SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability - Full text - MIT Libraries
N Ramanan, Y Shen, S Sarsfield, T Lemberger, G … - Nature Neuroscience, 2005 - neuroscience.jhu.edu
... IEGs in dentate gyrus neurons, which lack SRF, although these mice exhibited comparable
basal expression of Actb, Actg1 and Egr1 in SRF-positive hippocampal ...
Web Search - nature.com - nature.com - ncbi.nlm.nih.gov

ETS target genes: identification of egr1 as a target by RNA differential display and whole genome … - Full text - MIT Libraries
L Robinson, A Panayiotakis, TS Papas, I Kola, A … - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... Of interest, Egr1 was identified by both of these techniques, suggesting strongly
that it is ... gene Xegr-1 responds to the MAP kinase/Ets-SRF signal transduction ...
Cited by 29 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Differential Usage of Signal Transduction Pathways Defines Two Types of Serum Response Factor Target … - Full text - MIT Libraries
D Gineitis, R Treisman - J Biol Chem, 2001 - dx.doi.org
... In contrast, activation of fos and egr1 occurred independently of RhoA and actin ...
These results show that at least two classes of SRF target genes can be ...
Cited by 60 - Web Search - jbc.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

FLI 1 and EWS-FLI 1 function as ternary complex factors and ELK 1 and SAP 1 a function as ternary … - Full text - MIT Libraries
DK Watson, L Robinson, DR Hodge, I Kola, TS Papas, … - Oncogene, 1997 - nature.com
... II. Our results demonstrate that indeed ELK1, SAP1a, FLI1 and EWS-FLI1
are able to form ternary complexes with SRF on Egr1 SREs. ...
Cited by 41 - Web Search - nature.com - ncbi.nlm.nih.gov

… -expressed zinc finger gene Xegr-1 responds to the MAP kinase/Ets-SRF signal transduction pathway - Full text - MIT Libraries
F Panitz, B Krain, T Hollemann, A Nordheim, T … - The EMBO Journal, 1998 - embojournal.npgjournals.com
... induction seems to be regulated by transcription factors different from SRF-interacting
Ets ... subfamily located in the non-zinc finger region (FPQQQGD EGR1-3F, 5 ...
Cited by 17 - Web Search - nature.com - emboj.org - ncbi.nlm.nih.gov - all 6 versions »

The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex - Full text - MIT Libraries
M Hassler, TJ Richmond - The EMBO Journal, 2001 - embojournal.npgjournals.com
... The B-box dominates SAP-1–SRF interactions in the structure of the ternary
complex. ... 2. Structure of the SAP-1–SRF–DNA ternary complex. ...
Cited by 34 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 6 versions »

Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL … - Full text - MIT Libraries
A Selvaraj, R Prywes - BMC Molecular Biology, 2004 - biomedcentral.com
... This is consistent with our identification of SRF and vinculin as MKL target genes,
but we ... showed that the TCF factor SAP1 bound to the egr1 promoter, possibly ...
Cited by 4 - Cached - Web Search - dx.doi.org - pubmedcentral.nih.gov - citebase.eprints.org - all 7 versions »

Nuclear translocation of the SRF co-activator MAL in cortical neurons: role of RhoA signalling. - Full text - MIT Libraries
A Tabuchi, M Estevez, JA Henderson, R Marx, J … - Journal of Neurochemistry, 2005 - blackwell-synergy.com
... on whether the SRE binding sites present in their promoters bind preferentially
to SRF/TCF complexes or to SRF/MKL complexes, as found for Egr1 or vinculin ...
Web Search - ncbi.nlm.nih.gov

ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis - Full text - MIT Libraries
JD Norton - J. Cell Sci, 2000 - jcs.biologists.org
... pRB pRB ID E2F ID ID E2F pRB p21 cyclin D CDK4/6 bHLH bHLH bHLH bHLH EGR1 SRF TCF
EGR1 FOS TCF P cyclin E/A CDK2 S phase genes Progression through S phase ...
Cited by 141 - Web Search - jcs.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Regulation of MCL 1 through a Serum Response Factor/Elk-1-mediated Mechanism Links Expression of a … - Full text - MIT Libraries
KJ Townsend, P Zhou, L Qian, CK Bieszczad, CH … - J Biol Chem, 1999 - dx.doi.org
... through ERKs and transcriptional activation through SRF/Elk-1. This finding provides
a parallel to early response genes (eg c-FOS and EGR1) that affect ...
Cited by 31 - Web Search - jbc.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

The transcriptional effect of WT 1 is modulated by choice of expression vector. - Full text - MIT Libraries
JC Reddy, S Hosono, JD Licht - J Biol Chem, 1995 - jbc.org
... 1). The Egr1-CAT reporter contains nucleotides -957 to +248 of the murine Egr1 promoter
and includes binding sites for Egr1, AP-1, CREB, and SRF (27, 50) (Fig. ...
Cited by 26 - Web Search - jbc.org - ncbi.nlm.nih.gov

Identification of Transcription Factor Binding Sites Upstream of Human Genes Regulated by the … - Full text - MIT Libraries
JW Tullai, ME Schaffer, S Mullenbrock, S Kasif, GM … - J Biol Chem, 2004 - jbc.org
... antibody in comparison to GAPDH. As expected, the highest fold enrichment
was obtained with EGR1, which contains 6 SRF binding sites. ...
Cited by 7 - Web Search - bioinformatics.cs.vt.edu - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Context-dependent Transcriptional Regulation
TACB Achieved - cbr.med.harvard.edu
... 12-myristate 13-acetate; CDF-1, CDE-CHR binding factor-1; SRF, serum response ... of
GC-rich DNA-binding transcription fac- tors; binding of Sp1 and Egr1 is often ...
View as HTML - Web Search - genomecenter.ucdavis.edu - mcardle.oncology.wisc.edu - genomics.ucdavis.edu - all 6 versions »

Context-dependent Transcriptional Regulation - Full text - MIT Libraries
CJ Fry, PJ Farnham - J Biol Chem, 1999 - dx.doi.org
... Thus, Sp1 and Egr1 can differentially regulate transcription through the same binding
sites, depending ... and Egr, E2F and CDF-1 (CDE), and YY1 and SRF (SRE) can ...
Cited by 76 - Web Search - jbc.org - ncbi.nlm.nih.gov

Radiation-inducedtumour necrosis factor-a expression: Clinical application of transcriptional and …
RR WEICHSELBAUM, DW KUFE, S HELLMAN, HS RASMUSSEN, … - Lancet Oncol, 2002 - radiationbiology.dk
... ternary complex of transcription factors that include ELK1, the serum response factor,
and SRF accessory protein. Radiation induction of the EGR1 promoter has ...
Cited by 18 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Euroconference on tissue repair and ulcer/wound healing: molecular mechanisms, therapeutic targets …
M Braddock - Expert Opin. Investig. Drugs, 2005 - ashley-pub.com
... Provision of SRF gene therapy for 6 days reduced the average ulcer size by ... dermal
tissue repair in a rodent full-thickness excisional-wound model [25] ; EGR1 ...
Web Search - ashley-pub.com - ingentaconnect.com

Characterization of the Human elk-1 Promoter - Full text - MIT Libraries
U Lehmann, P Brocke, J Dittmer, A Nordheim - J Biol Chem, 1999 - jbc.org
... start site and exons I and II. Putative binding sites for transcription
factors Egr1, Elk-1 and SRF at these HSs are indicated. ...
Cited by 9 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Transcription factors as targets for DNA-interacting drugs
M Gniazdowski, WA Denny, SM Nelson, M Czyz - Curr. Med. Chem, 2003 - ingentaconnect.com
Page 1. Current Medicinal Chemistry, 2003, 10, 909-924 909 0929-8673/03
$41.00+.00 © 2003 Bentham Science Publishers Ltd. Transcription ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Ionizing radiation activates transcription of the EGRI gene via CArG elements - Full text - MIT Libraries
RR WEICHSELBAUM, DW KUFE - Proc. Natl. Acad. Sci. USA, 1992 - pnas.org
... i) the 0.7-kilobase (kb) non-zinc-finger insert ofa murine EGR1 cDNA (9 ... 13-acetate;
PKC, protein kinase C; SRE, serum response element; SRF, serum response ...
Web Search

Muscle Specificity Encoded by Specific Serum Response Factor-binding Sites - Full text - MIT Libraries
PS Chang, L Li, J McAnally, EN Olson - J Biol Chem, 2001 - jbc.org
... SRF. SRF bound strongly to the CArG elements from c-fos and egr1 and weakly
to CArG boxes from skeletal -actin, MCK, and SM22. The ...
Cited by 42 - Web Search - jbc.org - ncbi.nlm.nih.gov

Induction of the Early Growth Response Gene 1 Promoter by TCR Agonists and Partial Agonists: Ligand … - Full text - MIT Libraries
H Xi, GJ Kersh - J Immunol, 2003 - jimmunol.org
... A TC that contains SRF plus Elk-1 or SAP-1a form on the Egr1 promoter in
T cells. ... C, SRF binds to all six SREs in the Egr1 promoter. ...
Cited by 7 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Activation of the Wnt Pathway Interferes with Serum Response Element-driven Transcription of … - Full text - MIT Libraries
DA Tice, I Soloviev, P Polakis - J Biol Chem, 2002 - jbc.org
... At the fos SRE, for example, SRF forms a ternary complex with members of the ternary ...
and binding at the SRE is required to link the fos and egr1 promoters to ...
Cited by 5 - Web Search - jbc.org - ncbi.nlm.nih.gov

GEArray Q series Mouse cAMP/Ca2+ PathwayFinder Gene Array: AR-SAMM-028
FG Grouping - eurogentec.com
... SRE or the like enhancer sequence: Cnn1 (calponin), Cyr61, Egr1, Egr2, Fos, Fosb,
Hspa4 (hsp70), Junb, Nr4a2 (Nur77), Scg2 (secretogranin II), Srf, Thbs1 (TSP-1 ...
View as HTML - Web Search - eurogentec.be

GEArray Q series Human cAMP/Ca2+ PathwayFinder Gene Array: AR-SAHS-028
FG Grouping - eurogentec.com
... sequence: CNN1 (calponin), CYR61, EGR1, EGR2, FOS, FOSB, HSPA4 (Hsp70), JUNB, NR4A2
(Nur77), S100A6 (Calcyclin), SCG2 (secretogranin II), SRF, THBS1 (TSP-1 ...
View as HTML - Web Search - eurogentec.be

The Diaphanous-related formin mDia1 controls serum response factor activity through its effects on … - Full text - MIT Libraries
JW Copeland, R Treisman - Mol. Biol. Cell, 2002 - intl.molbiolcell.org
... previously that overexpression of wild-type actin inhibits signal-induced SRF
activation but does not block activation of the SRF target gene Egr1, which is ...
Cited by 27 - Web Search - pubmedcentral.nih.gov - dx.doi.org - molbiolcell.org - all 6 versions »

MALIGNANT TRANSFORMATION OF HUMAN NON-LYMPHOID CELL LINE INFECTED BY HTLV-I
E EEAaOIE, EHI AaEIAAaEA - Experimental Oncology, 2000 - exp-oncology.com.ua
... oncogenes [11, 37, 53], immediate early serum responsive genes egr1 and egr2 ... response
element binding protein (CREB/ATF), serum response factor (SRF), and the ...
Web Search - morion.kiev.ua

Thrombin Modulates the Expression of a Set of Genes Including Thrombospondin-1 in Human … - Full text - MIT Libraries
S Data - J. Biol. Chem, 2005 - jbc.org
... Analysis also predicted an experimentally determined model involving ETS and SRF
transcription factor family regulation of EGR1 via G i/o -mediated activation ...
Web Search - jbc.org - ncbi.nlm.nih.gov

Rays and arrays: the transcriptional program in the response of human epidermal keratinocytes to UVB … - Full text - MIT Libraries
S AIMS, P FINDINGS - The FASEB Journal, 2001 - fasebj.org
... several transcription factors such as junB, junD, c-fos, ETR101, EGR1, and HRY. ... UV
suppresses many transcription factors, including ets-2, BTEB2, SRF, TGIF, HLH ...
Cited by 38 - Web Search - fasebj.org - ncbi.nlm.nih.gov

Hepatitis B Virus X Protein: Structure, Function and Biology
S Murakami, S Murakami, FTC Alert - Intervirology, 1999 - content.karger.com
... s). Actually, several tran- scriptional activators of the bZip family and Egr1,
have been ... of XRE do not seem to interact with HBx such as NF-ÎB, SRF and Sp1. ...
Cited by 42 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Inducible Expression of Egr-1–Dependent Genes - Full text - MIT Libraries
LM Khachigian, T Collins - Circulation Research, 1997 - circresaha.org
... SRF, =, ternary complex factors. ... of the Icam-1 gene in antigen receptor- and phorbol
ester-stimulated B lymphocytes: role for transcription factor EGR1. ...
Cited by 64 - Web Search - circres.ahajournals.org - intl-circres.ahajournals.org - ncbi.nlm.nih.gov

MBC in Press, published on September 3, 2002 as 10.1091/mbc. 02-06-0092
J Copeland, R Treisman - molbiolcell.org
... We showed previously that over-expression of wildtype actin inhibits signal- induced
SRF activation but does not block activation of the SRF target gene Egr1, ...
Web Search

Identification of NAB1, a Repressor of NGFI-A-and Krox20-Mediated Transcription - Full text - MIT Libraries
MW Russo, BR Sevetson, J Milbrandt - Proceedings of the National Academy of Sciences - pnas.org
... Ehrig, SA Abdulkadir, MU Ehrengruber, MA Watson, and J. Milbrandt EGR1 Target Genes ...
finger gene Xegr-1 responds to the MAP kinase/Ets-SRF signal transduction ...
Cited by 77 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Cryptic translocation t (5; 11)(q35; p15. 5) with involvement of the NSD1 and NUP98 genes without 5q …
C Panarello, C Rosanda, C Morerio - Genes Chromosomes Cancer, 2002 - doi.wiley.com
... were tested for submicroscopic 5q deletions, although by use of only EGR1 and CSFR1 ...
Brown J, Jawad M, Twigg SRF, Saracoglu K, Sauerbrey A, Thomas AE, Eils R ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Transformation Blocks Differentiation-induced Inhibition of Serum Response Factor Interactions with … - Full text - MIT Libraries
W Ding, MM Witte, RE Scott - Cancer Res, 1999 - cancerres.aacrjournals.org
... early genes carry SREs within their regulatory regions, such as EGR1, cyr61, pip92 ...
of many immediate early genes, some studies suggest that SRF-SRE interaction ...
Cited by 5 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Induction of Early Growth Response Gene Egr2 by Basic Calcium Phosphate Crystals through a Calcium- …
FTC Alert, AW English, G Atlanta - Cells Tissues Organs, 2003 - content.karger.com
... and 3). These results suggest that transcription factors AP-1, MYC and SRF may be ...
the three zinc finger regions are 92% identical to those of Egr1, also known ...
Cited by 1 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Blockade of NGF-induced neurite outgrowth by a dominant-negative inhibitor of the egr family of … - Full text - MIT Libraries
Y Levkovitz, KJ O'Donovan, JM Baraban - J Neurosci, 2001 - jneurosci.org
... A reporter construct driven by a segment of the rat Egr1 promoter containing four ...
ternary complex factor that binds with the serum response factor (SRF) to the ...
Cited by 11 - Web Search - jneurosci.org - ncbi.nlm.nih.gov

GEArray Q Series Mouse NF-kB Signaling Pathway Gene Array: AR-SAMM-016
FG Grouping, NFBR Genes, E Ligands, I Il1a, T … - eurogentec.be
... C3 (C3 complement), Orm1 (Agp-1 B), Orm2, Saa1 (serum amyloid α1), Srf ... Transcription
Factors: Atf2 (CREB-2), Creb1 (CREB), Egr1, Elk1, Elk3, Fos, Jun, Max, Myc ...
View as HTML - Web Search - eurogentec.com

GEArray Q Series Mouse NFκB Signaling Pathway Gene Array
C No, K Size, FG Grouping, NFBR Genes, E Ligands, … - cosmobio.co.jp
... C3 (C3 complement), Orm1 (Agp-1 B), Orm2, Saa1 (serum amyloid α1), Srf ... Transcription
Factors: Atf2 (CREB-2), Creb1 (CREB), Egr1, Elk1, Elk3, Fos, Jun, Max, Myc ...
View as HTML - Web Search - cosmobio.co.jp - superarray.com

GEArray Q Series Human NFkB Signaling Pathway Gene Array: AR-SAHS-016.2
FG Grouping, NFBR Genes, E Ligands, ILB IL1A, T … - eurogentec.be
... angiotensinogen), BF, C3 (C3 complement), ORM1 (AGP1), SAA1 (serum amyloid A1),
SRF. ... Transcription Factors: ATF2 (CREB-2), CREB1, EGR1, ELK1, ELK3, FOS, JUN ...
View as HTML - Web Search - eurogentec.com

GEArray Q Series Human NFkB Signaling Pathway Gene Array Cat. No.* Kit Size HS-016-2/HS-016N-2 2 …
FG Grouping, NFBR Genes, E Ligands, ILB IL1A, T … - tebu-bio.com
... BF, C3 (C3 complement), ORM1 (AGP1), ORM2 (AGP2), SAA1 (serum amyloid A1), SRF ... TAB1
(TAK1), TBK1 Transcription Factors: ATF2 (CREB-2), CREB1, EGR1, ELK1, ELK3 ...
View as HTML - Web Search

GEArray Q Series Mouse NFkB Signaling Pathway Gene Array Cat. No.* Kit Size MM-016-2/MM-016N-2 2 …
FG Grouping, NFBR Genes, E Ligands, T Receptors, A … - tebu-bio.com
... C3 (C3 complement), Orm1 (Agp-1 B), Orm2, Saa1 (serum amyloid α1), Srf ... Transcription
Factors: Atf2 (CREB-2), Creb1 (CREB), Egr1, Elk1, Elk3, Fos, Jun, Max, Myc ...
View as HTML - Web Search

Decreased expression and activity of the immediate‐early growth response(Egr‐1) gene product … - Full text - MIT Libraries
M Meyyappan, K Wheaton, KT Riabowol - Journal of Cellular Physiology, 1999 - doi.wiley.com
... senescent cells, like that of c-fos, correlates with the loss of SRF bind- ing ... Our
results also suggest that Egr1 and Sp1 may bind syn- ergistically to their ...
Cited by 8 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

A ternary complex factor-dependent mechanism mediates induction of egr-1 through selective serum … - Full text - MIT Libraries
SB McMahon, JG Monroe - Mol Cell Biol, 1995 - mcb.asm.org
... A, and TIS8 (7, 24, 25, 30), encodes a transcription factor (EGR1) that has a ... with
published reports showing failure of this element to bind SRF at detectable ...
Cited by 43 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

GEArray S Series Mouse Autoimmune and Inflammatory Response Gene Array: AR-SAMM-602.3
FG Grouping, A Proteins, CS Receptors, ST Proteins … - eurogentec.com
... Transcription Factors: Atf2, Cebpb, Creb1, Crebbp, Egr1, Egr2, Egr3, Elk1, Elk3,
Fkbp1b ... ESTs, Raf1, Rel, Rela, Relb, Runx1, Runx2, Sp1, Sp3, Srf, Stat1, Stat4 ...
View as HTML - Web Search - eurogentec.be

GEArray S Series Human Autoimmune and Inflammatory Response Gene Array: AR-SAHS-602
FG Grouping, A Proteins, CS Receptors, ST Proteins … - eurogentec.be
... Transcription Factors: ATF2, CEBPB, CREB1, CREBBP, EGR1, EGR2, EGR3, ELK1, ELK3,
EP300 ... NFRKB, RAF1, REL, RELA, RELB, RUNX1, RUNX2, SP1, SP3, SRF, STAT1, STAT4 ...
View as HTML - Web Search - eurogentec.com

BMC Molecular Biology - Full text - MIT Libraries
A Selvaraj, R Prywes - BMC Molecular Biology, 2004 - biomedcentral.com
... MKL-Independent genes (122) Known SRF target genes ... rich protein 1 (Crp1) 6
prostaglandin-endoperoxide synthase 2 7 early growth response 1 (Egr1) 8 early ...
View as HTML - Web Search - dx.doi.org - bmc.ub.uni-potsdam.de

GEArray S Series Human Immunology Signaling Pathways Gene Array: AR-SAHS-605
FG Grouping, A Molecules, I ICAM, CS Molecules, C … - eurogentec.com
... Transcription Factors: ATF2, CEBPB, CREB1, CREBBP, EGFR, EGR1, EGR2, EGR3, ELK1,
ELK3 ... MST1, NPPB, NOS3, OAS1, ORM1, PIN1, SAA1, SFN, SLC2A4, SRF, TERT, YWHAZ. ...
View as HTML - Web Search - eurogentec.be

Opposing Roles of Elk-1 and Its Brain-specific Isoform, Short Elk-1, in Nerve Growth Factor-induced … - Full text - MIT Libraries
P Vanhoutte, JL Nissen, B Brugg, BD Gaspera, MJ … - J Biol Chem, 2001 - jbc.org
... response factor (SRF) in a ternary complex on the serum response element (SRE) present
in the promoter of many immediate early genes (c-fos, egr1, egr2, pip92 ...
Cited by 16 - Web Search - dx.doi.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors … - Full text - MIT Libraries
P Adiseshaiah, S Peddakama, Q Zhang, DV … - Oncogene, 2005 - nature.com
... in the regulatory regions of many immediate early genes such as fos-B, Egr1, Egr2,
and junB ... occupied both in vivo and in vitro by protein factors, SRF and Elk1 ...
Web Search - nature.com - ncbi.nlm.nih.gov

Id helix–loop–helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain … - Full text - MIT Libraries
PR Yates, GT Atherton, RW Deed, JD Norton, AD … - The EMBO Journal, 1999 - embojournal.npgjournals.com
... TCFs form DNA-bound complexes with the serum response factor (SRF) and are direct
targets of MAP kinase (MAPK) signal transduction cascades. ...
Cited by 53 - Web Search - nature.com - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »