Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a … - Full text - MIT Libraries
Y Fujitani, Y Kajimoto, T Yasuda, TA Matsuoka, H … - Mol Cell Biol, 1999 - mcb.asm.org
... factors such as TBP, USF, ATF2/CRE-BP1, Sp1, and c-Jun via its ... To investigate whether
E1A activates the Pax4 TAD through a similar mechanism, the possible ...
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Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue - Full text - MIT Libraries
H Inoue, J Nomiyama, K Nakai, A Matsutani, Y … - Biochem. Biophys. Res. Commun, 1998 - ingentaconnect.com
... Isolation of Full-Length cDNA of Mouse PAX4 Gene and Identification of
Its Human Homologue. Authors: Inoue H.; Nomiyama J.; Nakai ...
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Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem … - Full text - MIT Libraries
Y Moritoh, E Yamato, Y Yasui, S Miyazaki, J … - Diabetes, 2003 - diabetes.diabetesjournals.org
... Yusuke Moritoh , Eiji Yamato , Yumiko Yasui , Satsuki Miyazaki , and Jun-ichi Miyazaki ...
our feeder-free ES cells, expressed insulin 2, pdx-1, Pax4, and Isl1 and ...
Cited by 24 - Web Search - diabetes.diabetesjournals.org - ncbi.nlm.nih.gov

Genetics of type 2 diabetes: insight from targeted mouse mutants
D Accili, Y Kido, J Nakae, D Lauro, BC Park - Curr. Mol. Med, 2001 - ingentaconnect.com
... Domenico Accili*, Yoshiaki Kido, Jun Nakae, Davide Lauro and Byung-Chul Park ... or earlier
markers of pancreatic endocrine cells like PDX1, Pax4, Pax6, and NeuroD ...
Cited by 11 - Web Search - bentham.org - bentham.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic … - Full text - MIT Libraries
SB Smith, HC Ee, JR Conners, MS German - Mol. Cell. Biol, 1999 - mcb.asm.org
... 1998. Isolation of full-length cDNA of mouse PAX4 gene and identification of its
human homologue. Biochem. Biophys. Res. ... 20. Jun, S., and C. Desplan. 1996. ...
Cited by 34 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

High glucose is necessary for complete maturation of Pdx1− VP16-expressing hepatic cells into … - Full text - MIT Libraries
LZ Cao, DQ Tang, ME Horb, SW Li, LJ Yang - Diabetes, 2004 - diabetes.diabetesjournals.org
... 1 , Dong-Qi Tang 1 , Marko E. Horb 2 , Shi-Wu Li 1 , and Li-Jun Yang 1 ... We do not
however find any expression of the late-stage genes (Pax4, Pax6, Isl-1, and ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov

A missense mutation of Pax4 gene (R121W) is associated with type 2 diabetes in Japanese - Full text - MIT Libraries
Y Shimajiri, T Sanke, H Furuta, T Hanabusa, T … - Diabetes, 2001 - diabetes.diabetesjournals.org
... SB, Ee HC, Conners JR, German MS: Paired-homeodomain transcription factor PAX4 acts
as a ... Genes Dev 5:594–604, 1991[Abstract]; Xu W, Rould MA, Jun S, Desplan C ...
Cited by 14 - Web Search - diabetes.diabetesjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

IFN-gamma overexpression within the pancreas is not sufficient to rescue Pax4, Pax6, and Pdx-1 …
M Krakowski, B Yeung, R Abdelmalik, A Good, L … - Pancreas, 2000 - pancreasjournal.com
... The Pax4 gene is essential for differentiation of insulin-producing beta cells ... Li,
Ming; Miyagawa, Jun-ichiro; Moriwaki, Makoto; Yuan, Ming; Yang, Qin; Kozawa ...
Cited by 3 - Web Search - pancreasjournal.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

The diabetes-linked transcription factor PAX4 promotes ß-cell proliferation and survival in rat and … - Full text - MIT Libraries
T Brun, I Franklin, L St-Onge, A Biason-Lauber, EJ … - The Journal of Cell Biology - jcb.org
... The diabetes-linked transcription factor PAX4 promotes ß-cell proliferation and
survival in rat and human islets Thierry Brun 1 , Isobel Franklin 1 , Luc St ...
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Glucose homeostasis: lessons from knockout mice.
J Nakae, Y Kido, T Kitamura, D Accili - Current Opinion in Endocrinology & Diabetes, 2001 - co-endocrinology.com
... Nakae, Jun MD; Kido, Yoshiaki MD, PhD; Kitamura, Tadahiro MD, PhD; Accili, Domenico ...
or early markers of endocrine differentiation such as PDX1, Pax4, Pax6, and ...
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Genes expressed during the differentiation of pancreatic AR42J cells into insulin-secreting cells - Full text - MIT Libraries
H Mashima, S Yamada, T Tajima, M Seno, H Yamada, J … - Diabetes, 1999 - diabetes.diabetesjournals.org
... Hirosato Mashima, Shirou Yamada, Tomoko Tajima, Masaharu Seno, Hidenori Yamada,
Jun Takeda, and ... islet cells (4). Inactivation of BE TA2/NeuroD or Pax4 causes a ...
Cited by 16 - Web Search - diabetes.diabetesjournals.org - ncbi.nlm.nih.gov

GEArray Q Series Human Diabetes Gene Array: AR-SAHS-050
FG Grouping, N Receptors, P PPARA, M Enzymes, A … - eurogentec.com
... Transcription Factors: CEBPA, CEBPB, FOXC2, FOXG1B, FOXP3, HNF4A, IPF1 (PDX-1),
NEUROD1, NFKB1, NRF1, PAX4, PPARGC1A, PPARGC1B ... 2003 May-Jun; 14 (4): 169-75. ...
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Nestin-positive Cells in Adult Pancreas Express Amylase and Endocrine Precursor Cells
H Ueno, Y Yamada, RPD Watanabe, EPD Mukai, M … - Pancreas, 2005 - pancreasjournal.com
... MD * ; Toyokuni, Shinya MD, PhD † ; Yamaguchi, Masahiro MD, PhD ‡ ; Takeda, Jun
MD, PhD ... However, ngn3, Pax4, Pax6, Nkx2.2, and Nkx6.1were not detected in ...
Web Search

Origin of the paired domain - Full text - MIT Libraries
R Breitling, JK Gerber - Development Genes and Evolution, 2000 - springerlink.com
... One exception is the Pax4–6/eyeless subfamily which is extremely conserved, so that
an ... because this protein contains only a partial paired domain (Jun et al. ...
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Approaches for the cure of type 1 diabetes by cellular and gene therapy.
HS Jun, JW Yoon - Current Gene Therapy, 2005 - ingentaconnect.com
... Jun and Yoon ... and differentiation of islet cells have identified many transcription
factors such as Pdx- 1, Isl-1, ngn3, Nkx2.2, Nkx6.1, NeuroD1, Pax4, and Pax6 ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

In vitro cultivation of human fetal pancreatic ductal stem cells and their differentiation into … - Full text - MIT Libraries
ZX Yao, ML Qin, JJ Liu, XS Chen, DS Zhou - World J Gastroenterol, 2004 - wjgnet.com
... Zhong-Xiang Yao, Mao-Lin Qin, Jian-Jun Liu, Xing-Shu Chen, De ... Expression of Pax4
in embryonic stem cells promotes differentiation of nestin-positive progenitor ...
Cached - Web Search - wjgnet.com - wjgnet.com - ncbi.nlm.nih.gov - all 5 versions »

Contrasting patterns of expression of transcription factors in pancreatic alpha and beta cells - Full text - MIT Libraries
J Wang, G Webb, Y Cao, DF Steiner - Proc. Natl. Acad. Sci. USA, 2003 - pnas.org
... by interfering with E2A products (40), differences in expression of c-Jun and E2A ...
Pax4, which is restricted to pancreatic progenitors and is very low in adult ...
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Promoter elements in endocrine pancreas development and hormone regulation - Full text - MIT Libraries
C Brink - Cell Mol Life Sci, 2003 - ncbi.nlm.nih.gov
2003 Jun;60(6):1033-48 ... Transcription factors such as Pdx1, Hnf6, ngn3, NeuroD/BETA2,
Pax6 or Pax4 act within regulatory cascades and networks of transcriptional ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Hypoplasia of pancreatic islets in transgenic mice expressing activin receptor mutants - Full text - MIT Libraries
T Yamaoka, C Idehara, M Yano, T Matsushita, T … - J Clin Invest, 1998 - jci.org
... Makiko Yano * , Takaya Matsushita * , Taketo Yamada , Setsuko Ii * , Maki Moritani * ,
Jun-ich Hata ... M. Torres, G. Oliver, and P. Gruss (1997) The Pax4 gene is ...
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WFS 1(Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic … - Full text - MIT Libraries
K Takeda, H Inoue, Y Tanizawa, Y Matsuzaki, J Oba, … - Human Molecular Genetics, 2001 - hmg.oupjournals.org
... Takeda 1 ,+ , Hiroshi Inoue + ,1 , Yukio Tanizawa 1 , Yumiko Matsuzaki 2 , Jun Oba
2 ... Y. and Oka, Y. (1998) Isolation of full-length cDNA of mouse PAX4 gene and ...
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Transcription Factors Involved in Pancreatic Islet Development
HPHMJ Tsai - J Biomed Sci, 2000 - content.karger.com
... These genes include BETA2/NeuroD [21, 32], Isl1 [1], Pax6 [39, 46], Pax4 [44],
Nkx2.2 [48 ... ty to JIP-1 [9], a cytoplasmic inhibitor of the c-Jun amino- terminal ...
Cited by 14 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

In vitro cultivation of human islets from expanded ductal tissue - Full text - MIT Libraries
S Bonner-Weir, M Taneja, GC Weir, K Tatarkiewicz, … - Stem Cells, 2004 - dx.doi.org
... Kania, M. Wagner, U. Roll, L. St-Onge, and AM Wobus Expression of Pax4 in embryonic ...
Fujii, S. Kim, S. Bonner-Weir, and GC Weir Involvement of c-Jun N-terminal ...
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Identification of A Pax Paired Domain Recognition Sequence and Evidence for DNA-dependent …
N Genet - uphs.upenn.edu
... CD spectra of the I'm-ti paired domain were identical when the protein was prepared
and analyzed in either buffer, and the Pax4 paired domain was able to hind ...
View as HTML - Web Search

In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone- … - Full text - MIT Libraries
L Yang, S Li, H Hatch, K Ahrens, JG Cornelius, BE … - Am. J. Pathol, 2005 - dx.doi.org
... Home page, Diabetes Home page T. Okitsu, N. Kobayashi, HS Jun, S. Shin, SJ Kim,
J ... M. Wagner, U. Roll, L. St-Onge, and AM Wobus Expression of Pax4 in embryonic ...
Cited by 92 - Web Search - pnas.org - pubmedcentral.nih.gov - biol.vt.edu - all 6 versions »

[CITATION] Unsubscribed Journal Biochemical and Biophysical Research Communications
R Morishita, K Yamamoto, S Yamada, H Matsushita, N … - Biochemical and Biophysical Research Communications,, 1998
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The Pax 3-FKHR oncoprotein is unresponsive to the Pax 3-associated repressor hDaxx - Full text - MIT Libraries
AD Hollenbach, JE Sublett, CJ McPherson, G … - The EMBO Journal, 1999 - embojournal.npgjournals.com
... interaction with hDaxx. Pax3, the indicated Pax3 deletion mutants, Pax7 and
Pax4 were fused in-frame to the LexA bait vector. The Pax3 ...
Cited by 82 - Web Search - nature.com - emboj.org - ncbi.nlm.nih.gov - all 7 versions »

Genetic and biochemical diversity in the Pax gene family - Full text - MIT Libraries
DA Underhill - Biochem Cell Biol, 2000 - article.pubs.nrc-cnrc.gc.ca
... in α-cells (Hussain and Habener 1999), in contrast with Pax4, which represses ... recovered
that contained jux- taposed elements for each domain (Jun and Desplan ...
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Analysis of expression profiles of islet-associated transcription and growth factors during beta- …
M Li, J Miyagawa, M Moriwaki, M Yuan, Q Yang, J … - Pancreas, 2003 - pancreasjournal.com
... Reprints: Dr. Jun-ichiro Miyagawa, Department of Internal Medicine and Molecular
Science ... within the pancreas is not sufficient to rescue Pax4, Pax6, and Pdx-1 ...
Cited by 4 - Web Search - pancreasjournal.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... 01 N-Myc OCT1 02 Octamer factor 1 OCT1 03 Octamer factor 1 OCT1 04 Octamer factor
1 OCT1 Q6 Octamer factor 1 P300 01 p300 PAX3 B Pax3 binding sites PAX4 01 Pax ...
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[CITATION] The Human Metabotropic Glutamate Receptor 8 (GRM8) Gene: A Disproportionately Large Gene Located at …
SW Scherer, S Soder, RM Duvoisin, JJ Huizenga, LC …
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Valproic acid-induced changes in gene expression during neurulation in a mouse model
BC Wlodarczyk, JC Craig, GD Bennett, JA Calvin, RH … - Teratology, 1996 - doi.wiley.com
... a study was undertaken to examine differential changes in gene expression for selected
transcription factor (Pax-3, Emx-1, Emx-2, c-fos, c-jun, creb) and cell ...
Cited by 19 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Transcription factors in dysmorphology - Full text - MIT Libraries
D Lacombe - Clinical Genetics, 1999 - blackwell-synergy.com
... with two helix-turn-helix structures, and for some (PAX3/PAX7, PAX4/PAX6) a ... They
interact with transcription factors, such as TFIIB, Jun, Fos, Myb, E1A, E2F ...
Web Search - ncbi.nlm.nih.gov

Regulation of insulin gene transcription - Full text - MIT Libraries
D Melloul, S Marshak, E Cerasi - Diabetologia, 2002 - springerlink.com
... Whilst PAX6 expression in islets is maintained until adulthood, PAX4 is only expressed
in ... Inhibition of insulin transcription by c-Jun was also shown to act ...
Cited by 37 - Web Search - ncbi.nlm.nih.gov

Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker … - Full text - MIT Libraries
HE Xu, MA Rould, W Xu, JA Epstein, RL Maas, CO … - Genes Dev, 1999 - genesdev.org
... Jun and Desplan 1996 ; Sheng et al. 1997 ; Underhill and Gros 1997 ; Fortin et al.
1997 ) and the Ets domain (Fitzsimmons et al. 1996 ). Like Pax3, Pax4, and ...
Cited by 61 - Web Search - uphs.upenn.edu - 128.95.44.130 - pubmedcentral.nih.gov - all 8 versions »

Pax genes and eye organogenesis
F Pichaud, C Desplan - Curr. Opin. Genet. Dev, 2002 - wwworm.biology.uh.edu
... Pax3/7, as well as Pax4/6, contain both a HD and a PD. ... 5. Xu W, Rould MA, Jun S,
Desplan C, Pabo CO: Crystal structure of a paired domain-DNA complex at 2.5 Å ...
Cited by 20 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Fundamentals of Transcription Factors and Their Impact on Pancreatic Development and Cancer
JAKR Urrutia - Pancreatology, 2003 - content.karger.com
... Isl-1 activator development of endocrine pancreas 26, 27 Pax4 repressor beta and
delta cell development 28, 29 ... ngn3 NeuroD/beta2 Nk2.2 Pax4 Pdx1 Nkx6.1 ...
Web Search - content.karger.com

Redox Control of Signal Transduction, Gene Expression and Cellular Senescence
F Esposito, R Ammendola, R Faraonio, T Russo, F … - Neurochemical Research, 2004 - springerlink.com
... physical stress (23,24). Extracellular administration of H 2 O 2 acti- vates
MAPK and Jun kinase (1,25). To study the redox regulation ...
Cited by 2 - Web Search - kluweronline.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Eyg and Ey Pax proteins act by distinct transcriptional mechanisms in Drosophila development - Full text - MIT Libraries
JG Yao, YH Sun - The EMBO Journal, 2005 - embojournal.npgjournals.com
... DNA (Xu et al, 1999) and is divergent between Ey and Eyg (Jun et al, 1998 ... Pax2, Pax3,
Pax4, Pax5, and Pax8 can also function as repressors, in addition to being ...
Web Search - pubmedcentral.nih.gov - embojournal.npgjournals.com - ncbi.nlm.nih.gov

Rule Induction for Prediction of Protein-DNA Binding: An Application on the Paired Domain
M Huss, K Nordstroem - arxiv.org
... binding by methods such as mutagenesis and subsequent in vitro binding, footprinting
assays, or SELEX binding (eg Chalepakis and Gruss 1995, Jun and Desplan ...
View as HTML - Web Search - arxiv.org

Institut fuer Experimentelle Genetik GSF-Forschungszentrum fuer Umwelt und Gesundheit, Neuherberg
DBR Breitling - tumb1.biblio.tu-muenchen.de
Page 1. Institut für Experimentelle Genetik GSF-Forschungszentrum für Umwelt und
Gesundheit, Neuherberg Phylogenetische und bioinformatische Untersuchung der ...
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The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 … - Full text - MIT Libraries
A Abderrahmani, M Steinmann, V Plaisance, G … - Mol Cell Biol, 2001 - mcb.asm.org
... rat and human homologue of JIP-1, a murine inhibitor of the c-Jun amino-terminal ...
However, genes such as BETA2/NEUROD1, Islet-1, Pax4, Pax6, Nkx2.2, Brn4, and ...
Cited by 11 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Isolation and expression analysis of a Pax group III gene from the crustacean Cherax destructor - Full text - MIT Libraries
RBWTM Lamey, M Ziman, A Koenders - Dev Genes Evol, 2005 - springerlink.com
... analysis include: Mus musculus Pax1 (M69222), Pax2 (NM011037), Pax3 (X59358), Pax4
(P321 15 ... Mol Biol Evol 14:829–842 Bertuccioli C, Fasano L, Jun S, Wang S ...
Web Search - ncbi.nlm.nih.gov

Phosphorylation of the Transactivation Domain of Pax 6 by Extracellular Signal-regulated Kinase and … - Full text - MIT Libraries
I Mikkola, JA Bruun, G Bjoerkoey, T Holm, T … - J Biol Chem, 1999 - jbc.org
... extracellular-signal regulated kinase (ERK) and p38 kinase but not by Jun N-terminal ...
Pax6, like Pax3, Pax4, and Pax7, also harbors a second DNA-binding domain ...
Cited by 19 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Tissue-specific transcriptional activity of a pancreatic islet cell-specific enhancer sequence/Pax6- … - Full text - MIT Libraries
S Beimesche, A Neubauer, S Herzig, R Grzeskowiak, … - Mol Endocrinol, 1999 - mend.endojournals.org
... Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P 1997 The Pax4 gene is ... Kornhauser
JM, Nelson DE, Mayo KE, Takahashi JS 1992 Regulation of jun-B messenger RNA ...
Cited by 9 - Web Search - mend.endojournals.org - ncbi.nlm.nih.gov

Gene expression changes induced by bismuth in a macrophage cell line - Full text - MIT Libraries
NEMAL Joergen, RMKTF Oerntoft, M Stoltenberg - Cell Tissue Res, 2005 - springerlink.com
... Nerve growth factor, gamma 12 D −10.6 12-Regulation of transcription
1370140_a_at/AF053102 Pax4 Paired box gene 4 12 D −3.5 ...
Web Search

Role of histone and transcription factor acetylation in diabetes pathogenesis.
SG Gray, P De Meyts - Diabetes Metab Res Rev, 2005 - doi.wiley.com
... genes that are involved with both pan- creatic differentiation, glucose homeostasis
and insulin production including insulin, glucokinase, Pax4, islet amyloid ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Regulation of gene promoters of hypothalamic peptides
JPH Burbach - Front Neuroendocrinol, 2002 - www-unix.oit.umass.edu
... The null mutation of Pax4 leads to failing differentiation of pancreatic progenitors
to beta ... Jun, but not fos, both a constituent of the AP-1 protein complex ...
Cited by 3 - View as HTML - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Mutational analysis of PAX 6: 16 novel mutations including 5 missense mutations with a mild aniridia …
K Groenskov, T Rosenberg, A Sand, K Broendum- … - European Journal of Human Genetics, 1999 - nature.com
Page 1. ARTICLE Mutational analysis of PAX6: 16 novel mutations including
5 missense mutations with a mild aniridia phenotype Karen ...
Cited by 18 - Web Search - nature.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of … - Full text - MIT Libraries
H Mutoh, FJ Naya, MJ Tsai, AB Leiter - Genes Dev, 1998 - genesdev.org
... 1996 ), basic leucine zipper (bZIP) proteins including Jun, Fos, CREB (Arias et
al. ... factors in addition to BETA2, including Isl-1, PDX-1, Pax4, and Pax 6 ...
Cited by 58 - Web Search - genesdev.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Deciphering Regulatory Patterns of Inflammatory Gene Expression From Interleukin-1—Stimulated … - Full text - MIT Libraries
H Mayer, M Bilban, V Kurtev, F Gruber, O Wagner, … - Arteriosclerosis, Thrombosis, and Vascular Biology, 2004 - atvbaha.org
... mediate the immediate-early response are found in cluster 4 (JUN, FOS, EGR1 ... several
combinations of known TFBSs, involving AP2, FOXD3, FREAC7, HFH3, and PAX4. ...
Cited by 1 - Cached - Web Search - atvb.ahajournals.org - homepage.univie.ac.at - ncbi.nlm.nih.gov - all 10 versions »