Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable … - Full text - MIT Libraries
KR Calvo, DB Sykes, M Pasillas, MP Kamps - Mol Cell Biol, 2000 - dx.doi.org
... The Hoxa9-immortalized progenitor exhibited a promyelocytic transcriptional profile,
expressing PU.1, AML1, c-Myb, C/EBP alpha, and C/EBP epsilon as well as ...
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Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a … - Full text - MIT Libraries
JD Shaughnessy Jr, DA Largaespada, E Tian, CF … - Oncogene, 1999 - nature.com
... al., 1996). As expected, nearly all of the viral integrations at Myb, Hoxa7,
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Research Paper Routine expression profiling of microarray gene signatures in acute leukaemia by real … - Full text - MIT Libraries
E Sakhinia, M Faranghpour, JAL Yin, G Brady, JA … - British Journal of Haematology, 2005 - blackwell-synergy.com
... between the two groups, the difference in expression for each single gene was only
statistically significant for cystatin c, c-MYB and HOXA9, although each of ...
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A transcription-factor-binding surface of coactivator p 300 is required for haematopoiesis - Full text - MIT Libraries
LH Kasper, F Boussouar, PA Ney, CW Jackson, J Rehg … - Nature, 2002 - nature.com
... that activate transcription and mediate NUP98-HOXA9 oncogenicity. Mol. Cell. Biol.
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Application of Ingenuity Pathways Analysis to Identify Putative Biomarkers of Childhood Leukemia …
IA Spectrum - Cancer - ingenuity.com
... Sst, TR ALPHA CHD4,CPSF3, Creb,CREB1, CREBBP,HDAC1, HDAC2,HOXA9, HOXC8, KIAA0601,
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Myeloid Leukemia: Disease Genes and Mouse Models
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Estrogen-regulated Conditional Oncoproteins: Tools to Address Open Questions in Normal Myeloid Cell …
DB Sykes, MP Kamps - Leukemia & Lymphoma, 2003 - dx.doi.org
... Myb [42], Hoxa9 [27] and E2a-Pbx1 [30,43] are oncoproteins that immortalize primary
GM-CSF or IL-3-dependent myeloblasts and have been rendered estrogen ...
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Transcriptional regulation during myelopoiesis
N Lenny, JJ Westendorf, SW Hiebert - Mol Biol Rep, 1997 - springerlink.com
... Thus, c-Myb is a crucial determinant for myeloid cell proliferation and ... HOXA9 is
expressed in normal CD34 + marrow cells, particularly fractions enriched for ...
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Evi9 encodes a novel zinc finger protein that physically interacts with BCL6, a known human B-cell … - Full text - MIT Libraries
T Nakamura, Y Yamazaki, Y Saiki, M Moriyama, DA … - Mol. Cell. Biol, 2000 - mcb.asm.org
... encoding a hematopoietic cell growth and differentiation factor, Myb (myeloblastosis
oncogene); three homeobox genes, Hoxa7 (homeobox A7), Hoxa9 (homeobox A9 ...
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Activation of the Rap 1 Guanine Nucleotide Exchange Gene, CalDAG-GEF I, in BXH-2 Murine Myeloid … - Full text - MIT Libraries
AJ Dupuy, K Morgan, FC von Lintig, H Shen, H Acar, … - J Biol Chem, 2001 - jbc.org
... cell growth and differentiation factor, myeloblastosis oncogene (Myb); three homeobox
genes, homeobox A7 (Hoxa7), homeobox A9 (Hoxa9), and myeloid ecotropic ...
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Evi27 encodes a novel membrane protein with homology to the IL17 - Full text - MIT Libraries
J D Shaughnessy Jr - Oncogene, 2000 - nature.com
... cell growth and di€erentiation factor, myeloblastosis oncogene (Myb); three homeobox
genes, homeobox A7 (Hoxa7), homeobox A9 (Hoxa9), and myeloid ecotropic ...
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Applying machine learning techniques to analysis of gene expression data: cancer diagnosis
KB Hwang, DY Cho, SW Park, SD Kim, BY Zhang - Proceedings of the First Conference on Critical Assessment …, 2000 - bi.snu.ac.kr
... the cancer, the conditional probability P(Leukemia class | C- myb, MB-1 ... the 16 genes,
only “Zyxin” and “GB DEF = Homeodomain protein HoxA9 mRNA” were ...
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Molecular phenotyping of the immune system by microarray analysis.
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... [57] ALL vs. AML cells MB-1, Op18, Cyclin D3, MCM3, RbAp48, SNF2, c-MYB, E2A,
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Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias
N Genetics - Nature Genetics, 1996 - nature.com
... correlated with proviral activation of Meis1 implying that Hoxal and Hoxa9 cooperate
with ... DM, Smith, HR & Mushinski, JF Autoimmunity and c-myb transcription. ...
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Role of secondary structure in discrimination between constitutive and inducible activators - Full text - MIT Libraries
D Parker, M Rivera, T Zor, A Henrion-Caude, I … - Mol. Cell. Biol, 1999 - mcb.asm.org
... FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity ... interaction
between retinoic acid receptor and the oncoprotein Myb inhibits retinoic ...
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The Role of C/EBP {varepsilon} in the Terminal Stages of Granulocyte Differentiation - Full text - MIT Libraries
JA Lekstrom-Himes - Stem Cells, 2001 - stemcells.alphamedpress.org
... Deletional analysis of c-Myb shows loss of myeloid lineages with the ... HoxA9, HoxA10,
and HoxA5 are expressed early during myelopoiesis, with aberrant expression ...
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Retroviral insertional mutagenesis identifies oncogene cooperation. - Full text - MIT Libraries
T Nakamura - Cancer Science, 2005 - blackwell-synergy.com
... The use of genetically engineered mice such as NUP98-HOXA9 transgenic mice enabled
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S tem C ells - Full text - MIT Libraries
JA Lekstrom-Himes - Stem Cells, 2001 - immuneweb.xxmc.edu.cn
... Deletional analysis of c-Myb shows loss of myeloid lineages with the ... HoxA9, HoxA10,
and HoxA5 are expressed early during myelopoiesis, with aberrant expression ...
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An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation - Full text - MIT Libraries
GW Klappacher, VV Lunyak, DB Sykes, D Sawka- … - Cell, 2002 - rosenfeldlab.ucsd.edu
... DNA Synthesis (A) Northern blot analysis of mRNA derived from Hoxa9-immortalized
bone ... of METS results in significant repression of the c-Myc, c-Myb, and Cdc2 ...
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Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be … - Full text - MIT Libraries
DB Sykes, MP Kamps - Blood, 2001 - bloodjournal.org
... by transfection of E2a/Pbx1 and Hoxc8 (Figure 1E) or Hoxa9 (Figure 1F ... 28 , 29 c-Myb
and c-Myc showed characteristic down-regulation late in differentiation ...
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Demonstration of Permanent Factor-Dependent Multipotential (Erythroid/Neutrophil/Basophil) … - Full text - MIT Libraries
JS Greenberger, MA Sakakeeny, RK Humphries, CJ … - J. Biol. Chem, 2004 - pnas.org
... P. Zhou CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain
protein ... Reddy c-Myc Is Essential but Not Sufficient for c-Myb-mediated Block ...
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Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires … - Full text - MIT Libraries
GG Wang, MP Pasillas, MP Kamps - Blood, 2005 - bloodjournal.org
... immortalized by Hoxa9 plus Meis1 versus 3 others immortalized by Hoxa9 alone. This
analysis considered genes expressed as low as 1/30 that of c-Myb and one ...
Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

[PS] Analysis of an associative memory neural network for pattern identification in gene expression data
S Bicciato, M Pandin, G Didone, CD Bello - BIOKDD, 2001 - cs.rpi.edu
Page 1. BIOKDD01: Workshop on Data Mining in Bioinformatics (with SIGKDD01,
Conference) page 22 ANALYSIS OF AN ASSOCIATIVE MEMORY NEURAL ...
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E2a/Pbx1 induces the rapid proliferation of stem cell factor-dependent murine pro-T cells that cause … - Full text - MIT Libraries
DB Sykes, MP Kamps - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... B progenitors, and infection with retrovirus encoding Hoxb8, Hoxa9, or Nup98-HoxA9
did not ... 2). E2a/Pbx1 pro-T-cell proliferations also expressed c-myb and Egr2 ...
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Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin - Full text - MIT Libraries
K KAUSHANSKY, I LEMISCHKA - J. Immunol, 2005 - dx.doi.org
... K. Kirito, N. Fox, and K. Kaushansky Thrombopoietin Induces HOXA9 Nuclear Transport
in ... From The Cover: Suppressor screen in Mpl-/- mice: c-Myb mutation causes ...
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Identification of CCR2, flotillin, and gp49B genes as new G-CSF targets during neutrophilic …
S Iida, T Kohro, T Kodama, S Nagata, R Fukunaga - Journal of Leukocyte Biology, 2005 - jleukbio.org
... Key Words: DNA microarray • GM-CSF • M-CSF • SOCS • HoxA9. ... 1a (AML-1a), myeloid zinc
finger protein-1 or -2A (MZF-1/2A), PU.1, NF-Y, and c-Myb [ 13 14 ...
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HOX and Non-HOX Homeobox Genes in Leukemic Hematopoiesis - Full text - MIT Libraries
BM Owens, RG Hawley - Stem Cells, 2002 - stemcells.alphamedpress.org
... provided by experimental data showing that combining E2A-PBX1 with HOXA9 resulted
in ... also been identified as a downstream target of the Myb oncogene; therefore ...
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Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to … - Full text - MIT Libraries
A Yokoyama, Z Wang, J Wysocka, M Sanyal, DJ … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... proteins, both of which are implicated in maintenance of HoxA9 gene expression ... Manak
for generously providing a rabbit polyclonal anti-Drosophila Myb antibody, P ...
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The role of homeobox genes in hematopoiesis
MC Magli - Biotherapy, 1998 - ingentaconnect.com
... viral integration site 1), often in concomitance with Hoxa7 or Hoxa9 [65, 66 ... might
be mediated by nuclear proto- oncogenes (c-myc, c-myb), or, alternatively, by ...
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Tissue Classification Through Analysis of Gene Expression Data Using A New Family of ART …
I INTRODUCTION - ieeexplore.ieee.org
Page 1 0-7803-7278-6/02/$ 10.00 ©2002 IEEE 300 Tissue Classification Through Analysis
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Control of Self-Renewal and Differentiation of Hematopoietic Stem Cells: HOXB4 on the Threshold - Full text - MIT Libraries
H KLUMP, B SCHIEDLMEIER, C BAUM - Ann. NY Acad. Sci, 2005 - annalsnyas.org
... key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. ...
CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein ...
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Bioconductor’s multtest package
S Dudoit, Y Ge - mssm.edu
... homolog (HU-K5) mRNA" [23] "GB DEF = Homeodomain protein HoxA9 mRNA" [24 ... receptor"
[32] "TOP2B Topoisomerase (DNA) II beta (180kD)" [33] "C-myb gene extracted ...
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Transcriptional Profiling During the Early Differentiation of Granulocyte and Monocyte Progenitors …
DB Sykes, J Scheele, M Pasillas, MP Kamps - Leukemia & Lymphoma, 2003 - dx.doi.org
... b-actin were expressed at relative levels of 125,000 to 200,000, and a spectrum
of transcription factors important in myeloid cell function (CBFb, c-Myb, c/EBPa ...
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Bmi1, stem cells, and senescence regulation - Full text - MIT Libraries
IK Park, SJ Morrison, MF Clarke - J. Clin. Invest, 2004 - jci.org
... Enforced expression of Hoxa9/Meis-1 in both normal and Bmi1-deficient mouse ... G1/S
transition, such as DNA polymerase II, cyclin E, p19, myb, and dihydrofolate ...
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Interaction of AF 4 wild-type and AF 4· MLL fusion protein with SIAH proteins: indication for t (4; … - Full text - MIT Libraries
A Bursen, S Moritz, A Gaussmann, S Moritz, T … - Oncogene, 2004 - nature.com
... particular MLL fusion leads to leukemia, even in a Hoxa7- or Hoxa9-deficient genetic ...
corepressor N-CoR (Zhang et al., 1998), and the c-Myb protein (Tanikawa et ...
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Novel therapies for chronic myelogenous leukemia
BN Jahagirdar, JS Miller, A Shet, CM Verfaillie - Exp Hematol, 2001 - cmlsupport.com
... m-RNA of c-myb gene has been the target of several preclinical and clinical studies. ...
Data from early clinical studies of c-myb AS-ODNs are now emerging. ...
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Defects in yolk sac hematopoiesis in Mll-null embryos - Full text - MIT Libraries
JL Hess, BD Yu, B Li, R Hanson, SJ Korsmeyer - Blood, 1997 - bloodjournal.org
... myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein
HOXA9. ... expression of the hematopoietic stem cell antigen CD34: role of c-myb. ...
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S tem C ells
RA Shivdasani - immuneweb.xxmc.edu.cn
... gene in rare cases of acute myeloid leukemia (AML) [85], and HoxA9 –/– mice show ...
This group includes the proto-oncogenes SCL/Tal-1, c-Myc, c-Myb, and the ...
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Conquering the Curse of Dimensionality in Gene Expression Cancer Diagnosis: Tough Problem, Simple …
M Mramor, G Leban, J Demsar, B Zupan - ailab.si
... 0 C U77948 KAI1 414 26 CR X85116 EPB72 42 62 CR M91592 ZNF76 578 112 N U22376 MYB
50 9 CR M62982 ALOX12 143 872 CR Y12556 PRKAB1 123 3082 CR U82759 HOXA9 9 25 ...
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EFFECTIVE USE OF WEB-BASED PUBLIC GENOMIC DATABANKS FOR AUTOMATIC AND UPDATED PERSONAL ANNOTATIONS …
M Masseroli, A Stella, GE Carrara, M Mazzarani, M … - bioinformatics.polimi.it
... D G protein-coupled receptor 65 GPR65 X D homeo box A9 HOXA9 X X X ... D
v-myb myeloblastosis viral oncog homolog (avian) ene MYB X ...
Web Search - medinfopoli.polimi.it - bioinformatics.polimi.it - medinfopoli.polimi.it

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein - Full text - MIT Libraries
P Ernst, J Wang, M Huang, RH Goodman, SJ Korsmeyer - Mol Cell Biol, 2001 - mcb.asm.org
... 1 oncoprotein Tax inhibits the transcriptional activity of c-Myb through competition ...
bearing a targeted interruption of the homeobox gene HOXA9 have defects in ...
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[PS] CITATIONS FOR PROTEIN/DNA (REGULATORY) - Full text - MIT Libraries
PDA White, X Ding, JC Vanderspek, JR Murphy, D … - J. Biol. Chem, 2004 - aist.go.jp
Page 1. CITATIONS FOR PROTEIN/DNA (REGULATORY) NDB ID Citation 1O4X
DC.Williams, M.Cai, GM.Clore Molecular basis for synergistic ...
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Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid … - Full text - MIT Libraries
U Thorsteinsdottir, G Sauvageau, MR Hough, W … - Mol Cell Biol, 1997 - mcb.asm.org
... in rare cases of chronic myeloid leukemias, the N-terminal half of the nucleoporin
gene NUP98 is fused in frame with most of the coding region of the HOXA9 gene ...
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The use of genetic microarray analysis to classify and predict prognosis in haematological … - Full text - MIT Libraries
AP Levene, GJ Morgan, FE Davies - Clinical and Laboratory Haematology, 2003 - blackwell-synergy.com
... Significantly, HOXA9 is deregulated by the t(7;11)(p15;p15) chromosomal translocation ...
germinal centre differentiation, such as the nuclear factor A-myb and BCL ...
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The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in … - Full text - MIT Libraries
JF DiMartino, L Selleri, D Traver, MT Firpo, J … - Blood, 2001 - bloodjournal.org
... 34-36 The presence of extensive hemorrhages in Aml1, c-Myb, and Rb knockout ... Accordingly,
while mice deficient for individual Hox genes such as HoxA9, HoxB6, or ...
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G ENETIC P ROFILE OF A CUTE M YELOID L EUKEMIA - Full text - MIT Libraries
C Mecucci, R Rosati, R La Starza - Reviews in Clinical & Experimental Hematology, 2002 - blackwell-synergy.com
... The leukemogenic potential of NUP98/HOXA9 protein was tested in vitro by transformation ...
specific enhancer comprising recognition sites for GATA-1 and c-myb (112 ...
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Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT … - Full text - MIT Libraries
DE Zhang, P Zhang, ND Wang, CJ Hetherington, GJ … - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
Full Text of this Article. PDF Version of this Article. Similar articles found
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Homeodomain Proteins - Full text - MIT Libraries
WJ Gehring, M Affolter, T Burglin - Annual Review of Biochemistry, 1994 - biochem.annualreviews.org
Page 1. Annu. Rev. Biochem. 1994. 63.’487-526 Copyright © 1994 by Annual
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CONSEQUENCES OF CHROMOSOMAL ABNORMALITIES IN TUMOR DEVELOPMENT - Full text - MIT Libraries
I Sanchez-Garcia - Annual Review of Genetics, 1997 - dx.doi.org
... The NUP98-HOXA9 fusion (15, 91) may also be considered within this framework of ... Other
examples of this phenomenon are illustrated by v-Myb, which up-regulates ...
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Ethidium Bromide Provides a Simple Tool for Identifying Genuine DNA-Independent Associations - Full text - MIT Libraries
J Lai, W Herr - Proceedings of the National Academy of Sciences - pnas.org
... Biol. Home page WF Shen, S. Rozenfeld, A. Kwong, LG Komuves, HJ Lawrence, and C.
Largman HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells Mol. ...
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