A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway … - Full text - MIT Libraries
J Das, CH Chen, L Yang, L Cohn, P Ray, A Ray - Nat Immunol, 2001 - nature.com
... CD4 + T cells from p50 -/- mice failed to induce Gata3 expression under ... in the
development of airway eosinophilia, airway hyper-responsiveness (AHR) and serum ...
Cited by 108 - Web Search - nature.com - ncbi.nlm.nih.gov

JAK-STAT signaling in asthma - Full text - MIT Libraries
AB Pernis, PB Rothman - J Clin Invest, 2002 - dx.doi.org
... Similar findings in terms of AHR have also been reported. ... significant difference
in expression of the other characteristic Th2 transcription factors GATA3 and c ...
Cited by 22 - Web Search - jci.org - jci.org - pubmedcentral.nih.gov - all 7 versions »

Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice - Full text - MIT Libraries
SL Ewart, D Kuperman, E Schadt, C Tankersley, A … - Am J Respir Cell Mol Biol, 2000 - ajrcmb.org
... studies demonstrate that a dominant negative mutant of Gata3 inhibits allergen ... a
strong association between susceptibility to allergen-induced AHR and Th2 ...
Cited by 27 - Web Search - ajrcmb.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

CpG DNA: immunomodulation and remodelling of the asthmatic airway
VV Jain, JN Kline - Expert Opinion on Biological Therapy, 2004 - extenza-eps.com
... accelerated decline in airflow obstruction and airway hyper-reactivity (AHR), all
of ... transcription factors: T-bet promotes the Th1 phenotype, and GATA3 the Th2 ...
Web Search - ingentaconnect.com - ashley-pub.com - dx.doi.org - all 8 versions »

The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3 - Full text - MIT Libraries
H Kishikawa, J Sun, A Choi, SC Miaw, IC Ho - J Immunol, 2001 - jimmunol.org
... Furthermore, administration of rIL-13 to airways induced AHR, influx of eosinophils,
mucus ... with 10 µg of a GATA-3 expression vector, pcDNA-GATA3 (a gift from J ...
Cited by 27 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Th-2 cytokines in allergic disease
DS Robinson - British Medical Bulletin, 2000 - dx.doi.org
... IL-9 alone is sufficient for eosinophilic airway inflammation and AHR in mice ... of
factors important in determining murine IL-4 production, including GATA3, c-maf ...
Cited by 20 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Mouse Models for the Genetic Dissection of Atopy - Full text - MIT Libraries
A Heinzmann, A Daser, F Alert - International Archives of Allergy and Immunology, 2002 - content.karger.com
... Th2 cytokines Absence Th1 cytokines Increase Gata3–/– AE Decrease Zhang et al.
[18] Mucus Decrease Specific IgE Decrease Cd81–/– AHR Protection Deng et ...
Cited by 4 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

Atopic disorders: a vaccine around the corner - Full text - MIT Libraries
G Wohlleben, KJ Erb - Trends Immunol, 2001 - abayfor.de
... of specific, downstream transcription factors, such as c-Maf, GATA3, nuclear factor ...
eosinophilia and the development of airway hyperresponsiveness (AHR) 25,26 ...
Cited by 16 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Critical role of CD 81 in cognate T-B cell interactions leading to Th2 responses - Full text - MIT Libraries
J Deng, RH Dekruyff, GJ Freeman, DT Umetsu, S Levy - International Immunology, 2002 - intimm.oupjournals.org
... through its associated molecules, and magnify the intracellular signaling leading
to STAT6 phosphorylation and GATA3 expression. ... AHR—airway hyper-reactivity. ...
Cited by 15 - Web Search - intimm.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

GEArray Q Series Human Breast Cancer and Estrogen Receptor Signaling Gene Array: AR-SAHS-020
FG Grouping - eurogentec.com
... CDKN2A (p16INK4a), COL6A1, CTNNB1 (b-catenin), CTSB (cathepsin B), EGFR, ERBB2
(Her-2), ESR1, ESR2, F3 (TF), FOSL1 (FRA-1), GATA3, GSN (Gelsolin ... 3. Ahr A, et al ...
View as HTML - Web Search - eurogentec.be

GEArray Q Series Mouse Breast Cancer and Estrogen Receptor Signaling Gene Array: AR-SAMM-020
FG Grouping - eurogentec.com
... Cdkn1b (p27Kip1), Cdkn2a (p16INK4a), Col6a1, Ctsb (cathepsin B), Egfr, Erbb2
(Her-2), Esr1, Esr2, F3, Fosl1 (FRA-1), Gata3, Gsn (Gelsolin ... 3. Ahr A, et al. ...
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The Th1 and Th2 Concept in Atopic Allergic Disease
DS Robinson - Chem Immunol, 2000 - content.karger.com
... systemic production of IL-5 could restore eosinophil and AHR response to ... of factors
important in determining murine IL-4 production, including GATA3, c-maf, NIP ...
Cited by 3 - Web Search - content.karger.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Reduced expression of transforming growth factor b exacerbates pathology in an experimental asthma …
W Scherf, S Burdach, G Hansen - doi.wiley.com
... were calculated and data are expressed as percent above baseline (NaCl-induced AHR). ...
for signaling downstream of the TGF-bR, to interact with GATA3 and form a ...
Web Search

The Role of STATs in Inflammation and Inflammatory Diseases
S PATHWAY - Current Pharmaceutical Design, 2004 - ingentaconnect.com
... cytokines IFN-γ (T-bet) or IL-5, IL-4 and IL-13 (GATA3). ... to be involved in Th2-type
immune response process such as airway hyperreactivity (AHR) and allergen ...
Web Search

Cardiac Energetics in Mouse Models of Friedreich Ataxia
R Balaban, K Clarke - gpp.nih.gov
... Nature; 406: 419-422 (2000) GATA3 haplo-insufficiency causes human HDR syndrome. ...
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor ...
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Tregs and allergic disease - Full text - MIT Libraries
DS Robinson, M Larche, SR Durham - J. Clin. Invest, 2004 - jci.org
... 5. These cells also produce IL-9 and IL-13, which contribute to AHR in asthma ... master
switch for the regulatory phenotype in much the same way as do GATA3 and T ...
Cited by 7 - Web Search - pubmedcentral.nih.gov - immuneweb.xxmc.edu.cn - dx.doi.org - all 6 versions »

Modulation of Th1 and Th2 responses for immunotherapy
FJ Dumont - inflammation. - extenza-eps.com
... transcription factors, prin- cipally T-bet in Th1 cells and GATA3 in Th2 ... could blunt
allergen-induced inflammation and airway hyper- responsiveness (AHR) [19 ...
Cited by 5 - Web Search - ashley-pub.com - dx.doi.org - ingentaconnect.com - all 7 versions »

Identification of Novel IL-4/Stat6-Regulated Genes in T Lymphocytes - Full text - MIT Libraries
Z Chen, R Lund, T Aittokallio, M Kosonen, O … - The Journal of Immunology, 2003 - jimmunol.org
... IL-4ra (10), Prnp, Gata3, and Pros1 were induced by IL-4 at both early (2 and 6
h ... were induced by IL-4 mostly at late time points, eg, IL-4, Casp6, and Ahr (Fig ...
Cited by 6 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Emerging treatments for asthma
K Blease, A Lewis, HK Raymon - Expert Opinion on Emerging Drugs, 2003 - dx.doi.org
... has been shown in both acute and chronic rat and mouse models to reduce AHR, smooth
mus ... B cell lymphoma-6 (BCL-6), NF- κ B and GATA-binding protein 3 (GATA3). ...
Cited by 3 - Web Search - extenza-eps.com - ashley-pub.com - ingentaconnect.com - all 9 versions »

Distinct and Complementary Information Provided by Use of Tissue and DNA Microarrays in the Study of … - Full text - MIT Libraries
C Ginestier, E Charafe-Jauffret, F Bertucci, F … - development - ajp.amjpathol.org
... 6F11 1/60 FGFR1 Rabbit polyclonal Santa Cruz Biotechnology sc-121 1/200 GATA3 mmab
Santa Cruz Biotechnology sc-268 1/100 ... GATA3 Nucleus ( ) 26 12 7 10 ...
Cited by 24 - Web Search - ingentaconnect.com - utoronto.ca - ncbi.nlm.nih.gov - all 6 versions »

MINI REVIEW BREAST CANCER REVISITED USING DNA ARRAY-BASED GENE EXPRESSION PROFILING - Full text - MIT Libraries
F Bertucci, P Viens, P Hingamp, V Nasser, R … - Int. J. Cancer, 2003 - doi.wiley.com
... P53 and BCL2 and inhibits cell cycle, have a function potentially linked with a
role in breast cancer (Table I). 18 For others such as GATA3, the correlation ...
Cited by 22 - Web Search - ncbi.nlm.nih.gov

Selective Blockade of NF-{kappa} B Activity in Airway Immune Cells Inhibits the Effector Phase of … - Full text - MIT Libraries
C Desmet, P Gosset, B Pajak, D Cataldo, M Bentires … - The Journal of Immunology, 2004 - jimmunol.org
... 3 Abbreviations used in this paper: AHR, airway hyperresponsiveness; BALF,
bronchoalveolar lavage fluid ... A critical role for NF- B in GATA3 expression and TH2 ...
Cited by 2 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

A stage-specific functional role of the leucine zipper transcription factor c-Maf in lung Th2 cell … - Full text - MIT Libraries
M Hausding, IC Ho, HA Lehr, B Weigmann, C Lux, M … - European Journal of Immunology, 2004 - doi.wiley.com
... The development of allergic immune responses and airway hyperresponsiveness (AHR),
such as in allergic asthma, is believed to be mediated by CD4 + effector T ...
Web Search - ncbi.nlm.nih.gov

Induction of allergic inflammation by interleukin-18 in experimental animal models - Full text - MIT Libraries
H Tsutsui, T Yoshimoto, N Hayashi, H Mizutani, K … - Immunological Reviews, 2004 - blackwell-synergy.com
Full Article. View/Print PDF article (2463K). Download to reference manager.
Immunological Reviews Volume 202 Issue 1 Page 115 - December ...
Web Search - ncbi.nlm.nih.gov

T cell directives for transcriptional regulation in asthma
S Finotto, L Glimcher - Springer Seminars in Immunopathology, 2004 - springerlink.com
... T-bet in controlling the hallmark features of asthma such as AHR, peribronchial
collagen ... P, Ray A (2001) A critical role for NF-kappa B in GATA3 expression and ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms - Full text - MIT Libraries
ME Massari, C Murre, R Articles - Mol. Cell. Biol, 2000 - dx.doi.org
... the class VII HLH proteins are categorized by the presence of the bHLH-PAS domain
and include members such as the aromatic hydrocarbon receptor (AHR), the AHR ...
Cited by 292 - Web Search - mcb.asm.org - www-biology.ucsd.edu - sig.biostr.washington.edu - all 9 versions »

Protein kinase C theta is critical for the development of in vivo T helper (Th) 2 cell but not Th1 … - Full text - MIT Libraries
BJ Marsland, TJ Soos, G Spath, DR Littman, M Kopf - J. Exp. Med, 2004 - jem.org
... failed to develop allergic airway inflammation, IgE antibody responses, and AHR
in a ... A critical role for NF- B in Gata3 expression and Th2 differentiation in ...
Cited by 9 - Web Search - dx.doi.org - jem.org - ncbi.nlm.nih.gov

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
Page 1. BioSystems xxx (2005) xxx–xxx A statistical analysis of the TRANSFAC database
Gary B. Fogel a , Dana G. Weekes a , Gabor Varga b , Ernst R. Dow b , ...
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Allergy: Is It a Th2-Predominant Disease? Pro
S Romagnani - content.karger.com
... the Th1-specific T-bet and the Th2-specific GATA3 transcription factors ... airway
eosinophilia, mucus hypersecretion, and airway hyper-responsiveness (AHR) [48, 49 ...
Web Search - content.karger.com

The Journal of Experimental Medicine
BJ Marsland, TJ Soos, G Spaeth, DR Littman, M Kopf - saturn.med.nyu.edu
... Abbreviations used in this paper: AHR, airway hyperresponsiveness; BAL, bronchoalveolar
lavage; in, intranasal(ly); MetCh, methacholine chloride; Nb ...
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Molecular therapy versus standard treatment in allergy (Review). - Full text - MIT Libraries
K GRZELA, M LAZARCZYK, P DZIUNYCZ, L MILEWSKI, J … - INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2004 - 147.52.72.117
... airways. Indeed, Thomas and coworkers reported that TNF inhaled by normal
subjects induced airway hyperresponsiveness (AHR) (51). ...
Cited by 1 - View as HTML - Web Search - ncbi.nlm.nih.gov

Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease
P Kidd - Altern Med Rev, 2003 - thorne.com
Page 1. Copyright©2003 Thorne Research, Inc. All Rights Reserved. No Reprint
Without Written Permission Alternative Medicine Review ...
Cited by 16 - View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

A selective novel low-molecular-weight inhibitor of I kappa B kinase-bold italic beta (IKK-bold … - Full text - MIT Libraries
K Ziegelbauer, F Gantner, NW Lukacs, A Berlin, K … - British Journal of Pharmacology, 2005 - nature.com
... A549, human alveolar type II epithelium-like lung adenocarcinoma; AA, arachidonic
acid; AHR, airway hyperreactivity; AP-1, activator protein-1; AUC, area under ...
Web Search - nature.com

Transcription Factors: New Targets for Antiallergic Therapy
DQE Hamelmann - Pathobiology, 2002 - content.karger.com
... 1 sig- naling may lead to attenuated development of airway inflammatory responses
and AHR in a ... P, Ray A: A critical role for NF-kappa B in GATA3 expression and ...
Web Search - content.karger.com

A selective novel low-molecular-weight inhibitor of IjB kinase-b (IKK-b) prevents pulmonary …
H Komura, T Murata, T Lowinger, KB Bacon - British Journal of Pharmacology, 2005 - nature.com
... transcription factors Abbreviations: A549, human alveolar type II epithelium-like
lung adenocarcinoma; AA, arachidonic acid; AHR, airway hyperreactivity; AP-1 ...
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Insights into the Pathogenesis of Asthma Utilizing Murine Models - Full text - MIT Libraries
C Taube, A Dakhama, EW Gelfand, F Alert - International Archives of Allergy and Immunology, 2004 - content.karger.com
... as well as mast cell-dependent and mast cell-independent components, leading to
AHR and airway ... P, Ray A: A critical role for NF-kappa B in GATA3 expression and ...
Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

Do Mouse Models of Allergic Asthma Mimic Clinical Disease? - Full text - MIT Libraries
MM Epstein, E Immunoglobulin, F Alert - International Archives of Allergy and Immunology, 2004 - content.karger.com
... a clinical syndrome that closely resembles allergic asthma, characterized by eo-
sinophilic lung inflammation, airway hyperresponsive- ness (AHR), increased IgE ...
Cited by 2 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 6 versions »

Svetlana P. Chapoval and Chella S. David
BEHP Publications, VS Cart, C Opportunities, REHP … - Environmental Health Perspectives, 2003 - ehp.niehs.nih.gov
... 2001. Intrinsic AHR in IL-5 transgenic mice is dependent on CD4(+) cells and CD49d ...
A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in ...
Cached - Web Search - ehis.niehs.nih.gov - ehpnet1.niehs.nih.gov - ehp.niehs.nih.gov - all 6 versions » - Get it from MIT Libraries

Identification of Antigenic Epitopes on Human Allergens: Studies with HLA Transgenic Mice - Full text - MIT Libraries
T Mice - Environmental Health Perspectives, 2003 - ehpnet1.niehs.nih.gov
... produced different effects on several parameters of experimental allergen-induced
asthma (levels of BAL eosinophilia, pulmonary inflammation, AHR, BAL cytokine ...
Cited by 2 - View as HTML - Web Search - ehis.niehs.nih.gov - earthscape.org - ehp.niehs.nih.gov - all 5 versions »

BMC Genomics - Full text - MIT Libraries
JJ Hutton, AG Jegga, S Kong, A Gupta, C Ebert, S … - BMC Genomics, 2004 - biomedcentral.com
... Examples include PU.1/Ets, Ikaros, E2A, EBF, PAX5, GATA3, NFAT, cMYB, and OCT ... signaling
path- way during positive selection in the thymus [32]; and AhR is known ...
Cited by 1 - View as HTML - Web Search - dx.doi.org - pubmedcentral.nih.gov - bmc.ub.uni-potsdam.de - all 8 versions »

S tem C ells
FJT Staal, F Weerkamp, AW Langerak, RW Hendriks, … - immuneweb.xxmc.edu.cn
... Finally, class VII proteins, of which AHR is an example, contain a bHLH domain
as well as a PAS domain. ... Class VII bHLH-PAS proteins AHR Page 5. ...
View as HTML - Web Search

Expression profiling of the estrogen responsive genes for evaluation of estrogen activity among …
JT Akaba, H Sone, J Yonemoto, M Tanji, R Kiyama - ehp.niehs.nih.gov
... with the expression markers: AHR, CCND1, CYP19A1, CYP1A1, ERBB2, ESR1, ESR2,
HSD17B2, NCOA1, NCOA3, PGR, STS, TFF1, and the calibration ...
View as HTML - Web Search - ehp.niehs.nih.gov

Microarray analysis of gene expression in human donor sclera - Full text - MIT Libraries
TL Young, GS Scavello, PC Paluru, JD Choi, EF … - Mol Vis, 2004 - molvis.org
... binding protein 1 AEBP1 7p13 NM_001621 aryl hydrocarbon receptor AHR 7p15 NM_006885 ...
specific 7 GAS7 17p NM_002051 GATA binding protein 3 GATA3 10p15 NM_004492 ...
Cited by 3 - View as HTML - Web Search - molvis.org - scavello.net - ncbi.nlm.nih.gov

Transcriptional Control of T Lymphocyte Differentiation - Full text - MIT Libraries
FJT Staal, F Weerkamp, AW Langerak, RW Hendriks, … - Stem Cells, 2001 - stemcells.alphamedpress.org
... Finally, class VII proteins, of which AHR is an example, contain a bHLH ... Targeted
disruption of the GATA3 gene causes severe abnormalities in the nervous system ...
Cited by 17 - Web Search - dx.doi.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Using a Customized DNA Microarray for Expression Profiling of the Estrogen-Responsive Genes to … - Full text - MIT Libraries
S Terasaka, Y Aita, A Inoue, S Hayashi, M … - Environmental Health Perspectives, 2004 - earthscape.org
... NM_173481, and NM_024092), along with the expression markers AHR, CCND1, CYP19A1 ...
deacetylase (HDAC6) –2.6 GATA-binding protein 3 (GATA3) –2.8 General ...
Cited by 3 - View as HTML - Web Search - ehis.niehs.nih.gov - dx.doi.org - csa.com - all 7 versions »

Human aldehyde dehydrogenases: Potential pathological, pharmacological, and toxicological impact
NE Sladek - Journal of Biochemical and Molecular Toxicology, 2003 - doi.wiley.com
Page 1. J BIOCHEM MOLECULAR TOXICOLOGY Volume 17, Number 1, 2003 Human Aldehyde
Dehydrogenases: Potential Pathological, Pharmacological ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - csa.com - Get it from MIT Libraries

Gene disruption in mice: Models of development and disease
BS Shastry - Mol. Cell. Biochem, 1998 - springerlink.com
... BPAG1 stratified epithelia neurologic degeneration 175 AHR widespread hepatic fibrosis
176 BDNF/or NT4 brain sensory neuronal deficits 177, 178 ...
Cited by 15 - Web Search - kluweronline.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

IL-4 Signaling, Gene Transcription Regulation, and the Control of Effector T Cells
JR Sheller, S Goenka, L Stephenson - Immunologic Research, 2001 - neurosci.humanapress.com
... In contrast to the relatively well-formed pic- ture that relates the first effector
Th2 response to airway hyperreactivity (AHR), few mech- anistic insights ...
Web Search - biomed.humanapress.com - journals.humanapress.com - ingentaconnect.com

Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB - Full text - MIT Libraries
B Hartenstein, S Teurich, J Hess, J Schenkel, M … - The EMBO Journal, 2002 - embojournal.npgjournals.com
... wall and lumen, mucus production in the airways, airway hyperresponsiveness (AHR)
and elevated ... Ray,A. (2001) A critical role for NF- B in GATA3 expression and ...
Cited by 14 - Web Search - nature.com - emboj.org - dkfz.de - all 8 versions »

Breast cancer gene expression profiling: clinical trial and practice implications
DNA Currently - Pharmacogenomics, 2005 - dx.doi.org
... subgroup A, which was characterized by the highest ER expression, as well as a high
expression of the gene encoding GATA- binding protein 3 (GATA3); and a ...
Web Search - futuremedicine.com - futuremedicine.com - ncbi.nlm.nih.gov - Get it from MIT Libraries