Lmo 2 and Scl/Tal 1 convert non-axial mesoderm into haemangioblasts which differentiate into … - Full text - MIT Libraries
M Gering, Y Yamada, TH Rabbitts, RK Patient - Development, 2003 - dev.biologists.org
... This restriction correlates well with activation of gata1 transcription and
co-injection of gata1 mRNA along with scl/tal1 and lmo2 induces erythropoiesis more ...
Cited by 10 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell … - Full text - MIT Libraries
Y Ono, N Fukuhara, O Yoshie - Mol. Cell. Biol, 1998 - mcb.asm.org
... element(s). The TAL1-LMO-GATA3 complex in T-ALL may contain Ldb1 (also called NL1
or CLIM2) (1, 3, 25), like the TAL1-LMO2-GATA1 complex in erythroid cells (60 ...
Cited by 39 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Promoter 1 of LMO2, a master gene for hematopoiesis, is regulated by the erythroid specific …
HH Anthropology, M Genetics, G Berlin - Gene Funct. Dis, 2000 - doi.wiley.com
... site [7]. To show whether these sites in- deed bind these proteins EMSA analysis
using a 29 bp oligo- nucleotide from P1 of LMO2 containing two GATA1 sites and ...
Web Search

Identification of novel vascular endothelial–specific genes by the microarray analysis of the … - Full text - MIT Libraries
S Sumanas, T Jorniak, S Lin - Blood, 2005 - bloodjournal.org
... Expression of all known blood or endothelial cell–specific genes, including scl,
lmo2, gata1, gata2, flt1, and flt4, is almost completely lost in cloche ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Microarray Analysis of Zebrafish cloche Mutant Using Amplified cDNA and Identification of Potential …
F Qian, F Zhen, C Ong, SW Jin, HM Soo, DYR … - Key words, 2005 - doi.wiley.com
... The RNA samples were then “genotyped” by examining the expressions of flk1, scl,
lmo2, gata1, and e1-globin that are known to be either absent or greatly ...
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The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in … - Full text - MIT Libraries
Y Yamada, R Pannell, A Forster, TH Rabbitts - EMBO J, 2004 - dx.doi.org
... and RK Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts
which differentiate into endothelial cells in the absence of Gata1 Development ...
Cited by 25 - Web Search - pnas.org - pubmedcentral.nih.gov - invivo.caltech.edu - all 7 versions »

The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis - Full text - MIT Libraries
Y Yamada, AJ Warren, C Dobson, A Forster, R … - Physiol Genomics, 2004 - dx.doi.org
... and RK Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts
which differentiate into endothelial cells in the absence of Gata1 Development ...
Cited by 78 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Helix-loop-helix(E 2-5, HEB, TAL 1 and Id 1) protein interaction with the TCRalphadelta enhancers - Full text - MIT Libraries
M Bernard, E Delabesse, L Smit, C Millien, IR … - International Immunology, 1998 - intimm.oupjournals.org
Page 1. International Immunology, Vol. 10, No. 10, pp. 1539–1549 © 1998 Oxford
University Press Helix-loop-helix (E2-5, HEB, TAL1 and Id1) ...
Cited by 6 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Differences in the chromatin structure and cis-element organization of the human and mouse GATA1 … - Full text - MIT Libraries
V Valverde-Garduno, B Guyot, E Anguita, I Hamlett, … - Blood, 2004 - bloodjournal.org
... In vivo, they both bind the transcription factors GATA1, SCL, LMO2, and Ldb1. ... At
mHS+3.5 we detect only GATA1 but not SCL/E2A/LMO2/Ldb-1 binding. ...
Cited by 3 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

Hematopoietic regulatory domain of gata1 gene is positively regulated by GATA1 protein in zebrafish … - Full text - MIT Libraries
M Kobayashi, K Nishikawa, M Yamamoto - Development, 2001 - dev.biologists.org
... Lmo2 was demonstrated to interact directly with the fingers in GATA1 and is assumed
to act as a bridging molecule for GATA1, SCL/Tal-1, and Ldb1 (Osada et al ...
Cited by 17 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Non-cell autonomous requirement for the bloodless gene in primitive hematopoiesis of zebrafish - Full text - MIT Libraries
EC Liao, NS Trede, D Ransom, A Zapata, M Kieran, … - Development, 2002 - dev.biologists.org
... Factors important for the development of both primitive and definitive hematopoiesis
such as Scl, Lmo2, Gata1, Gata2 and Flk1 (Kdr) have been described (Pevny ...
Cited by 12 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Alterations in Gene Expression in Cadaveric vs. Live Donor Kidneys Suggest Impaired Tubular … - Full text - MIT Libraries
A Kainz, C Mitterbauer, P Hauser, C Schwarz, HM … - American Journal of Transplantation, 2004 - blackwell-synergy.com
... the distance 400 to 51 upstream of the transcription start site, includes binding
sites for the transcription factors (TF) LMO2, GATA1, WHN, and AREB6. ...
Cited by 1 - Web Search - ingentaconnect.com - akh-wien.ac.at - ncbi.nlm.nih.gov

Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem … - Full text - MIT Libraries
S Gerecht-Nir, JE Dazard, M Golan-Mashiach, S … - Developmental Dynamics, 2005 - doi.wiley.com
... 2003), CD45 (Mikkola et al., 2003; Ferkowicz et al., 2003), and transcrip- tion
factors TAL1, LMO2, GATA1, GATA2, and GATA3, although up-reg- ulation of the ...
Cited by 2 - Web Search - weizmann.ac.il - weizmann.ac.il - ncbi.nlm.nih.gov

Transcriptional control of fetal liver hematopoiesis: dominant negative effect of the overexpression …
T Terano, Y Zhong, S Toyokuni, H Hiai, Y Yamada - Exp Hematol, 2005 - ncbi.nlm.nih.gov
... The LIM-finger protein LMO2 forms a transcription factor complex with other
hematopoietic regulator proteins, such as TAL1 (SCL), LDB1, GATA1, 2, and 3, in ...
Web Search - Get it from MIT Libraries

[CITATION] Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined … - Full text - MIT Libraries
MP McCormack, TH Rabbitts - N. Engl. J. Med, 2004
... Although LMO2 is found in DNA-binding transcription-factor complexes involving the
pro- teins TAL1 (or SCL), E47, LDB1, and GATA1 in normal erythroid cells ...
Cited by 17 - Web Search - frontiers-in-genetics.org - lsic.ucla.edu - ncbi.nlm.nih.gov - all 7 versions »

Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites - Full text - MIT Libraries
A Manaia, V Lemarchandel, M Klaine, I Max-Audit, P … - Development, 2000 - dev.biologists.org
... Besides common signaling pathways involving, for example, Tal-1/SCL, Lmo2,
GATA-1 and GATA- 2, a number of specific genes (including GATA-3, c-myb, AML- 1 ...
Cited by 37 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Uroporphyrinogen III synthase erythroid promoter mutations in adjacent GATA1 and CP2 elements cause … - Full text - MIT Libraries
C Solis, GI Aizencang, KH Astrin, DF Bishop, RJ … - J Clin Invest, 2001 - jci.org
... genes (28, 29) and forms transcriptional complexes with several erythroid
transcriptional factors including "friend of GATA1" (FOG), EKLF, TAL1, and LMO2 ( ...
Cited by 10 - Web Search - jci.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

GATA1 Function, a Paradigm for Transcription Factors in Hematopoiesis - Full text - MIT Libraries
R Ferreira, K Ohneda, M Yamamoto, S Philipsen - Mol Cell Biol, 2005 - mcb.asm.org
... GATA1 interacts directly with Lmo2, but not with Tal-1, in erythroid cells
(82, 83). These authors also showed that GATA1 and Tal ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

The GATA-E box-GATA motif in the EKLF promoter is required for in vivo expression - Full text - MIT Libraries
KP Anderson, SC Crable, JB Lingrel - Blood, 2000 - bloodjournal.org
... describing a physical association in erythroid cells between GATA1, Tal1/E2A, Ldb1,
and Lmo2, where Lmo2 acts as a bridging molecule between GATA1 and Tal1. ...
Cited by 8 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

