUMAN NEUROBLASTOMA
E Bergmann, M Wanzel, A Weber, I Shin, H … - Int. J. Cancer (Pred. Oncol.), 2001 - doi.wiley.com
... argue against a role for MYCN as a critical regulator of p27 protein function in
these tumors. In further studies we tested expression levels of E2F2, a pro ...
Cited by 7 - Web Search - doi.wiley.com - uni-marburg.de - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Expression of p27 KIP1 is prognostic and independent of MYCN amplification in
E Bergmann, M Wanzel, A Weber, I Shin, H … - imt.uni-marburg.de
... against a role for MYCN as a critical regulator of p27 protein function in these
tumors. In further studies we tested expression levels of E2F2, a proposed ...
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Detailed molecular analysis of 1 p 36 in neuroblastoma
PS White, PM Thompson, BA Seifried, EP Sulman, SJ … - Medical and Pediatric Oncology, 2001 - doi.wiley.com
... candidate neuroblastoma suppressor genes, including CDC2L1, TP73, HKR3, TNFR2, RIZ,
PAX7, DAN, E2F2, and ID3 [4 ... No MYCN amplification was detected in the tumor. ...
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CpG methylation as a mechanism for the regulation of E2F activity - Full text - MIT Libraries
MR Campanero, MI Armstrong, EK Flemington - Am J Physiol Renal Physiol, 2004 - dx.doi.org
... the c-myc and c-myb promoters minimally affects the binding of E2F2, E2F3, E2F4 ... E2F
and Sp1/Sp3 Synergize but Are Not Sufficient to Activate the MYCN Gene in ...
Cited by 26 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Biology and genetics of human neuroblastomas
GM Brodeur, JM Maris, DJ Yamashiro, MD Hogarty, PS … - J Pediatr Hematol Oncol, 1997 - jpho-online.com
... and a second proximal locus may be deleted in cases with MYCN amplification. ... elongation
factor TCEB3 (elongin A) (42,43); and the transcription factor E2F2 (44 ...
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Direct recruitment of N-myc to target gene promoters - Full text - MIT Libraries
SM Mac, CA D'Cunha, PJ Farnham - Molecular Carcinogenesis, 2000 - doi.wiley.com
... Because we found that one gene that was regulated by N-myc was E2F2, we expanded
our studies to include other E2Fs. ... 1 3 2 E2F1 1 2 2 E2F2 2 3 NE E2F3 1 2 1 ...
Cited by 11 - Web Search - mcardle.oncology.wisc.edu - genomecenter.ucdavis.edu - ncbi.nlm.nih.gov - all 8 versions »

retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently … - Full text - MIT Libraries
F Cerignoli, X Guo, B Cardinali, C Rinaldi, J … - Cancer Res, 2002 - cancerres.aacrjournals.org
... 36.1, is associated with and might be involved in controlling MYCN amplification
and ... control and survival (including p73, RIZ, TNFR2, ID3, DAN, E2F2) caused by ...
Cited by 7 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

M OLECULAR G ENETICS OF L UNG C ANCER - Full text - MIT Libraries
Y Sekido, KM Fong, JD Minna - Annual Review of Medicine, 2003 - med.annualreviews.org
... of other cellular proteins, including the transcription factors E2F1, E2F2, and
E2F3 ... The three major MYC family members (MYC, MYCN, and MYCL) comprise yet ...
Cited by 21 - Web Search - med.annualreviews.org - intl-med.annualreviews.org - ncbi.nlm.nih.gov

The identification of E 2 F 1-specific target genes - Full text - MIT Libraries
J Wells, CR Graveel, SM Bartley, SJ Madore, PJ … - Proceedings of the National Academy of Sciences, 2002 - intl.pnas.org
... and AM Zubiaga Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2
double-mutant ... page V. Strieder and W. Lutz E2F Proteins Regulate MYCN Expression ...
Cited by 21 - Web Search - mcardle.oncology.wisc.edu - genomics.ucdavis.edu - zlab.bu.edu - all 10 versions »

Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at other tumor suppressor … - Full text - MIT Libraries
PM Thompson, JM Maris, MD Hogarty, RC Seeger, CP … - Cancer Res, 2001 - cancerres.aacrjournals.org
... MYCN amplification and 1p allelic loss determinations were performed as described ...
the proposed 1p36 TSGs (TNFRSF1B, RIZ, PAX7, NBL1, TCEB3, E2F2, C1ORF4, LAP18 ...
Cited by 15 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The role of p53 and pRB in apoptosis and cancer
ES Hickman, MC Moroni, K Helin - Curr Opin Genet Dev, 2002 - microarray1.princeton.edu
... However, a causal role for the regu- lation of APAF1 by the E2Fs has been suggested
by the finding that the ability of E2F1, E2F2 and E2F3 to induce apoptosis ...
Cited by 41 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

synMuv verite--Myb comes into focus - Full text - MIT Libraries
JS Lipsick - Genes & Development, 2004 - dx.doi.org
... Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. ... tumors
is a poor prognostic factor independent from MYCN amplification. ...
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Regulation of N-myc expression in development and disease - Full text - MIT Libraries
V Strieder, W Lutz - Cancer Lett, 2002 - imt.uni-marburg.de
... activation of the proliferation stimulating E2F-family members E2F1, E2F2 and E2F3 ...
Bishop, Targeted expression of MYCN causes neuroblas- toma in transgenic mice ...
Cited by 12 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Molecular genetics in the diagnosis and prognosis of solid pediatric tumors - Full text - MIT Libraries
PS Thorner, JA Squire - Pediatr Dev Pathol, 1998 - springerlink.com
... imprinted and show random parental loss of DNA, but are associated with MYCN
amplification. ... also known as PITSLRE or p58 [73]); (4) DAN [74]; (5) E2F2 [75]; ( ...
Cited by 13 - Web Search - ncbi.nlm.nih.gov

Identification of Target Genes of Oncogenic Transcription Factors - Full text - MIT Libraries
KE Boyd, PJ Farnham - Proceedings of The Society for Experimental Biology and …, 1999 - ebmonline.org
... To date six different mammalian E2Fs (E2F1, E2F2, E2F3, E2F4, E2F5, and E2F6) have
been cloned; each of them can heterodimerize with either DP1 or DP2. ...
Cited by 14 - Web Search - ebmonline.org - ncbi.nlm.nih.gov

Retinoblastoma‐related protein pRb 2/p 130 and its binding to the Bmyb promoter increase during … - Full text - MIT Libraries
G Raschella, B Tanno, F Bonetto, R Amendola, T … - Journal of Cellular Biochemistry, 1997 - doi.wiley.com
... p130 and p107 bind preferen- tially to E2F4 and pRb to E2F1, E2F2, and E2F3 ... of
proliferation rate and induc- tion of differentiation by a MYCN antisense DNA ...
Cited by 21 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Identification of Target Genes of Oncogenic Transcription Factors (44425)
KE Boyd, PJ Farnham - ingentaconnect.com
... To date six different mammalian E2Fs (E2F1, E2F2, E2F3, E2F4, E2F5, and E2F6) have
been cloned; each of them can heterodimerize with either DP1 or DP2. ...
Web Search - genomics.ucdavis.edu - mcardle.oncology.wisc.edu

Induction of apoptosis in cancer: new therapeutic opportunities
HF Ding, DE Fisher - Annals of Medicine, 2002 - dx.doi.org
... Third, enforced c-Myc expression in quiescent ®broblasts induces expression of
E2F1 and other E2F family members, such as E2F2 and E2F3 (184). ...
Cited by 4 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries