Role of Hand1/eHAND in the Dorso-Ventral Patterning and Interventricular Septum Formation in the … - Full text - MIT Libraries
K Togi, T Kawamoto, R Yamauchi, Y Yoshida, T Kita, … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... genes were normally expressed in Hand1/eHAND KI embryos (data not shown). Homozygous
Splotch mutant mice that lack the transcription factor Pax3 also showed ...
Web Search - mcb.asm.org - ncbi.nlm.nih.gov

Combinatorial transcriptional interaction within the cardiac neural crest: A pair of HANDs in heart …
AB Firulli, SJ Conway - Birth Defects Research Part C Embryo Today Reviews, 2004 - doi.wiley.com
... Some genes, including pax3, are ex- pressed in the migrating cardiac NC cells ... NC
is mediated by transcription fac- tors, including Mf1/Mfh1, HAND1/ HAND2, and ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Table 2. Gene Mutations Demonstrating Cardiac Phenotypes
N Phenotype - ahavj.ahajournals.org
... Hand1 (eHand/heart and neural crest derivatives expressed 1), Looping abnormality,
97, 98. ... Pax3 (paired box gene 3), PTA, CT defects, 109. ...
Web Search

The Polycomb-group gene Rae28 sustains Nkx2. 5/Csx expression and is essential for cardiac … - Full text - MIT Libraries
M Shirai, T Osugi, H Koga, Y Kaji, E Takimoto, I … - J Clin Invest, 2002 - jci.org
... Pax3 is required for cardiac neural crest migration in the mouse: evidence ... mesodermal
defects in mouse embryos lacking the bHLH transcription factor Hand1. ...
Cited by 2 - Web Search - jci.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 7 versions »

Implications for Congenital Heart Disease - Full text - MIT Libraries
D Srivastava - Annu. Rev. Physiol, 2001 - physiol.annualreviews.org
... Mice harboring mutations in the homeodomain protein, pax3, or mutations in retinoic
acid receptors also have a variety of outflow tract and aortic arch defects ...
Cited by 31 - Web Search - phyto.annualreviews.org - ncbi.nlm.nih.gov

Development Gone Awry - Full text - MIT Libraries
CH Disease - Circulation Research, 2004 - circresaha.org
... Pax3-expressing neural crest derivatives populate the conotrunus in a rostral to ...
The bHLH transcription factor gene Hand1 is predominantly restricted to the ...
Cached - Web Search - circres.ahajournals.org - ahavj.ahajournals.org - uphs.upenn.edu - all 8 versions »

Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse - Full text - MIT Libraries
K Niederreither, J Vermot, N Messaddeq, B … - Development, 2001 - dev.biologists.org
... Further molecular evidence comes from the restricted expression of Hand1 (Niederreither
et al., 1999) and Irx4 and Irx5 (see below) in the ventral portion ...
Cited by 58 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

A signaling cascade involving endothelin-1, dHAND and Msx1 regulates development of neural-crest- … - Full text - MIT Libraries
T Thomas, H Kurihara, H Yamagishi, Y Kurihara, Y … - Development, 1998 - dev.biologists.org
... Mutations in Pax3 affect the migration of cranial neural crest cells and result
in cardiac neural crest defects and craniofacial defects in mice (Epstein et al ...
Cited by 71 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Annual Review of Physiology - Full text - MIT Libraries
D Srivastava - Annual Review of Physiology, 2001 - physiol.annualreviews.org
... Mice harboring mutations in the homeodomain protein, pax3, or mutations in retinoic
acid receptors also have a variety of outflow tract and aortic arch defects ...
Web Search - physiol.annualreviews.org - phyto.annualreviews.org - phyto.annualreviews.org

Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural … - Full text - MIT Libraries
NS Hamblet, N Lijam, P Ruiz-Lozano, J Wang, Y Yang … - Development, 2002 - dev.biologists.org
... Pitx2 is co-expressed with Pax3, connexin 43 and the endothelin receptor A in the ...
looping such as Nkx2.5, Mef2c, as well as the bHLH proteins Hand1 and Hand2 ...
Cited by 33 - Web Search - dx.doi.org - dev.biologists.org - ncbi.nlm.nih.gov

Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities … - Full text - MIT Libraries
C Roberts, HF Sutherland, H Farmer, W Kimber, S … - Mol. Cell. Biol, 2002 - mcb.asm.org
... Expression analysis of Hand1, a marker for the left ventricle and lateral plate ... along
the entire anterior-posterior axis of the neuroepithelium (Pax3) and in ...
Cited by 7 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Developmental Spectrum of Cardiac Outflow Tract Anomalies Encompassing Transposition of the Great …
M Embryo - THE ANATOMICAL RECORD, 1999 - doi.wiley.com
... The HAND1 (eHAND) gene, which encodes a helix-loop-helix transcription factor, was ...
Pax3 is required for cardiac neural crest migration in the mouse: Evidence ...
Cited by 6 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecular Determinants of Left and Right Outflow Tract Obstruction
JA TOWBIN, J BELMONT - American Journal of Medical Genetics (Semin. Med. Genet.), 2000 - doi.wiley.com
... the conotruncal heart defects within the Splotch (Sp(2H))/Pax3 mouse mutant ... nic
mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. ...
Cited by 8 - Web Search - doi.wiley.com - cardiogene.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecular Embryogenesis of the Heart - Full text - MIT Libraries
ML Kirby, KL Waldo - Pediatric and Developmental Pathology, 2002 - springerlink.com
Page 1. PERSPECTIVES IN PEDIATRIC PATHOLOGY Molecular Embryogenesis of the Heart
M ARGARET L. K IRBY , * AND WITH ILLUSTRATIONS BY K AREN L. W ALDO ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov

Proof of genetic heterogeneity in cardiac septal defects and in heterotaxy
F de Medecine - edoc.bib.ucl.ac.be
... H HA: hyaluronic acid HAND1: heart and neural crest derivatives expressed 1 HAND2 ...
PAAs: pharyngeal arch arteries PA26: p53-regulated protein 26 Pax3: paired box ...
View as HTML - Web Search