Activation of the Murine Dihydrofolate Reductase Promoter by E2F1 - Full text - MIT Libraries
CJ Fry, A Pearson, E Malinowski, SM Bartley, J … - J Biol Chem, 1999 - jbc.org
... 5B). We next wanted to determine the contributions of TBP, TFIIH, and CBP ... In support
of this prediction, the transactivation domains of E2F2-5 also contain ...
Cited by 20 - Web Search - genomics.ucdavis.edu - mcardle.oncology.wisc.edu - ncbi.nlm.nih.gov - all 8 versions »

Retinoblastoma protein meets chromatin - Full text - MIT Libraries
A Brehm, T Kouzarides - Trends Biochem. Sci, 1999 - unb.br
... Three transcription factors of the E2F family (E2F1, E2F2 and E2F3) are the ... of the
general transcription machinery, such as the TATA-box-binding protein (TBP). ...
Cited by 66 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Context-dependent Transcriptional Regulation - Full text - MIT Libraries
CJ Fry, PJ Farnham - J Biol Chem, 1999 - dx.doi.org
... YY1 protein brings NF1 closer to the basal transcription complex (eg TBP); placement
of ... Sp1 can bind to the N-terminal region of E2F1, E2F2, and E2F3, but not ...
Cited by 76 - Web Search - jbc.org - ncbi.nlm.nih.gov

Context-dependent Transcriptional Regulation
TACB Achieved - cbr.med.harvard.edu
... YY1 protein brings NF1 closer to the basal transcription complex (eg TBP); placement
of ... Sp1 can bind to the N-terminal region of E2F1, E2F2, and E2F3, but not ...
View as HTML - Web Search - genomecenter.ucdavis.edu - mcardle.oncology.wisc.edu - genomics.ucdavis.edu - all 6 versions »

RbAp 48 Belongs to the Histone Deacetylase Complex That Associates with the Retinoblastoma Protein - Full text - MIT Libraries
E Nicolas, V Morales, L Magnaghi-Jaulin, A Harel- … - J Biol Chem, 2000 - jbc.org
... Rb is able to repress E2F1-, E2F2-, E2F3-, and in some cases E2F4 ... inhibit the
transactivating capacities of E2F1, for example by preventing TBP recruitment by ...
Cited by 34 - Web Search - jbc.org - ncbi.nlm.nih.gov

The p 53 Tumor Suppressor Inhibits Transcription of the TATA-less Mouse DP 1 Promoter - Full text - MIT Libraries
RV Gopalkrishnan, EWF Lam, C Kedinger - J Biol Chem, 1998 - intl.jbc.org
... of cell cycle regulators such as the cyclins A, D, and E, E2F1, E2F2, and c-Myc ... The
Mdm2, TBP, and TAF II 70 2 expression constructs have been described in Dubs ...
Cited by 14 - Web Search - jbc.org - ncbi.nlm.nih.gov

MDM2: life without p53
S Daujat, H Neel, J Piette - Trends Genet, 2001 - bio.kaist.ac.kr
... A specific interaction of the oncoprotein with the basal transcription factors TBP
(TATA-binding ... includes p107 and p130, and the E2F family also has E2F2 to 6 ...
Cited by 40 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Ordered recruitment: gene-specific mechanism of transcription activation - Full text - MIT Libraries
MP Cosma - Mol. Cell, 2002 - cromatina.icb.ufmg.br
... Woychik and Hampsey, 2002) TFIIA Binds TBP and stabilizes the TBP-DNA interaction ...
activation (Hu and Perlmutter, 1999; Rollini et al., 1999) E2F1 E2F2 E2F3 Bind ...
Cited by 64 - View as HTML - Web Search - cx.unibe.ch - cm.utexas.edu - ingentaconnect.com - all 8 versions »

Identification of the novel role of pRB in eye cancer - Full text - MIT Libraries
H Lai, F Ma, S Lai, M Baltimore, F Miami - Journal of Cellular Biochemistry, 2003 - doi.wiley.com
... pRB prevents E2F from interacting with factors such as TBP. ... PhosphorylatedpRBnolo
ngerinteractswithits associated proteins, such as E2F2 and HDACs, and release ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to … - Full text - MIT Libraries
S Taubert, C Gorrini, SR Frank, T Parisi, M Fuchs, … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... Consistent with this hypothesis, E2Fs have been shown to bind TBP, TFIIH (8, 17,
36 ... 20 (sc-193; Santa Cruz), KH20 and KH95 (05-379; Upstate Biotech), E2F2 C-20 ...
Cited by 6 - Web Search - dx.doi.org - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Identifizierung und Charakterisierung von KIAA0767/Dip als neuer E2F1-induzierter Faktor mit pro- …
E des Doktorgrades, J Stanelle - miless.uni-essen.de
... Domänen. E2F1, E2F2 und E2F3 binden exklusiv pRb und fungieren als ... Myb, E2F1 und
E2F2, sowie Enzyme der DNA-Synthese wie die Dihydrofolatreduktase, ...
View as HTML - Web Search

Pocket protein-independent repression of urokinase-type plasminogen activator and plasminogen … - Full text - MIT Libraries
M Koziczak, W Krek, Y Nagamine - Mol. Cell. Biol, 2000 - mcb.asm.org
... However, in our studies, E2F1, E2F2, and E2F3 but not E2F4 and E2F5 ... basal transcription
machinery by binding TATA box-binding protein (TBP) and transcription ...
Cited by 17 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

FMGA: finding motifs by genetic algorithm
FFM Liu, JJP Tsai, RM Chen, SN Chen, SH Shih - Bioinformatics and Bioengineering, 2004. BIBE 2004. …, 2004 - ieeexplore.ieee.org
... Besides TBP and Sp1 factors, there are also other factors to aid the ... Group1: E2F1,
E2F2, E2F3, E2F4, E2F5, E2F6 Group2: TGFB1 (transforming growth factor, beta ...
Cited by 1 - Web Search - doi.ieeecomputersociety.org - ieeexplore.ieee.org

Interaction of Sp1 with the growth-and cell cycle-regulated transcription factor E2F - Full text - MIT Libraries
J Karlseder, H Rotheneder, E Wintersberger - Mol. Cell. Biol, 1996 - mcb.asm.org
... For this interaction, the C-terminal part of Sp1 and the N terminus of E2F1, a domain
also present in E2F2 and E2F3 but absent in E2F4 and E2F5, were essential ...
Cited by 182 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

A role for a bent DNA structure in E2F-mediated transcription activation - Full text - MIT Libraries
WD Cress, JR Nevins - Mol. Cell. Biol, 1996 - mcb.asm.org
... 20). CMV-E2F2 85–437 and CMV ... 23). The E2F1, E2F2, and E2F3 products can
bend the E2F1 promoter DNA toward the minor groove. The ...
Cited by 37 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice - Full text - MIT Libraries
ER Lukas, SM Bartley, CR Graveel, ZM Diaz, N Dyson … - MOLECULAR CARCINOGENESIS, 1999 - doi.wiley.com
... include genes such as cdc2, cyclin D1, cyclin E, Rb, p107, E2F1, E2F2, B-myb ... was
assessed by analysis of the levels of TATA binding protein (TBP) by using an ...
Cited by 8 - Web Search - mcardle.oncology.wisc.edu - genomics.ucdavis.edu - ncbi.nlm.nih.gov - all 8 versions »

Repression of fibroblast growth factor receptor 1 gene expression by E 2 F 4 in skeletal muscle … - Full text - MIT Libraries
R Parakati, JX DiMario - Developmental Dynamics, 2005 - doi.wiley.com
... Immunodetection studies revealed that endogenous E2F1 and E2F2 proteins were
cytoplasmic in myoblasts and myotubes, whereas E2F4 was abundant in the nuclei of ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Differential control of transcription by DNA-bound cyclins - Full text - MIT Libraries
TY Kim, WG Kaelin Jr - Mol. Biol. Cell, 2001 - pubmedcentral.nih.gov
... Zhu et al., 1995a ; Smith et al., 1998 ), the E2F family members E2F1, E2F2, and
E2F3 ... We found that both cyclin A and cyclin E can phosphorylate TBP and CTD in ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov

Control of cell proliferation by Myc
C Bouchard, P Staller, M Eilers - trends in CELL BIOLOGY (Vol. 8), 1998 - biologie.uni-osnabrueck.de
... Bin1 p107 TBP α-tubulin TRAP-1 ... proteins that compete for the same binding site on
Cdk2 complexes – several proteins (including Cdc25A and E2F2, encoded by ...
Cited by 97 - View as HTML - Web Search - imt.uni-marburg.de - ingentaconnect.com - all 6 versions »

Identification of Target Genes of Oncogenic Transcription Factors - Full text - MIT Libraries
KE Boyd, PJ Farnham - Proceedings of The Society for Experimental Biology and …, 1999 - ebmonline.org
... E2F1, E2F2, and E2F3 have nuclear localization signals and are predominantly nuclear ...
basal RNA polymerase II transcriptional machinery, such as TBP, TFIIH, and ...
Cited by 14 - Web Search - ebmonline.org - ncbi.nlm.nih.gov

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA … - Full text - MIT Libraries
KD Robertson, PA Jones - Mol. Cell. Biol, 1998 - mcb.asm.org
... 58, 69) through sequestration of the TATA binding protein (TBP) and inhibition ... were
elevated after infection with adenoviruses expressing E2F1 and E2F2 but not ...
Cited by 156 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Identification of Target Genes of Oncogenic Transcription Factors (44425)
KE Boyd, PJ Farnham - ingentaconnect.com
... E2F1, E2F2, and E2F3 have nuclear localization signals and are predominantly nuclear ...
basal RNA polymerase II transcriptional machinery, such as TBP, TFIIH, and ...
Web Search - genomics.ucdavis.edu - mcardle.oncology.wisc.edu

Differential Control of Transcription by DNA-bound Cyclins
M Editor, MJ Solomon - molbiolcell.org
... Zhu et al., 1995a ; Smith et al., 1998 ), the E2F family members E2F1, E2F2, and
E2F3 ... We found that both cyclin A and cyclin E can phosphorylate TBP and CTD in ...
Web Search - intl.molbiolcell.org

E 2 F 1-mediated transcriptional inhibition of the plasminogen activator inhibitor type 1 gene - Full text - MIT Libraries
M Koziczak, H Muller, K Helin, Y Nagamine - European Journal of Biochemistry, 2001 - content.febsjournal.org
... domain also interacts with the basal transcription machinery by binding TBP (TATA
box ... In our previous work, we showed that overexpression of E2F1, E2F2 and E2F3 ...
Cited by 10 - Cached - Web Search - ejbiochem.org - blackwell-synergy.com - ingentaconnect.com - all 8 versions »

Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription … - Full text - MIT Libraries
AE Kel, OV Kel-Margoulis, PJ Farnham, SM Bartley, … - J. Mol. Biol, 2001 - mcardle.oncology.wisc.edu
... domain are regions which mediate interaction of E2F family members with components
of the gen- eral transcriptional machinery such as TBP, TFIIH, and CBP. ...
Cited by 59 - Web Search - genomics.ucdavis.edu - rulai.cshl.edu - rulai.cshl.org - all 12 versions »

Transcription factors
V GUASCONI, Y Hakima, A Slimane - caroll.vjf.cnrs.fr
... E2F2 and 3 are highly homologous to E2F1, and show similar DNA-binding and
transactivation properties. ... Crystal structure of a yeast TBP/TATA-box complex. ...
Cached - Web Search

Regulation of E 2 F 1 activity by acetylation - Full text - MIT Libraries
MA Martinez-Balbas, UM Bauer, SJ Nielsen, A Brehm, … - The EMBO Journal, 2000 - embojournal.npgjournals.com
... Positively acting proteins include TATA box-binding protein (TBP; Hagemeier et al.,
1993 ... sequence alignment of E2F1 (amino acids 114-185) with E2F2, E2F3, E2F4 ...
Cited by 127 - Web Search - emboj.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Structural Investigations on Proteins Involved in Cancer Development
A Strukturforschung, NMR Biologische - tumb1.biblio.tu-muenchen.de
... E2F1 E2F2 E2F3 E2F4 E2F5 ... RB binding domain, which is a binding domain for TBP (TATA
binding protein) as well, partially covers transactivation domain of E2F. ...
View as HTML - Web Search - deposit.ddb.de

Regulation of E2F1 activity by acetylation - Full text - MIT Libraries
MA Martıns, UM Bauer, SJ Nielsen, A Brehm, T … - EMBO J, 2000 - nature.com
... include TATA box-binding protein (TBP; Hagemeier et al., ... to arginines, and polypeptide
sequence alignment of E2F1 (amino acids 114–185) with E2F2, E2F3, E2F4 ...
Cited by 4 - Web Search - imt.uni-marburg.de

The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of … - Full text - MIT Libraries
F D'Alo, LM Johansen, EA Nelson, HS Radomska, EK … - Blood, 2003 - bloodjournal.org
... To detect E2F2 or E2F4 protein, membranes were hybridized with a 1:250 dilution
of E2F2 or E2F4 antibody (sc-633x and sc-1082x, respectively; Santa Cruz ...
Cited by 7 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov - all 6 versions »

The Tip60 HAT-Complex is Recruited to Chromatin by the Transcription Factors E2F and Myc
S Taubert - ethesis.unifr.ch
... S S-Phase of the cell cycle SDS Sodium dodecylsulfate sec seconds Spt3 Suppressor
of Ty 3 protein TAD transactivation domain TAF TBP associated factor TBP TATA ...
View as HTML - Web Search - doc.rero.ch

Molecular interaction map of the mammalian cell cycle control and DNA repair systems - Full text - MIT Libraries
KW Kohn - Mol. Biol. Cell, 1999 - molbiolcell.org
... In addition to binding p53, Mdm2 reportedly binds E2F1:DP1 (P35), pRb (P35),
TATA-binding protein (TBP) (P36), TBP-associated factor II250 (TAF II 250) (P37 ...
Cited by 163 - Web Search - pubmedcentral.nih.gov - genopole-lille.fr - csb.yale.edu - all 11 versions »

Histone Acetylation/Deacetylation and Cancer: An “Open” and “Shut” Case?
G SG, BT Teh - Current Molecular Medicine, 2001 - ingentaconnect.com
... ACTR [534] AR [180] c-Myb [535,536] CIITA [537] CCAAT displacement/cut [538]
GATA-1 [539,540] GATA-3 [541] EKLF [542,543] E1A [544] E2F1 [8,271] E2F2 [8] E2F3 ...
Cited by 14 - Web Search - hagedorn.dk - ncbi.nlm.nih.gov - Get it from MIT Libraries

Transcriptional Control by Cell-Cycle Regulators: A Review - Full text - MIT Libraries
RBPPAS COREGULATORS, OFG TRANSCRIPTION - JOURNAL OF CELLULAR PHYSIOLOGY, 1999 - doi.wiley.com
... pRb interacts more specifically with E2F1, E2F2, and E2F3, p107 with E2F4, and ... and
transcriptional mediator and/or other basal factors, such as TBP, which is ...
Web Search - doi.wiley.com

The histone deacetylase HDAC 3 targets RbAp 48 to the retinoblastoma protein - Full text - MIT Libraries
E Nicolas, S Ait-Si-Ali, D Trouche - Nucleic Acids Research, 2001 - nar.oupjournals.org
... is recruited to E2F-responsive genes through direct binding to E2F1, E2F2 or E2F3 ...
protein binds E2F residues required for activation in vivo and TBP binding in ...
Cited by 3 - Web Search - nar.oupjournals.org - pubmedcentral.nih.gov

Functions of the retinoblastoma protein - Full text - MIT Libraries
WG Kaelin - BioEssays, 1999 - doi.wiley.com
... pRB family members. E2F1, E2F2, and E2F3 bind preferentially to pRB, whereas
E2F4 binds to pRB, p107, and p130. Intriguingly, the ...
Cited by 98 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Purification of General RNA Polymerase II Transcription Factors from Mouse for Studies of …
I Kotova - diva-portal.org
... Accurate initiation of transcription by RNA polymerase II depends on general
transcription factors (GTFs), which include the TATA-binding protein (TBP) and the ...
Web Search - publications.uu.se

T HE M YC/M AX/M AD N ETWORK AND THE T RANSCRIPTIONAL C ONTROL OF C ELL B EHAVIOR - Full text - MIT Libraries
C Grandori, SM Cowley, LP James, RN Eisenman - Annual Review of Cell and Developmental Biology, 2000 - cellbio.annualreviews.org
... related to TRRAP as a component of the SAGA complex, a molecular assembly containing
the HAT GCN5 and other components which facilitate TBP positioning (Grant ...
Cited by 259 - Web Search - rkblab.biochem.uci.edu - issoonline.com - ncbi.nlm.nih.gov - all 9 versions »

Histone acetylation and disease - Full text - MIT Libraries
S Timmermann, H Lehrmann, A Polesskaya, A Harel- … - Cell. Mol. Life Sci, 2001 - springerlink.com
... cancer. TAF II 250 TAF II 250 (TBP-associated factor) is a subunit of the
gen- eral transcription factor TFIID. While human TAF II 250 ...
Cited by 53 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The regulation of E2F by pRB-family proteins
N Dyson - Cell Cycle, 1998 - genesdev.org
... At least three different mechanisms have been suggested. In vitro, E2F-1 can
bind to TBP (Hagemeier et al. 1993 ; Emili and Ingles 1995 ). ...
Cited by 846 - Web Search - milkpa.idv.tw - biologie.uni-muenchen.de - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Investigating the activation and regulation of the proteasome, an essential proteolytic complex
P Masson - diva-portal.org
Page 1. 1 Investigating the activation and regulation of the proteasome, an
essential proteolytic complex Patrick Masson Institutionen ...
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[BOOK] The transcriptional function of the c-Myc oncoprotein and its regulation by the ubiquitin/proteasome …
N von der Lehr - 2003 - diss-epsilon.slu.se
... serial analysis of gene expression SCF Skp1, Cullin, F-box complex SID Sin-3
interacting domain TAD transcriptional activation domain TAF TBP associated factor ...
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Balancing protein similarity and gene co-expression reveals new links between genetic conservation … - Full text - MIT Libraries
C Lefebvre, JC Aude, E Glemet, C Neri - Bioinformatics, 2004 - bioinformatics.oupjournals.org
... like, Doa (Darkener of apricot), cg (combgap), Taf80 (TBP-associated factor ... 2003)
Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to ...
Cited by 1 - Web Search - bioinformatics.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

[BOOK] Characterization of the retinoblastoma binding protein 2 (RBP2
RG Cote - 2003 - flubu.com
... SDS-PAGE Sodium-dodecyl-sulfate polyacrylamide gel electrophoresis TBP TATA-box
binding protein ... Rb, p107 E2F1, E2F2, E2F3a cdc2, cdc6, cdc25A, cdc25C ...
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Cell Cycle Genes: pRb AND p53
N Sang, A Giordano - doi.wiley.com
Page 1. CHAPTER 14 C ELL C YCLE G ENES : pRb AND p53 N IANLI S ANG AND A NTONIO
G IORDANO C ELL D IVISION AND C ELL D EATH : AS IMPLIFIED M ODEL ...
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Histone modification enzymes: novel targets for cancer drugs
R Kristeleit, L Stimson, P Workman, W Aherne - Expert Opinion on Emerging Drugs, 2004 - dx.doi.org
... 250 - - 150 H3, H4 H3, H4 H3, H4 H3, H4 TBP-associated factor Steroid receptor
co-activator Steroid receptor co-activator TFIIE, TFIID MOZ, p300/CBP p300/CBP ...
Web Search - extenza-eps.com - ashley-pub.com - ingentaconnect.com - all 8 versions »

Functional Characterisation of γ 2-Herpesviral orf73 Proteins and their Interaction with the …
M Ottinger - elib.tiho-hannover.de
Page 1. Department of Virology Hannover Medical School Functional Characterisation
of γ 2 -Herpesviral orf73 Proteins and their Interaction with the ...
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Expression of the E2F family of transcription factors during murine development
JC Kusek, RM Greene, P Nugent, MM Pisano - Int. J. Dev. Biol, 2000 - ijdb.ehu.es
Page 1. E2F expression during development 267 Original Article Expression of the
E2F family of transcription factors during murine development ...
Cited by 9 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - ijdb.ehu.es - Get it from MIT Libraries

HUMAN DNA POLYMERASE
B Oulu - herkules.oulu.fi
... Furthermore, mitogenic control of the promoter required an intact E2F binding element,
and binding of E2F2, E2F4 and p107 was demonstrated in vitro. ...
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