Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: A model for … - Full text - MIT Libraries
GM Cuenco, G Nucifora, R Ren - J. Clin. Invest, 2004 - dx.doi.org
... Brace, H. Ni, Y. Saunthararajah, and G. Nucifora EVI1 induces myelodysplastic ... Sauvageau
Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by ...
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Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging … - Full text - MIT Libraries
N Mayotte, DC Roy, J Yao, E Kroon, G Sauvageau - Blood, 2002 - bloodjournal.org
... In particular, the interaction between BCR-ABL and NUP98-HOXA9 is potentially relevant
to ... a recent study suggested that BCR-ABL and AML1/MDS1/EVI1 (AME) also ...
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A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease … - Full text - MIT Libraries
A Barbouti, M Hoglund, B Johansson, C Lassen, PG … - Cancer Res, 2003 - cancerres.aacrjournals.org
... CML progression are given by the occurrence of AML-associated translocations/fusion
genes, eg, t(3;21)(q26;q22)/RUNX1-EVI1, t(7;11)(p15;p15)/NUP98-HOXA9, t(8;21 ...
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Evi27 encodes a novel membrane protein with homology to the IL17 - Full text - MIT Libraries
J D Shaughnessy Jr - Oncogene, 2000 - nature.com
... Four of the genes are proven or suspected human disease genes: EVI1, NF1 and HOXA9
are causally associated with myeloid leukemia and EVI5 with stage 4S ...
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Comprehensive genotypic analysis of leukemia: clinical and therapeutic implications
L Kelly, J Clark, DG Gilliland - Curr. Opin. Oncol, 2002 - co-oncology.com
... Published examples of progression in BCR/ABL positive CML include acquisition
of t(3;21) AML1/EVI1 or t(7;11) NUP98/HOXA9 gene rearrangements. ...
Cited by 11 - Web Search - siteman.wustl.edu - co-oncology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Leukemia fusion proteins and co-repressor complexes: Changing paradigms - Full text - MIT Libraries
RL Redner, JM Liu, N York, N York - Journal of Cellular Biochemistry, 2005 - doi.wiley.com
... leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. ... Human
AML1/ MDS1/EVI1 fusion protein induces an acute myelogen- ous leukemia ...
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Sox4 blocks cytokine-induced differentiation of 32Dcl3 cells and is a possible cooperating partner …
KE Boyd, A Poholek, O Mironenko, NG Copeland, NA … - yalepath.org
... and transcription factors including cMyb, Hoxa9, Hoxa7, Fli1, Meis1, and
Evi1 8-12 . The Evi1 locus (ecotropic viral integration ...
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Blood First Edition Paper, prepublished online August 1, 2002; DOI 10.1182/blood-2002-04-1244
W Count - bloodjournal.org
... Supporting this, a recent study suggested that BCR-ABL and AML1/MDS1/EVI1 (AME) ... Since
both NUP98-HOXA9 and HOXA9 collaborate with BCR-ABL and with Meis1 ...
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Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t (12; 13 … - Full text - MIT Libraries
VPS Rawat, M Cusan, A Deshpande, W Hiddemann, L … - Proc Natl Acad Sci US A, 2004 - pubmedcentral.nih.gov
... But, in contrast to HOXA9 and HOXA10, which are normally expressed at high ... affecting
ETV6, in which expression of the putative protooncogene EVI1 is activated ...
Cited by 6 - Web Search - dx.doi.org - intl.pnas.org - pnas.org - all 8 versions »

Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t (12; 13 … - Full text - MIT Libraries
A Chase, A Reiter, L Burci, G Cazzaniga, A Biondi, … - Blood, 1999 - bloodjournal.org
... the function of ETV6 in these cases was to drive the inappropriate expression of
MDS1/EVI1. ... HOXA9 is fused to the nucleoporin gene NUP98 by the t(7;11) in AML. ...
Cited by 45 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Chromosomal Translocations in Hematologic Malignancies
CG Brunstein, SJ Dylla, CM Verfaillie - Current Genomics, 2002 - ingentaconnect.com
... 142]. HOXA9 and HOXA10 are highly expressed in early myeloid precursors,
but have low expression in differentiated CD34 - cells. ...
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A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP 98/HOXA 9 - Full text - MIT Libraries
AB Dash, IR Williams, JL Kutok, MH Tomasson, E … - Proceedings of the National Academy of Sciences, 2002 - pnas.org
... the acquisition of either t(7;11)(p15;p15) or t(3;21)(q26;q22) associated with
expression of the NUP98/HOXA9 fusion (20, 21, 28-30) or the AML1/EVI1 fusion (31 ...
Cited by 23 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Estrogen-regulated Conditional Oncoproteins: Tools to Address Open Questions in Normal Myeloid Cell …
DB Sykes, MP Kamps - Leukemia & Lymphoma, 2003 - dx.doi.org
... Ren, R. (2001) “Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking ... KR, Sykes,
DB, Pasillas, MP and Kamps, MP (2002) “Nup98-HoxA9 immortalizes myeloid ...
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An Overview of Translocation-Related Oncogenesis in the Chronic Myeloid Leukaemias
BJ Bain - Acta Haematologica, 2002 - content.karger.com
... a NUP98-HOXA11 fusion gene but transcripts of both NUP98-HOXA9 and NUP98 ... Miscellaneous
mechanisms associated with CMLs in- clude activation of EVI1, a sequence ...
Cited by 3 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Advances in targeted therapy for chronic myeloid leukemia
KW Yee, A Keating - Expert Rev Anticancer Ther, 2003 - dx.doi.org
... tumor suppressor gene, upregulation of the oncogene c-myc and EVI1 expression and
generation of fusion proteins AML1/MDS1/EVI1, AML1/ETO, NUP98/HOXA9, CBF β ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Therapy of acute myeloid leukemia: towards a patient-oriented, risk-adapted approach
F Mandelli, MC Petti, FL Coco - decisions - haematologica.it
... t(3;v) ? EVI1/ v unfavorable t(6;9) 1% DEK/CAN unfavorable t(11;16) ? MLL/CBP
unfavorable t(16;21) 1% FUS/ERG unfavorable t(7;11) 1% NUP98/HOXA9 ? ...
Cited by 19 - View as HTML - Web Search - haematologica.it - haematologica.org - haematologica.org - all 8 versions »

G ENETIC P ROFILE OF A CUTE M YELOID L EUKEMIA - Full text - MIT Libraries
C Mecucci, R Rosati, R La Starza - Reviews in Clinical & Experimental Hematology, 2002 - blackwell-synergy.com
... Overexpression of EVI1, possibly due to translocation, was demonstrated by RT-PCR. ...
In this translocation, the NUP98 partner is the homeobox gene HOXA9. ...
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Mechanisms of BCR–ABL in the pathogenesis of chronic myelogenous leukaemia - Full text - MIT Libraries
R Ren - Nature Reviews Cancer, 2005 - nature.com
... AML1–EVI1 — this fusion gene is also called AML1–MDS1–EVI1, and is ... which results
from the t(8;21)(q22;q22) translocation; NUP98–HOXA9,which results ...
Cited by 2 - Web Search - nature.com - ncbi.nlm.nih.gov

Cooperation of Cytokine Signaling with Chimeric Transcription Factors in Leukemogenesis: PML- … - Full text - MIT Libraries
VT Phan, DB Shultz, BTH Truong, TJ Blake, AL Brown … - Mol Cell Biol, 2003 - mcb.asm.org
... idea is supported by the observations that activated FLT3 cooperates with PML-RAR
(27, 53) and that BCR-ABL cooperates with AML1-MDS1-EVI1 or NUP98-HOXA9 (4, 6 ...
Cited by 5 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Molecular pathogenesis of chronic myeloid leukaemia
DL Smith, J Burthem, AD Whetton - Expert Reviews in Molecular Medicine, 2003 - journals.cambridge.org
Page 1. Accession information: DOI: 10.1017/S1462399403006835; Vol. 5; 25 November
2003 ©2003 Cambridge University Press http://www.expertreviews.org/ ...
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The peripheral cannabinoid receptor Cb2, a novel oncoprotein, induces a reversible block in … - Full text - MIT Libraries
MA Jorda, B Lowenberg, R Delwel - Blood, 2003 - bloodjournal.org
... Alterations in the G-CSF-R, signaling molecules (eg, MEK, STAT1/3, SHP-2, Grb2,
shc), or transcription factors (eg, Evi1, C/EBP , Hoxa9, Hoxb8, Meis) have been ...
Cited by 7 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Clinical importance of cytogenetics in acute myeloid leukaemia
K Heinonen - Best Practice & Research Clinical Haematology, 2001 - siteman.wustl.edu
... t(3;3)(q21;q26) f,h EVI1 t(3;11)(q21;q13) d Involving band 3q26 t(3;12)(q26;p12)
c,d t(3;17)(q26 ... t(7;11)(p15;p15) f HOXA9-NUP98 t(11;20)(p15;q11) d NUP98-TOP1 ...
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Translocations, fusion genes, and acute leukemia - Full text - MIT Libraries
V Saha, BD Young, PS Freemont - Journal of Cellular Biochemistry, 1998 - doi.wiley.com
... ETO 8q22 ZF AML EAP/EVI1 3q26 ZF AML ... NUP98 part- ners 11p15 GLGF motif RNA binding
DDX10 11q22 RNA helicase domain DEAD box AML HOXA9 7p15 HD AML ...
Cited by 16 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Animal models of acute myelogenous leukaemia– development, application and future perspectives
E Mc Cormack, O Bruserud, BT Gjertsen - Leukemia, 2005 - nature.com
... Subsequently, cotransduction and transplantation of doubly BCR/ABL-AML1/MDS1/EVI1,
446 Hoxa9-Meis1 447 and Hoxa9-E2A/Pbx1 448 transfected cells into syngeneic ...
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Transcriptional regulation during myelopoiesis
N Lenny, JJ Westendorf, SW Hiebert - Mol Biol Rep, 1997 - springerlink.com
... 1 fused to several alternate transcripts, including the Evi1 transcription regulator ...
HOXA9 is expressed in normal CD34 + marrow cells, particularly fractions ...
Cited by 41 - Web Search - kluweronline.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

How sugar-containing drinks might increase adiposity in children - Full text - MIT Libraries
F Bellisle, MF Rolland-Cachera - Appetite, 1999 - drbailey.ca
... CBP (16p13) MOZ (8p11) AML1(=CBFA) (21q22) ETO (8q22) EVI1,EAP and MDS1(3q26) ... MSF
(17q25) hCDCrel (22q11) HOXA9 (7p15) HOXD13 (2q31) TOP1 (20q11) BTL (4q11) ...
Cited by 9 - View as HTML - Web Search - asu.edu - ncbi.nlm.nih.gov

Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced …
A Barbouti, B Johansson, M Hoeglund, N Mauritzson, … - Genes Chromosomes and Cancer, 2002 - doi.wiley.com
... or fusion genes typical of myelodysplastic syndromes or acute myeloid leukemias
(AMLs) (eg, t(3;21)(q26;q22)/CBFA2-EVI1, t(7;11)(p15; p15)/NUP98-HOXA9, t(8;21 ...
Cited by 6 - Web Search - lu-research.lub.lu.se - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias … - Full text - MIT Libraries
J Cools, N Mentens, MD Odero, P Peeters, I … - Blood, 2002 - bloodjournal.org
... believed to represent ectopic expression of the transcription factors EVI1 and CDX2 ...
In this regard, the ectopic expression of Hoxa9 by retroviral insertion in ...
Cited by 13 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

t (8; 21) Breakpoints on Chromosome 21 in Acute Myeloid Leukemia are Clustered within a Limited … - Full text - MIT Libraries
H Miyoshi, K Shimizu, T Kozu, N Maseki, Y Kaneko, … - Proceedings of the National Academy of Sciences - pnas.org
... Humphries, and G. Sauvageau Overexpression of the myeloid leukemia-associated Hoxa9
gene in ... Cuenco, G. Nucifora, and R. Ren Human AML1/MDS1/EVI1 fusion protein ...
Cited by 241 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia - Full text - MIT Libraries
J Pedersen-Bjergaard, MK Andersen, DH Christiansen … - Blood, 2002 - bloodjournal.org
... Thus, the AML1-MDS1-EVI1 fusion gene, primarily observed in the t(3;21 ... myeloid leukaemia
fuses the genes for nycleoporin NUP98 and class I homeoprotein HOXA9. ...
Cited by 35 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov

[CITATION] Anomalies chromosomiques dans les leucemies aigues myeloides
F Mugneret, P Callier, B Favre-Audry
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NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that … - Full text - MIT Libraries
YW Lin, C Slape, Z Zhang, PD Aplan - Blood, 2005 - bloodjournal.org
... 38 These findings are consistent with those obtained using a similar NUP98 fusion
gene, NUP98-HOXA9, which has been shown to induce acute leukemia in concert ...
Cited by 1 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Fusion of the TEL Gene on 12p13 to the AML1 Gene on 21q22 in Acute Lymphoblastic Leukemia - Full text - MIT Libraries
TR Golub, GF Barker, SK Bohlander, SW Hiebert, DC … - Proceedings of the National Academy of Sciences, 1995 - pnas.org
... CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9 PNAS, May
28 ... page GM Cuenco, G. Nucifora, and R. Ren Human AML1/MDS1/EVI1 fusion protein ...
Cited by 349 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Acute Myeloid Leukemia
TR Golub - Hematology, 1999 - doe.unimo.it
... transcription factor t(3;21)(q26;q22) AML1 Transcription factor EVI1 Transcription
factor t ... of MLL target genes such as HOX genes in- cluding HOXA9, known to be ...
Cited by 3 - View as HTML - Web Search - hematology.org - Get it from MIT Libraries

Prevalence estimates of recurrent balanced cytogenetic aberrations and gene fusions in unselected …
F Mitelman, F Mertens, B Johansson - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
Page 1. Prevalence Estimates of Recurrent Balanced Cytogenetic Aberrations and
Gene Fusions in Unselected Patients with Neoplastic Disorders ...
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Molecular pathogenesis of MDS
H Hirai - Int J Hematol, 2002 - haem.nus.edu.sg
... p15;p15), t(2;11)(q31;p15), t(11;17) (p15;q21), t(11;12)(p15;q13), t(11;20)(p15;
q11), and inv(11) (p15q22) result in generation of NUP98/HOXA9, NUP98/ HOXD13 ...
Cited by 3 - View as HTML - Web Search - ishapd.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

The Biology and Treatment of Acute Myeloid Leukemia
A Introduction - doe.unimo.it
... CML-BC EVI1 (3q26) Multiple zinc fingers MDS ... In addition, HOXA10 and HOXA9 immor-
talize and transform myeloid progenitors, and HoxA7 and HoxA9 are targets for ...
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Molecular Mechanisms of Myelodysplastic Syndrome - Full text - MIT Libraries
H Hirai - Japanese Journal of Clinical Oncology, 2003 - jjco.oupjournals.org
... Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t ... gene
at 3q21 associated with the transcriptional activation of the EVI1 gene in ...
Cited by 5 - Web Search - jjco.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Gene Expression Profiling of Adult Acute Myeloid Leukemia Identifies Novel Biologic Clusters for …
CS Wilson, GS Davidson, SB Martin, E Andries, Y Xu … - hsc.unm.edu
... tyrosine kinase (FLT3), Wilms tumor (WT1), EVI1, RAS, and CEBPA in AML have ... An
interesting finding is the decreased expression of homeobox A9 (HoxA9) and A10 ...
View as HTML - Web Search - hsc.unm.edu

Prognostic value of cytogenetic findings in adults with acute myeloid leukemia
K Mrozek, K Heinonen, CD Bloomfield - Int J Hematol, 2000 - static.cjp.com
... Affecting the EVI1 gene at 3q26 inv(3)(q21q26)† EVI1 t(3;3)(q21;q26)†,‡ EVI1 ... NUP98
at 11p15 t(6;9)(p23;q34)† DEK-CAN t(7;11)(p15;p15)† HOXA9-NUP98 inv ...
Cited by 19 - View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, … - Full text - MIT Libraries
PJ Valk, Y Vankan, M Joosten, NA Jenkins, NG … - J Virol, 1999 - jvi.asm.org
... 35, 36, 40) or inactivation of tumor suppressor genes (7). Multiple human
proto-oncogenes and tumor suppressors, eg, EVI1 (34), NF1 (47), and HOXA9 (39) have ...
Cited by 15 - Web Search - pubmedcentral.nih.gov - jvi.asm.org - ncbi.nlm.nih.gov

acquises de la cellule souche hematopoietique ou d’un precurseur deja commis vers les lignees …
S YNTHESE - MEDECINE/SCIENCES, 2003 - ist.inserm.fr
... q22) AML1 (21q22) Sous-unité CBFα du CBF LAM secondaires EVI1 (3q26) Protéine ... LAM
secondaires (protéine associée au pore nucléaire) HOXA9 (7p15) Facteur ...
View as HTML - Web Search - erudit.org

G ENETICS OF M YELOID L EUKEMIAS - Full text - MIT Libraries
LM Kelly, DG Gilliland - Annual Review of Genomics and Human Genetics, 2002 - genom.annualreviews.org
... For example, some cases of BCR/ABL-positive CML progress to AML with acquisition
of at[7;11] resulting in expression of a NUP98/HOXA9 fusion gene (3, 100). ...
Cited by 35 - Web Search - 128.194.251.107 - fluid.annualreviews.org - ncbi.nlm.nih.gov - all 5 versions »

Cytogenetic and Molecular Genetic Evolution of Chronic Myeloid Leukemia
A Haematologica - Acta Haematologica, 2002 - content.karger.com
... in CBFA2/EAP and CBFA2/MDS1 chimeras, but most often the EVI1 gene is ... been described
in CML, namely CBFA2/ETO, CBFB/MYH11, and NUP98/HOXA9, corresponding to t(8 ...
Web Search - dx.doi.org - content.karger.com - karger.com

Cytogenetic and Molecular Genetic Evolution of Philadelphia-Chromosome-Positive Chronic Myeloid …
BJTFF Mitelman - content.karger.com
... genetic abnormalities preceding, or occurring during, BC include overexpression
of the BCR/ABL transcript, up-regula- tion of the EVI1 gene, increased ...
Web Search - content.karger.com

Rare recurring balanced chromosome abnormalities in therapy-related myelodysplastic syndromes and …
AW Block, AJ Carroll, A Hagemeijer, L Michaux, K … - Genes Chromosomes Cancer, 2002 - doi.wiley.com
Page 1. Rare Recurring Balanced Chromosome Abnormalities in Therapy-Related
Myelodysplastic Syndromes and Acute Leukemia: Report From an International Workshop ...
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The biology of CML blast crisis - Full text - MIT Libraries
C Cycle, S Transduction, G Expression - Blood, 2004 - bloodjournal.org
... Two other genes up-regulated by BCR/ABL in CML-BC are Evi-1 and HOXA9, 2 transcription
factors that can cooperate with BCR/ABL in blocking myeloid ...
Web Search - dx.doi.org - bloodjournal.org

CONSEQUENCES OF CHROMOSOMAL ABNORMALITIES IN TUMOR DEVELOPMENT - Full text - MIT Libraries
I Sanchez-Garcia - Annual Review of Genetics, 1997 - dx.doi.org
... Studies carried out with AML1-ETO (68), AML1-EVI1 (87), and CBFB-MYHI1 (77 ... The
NUP98-HOXA9 fusion (15, 91) may also be considered within this framework of ...
Cited by 25 - Web Search - wwwlib.bionet.nsc.ru - genet.annualreviews.org - ncbi.nlm.nih.gov - all 6 versions »

The gene encoding the transcriptional regulator Yin Yang 1 (YY1) is a myeloid transforming gene … - Full text - MIT Libraries
SJ Erkeland, M Valkhof, C Heijmans-Antonissen, R … - Blood, 2003 - bloodjournal.org
... by Hoxa9, Hoxb8, and Meis homeobox genes. Exp Hematol. 2001;29:856-863[CrossRef][
Medline] [Order article via Infotrieve]. 8. Nucifora G. The EVI1 gene in ...
Cited by 9 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Inaugural-Dissertation zur Erlangung des Doktorgrades der Naturwissenschaftlichen Fakultaet der …
U Fuchs - deposit.ddb.de
Page 1. Charakterisierung der 11q23/MLL-Fusionspartnergene GRAF und FBP17
Inaugural-Dissertation zur Erlangung des Doktorgrades der ...
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