THE LMO2 MASTER GENE; ITS ROLE AS A TRANSCRIPTION REGULATOR DETERMINING CELL FATE IN LEUKEMOGENESIS …
C TRANSLOCATIONS, D REGULATION - doi.wiley.com
... In this model, as differentiation proceeds, Gata2 of a Lmo2/Tal1/Gata2 complex,
in an early hematopoietic progenitor, is replaced by Gata1 in erythroid ...
Web Search

Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels … - Full text - MIT Libraries
DS Chervinsky, XF Zhao, DH Lam, M Ellsworth, KW … - Mol Cell Biol, 1999 - mcb.asm.org
... both LMO1 and LMO2 in vivo (46) and that a pentameric transactivating complex
consisting of SCL, E2A, LMO2, GATA1, and LDB1 can be detected in vivo (47); this ...
Cited by 34 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during … - Full text - MIT Libraries
DA Kenny, LW Jurata, Y Saga, GN Gill - Developmental Biology, 1998 - dx.doi.org
... and RK Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts
which differentiate into endothelial cells in the absence of Gata1 Development ...
Cited by 36 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Mutant-specific gene programs in the zebrafish - Full text - MIT Libraries
GJ Weber, SE Choe, KA Dooley, NN Paffett-Lugassy, … - Blood, 2005 - bloodjournal.org
... lineage-specific regulation of the hematopoietic genetic program, since we detect
early critical transcription factors, such as scl, lmo2, and gata1, as well ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter … - Full text - MIT Libraries
TH Rabbitts - Genes Dev, 1998 - genesdev.org
... The ability of the Lmo2 protein to interact with Tal1 and with GATA1 appears to
facilitate the formation of a complex in which two DNA contacting regions ...
Cited by 50 - Web Search - genesdev.org - ncbi.nlm.nih.gov

Runx 3 is required for hematopoietic development in zebrafish - Full text - MIT Libraries
ML Kalev-Zylinska, JA Horsfield, MVC Flores, JH … - Developmental Dynamics, 2003 - doi.wiley.com
... Early Expression of scl, lmo2, and gata1 Is Preserved in runx3-Morpholino Injected
Embryos To further investigate the nature and the time of onset of the ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

The LIM Protein RBTN2 and the Basic Helix-Loop-Helix Protein TAL1 are Present in a Complex in … - Full text - MIT Libraries
VE Valge-Archer, H Osada, AJ Warren, A Forster, J … - Proceedings of the National Academy of Sciences - pnas.org
... and RK Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts
which differentiate into endothelial cells in the absence of Gata1 Development ...
Cited by 93 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Lineage analysis of the hemangioblast as defined by FLK 1 and SCL expression - Full text - MIT Libraries
YS Chung, WJ Zhang, E Arentson, PD Kingsley, J … - Development, 2002 - dev.biologists.org
... to a nylon membrane, and hybridized with 32 P randomly primed cDNA probe corresponding
to the 3' end of the L32, Flk1, Scl, Gata1, Gata2 and Lmo2 genes. ...
Cited by 28 - Web Search - dev.biologists.org - dx.doi.org - ncbi.nlm.nih.gov

Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia - Full text - MIT Libraries
R Hubmann, JD Schwarzmeier, M Shehata, M Hilgarth, … - Blood, 2002 - bloodjournal.org
... core promoter region revealed a complex array of potential regulatory elements,
including CBF1, STAT6, NF- B, Pax5 (BSAP), Ikaros, GATA1-3, LMO2, and MZF1. ...
Cited by 17 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Zebrafish: a genetic approach in studying hematopoiesis
BH Paw, LI Zon - Curr. Opin. Hematol, 2000 - co-hematology.com
... Expression of GATA1 and c -myb is greatly reduced in the ICM as well as in the dorsal
aorta with normal expression of LMO2 and GATA2 in the posterior portion ...
Cited by 16 - Web Search - co-hematology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Expression of alpha4-integrin defines the earliest precursor of hematopoietic cell lineage diverged … - Full text - MIT Libraries
M Ogawa, M Kizumoto, S Nishikawa, T Fujimoto, H … - Blood, 1999 - bloodjournal.org
... 40 some mature primitive erythrocytes may contaminate into sorted fractions and
might result in the overall detection of Gata1 and Lmo2 transcripts. ...
Cited by 35 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Intraembryonic Hematopoietic Cell Migration During Vertebrate Development - Full text - MIT Libraries
IIID HW, MW Kieran, FY Chan, LM Barone, K Yee, JA … - Proceedings of the National Academy of Sciences - pnas.org
... and RK Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts
which differentiate into endothelial cells in the absence of Gata1 Development ...
Web Search

Scl is required for dorsal aorta as well as blood formation in zebrafish embryos - Full text - MIT Libraries
LJ Patterson, M Gering, R Patient - Blood, 2005 - bloodjournal.org
... 10,50,51 Lmo2 and Gata2, activated before gata1 in the PLM, are likely partners
for Scl in this activation, although gain-of-function experiments show that ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Mapping and characterization of the mouse and human SS18 genes, two human SS18-like genes and a …
DRH de Bruijn, E Kater-Baats, M Eleveld, G Merkx, … - Cytogenet Cell Genet, 2001 - content.karger.com
... Binding sites for the hematopoietic specific transcription factors IK2, c-ETS I
MZF1, LMO2 and GATA1, as well as the general transcription factors AP2, AP4, SP1 ...
Cited by 7 - Web Search - content.karger.com - dx.doi.org - karger.com

Zebrafish: An emerging genetic model for the study of cytokines and hematopoiesis in the era of …
GJ Lieschke - Int. J. Hematol, 2001 - cardenjennings.metapress.com
... orthologue are provided): scl AF038873, AF045432, U01530 [22,23]; gata2 U18312 and
reference 24, NP_032116; gata1 U18311, S04655 [24]; lmo2 AF191560, NM_008505 ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Positive and Negative Transcriptional Control by the TAL1 Helix-Loop-Helix Protein - Full text - MIT Libraries
H Hsu, I Wadman, JT Tsan, R Baer - Proceedings of the National Academy of Sciences - pnas.org
... and RK Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts
which differentiate into endothelial cells in the absence of Gata1 Development ...
Cited by 34 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

LMO3 Interacts with Neuronal Transcription Factor, HEN2, and Acts as an Oncogene in Neuroblastoma - Full text - MIT Libraries
M Aoyama, T Ozaki, H Inuzuka, D Tomotsune, J … - Cancer Research, 2005 - cancerres.aacrjournals.org
... 39). On the other hand, a stable complex comprising LMO2, TAL1, and GATA1
was required to promote erythroid differentiation (32). ...
Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

Organogenesis--Heart and Blood Formation from the Zebrafish Point of View - Full text - MIT Libraries
C Thisse, LI Zon - Science, 2002 - sciencemag.org
... hematopoietic and vasculogenic cells can first be seen between the 5- and 7-somite
stages, when Gata1 and Flk1 are ... 2) and the LIM domain protein LMO2 (49, 52). ...
Cited by 25 - Web Search - genetics.med.harvard.edu - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)–dependent window … - Full text - MIT Libraries
TM Schlaeger, HK Mikkola, C Gekas, HB Helgadottir, … - Blood, 2005 - bloodjournal.org
... 10,11 When expressed with its partners LIM only protein 2 (LMO2) and GATA binding
factor 1 (GATA1), SCL induces ectopic blood cell development. ...
Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

Leukaemia- a developmental perspective - Full text - MIT Libraries
S Izraeli - British Journal of Haematology, 2004 - blackwell-synergy.com
... paradigm of leukaemogenesis: RUNX1 abnormalities in acute leukaemias, GATA1 mutations
in the leukaemias of Down syndrome, and SCL and LMO2 ectopic expression ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

acquises de la cellule souche hematopoietique ou d’un precurseur deja commis vers les lignees …
S YNTHESE - MEDECINE/SCIENCES, 2003 - ist.inserm.fr
... MLL (11q23) OTT-MAL t(1;22) GATA1 Précurseur lymphocytaire LYL1 TAL1 LMO2 HOX11
HOX11L2 ProB Mégacaryoblaste BCR-ABL t(9;22) TEL-AML1 t(9;21) ...
View as HTML - Web Search - erudit.org

The‘definitive’(and‘primitive’) guide to zebrafish hematopoiesis - Full text - MIT Libraries
AJ Davidson, LI Zon - Oncogene, 2004 - nature.com
... (a) Expression of scl (red) and gata1 (purple). Transcripts for gata1 are found
in a subset of scl þ cells in the posterior. (b) Expression of lmo2. ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

TAL 1 expression does not occur in the majority of T-ALL blasts - Full text - MIT Libraries
E Delabesse, M Bernard, VE Meyer, L Smit, K … - British Journal of Haematology, 1998 - blackwell-synergy.com
... detecting 1% of TAL1-positive cells, the unexplained TAL1 (and GATA1) transcripts
observed ... by Abelson virus infection ( Elwood et al, 1993) or LMO2 (rhombotin-2 ...
Cited by 13 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

A nonsense mutation in zebrafish gata 1 causes the bloodless phenotype in vlad tepes - Full text - MIT Libraries
SE Lyons, ND Lawson, L Lei, PE Bennett, BM … - Proceedings of the National Academy of Sciences, 2002 - pnas.org
... and RK Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts
which differentiate into endothelial cells in the absence of Gata1 Development ...
Cited by 12 - Web Search - med.umich.edu - pubmedcentral.gov - dx.doi.org - all 8 versions »

Characterization of the Lmo 4 gene encoding a LIM-only protein: genomic organization and comparative … - Full text - MIT Libraries
E Tse, G Grutz, AA Garner, Y Ramsey, NP Carter, N … - Mammalian Genome, 1999 - springerlink.com
... LMO2 plays a crucial role in both embryonic erythropoiesis (Warren et al. ... in multimeric
protein complexes with transcription factors TAL1, E47, GATA1, and LDB1 ...
Cited by 9 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein Lmo4 or … - Full text - MIT Libraries
K Hahm, EYM Sum, Y Fujiwara, GJ Lindeman, JE … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... LMO2 has been established to form a complex comprising the hematopoietic transcription
factors SCL(TAL-1)/E2A and GATA1 as well as the cofactor Ldb1 (42). ...
Cited by 7 - Web Search - dx.doi.org - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Studies of the Ribosomal Protein S19 in Erythropoiesis
H MATSSON - publications.uu.se
... devel- opment is regulated by several transcription factors including TAL1, LMO2
and GATA2 ... GATA1 and its cofactor Friend of GATA1 (FOG1) are needed at a later ...
Web Search - diva-portal.org

Circulation is established in a stepwise pattern in the mammalian embryo - Full text - MIT Libraries
KE McGrath, AD Koniski, J Malik, J Palis - Blood, 2003 - bloodjournal.org
... the fact that embryos mutant in genes necessary for initial establishment of the
endothelial networks (VEGFR-2), red blood cell synthesis (GATA1, LMO2, and Tal1 ...
Cited by 13 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Zebrafish myelopoiesis and blood cell development
K Hsu, JP Kanki, AT Look - Curr Opin Hematol, 2001 - co-hematology.com
... factor genes such as Gata-2, Tal1/Scl, and Lmo2 are appropriately expressed ... of early
endothelial and blood differentiation genes such as fli1, flk1, and gata1. ...
Cited by 8 - Web Search - co-hematology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Circulation is Established in a Step-Wise Pattern in the Mammalian Embryo Running Title: Step-wise …
KE McGrath, AD Koniski, J Malik, J Palis, S … - bloodjournal.org
... that embryos mutant in genes necessary for initial establishment of the endothelial
networks (ie in VEGFR2), red blood cell synthesis (ie GATA1, LMO2 and Tal1 ...
Web Search

Synergistic role of E 1 A-Binding proteins and tissue-specific transcription factors in … - Full text - MIT Libraries
G Condorelli, A Giordano - Journal of Cellular Biochemistry, 1997 - doi.wiley.com
... by cyclin D1 [Condorelli et al., submitted].Aprotein interact- ing with both Lmo2
and p105 ... The Zinc finger protein GATA1 also might be part of this process. ...
Cited by 17 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov