A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease … - Full text - MIT Libraries
A Barbouti, M Hoglund, B Johansson, C Lassen, PG … - Cancer Res, 2003 - cancerres.aacrjournals.org
... occurrence of AML-associated translocations/fusion genes, eg, t(3;21)(q26;q22)/RUNX1-
EVI1, t(7;11)(p15;p15)/NUP98-HOXA9, t(8;21)(q22;q22)/RUNX1/CBFA2T1, and inv ...
Cited by 8 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - lu-research.lub.lu.se - all 5 versions »

t (8; 21) Breakpoints on Chromosome 21 in Acute Myeloid Leukemia are Clustered within a Limited … - Full text - MIT Libraries
H Miyoshi, K Shimizu, T Kozu, N Maseki, Y Kaneko, … - Proceedings of the National Academy of Sciences - pnas.org
... Beau, RA Larson, and JD Rowley Genomic DNA breakpoints in AML1/RUNX1 and ETO ... and
G. Sauvageau Overexpression of the myeloid leukemia-associated Hoxa9 gene in ...
Cited by 241 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t (11; 12)(p …
R La Starza, M Trubia, B Crescenzi, C Matteucci, M … - Genes Chromosomes Cancer, 2003 - doi.wiley.com
... Although NUP98/HOXA9 has been proved to be leukemogenic per se in mouse models ... by
Dr. M. Rocchi, University of Bari, Italy), which spans the RUNX1 gene at 21q22 ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Fusion of the TEL Gene on 12p13 to the AML1 Gene on 21q22 in Acute Lymphoblastic Leukemia - Full text - MIT Libraries
TR Golub, GF Barker, SK Bohlander, SW Hiebert, DC … - Proceedings of the National Academy of Sciences, 1995 - pnas.org
... JH Bushweller, and NA Speck Energetic Contribution of Residues in the Runx1 Runt
Domain ... crisis induced by cooperation between BCR/ABL and NUP98/HOXA9 PNAS, May ...
Cited by 349 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of …
S Debernardi, DM Lillington, T Chaplin, S … - Genes Chromosomes and Cancer, 2003 - doi.wiley.com
... Furthermore, the creation of a conditional RUNX1-CBFA2T1 fusion in mice has shown
that sec ... 11q23 overexpression HOXA9 U41813 7p15–p14 001885038 Homeobox A9 ...
Cited by 27 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Dimerization: a versatile switch for oncogenesis - Full text - MIT Libraries
CW So, ML Cleary - Blood, 2004 - bloodjournal.org
... Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis. ...
of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. ...
Cited by 5 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t (2; 11)(q31; p15) - Full text - MIT Libraries
T Taketani, T Taki, N Shibuya, E Ito, J Kitazawa, … - Cancer Res, 2002 - cancerres.aacrjournals.org
... specific subtypes of hematological malignancies (1, 2, 3) . The AML1 (RUNX1), MLL,
MOZ ... reported to be fused to seven different partner genes, HOXA9 (7p15) (4 , 5 ...
Cited by 26 - Web Search - intl-cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Comprehensive genotypic analysis of leukemia: clinical and therapeutic implications
L Kelly, J Clark, DG Gilliland - Curr. Opin. Oncol, 2002 - co-oncology.com
... with acquisition of second mutations such as the NUP98/HOXA9 rearrangement noted ...
AML1 (also known as RUNX1, CBFA2) is a frequent target of translocations in ...
Cited by 11 - Web Search - siteman.wustl.edu - co-oncology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Prevalence estimates of recurrent balanced cytogenetic aberrations and gene fusions in unselected …
F Mitelman, F Mertens, B Johansson - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
Page 1. Prevalence Estimates of Recurrent Balanced Cytogenetic Aberrations and
Gene Fusions in Unselected Patients with Neoplastic Disorders ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Gene Expression Profiling and Microarrays Gene expression profiling of leukemic cell lines reveals …
A Andersson, P Eden, D Lindgren, J Nilsson, C … - Leukemia, 2005 - nature.com
... 28 In our data set, two cell lines harbored RUNX1/CBFA2T1 and CBFA2T1 was ... Hoxa9 and
Meis1 are key targets for MLL-ENL-mediated cellular immortalization. ...
Web Search - nature.com

Hematopoietic, angiogenic and eye defects in Meis 1 mutant animals - Full text - MIT Libraries
T Hisa, SE Spence, RA Rachel, M Fujita, T Nakamura … - The EMBO Journal, 2004 - embojournal.npgjournals.com
... shown that MEIS1 can also physically interact with HOX proteins (HOXA9) by forming ...
transcription factors such as GATA3 (Pandolfi et al, 1995), RUNX1 (Okuda et ...
Cited by 9 - Web Search - nature.com - embojournal.npgjournals.com - ncbi.nlm.nih.gov

Molecular complexities of stem cells
C Joshi, T Enver - Curr Opin Hematol, 2003 - co-hematology.com
... An understanding of the transcriptional networks targeted by genes such as Runx1
and SCL ... genes shown to be enriched in LT-HSCs include Notch, HoxA9, NEDD4, and ...
Cited by 3 - Web Search - co-hematology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

AML 1/RUNX 1 mutations are infrequent, but related to AML-M 0, acquired trisomy 21, and leukemic …
T Taketani, T Taki, J Takita, M Tsuchida, R Hanada … - Genes Chromosomes and Cancer, 2003 - doi.wiley.com
... of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9. ... Mutation of the
AML1/RUNX1 gene in a transient myeloproliferative disorder patient with Down ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Inherited thrombocytopenias: toward a molecular understanding of disorders of platelet production
AE Geddis, K Kaushansky - Curr Opin Pediatr, 2004 - co-pediatrics.com
... 31-34], and by manipulating the levels of HoxB4 and HoxA9 in mice ... transactivation
domain or aberrantly fused to the transcriptional repressor Eto (Runx1-Eto or ...
Cited by 2 - Web Search - co-pediatrics.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

The Molecular Basis of Leukemia - Full text - MIT Libraries
DG Gilliland, CT Jordan, CA Felix, CT Jordan - Hematology, 2004 - asheducationbook.org
... When mutations such as RUNX1-ETO are expressed alone, they impair differentiation ...
with MLL translocations, it recently was observed that the Hoxa9 and Meis1 ...
Cited by 1 - Web Search - neuroscienzemolecolari.it - asheducationbook.org - ncbi.nlm.nih.gov

Analysis of translocations that involve the NUP98 gene in patients with 11p15 chromosomal …
YN Kobzev, J Martinez-Climent, S Lee, J Chen, JD … - GENES, CHROMOSOMES & CANCER, 2004 - doi.wiley.com
... Indeed, as an example, the RUNX1 (AML1) gene, which also has multiple ... who found,
using microarray analysis, that trans- fecting the NUP98–HOXA9 fusion gene ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

BIO-TECHNICAL METHODS (BTS)
J Qiu, P Gunaratne, LE Peterson, D Khurana, N … - Leukemia, 2003 - nature.com
... DAD1 and MEIS1 expression was consistently elevated in the t(4;11) subgroup but
HOXA9 expression was ... 12 21–30 AML1, RUNX1 Acute myeloid leukemia 1 gene 21 ...
Web Search

Chromatin modifying activity of leukaemia associated fusion proteins - Full text - MIT Libraries
L Di Croce - Human Molecular Genetics, 2005 - hmg.oupjournals.org
... of recurrent translocations in leukaemia with several homeobox genes (eg HOXA9,
HOXD13, PMX1 ... factor composed of a DNA-binding component, AML1 (RUNX1/CBFA2) and ...
Web Search - hmg.oupjournals.org - ncbi.nlm.nih.gov

Progress in Hematology
M Eguchi, M Eguchi-Ishimae, M Greaves - Int J Hematol, 2005 - cardenjennings.metapress.com
... deficient mice displayed a more immature phenotype, suggesting that HoxA9 contributes
to ... for example, in childhood ALL with TEL-AML1 (ETV6- RUNX1) fusion or in ...
Web Search

G ENETICS OF M YELOID L EUKEMIAS - Full text - MIT Libraries
LM Kelly, DG Gilliland - Annual Review of Genomics and Human Genetics, 2002 - genom.annualreviews.org
... of a DNA-binding component, AML1 (also known by the HUGO designation RUNX1, CBFA2,
and PEBP2A ... of at[7;11] resulting in expression of a NUP98/HOXA9 fusion gene (3 ...
Cited by 35 - Web Search - 128.194.251.107 - fluid.annualreviews.org - ncbi.nlm.nih.gov - all 5 versions »

Children and adults with acute lymphoblastic leukaemia have similar gene expression profiles. - Full text - MIT Libraries
E Kuchinskaya, M Heyman, D Grander, M Linderholm, … - European Journal Of Haematology, 2005 - blackwell-synergy.com
... included into the study: 7 with MLL rearrangement, 8 with ETV6/RUNX1, 5 with ... which
corresponded to T-lineage leukaemia (p<0.0001), rearrangements of ETV6/RUNX1 ...
Web Search - blackwell-synergy.com - ejh.dk - ncbi.nlm.nih.gov

Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem …
E Passegue, CH Jamieson, LE Ailles, IL Weissman - Proceedings of the National Academy of Sciences - pnas.org
... Expression of some of the Hox genes, such as HoxB4 and HoxA9, has been intimately ...
the AML-1 gene (AML1 also known as CBFA2, PEBP2 B, and RUNX1) on chromosome ...
Cited by 42 - Web Search - 171.66.122.165 - biol.sc.edu - olemiss.edu - all 10 versions » - Get it from MIT Libraries

Molecular pathogenesis of MDS
H Hirai - Int J Hematol, 2002 - haem.nus.edu.sg
... MLL/CBP Nucleoporin abnormality t(7;11)(p15;p15) NUP98/HOXA9 inv(11 ... The AML1 (Runx1)
gene encoding the heterodimeric transcription factor, which binds to DNA ...
Cited by 3 - View as HTML - Web Search - ishapd.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Gene expression profiling of pediatric acute myelogenous leukemia - Full text - MIT Libraries
ME Ross, R Mahfouz, M Onciu, HC Liu, X Zhou, G … - Blood, 2004 - bloodjournal.org
... these are genes that are expressed in the majority of MLL chimeric fusion
gene–containing cases, including MBNL1, MEIS1, HOXA4, HOXA5, HOXA9 HOXA10, and MYH9 ...
Cited by 8 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov

G ENETIC P ROFILE OF A CUTE M YELOID L EUKEMIA - Full text - MIT Libraries
C Mecucci, R Rosati, R La Starza - Reviews in Clinical & Experimental Hematology, 2002 - blackwell-synergy.com
... hypothesized. In this translocation, the NUP98 partner is the homeobox gene HOXA9. ...
region. The reciprocal HOXA9/NUP98 has never been detected. ...
Cited by 4 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

acquises de la cellule souche hematopoietique ou d’un precurseur deja commis vers les lignees …
S YNTHESE - MEDECINE/SCIENCES, 2003 - ist.inserm.fr
... qui comporte deux sous-unités CBFA2 (ou AML1, RUNX1) et CBFβ, et ... Nucléoporine LAM
secondaires (protéine associée au pore nucléaire) HOXA9 (7p15) Facteur ...
View as HTML - Web Search - erudit.org

Molecular Mechanisms of Myelodysplastic Syndrome - Full text - MIT Libraries
H Hirai - Japanese Journal of Clinical Oncology, 2003 - jjco.oupjournals.org
... and inv(11)(p15q22) result in the generation of NUP98/HOXA9, NUP98/HOXD13 ... AML1 gene
The AML1 (Runx1) gene encoding the heterodimeric transcription factor, which ...
Cited by 5 - Web Search - jjco.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

The Kinetic Status of Hematopoietic Stem Cell Subpopulations Underlies a Differential Expression of … - Full text - MIT Libraries
R Manfredini, R Zini, S Salati, M Siena, E … - Stem Cells, 2005 - stemcells.alphamedpress.org
... CD34 + cells, because TPO response genes, such as HOXB4, CBFß, Runx1, Nfe-2 ... Among
them, HOXA5, HOXA9, HOXA10, HOXB2, HOXB5, Meis1, and PBX2 are preferentially ...
Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

Issues in Development
MAS MOORE - dx.doi.org
... The Runx1/AML1 gene plays a critical role in estab- lishment of definitive
hematopoiesis in the AGM. Runx1 expression is initiated ...
Web Search - liebertonline.com - liebertonline.com

Analysis of transcriptional regulation of the small leucine rich proteoglycans. - Full text - MIT Libraries
ES Tasheva, B Klocke, GW Conrad - Mol Vis, 2004 - molvis.org
... There are three Runx genes in mammals: Runx1 is required for the formation of ... D,
Deschamps S, Pellerin I. A conserved non-homeodomain Hoxa9 isoform interacting ...
Cached - Web Search - ncbi.nlm.nih.gov

Pathogenesis of acute myeloid leukaemia and inv (16)(p 13; q 22): a paradigm for understanding … - Full text - MIT Libraries
JT Reilly - British Journal of Haematology, 2005 - blackwell-synergy.com
... CBF ) and one of three CBF subunits, CBF 1, AML1 (also known as RUNX1 or CBF 2 ... Kojima
et al, 1999), AML1-EVI1 (Cuenco & Ren, 2001) and NUP98 HOXA9 (Yamamoto et ...
Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

A stable human-derived packaging cell line for production of high titer retrovirus/vesicular … - Full text - MIT Libraries
DS Ory, BA Neugeboren, RC Mulligan - J. Biol. Chem, 2004 - dx.doi.org
Vol. 93, Issue 21, 11400-11406, October 15, 1996. This paper was presented
at a colloquium entitled "Genetic Engineering of Viruses ...
Cited by 320 - Web Search - pnas.org - ncbi.nlm.nih.gov - adsabs.harvard.edu - all 6 versions »

Epigenetics and cancer - Full text - MIT Libraries
AH Lund, M van Lohuizen - Genes & Development, 2004 - genesdev.org
... Intriguingly, the known MLL target genes HoxA7 and HoxA9 are both required for leukemia
induction by an MLL fusion oncogene (Ayton and Cleary 2003 ). ...
Cited by 11 - Web Search - dx.doi.org - genesdev.org - ncbi.nlm.nih.gov

[PS] CITATIONS FOR PROTEIN/DNA (REGULATORY) - Full text - MIT Libraries
PDA White, X Ding, JC Vanderspek, JR Murphy, D … - J. Biol. Chem, 2004 - aist.go.jp
... PD0210 J.Bravo, Z.Li, NA.Speck, AJ.Warren The Leukemia-Associated Aml1 (Runx1)-Cbfbeta
Complex Functions as a DNA-Induced Molecular Clamp Nat.Struct.Biol., 8 ...
Cited by 10 - View as HTML - Web Search - ndbserver.rutgers.edu - ndbserver.rutgers.edu

Mechanisms of BCR–ABL in the pathogenesis of chronic myelogenous leukaemia - Full text - MIT Libraries
R Ren - Nature Reviews Cancer, 2005 - nature.com
... ETO,which results from the t(8;21)(q22;q22) translocation; NUP98–HOXA9,which results ...
AML1 (also known as RUNX1 and CBFα2),part of which is fused to EVI1 in ...
Cited by 2 - Web Search - nature.com - ncbi.nlm.nih.gov

The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases - Full text - MIT Libraries
XJ Yang - Nucleic Acids Research, 2004 - nar.oupjournals.org
... Consistent with their roles in leukemogenesis, these acetyltransferases interact
with Runx1 (or AML1), one of the most frequent targets of chromosomal ...
Cited by 14 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Cytogenetic abnormalities in childhood acute myeloid leukaemia: a Nordic series comprising all … - Full text - MIT Libraries
E Forestier, S Heim, E Blennow, G Borgstrom, G … - British Journal of Haematology, 2003 - ingentaconnect.com
... or, more precisely, characterize the chromoso- mal abnormalities found, as well
as to detect MLL rear- rangements (11q23-translocations) and RUNX1/CBFA2T1 [t(8 ...
Cited by 1 - Web Search - lu-research.lub.lu.se

Genetic programs regulating HSC specification, maintenance and expansion - Full text - MIT Libraries
J Lessard, A Faubert, G Sauvageau - Oncogene, 2004 - nature.com
... 2 or ttg-2), which are essential for primitive and definitive hematopoiesis and
AML-1 (Okuda et al., 1996; Lacaud et al., 2002) (also known as RUNX1/CBFA2 and ...
Web Search - ncbi.nlm.nih.gov

Animal models of acute myelogenous leukaemia– development, application and future perspectives
E Mc Cormack, O Bruserud, BT Gjertsen - Leukemia, 2005 - nature.com
... Firstly, the AML1(Cbfa2, Runx1, Pebp2 B) 84 oncogene targeted by chromosomal
translocation ... 110 Secondly, the HOXA9 80, 111 oncogene, a poor prognosis marker in ...
Web Search - nature.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Altered differentiation in acute myeloid leukemias; Role of ERG and FUS-ERG fusion protein
MC Doarn - 2005 - kb.osu.edu
... include the translocation (t) between chromosomes 8 and 21 AML1/ETO, t(15;17) PML-
RARα, t(9;11) AF9-MLL, t(7;11) Nup98-HOXA9, and t(16;21)(p11;q22) FUS-ERG ...
View as HTML - Web Search - kb.osu.edu

Dissecting the Molecular Mechanism of Chronic Myelogenous Leukemia Using Murine Models
R Ren - Leukemia & Lymphoma, 2002 - dx.doi.org
Page 1. Dissecting the Molecular Mechanism of Chronic Myelogenous Leukemia
Using Murine Models RUIBAO REN Rosenstiel Basic Medical ...
Cited by 2 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Appearance of leukemia in peripheral blood
A Neutropenia, B Anemia, C Thrombocytopenia, C Mac - bloodjournal.org
... Non-lymphoid Hematopoietic Sarcomas. Granulocytic sarcoma. ENU treated Runx1-ETO
knock-in mice. Histiocytic sarcoma. Retroviral transduction with BCR-ABL Fusion ...
Web Search

Bibliography Current World Literature
L Benboubker, H Watier, A Carion, MT Georget, I … - Current Opinion in Hematology, 2002 - co-hematology.com
... Fujino T, Yamazaki Y, Largaespada DA, Jenkins NA, Copeland NG, Hirokawa K, Nakamura
T: Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox ...
Web Search

SUPPLEMENTARY DATA FOR CLASSIFICATION, SUBTYPE DISCOVERY, AND PREDICTION OF OUTCOME IN PEDIATRIC …
I Section, E Methods, II Section, P Dataset - stjuderesearch.org
Page 1. SUPPLEMENTARY DATA FOR CLASSIFICATION, SUBTYPE DISCOVERY, AND PREDICTION
OF OUTCOME IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA ...
View as HTML - Web Search

Novel transcription factors in human CD34 antigen-positive hematopoietic cells - Full text - MIT Libraries
I Gomes, TT Sharma, S Edassery, N Fulton, BG Mar, … - Blood, 2002 - bloodjournal.org
... 13.7 I W Hs.129914 RUNX1 Runt-related transcription factor 1 (acute myeloid
leukemia 1; aml1 oncogene) 21q22.3 13.6 I W Hs.247433 ...
Cited by 3 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Bibliography Current World Literature
JY Bertrand, S Giroux, R Golub… - Current Opinion in Hematology, 2005 - co-hematology.com
... R, Gao H, et al.: Early B cell factor cooperates with Runx1 and mediates ... Dorsam GP,
et al.: The transcriptome of the leukemogenic homeoprotein HOXA9 in human ...
Web Search - co-gastroenterology.com - co-ophthalmology.com - coronary-artery.com

Transcriptional Profiling During the Early Differentiation of Granulocyte and Monocyte Progenitors …
DB Sykes, J Scheele, M Pasillas, MP Kamps - Leukemia & Lymphoma, 2003 - dx.doi.org
Page 1. Transcriptional Profiling During the Early Differentiation of
Granulocyte and Monocyte Progenitors Controlled by Conditional ...
Cited by 2 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

[BOOK] Cytogenetic and molecular genetic changes in childhood acute leukaemias
T Niini - 2002 - ethesis.helsinki.fi
Page 1. Department of Medical Genetics Haartman Institute University of Helsinki
Finland Cytogenetic and Molecular Genetic Changes in Childhood Acute Leukaemias ...
View as HTML - Web Search - Get it from MIT Libraries - Library Search

Bibliography Current World Literature
CD Bloomfield, KJ Archer, K Mrozek, DM Lillington, … - Current Opinion in Oncology, 2003 - co-oncology.com
January 2003, 15:1 > Bibliography Current World Literature. < Previous |
Next >. ARTICLE LINKS: Permissions | View full size inline ...
Web Search