Chance or necessity? Insertional mutagenesis in gene therapy and its consequences - Full text - MIT Libraries
C Baum, C von Kalle, FJ Staal, Z Li, B Fehse, M … - Mol Ther, 2004 - angt.net
... 2). The first postulates that LMO2 and Evi1 represent members of a yet poorly defined
class of high-risk proto-oncogenes whose activation (in primi- tive ...
Cited by 20 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Recurrent retroviral vector integration at the MDS1-EVI1 locus in non-human primate hematopoietic … - Full text - MIT Libraries
B Calmels, C Ferguson, MO Laukkanen, R Adler, M … - Blood, 2005 - ncbi.nlm.nih.gov
... Recent reports linking insertional activiation of LMO2 following gene therapy for
X-SCID ... genes, we detected insertion into one locus, the MDS1-EVI1 region, a ...
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Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking. - Full text - MIT Libraries
O Kustikova, B Fehse, U Modlich, M Yang, J … - Science, 2005 - sciencemag.org
... insertion into Evi1 was sufficient for leukemogenesis in mice. Similarly, unusual
lymphatic leukemias occurred after insertional up-regulation of the LMO2 proto ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Progress in Hematology
T Yamagata, K Maki, K Mitani - Int J Hematol, 2005 - cardenjennings.metapress.com
... Maintained expres- sion of the PU.1 gene and down-regulation of the LMO2 and SCL
genes in Runx1-Evi1 knock-in cells might be the under- lying causes for such a ...
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Report from the 2 ndStem Cell Clonality and Genotoxicity Retreat
RM Frederickson - Molecular Therapy, 2005 - asgt.org
... results provide strong evidence in favor of the idea that LMO2 and IL2 ... Activating
insertions in the zinc finger transcription factor homolog MDS1/EVI1 and two ...
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CONSEQUENCES OF CHROMOSOMAL ABNORMALITIES IN TUMOR DEVELOPMENT - Full text - MIT Libraries
I Sanchez-Garcia - Annual Review of Genetics, 1997 - dx.doi.org
... involvement, especially breakpoints within the chromosome band 11p13 that activate
LMO2 (112). ... Studies carried out with AML1-ETO (68), AML1-EVI1 (87), and CBFB ...
Cited by 25 - Web Search - wwwlib.bionet.nsc.ru - genet.annualreviews.org - ncbi.nlm.nih.gov - all 6 versions »

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor … - Full text - MIT Libraries
P Hematti, BK Hong, C Ferguson, R Adler, H Hanawa, … - PLoS Biol, 2004 - dx.doi.org
... numbers (http:/ / www.ncbi.nlm.nih.gov/ LocusLink/ ) for the genes discussed in
this paper are ARHGEF12 (23365), EVI1 (2122), HMGA2 (8091), LMO2 (4005), MDS1 ...
Cited by 6 - Web Search - medicine.plosjournals.org - plme.allenpress.com - plosbiology.org - all 11 versions »

Occurrence of leukaemia following gene therapy of X-linked SCID - Full text - MIT Libraries
DB Kohn, M Sadelain, JC Glorioso - Nature Reviews Cancer, 2003 - nature.com
... The retroviral vector was inserted near the Evi1 locus -- a gene that is ... The effect
of chromosomal translocations in acute leukemias: the LMO2 paradigm in ...
Cited by 43 - Web Search - nature.com - ncbi.nlm.nih.gov - csa.com

TRANSCRIPTION FACTORS
OFB CELLS - doi.wiley.com
... 22 EVI1 Rearrangements in Malignant Hematopoiesis ... 27 The LMO2 Master Gene; Its Role
as a Transcription Regulator Determining Cell Fate in Leukemogenesis and in ...
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Transcription Factors: Normal and Malignant Development of Blood Cells
IJ Hematol - Int J Hematol, 2001 - cardenjennings.metapress.com
... nine factors: retinoic acid receptor (RAR) , inv(16), EVI1, t(8;21), TEL/ETV6, mixed
lineage leukemia (MLL), coacti- vators, LMO2, and acetyltransferases CREB ...
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Home page Blood Home page - Full text - MIT Libraries
I Nishikata, H Sasaki, M Iga, Y Tateno, S Imayoshi … - Blood, 2003 - pnas.org
... Tateno, S. Imayoshi, N. Asou, T. Nakamura, and K. Morishita A novel EVI1 gene family ...
H. Westphal, A. Forster, and T. H. Rabbitts The LIM-only protein Lmo2 is a ...
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Gene therapy for severe combined immune deficiency
W Qasim, HB Gaspar, AJ Thrasher - Expert Reviews in Molecular Medicine, 2004 - journals.cambridge.org
Page 1. Accession information: DOI: 10.1017/S1462399404007884; Vol. 6; Issue 13;
2 July 2004 ©2004 Cambridge University Press http://www.expertreviews.org/ ...
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A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... EVI1 06 Ectopic viral integration site 1 encoded factor Core should be ACAAGAT not
AGAT ... LMO2COM 01 Complex of Lmo2 bound to Tal-1, E2A proteins, and GATA-1 ...
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Gene transfer in experimental medicine
G Romano - Drug News Perspect, 2003 - prous.com
... which in both cases took place in the proximity of the LMO2 gene. ... copy of the retroviral
transfer vector integrated into the murine gene Evi1 (ecotropic viral ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Cytogenetics and molecular genetics of childhood leukemia
SK Ma, TSK Wan, LC Chan - Hematological Oncology, 1999 - doi.wiley.com
... 9)(q34;q34) TAN1-TCRb T <1 t(8;14)(q24;q11) myc-TCRa/d T <1 t(11;14)(p15;q11)
LMO1-TCRd T <1 t(11;14)(p13;q11) LMO2-TCRd T ... t(3;21)(q26;q22) EVI1-AML1 1±2 AML ...
Cited by 15 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial … - Full text - MIT Libraries
U Modlich, OS Kustikova, M Schmidt, C Rudolph, J … - Blood, 2005 - bloodjournal.org
... the cytoplasmically deleted p75 neurotrophin receptor had activated the Evi1
proto-oncogene ... 17 In both patients, the proto-oncogene LMO2 was upregulated in the ...
Cited by 2 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

acquises de la cellule souche hematopoietique ou d’un precurseur deja commis vers les lignees …
S YNTHESE - MEDECINE/SCIENCES, 2003 - ist.inserm.fr
... transcriptionnels comme les protéines LYL1, TAL1/SCL, LMO1 et LMO2, HOX11 et ... Dans
les leucémies myéloïdes, le gène EVI1 est surex- primé dans de rares ...
View as HTML - Web Search - erudit.org

Pathogenese und Biologie der Leukaemien - Full text - MIT Libraries
M Feuring-Buske, W Hiddemann, C Buske - Der Internist, 2002 - springerlink.com
... t(8;21)(q22;q22) AML1 Transkriptionsfaktor ETO Wahrscheinlich Transkriptionsfaktor
t(3;21)(q26;q22) AML1 Transkriptionsfaktor EVI1 Transkriptionsfaktor t(3;21 ...
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Functional Analysis of Human Hematopoietic Stem Cell Gene Expression Using Zebrafish - Full text - MIT Libraries
CE Eckfeldt, EM Mendenhall, CM Flynn, TF Wang, MA … - PLoS Biol, 2005 - medicine.plosjournals.org
... 12775), CDKN1A (1026), chd (30161), cmyb (30519), CRYGD (1421), EVI1 (2122), EZH2 ...
KIAA1102 (22998), KLF5 (688), lcp1 (30583), LEF1 (51176), LMO2 (4005), lmo2 ...
Cached - Web Search - plme.allenpress.com - biology.plosjournals.org - pubmedcentral.nih.gov

Side effects of retroviral gene transfer into hematopoietic stem cells - Full text - MIT Libraries
C Baum, J Dullmann, Z Li, B Fehse, J Meyer, DA … - Blood, 2003 - bloodjournal.org
... The same configuration occurred in the murine monocytic leukemia originating in
association with retroviral insertional up-regulation of Evi1 in hematopoietic ...
Cited by 71 - Web Search - viro.med.uni-erlangen.de - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Oncogenes et leucemies: historique et perspectives
S Gisselbrecht, BG Roussy - M e decine et Science, 2003 - erudit.org
... transcriptionnels comme les protéines LYL1, TAL1/SCL, LMO1 et LMO2, HOX11 et ... 14Dans
les leucémies myéloïdes, le gène EVI1 est surexprimé dans de rares ...
Cited by 2 - Cached - Web Search

Molecular signatures of self-renewal, differentiation, and lineage choice in multipotential … - Full text - MIT Libraries
L Bruno, R Hoffmann, F McBlane, J Brown, R Gupta, … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... and Irx3, the stem and erythroid cell-associated Lim-only protein Lmo2, and the ... present
in these clusters, including Raf1, ETS2 (a homolog of EVI1), EVI5, LRF1 ...
Cited by 4 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov

T cell suicide gene therapy to aid haematopoietic stem cell transplantation.
W Qasim, HB Gaspar, AJ Thrasher - Current Gene Therapy, 2005 - ingentaconnect.com
... combination with an insertional event leading to transcriptional activation of Evi1,
could cause ... have occurred on chromosome 11 in the region of the LMO2 gene. ...
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Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL - Full text - MIT Libraries
LC Wang, F Kuo, Y Fujiwara, DG Gilliland, TR Golub … - The EMBO Journal, 1997 - embojournal.npgjournals.com
... factors AML-1 (Golub et al., 1995; Romana et al., 1995a ), EVI1 (Raynaud et ... several
instances, notably SCL/tal-1(Porcher et al., 1996 ), Rbtn-2/LMO2 (Warren et ...
Cited by 94 - Web Search - nature.com - emboj.org - ncbi.nlm.nih.gov - all 6 versions »

Genetic Vaccines and Therapy - Full text - MIT Libraries
DS Anson - Genetic Vaccines and Therapy, 2004 - immuneweb.xxmc.edu.cn
Page 1. ...
View as HTML - Web Search - bmc.ub.uni-potsdam.de

The use of retroviral vectors for gene therapy-what are the risks? A review of retroviral … - Full text - MIT Libraries
D Anson - Genetic Vaccines and Therapy, 2004 - dx.doi.org
... cellular genes (Ahi1, Bla1, Bmi1, Cyclin D2, Dsi1, Emi1, Ets1, Evi1, Gfi1,
c-Ha-ras ... Specifically, LMO2, the oncogene activated in the X-SCID trial, is normally ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - gvt-journal.com - citebase.eprints.org - all 9 versions »

Protection and selection for gene therapy in the hematopoietic system - Full text - MIT Libraries
MD Milsom, LJ Fairbairn - The Journal of Gene Medicine, 2004 - doi.wiley.com
Page 1. THE JOURNAL OF GENE MEDICINE REVIEW ARTICLE J Gene Med 2004; 6: 133–146.
Published online in Wiley InterScience (www.interscience.wiley.com). ...
Web Search - angt.net - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

PAINT: A Promoter Analysis and Interaction Network Generation Tool for Gene Regulatory Network …
R Vadigepalli, P Chakravarthula, DE Zak, JS … - Omics A Journal of Integrative Biology, 2003 - dx.doi.org
Page 1. 235 OMICS A Journal of Integrative Biology Volume 7, Number 3, 2003 © Mary
Ann Liebert, Inc. PAINT: A Promoter Analysis and Interaction Network ...
Cited by 4 - Web Search - liebertonline.com - che.udel.edu - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Improving the ex vivo retroviral-mediated suicide-gene transfer process in T lymphocytes to preserve …
E Robinet, B Fehse, S Ebeling, D Sauce, C Ferrand, … - Cytotherapy, 2005 - taylorandfrancis.metapress.com
... Cooperation of the Evi1 proto-oncogene, activated as the result of a promoter insertion
of the retroviral vector, with the DLNGFR gene, resembling a decoy ...
Cited by 1 - Web Search - ingentaconnect.com

CLUB ESPANOL DE CITOLOGIA HEMATOLOGICA: EL LINFOBLASTO EN EL CONTEXTO
A DE LA LEUCEMIA LINFOBLASTICA - db2.doyma.es
Page 1. CLUB ESPAÑOL DE CITOLOGÍA HEMATOLÓGICA: EL LINFOBLASTO EN EL CONTEXTO DE
LA LEUCEMIA LINFOBLÁSTICA AGUDA C OORDINADORAS : M.ªC. J IMÉNEZ . ...
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Translocation Breakpoints in Cancer
AM Oliveira, JA Fletcher - ehgonline.net
... syndrome 1 (MDS1) in myelodysplastic (preleukemic) syndromes, RUNX1±ecotropic viral
integration site 1 (EVI1) in chronic myelogenous leukemia in blast crisis ...
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NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that … - Full text - MIT Libraries
YW Lin, C Slape, Z Zhang, PD Aplan - Blood, 2005 - bloodjournal.org
... A large number of genes typically expressed in erythroid precursors (LMO2, Eraf,
HbbY, EpoR, and glycophorin A) were more than 8-fold elevated in the invaded ...
Cited by 1 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Gene therapy for chronic granulomatous disease
CN Barese, WS Goebel, MC Dinauer - Expert Opinion on Biological Therapy, 2004 - extenza-eps.com
... transduced with a ∆LNGFR-containing retroviral vector, in which a copy of the provirus
had apparently randomly integrated into the murine Evi1 proto-oncogene ...
Cited by 2 - Web Search - ashley-pub.com - dx.doi.org - ingentaconnect.com - all 8 versions »

Current World Literature; Bibliography
T Blake, N Adya, CH Kim… - Current Opinion in Hematology, 2001 - co-hematology.com
... Leukemia 2000, 14:1885-1891. Davenport J, Neale GAM, Goorha R: Identification
of genes potentially involved in LMO2-induced leukemogenesis. ...
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Molecular genetic analysis of haematological malignancies: I. Acute leukaemias and … - Full text - MIT Libraries
AJ BENCH, WN ERBER, MA SCOTT - Clinical & Laboratory Haematology, 2005 - blackwell-synergy.com
... Other translocations in T-ALL involving the TCR loci include t(11;14) that results
in overexpression of LMO1 or LMO2, t(7;19) that results in an aberrant LYL1 ...
Web Search - ncbi.nlm.nih.gov

GATA Motifs Regulate Early Hematopoietic Lineage-Specific Expression of the Gata2 Gene
M Kobayashi-Osaki, O Ohneda, N Suzuki, N Minegishi … - mcb.asm.org
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