Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic … - Full text - MIT Libraries
PD Brophy, L Ostrom, KM Lang, GR Dressler - Development, 2001 - dev.biologists.org
... because of suppression of Pax2 in the metanephric mesenchyme. A negative regulator
of GDNF expression is the forkhead transcription factor Foxc1 (Kume et al ...
Cited by 31 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate - Full text - MIT Libraries
B Wilm, RG James, TM Schultheiss, BLM Hogan - Developmental Biology, 2004 - cellbio.duke.edu
... The resulting cFoxc2-GFP and Foxc1-GFP plasmids were separately electroporated into ...
Nephric tissue was identified with antibodies to Pax2, and somitic tissue ...
View as HTML - Web Search - note.cellbio.duke.edu - ncbi.nlm.nih.gov

Paradigm shift from classic anatomic theories to contemporary cell biological views of CAKUT - Full text - MIT Libraries
I Ichikawa, F Kuwayama, JC Pope, FD Stephens, Y … - Kidney International, 2002 - blackwell-synergy.com
... concurrently cause kidney and ureter anomalies. In addition to Agtr2, Bmp4
and Foxc1 documented above, those include Pax2 and Eya1. ...
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Functional interactions between alternatively spliced forms of Pax 6 in crystallin gene regulation … - Full text - MIT Libraries
BK Chauhan, Y Yang, K Cveklova, A Cvekl - Nucleic Acids Research, 2004 - pubmedcentral.nih.gov
... A significant proportion of genes encoding transcription factors (eg FOXC1, PAX2,
PAX3, PAX6, PITX2, PITX3, SIX6 and TBX1) are dosage-sensitive (3,32,53–56). ...
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Tubulogenesis in the developing mammalian kidney - Full text - MIT Libraries
G Dressler - Trends Cell Biol, 2002 - cb207.med.harvard.edu
... Expression of Pax2 in the mesenchyme is required for GDNF activation [9], whereas ...
at the anterior boundary through the concerted action of the FoxC1 and FoxC2 ...
Cited by 18 - View as HTML - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov

Genetic determination of nephrogenesis: the Pax/Eya/Six gene network - Full text - MIT Libraries
S Brodbeck, C Englert - Pediatric Nephrology, 2004 - springerlink.com
... Many of the genes that play a crucial role in early kidney development, such as
Pax2, Eya1, Six1, Six2, Sall1, Foxc1, Wt1, and the Hox11 genes, are expressed ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov

Genetic Regulation of Branching Morphogenesis: Lessons Learned from Loss-of-Function Phenotypes
CTD BRANCHING - PEDIATRIC RESEARCH, 2003 - pedresearch.org
... Thus, PAX2 and EYA1 working in opposition to FOXC1 may control the number and site
of ureteric bud outgrowths. Ureteric bud and collecting duct branching. ...
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SLIT2-Mediated ROBO2 Signaling Restricts Kidney Induction to a Single Site
F Wang, M Tessier-Lavigne, GR Martin - ucsf.edu
... the observation that when Gdnf dosage is reduced in of Eya1, Pax2, and Foxc1, presumed
transcriptional reg- Slit2 mutants and the supernumerary UB phenotype is ...
View as HTML - Web Search - smbs.buffalo.edu

Transcriptional Control of Epithelial Differentiation during Kidney Development - Full text - MIT Libraries
D Ribes, E Fischer, A Calmont, J Rossert - J Am Soc Nephrol, 2003 - jasn.org
... genes (17), Foxc1 may inhibit the expression of Eya1, which, in turn, inhibits the
expression of Gdnf (Figure 1). The Pax2-Eya1-Six2-Hox11-Foxc1 pathway is not ...
Web Search - intl.jasn.org - ncbi.nlm.nih.gov

Organogenesis: Coordinating early kidney development: lessons from gene targeting - Full text - MIT Libraries
S Vainio, Y Lin - Nature Reviews Genetics, 2002 - nature.com
... Shows that Pax2 might participate in the initiation of kidney development by
controlling ... K. & Hogan, BL Murine forkhead/winged helix genes Foxc1 (Mf1) and ...
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Feature Article Ontogeny of congenital anomalies of the kidney and urinary tract, CAKUT - Full text - MIT Libraries
Y Miyazaki, I Ichikawa - Pediatrics International, 2003 - blackwell-synergy.com
... In this regard, PAX2, a paired-box transcription factor, has been identified as ... we
analyzed mutant mice carrying a null mutation of the Foxc1 gene (formerly Mf1 ...
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The Life of the Human Kidney Before Birth: Its Secrets Unfold - Full text - MIT Libraries
A STUDIES - Pediatric Research, 2001 - pedresearch.org
... Kume T, Deng K, Hogan BLM 2000 Murine forkhead/winged helix genes Foxc1 (Mf1) and ...
Blanquet V, Grimes P, Sporle R, Schughart K 1996 The mouse Pax2 1Neu mutation ...
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The genetic and molecular basis of congenital eye defects - Full text - MIT Libraries
J Graw - Nature Reviews Genetics, 2003 - nature.com
... 38. Nishimura, DY et al. A spectrum of FOXC1 mutations suggests gene dosage as a
mechanism for developmental defects of the anterior chamber of the eye. Am. ...
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Implications of Gene Networks for Understanding Resilience and Vulnerability in the Kidney Branching … - Full text - MIT Libraries
RV Sampogna, SK Nigam - Physiology (Bethesda), 2004 - physiologyonline.physiology.org
... between GDNF and GRF 1/Ret) or whether they represent tightly linked upstream or
downstream regulatory interactions between genes (eg, Pax2, Foxc1, and Eya1 ...
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The molecular control of renal branching morphogenesis: current knowledge and emerging insights - Full text - MIT Libraries
TD Piscione, ND Rosenblum, C Boudreau-Lariviere, R … - Differentiation, 2002 - ingentaconnect.com
... bud outgrowth. Pax2, Foxc1, and Eya1 regulate expression of Gdnf in
undifferentiated mesenchyme (Light grey zone). To spe- cify ...
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The winged helix transcription factor Foxc 1 a is essential for somitogenesis in zebrafish - Full text - MIT Libraries
JM Topczewska, J Topczewski, A Shostak, T Kume, L … - Genes & Development, 2001 - genesdev.org
... pax2.1- and deltaC-positive pronephros primordium present in wild-type but not
MO-injected embryos. Immunohistochemistry showed the complete absence of Foxc1 ...
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Transcriptional control of kidney development - Full text - MIT Libraries
M Bouchard - Differentiation, 2004 - blackwell-synergy.com
... In contrast to Pax2, the zinc-finger transcription factor Wt1 (Call et al ... Noticeably,
embryos mutant for the forkhead transcription factor Foxc1 induce ectopic ...
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ANOMALIES DU DEVELOPPEMENT ET MECANISMES DES MALFORMATIONS DU REIN ET DE L’APPAREIL URINAIRE
A WOOLF - soc-nephrologie.org
... de facteur de croissance [28], un facteur de trans- cription FOXC1 [29], ou ... où des
mutations hétéro- zygotes du facteur de transcription PAX2 s’accompagne ...
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Evolving concepts in human renal dysplasia - Full text - MIT Libraries
AS Woolf, KL Price, PJ Scambler, PJD Winyard - J Am Soc Nephrol, 2004 - jasn.org
... E) PAX2 in dysplastic ... UB ectopia with RD-like lesions occurs in mice with ablation
of AT2 (46), FOXC1 transcription factor (47), and bone morphogenetic protein ...
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First Genomic Localization of Oculo-Oto-Dental Syndrome with Linkage To Chromosome 20q13. - Full text - MIT Libraries
H Vieira, K Gregory-Evans, N Lim, JL Brookes, LA … - Investigative Ophthalmology and Visual Science, 2002 - iovs.org
... Assessment Candidate loci encompassing the developmental genes PAX6, PAX2, TGFB2,
DLX2, BMP4, RIEG1, ODD, MSX1, HOXC, PDGFRA, DLX3, HOXA1, FOXC1, RIEG2, MAF ...
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Novel ENU-induced eye mutations in the mouse: models for human eye disease - Full text - MIT Libraries
C Thaung, K West, BJ Clark, L McKie, JE Morgan, K … - Human Molecular Genetics, 2002 - hmg.oupjournals.org
... of Krd/+ mice is attributed to the loss of one copy of Pax2 (23). ... with appropriate
flanking markers showed that Dilp4 is also not linked to Foxc1, Foxc2 and ...
Cited by 19 - Web Search - hmg.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Status of the Human Malformation Map: 2002
JC CAREY, DH VISKOCHIL - American Journal of Medical Genetics (Semin. Med. Genet.), 2002 - doi.wiley.com
... 108900 600584 5q34 NKX2E NK2 transcription factor, Drosophila, homolog of, E Axenfeld
anomaly 601090 601090 6p25 FOXC1 Forkhead, Drosophila, homolog-like 7 ...
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Wnt 11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney … - Full text - MIT Libraries
A Majumdar, S Vainio, A Kispert, J McMahon, AP … - Development, 2003 - dev.biologists.org
... Similarly, in the Foxc1 mutant, an expanded mesenchymal Gdnf expression domain is
the ... the following templates Wnt11 (XhoI/T3), Ret (BamHI/T7), Pax2 (XbaI/T3 ...
Cited by 14 - Web Search - dx.doi.org - dev.biologists.org - ncbi.nlm.nih.gov

Toward an etiological classification of developmental disorders of the kidney and upper urinary … - Full text - MIT Libraries
M Pohl, V Bhatnagar, SA Mendoza, SK Nigam - Kidney International, 2002 - ingentaconnect.com
... PAX2 Nephrogenesis Process 1: Ureteric bud induction WT1, Eya-1, GDNF, c-ret, ld,
integrin 8, Hoxa11/d11, Foxc1/Mf1, Mf2, Foxc2/Mfh1, (Kal), PAX2, laminin 5 ...
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Molecular aspects of vertebrate retinal development
SS Zhang, XY Fu, CJ Barnstable - Mol. Neurobiol, 2002 - biomed.humanapress.com
... Position specification Vax2 TF y (29, 31) Pax2 TF y (22) Tbx5 TF y (73) Mitf TF
y (14) ... Chx10 TF y (16) Mitf TF y (13, 14, 15) Foxc1 TF y (75) Foxc2 TF y (75) ...
Cited by 9 - Web Search - neurosci.humanapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Molecular Mechanisms of Human Embryogenesis: Developmental Pathogenesis of Renal Tract Malformations - Full text - MIT Libraries
AS Woolf, PJD Winyard - Pediatric and Developmental Pathology, 2002 - springerlink.com
... 29] FOXc1/FOXc2 b Urinary tract duplications Kume et al., 2000 [33] ... 38]
PAX2 a,c Small or absent kidneys Torres et al., 1995 [39] ...
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Genetic analysis of Gremlin functions during mouse organogenesis
O Michos - 2004 - dspace.library.uu.nl
... Lim1 deficient mouse embryos fail to activate Pax2 , which is in turn also essential
for metanephric kidney development (Torres et al., 1995). ... Pax2 in the ...
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Morphogenesis of the Metanephric Kidney
ITOV KIDNEYS - TheScientificWorldJOURNAL, 2002 - thescientificworld.com
... factors Pax2 and Pax5 in mouse development. Development 127, 3703–3713. 9. Kume,
T., Deng, K., and Hogan, BL (2000) Murine forkhead/winged helix genes Foxc1 ( ...
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Evolving eyes.
RD FERNALD - Int. J. Dev. Biol, 2004 - stanford.edu
... paired domain, eya-eyes absent, eyg-eye gone homeodomain, FOXC1-forkhead box gene ...
optix-homeodomain/six domain, OTX1-orthodenticle homologue 1, PAX2-paired box ...
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Eyes: Variety, Development and Evolution - Full text - MIT Libraries
F Alert, RG Northcutt, C San Diego, MS Northcutt, … - Brain, Behavior and Evolution, 2004 - content.karger.com
... domain; eya, eyes absent; eyg, eye gone homeodomain; FOXC1, forkhead box gene ... optix,
homeodomain/six domain; OTX1, orthodenticle homologue 1; PAX2, paired box ...
Web Search - dx.doi.org - content.karger.com - karger.com

Genes and Proteins in Renal Development
E Nephrology - Experimental Nephrology, 2002 - content.karger.com
... Pax2/5/8 family: Dependency of Pax5 and Pax8 expression on the Pax2.1 (noi ... 11 Kume
T, Deng K, Hogan BL: Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 ...
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Animal models of fetal renal disease
CA Peters - Prenatal Diagnosis, 2001 - doi.wiley.com
... 1997; Tang et al., 1998) murine forkhead/ winged helix gene (Foxc1 (Mf1) (Kume ... Increased
relative expression levels of growth factors, for example PAX2 and TGF ...
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Congenital anomalies of the kidney and urinary tract–role of the loss of function mutation in the …
JC Pope, JW Brock III, MC Adams, Y Miyazaki, FD … - J Urol, 2001 - jurology.com
... T., Deng, K. and Hogan, BL: Murine forkhead/winged helix genes Foxc1 (Mf1) and ...
Sanyanusin, P., Schimmenti, LA, McNoe, LA et al: Mutation of the PAX2 gene in a ...
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Branching morphogenesis and kidney disease - Full text - MIT Libraries
MM Shah, RV Sampogna, H Sakurai, KT Bush, SK Nigam - Development, 2004 - med.umich.edu
... include Wilms tumor-suppressor gene 1 (Wt1), Lim1, Paired-box gene 2 (Pax2), Eyes
absent 1 ... that limit the expression of GDNF in the MM, such as Foxc1 (Mf1), or ...
Cited by 8 - View as HTML - Web Search - dx.doi.org - dev.biologists.org - ncbi.nlm.nih.gov - all 6 versions »

Eyes: Variety, Development and Evolution - Full text - MIT Libraries
RD Fernald - Brain Behavior and Evolution, 2004 - content.karger.com
... paired domain; eya, eyes absent; eyg, eye gone homeodomain; FOXC1, forkhead box ... ho-
meodomain/six domain; OTX1, orthodenticle homologue 1; PAX2, paired box ...
Web Search - stanford.edu - gurdon.cam.ac.uk - ncbi.nlm.nih.gov - all 5 versions »

Absence of SIX 6 Mutations in Microphthalmia, Anophthalmia, and Coloboma - Full text - MIT Libraries
S Aijaz, BJ Clark, K Williamson, V van Heyningen, … - Investigative Ophthalmology & Visual Science, 2004 - iovs.org
... Renal-coloboma syndrome: a multi-system developmental disorder caused by PAX2 mutations. ...
have on the structure and function of the winged-helix protein FOXC1. ...
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E ARLY E YE D EVELOPMENT IN V ERTEBRATES - Full text - MIT Libraries
RL Chow, RA Lang - Annual Review of Cell and Developmental Biology, 2001 - cellbio.annualreviews.org
... Pax2 and Pax6 reciprocal repression at the PV-DD boundary is believed to occur
gradually (B and C) until a sharp boundary (D) forms between neural retina and ...
Cited by 65 - Web Search - cellbio.annualreviews.org - astro.annualreviews.org - ncbi.nlm.nih.gov - all 5 versions »

GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor … - Full text - MIT Libraries
G Haase, E Dessaud, A Garces, B de Bovis, M … - Neuron, 2002 - neuro.med.harvard.edu
Page 1. Neuron, Vol. 35, 893–905, August 29, 2002, Copyright 2002 by
Cell Press GDNF Acts through PEA3 to Regulate Cell Body ...
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Overexpression of RET leads to vesicoureteric reflux in mice - Full text - MIT Libraries
OH Yu, IJ Murawski, DB Myburgh, IR Gupta - Am J Physiol Renal Physiol, 2004 - ajprenal.physiology.org
... Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived ...
Deng K, and Hogan B. Murine forkhead/winged helix genes Foxc1 (Mf1) and ...
Web Search - ajprenal.physiology.org - ncbi.nlm.nih.gov

An expression pattern screen for genes involved in the induction of the posterior nervous system of … - Full text - MIT Libraries
H Yoda, A Momoi, CV Esguerra, D Meyer, W Driever, … - Differentiation, 2003 - blackwell-synergy.com
... 4A''), sna1 (C''), deltaD (E''), her1 (G''), and foxc1 (M'') and are suggested for
specification or segmentation of somites (Thisse et al., 1993; Odenthal and ...
Cited by 3 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Luciferase Reporters: Less is More
A Paguio, B Almond, F Fan, P Stecha, D Garvin, M … - promega.com
... v-Myb v-Myb v-Myb PAX2/5/8 c-Myb C-Myb ... IRF1 Nkx2.5 Tal-1a GBF3 AD-b OBF1 FOXC1
Brn-3 Cdx-2 GBF1 NUDR TCF/LEF1 CDF1 AP1 MIT/TFE Runt-2 COMP1 CDP Avian C Pbx1 ...
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Cell fate specification along the anterior-posterior axis of the intermediate mesoderm - Full text - MIT Libraries
H Barak, L Rosenfelder, TM Schultheiss, R Reshef - Developmental Dynamics, 2005 - doi.wiley.com
Page 1. RESEARCH ARTICLE Cell Fate Specification Along the Anterior–Posterior
Axis of the Intermediate Mesoderm Hila Barak, 1 Lea ...
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The Glial Cell–Derived Neurotrophic Factor Signaling Pathway
LF REICHARDT - ucsf.edu
... as Emx2 (Miyamoto et al., 1997), Eya1 (Xu et al., 1999), Pax2 (Brophy et ... GDNF in
the intermediate mes- enchyme is expanded anteriorly in double Foxc1 and Foxc2 ...
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A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine … - Full text - MIT Libraries
MF Lyon, RV Jamieson, R Perveen, PH Glenister, R … - Human Molecular Genetics, 2003 - hmg.oupjournals.org
... specific gap junction protein Gja8, and the transcription factors Pax2, and Pax6 ...
John, SW (2000) Haploinsufficiency of the transcription factors FOXC1 and FOXC2 ...
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Long-Range Control of Gene Expression: Emerging Mechanisms and Disruption in Disease - Full text - MIT Libraries
DA Kleinjan, V van Heyningen - The American Journal of Human Genetics, 2005 - journals.uchicago.edu
... Lehmann et al. 2003). FOXC1 (previously, FKHL7) lies in a cluster of forkhead
genes on chromosome 6p25. Mutations cause ocular malformations ...
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pGL3 Luciferase Reporter Vectors
I Description, IIIP Components, IVC Methods, I … - promega.com
... Runt-2 Pbx-1 TEF-1 pGL4 Backbone pGL3 Backbone Nco I Cdx-2 Brn-3 FOXC1 Cart-1
OBF-1 AB-D GBF3 GBF1 GBF1 GBF1 ... HNF1 CDE HNF3 HNF4 MEIS1 Msx-1 Pax2/5/8 TALE GBF1 ...
Web Search - genomics.sbg.ac.at - sci.sdsu.edu - shpromega.cn - all 8 versions »

Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and … - Full text - MIT Libraries
H Suh, PJ Gage, J Drouin, SA Camper - Development, 2002 - dev.biologists.org
... Reduced Pax2 Gene Dosage Increases Apoptosis and Slows the Progression of ...
Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ...
Cited by 26 - Web Search - ircm.qc.ca - dev.biologists.org - ncbi.nlm.nih.gov - all 5 versions »

Hairy/E (spl)-related (Her) genes are central components of the segmentation oscillator and display … - Full text - MIT Libraries
AC Oates, RK Ho - Development, 2002 - dev.biologists.org
Summary of this Article. Figures Only for this Article. PDF Version of this
Article. Email this article to a friend. Similar articles ...
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Genes and Proteins in Renal Development
JADCE Fisher - Exp Nephrol, 2002 - content.karger.com
Page 1. Exp Nephrol 2002;10:102–113 Genes and Proteins in Renal Development
Jamie A. Davies Carolyn E. Fisher Centre for Developmental ...
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