Zebrafish: a genetic approach in studying hematopoiesis
BH Paw, LI Zon - Curr. Opin. Hematol, 2000 - co-hematology.com
... Expression of GATA1 and c -myb is greatly reduced in the ICM as well as in the dorsal
aorta with normal expression of LMO2 and GATA2 in the posterior portion ...
Cited by 16 - Web Search - co-hematology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

The‘definitive’(and‘primitive’) guide to zebrafish hematopoiesis - Full text - MIT Libraries
AJ Davidson, LI Zon - Oncogene, 2004 - nature.com
... Consistent with this, transcripts for scl, lmo2, gata2, and fli1a are found in the
RBI between the 3- to 5-somite stages (Figures 3 and 5; Liao et al., 1998 ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

Zebrafish myelopoiesis and blood cell development
K Hsu, JP Kanki, AT Look - Curr Opin Hematol, 2001 - co-hematology.com
... These cells appear later than those expressing scl, lmo2 and gata2, and this is
consistent with findings in mammals that the expression of Pu.1 may represent a ...
Cited by 8 - Web Search - co-hematology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Scl is required for dorsal aorta as well as blood formation in zebrafish embryos - Full text - MIT Libraries
LJ Patterson, M Gering, R Patient - Blood, 2005 - bloodjournal.org
... 10,50,51 Lmo2 and Gata2, activated before gata1 in the PLM, are likely partners
for Scl in this activation, although gain-of-function experiments show that ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

THE LMO2 MASTER GENE; ITS ROLE AS A TRANSCRIPTION REGULATOR DETERMINING CELL FATE IN LEUKEMOGENESIS …
C TRANSLOCATIONS, D REGULATION - doi.wiley.com
... In this model, as differentiation proceeds, Gata2 of a Lmo2/Tal1/Gata2 complex,
in an early hematopoietic progenitor, is replaced by Gata1 in erythroid ...
Web Search

Studies of the Ribosomal Protein S19 in Erythropoiesis
H MATSSON - publications.uu.se
... The commitment of hematopoietic cells to undergo erythroid devel- opment is regulated
by several transcription factors including TAL1, LMO2 and GATA2 (4). ...
Web Search - diva-portal.org

Zebrafish scl functions independently in hematopoietic and endothelial development. - Full text - MIT Libraries
KA Dooley, AJ Davidson, LI Zon - Dev Biol, 2005 - ncbi.nlm.nih.gov
... However, the expression of early hematopoietic genes, gata2 and lmo2, was unaffected,
suggesting that hematopoietic cells were present but unable to further ...
Cited by 1 - Web Search

GATA Motifs Regulate Early Hematopoietic Lineage-Specific Expression of the Gata2 Gene
M Kobayashi-Osaki, O Ohneda, N Suzuki, N Minegishi … - mcb.asm.org
... GATA Motifs Regulate Early Hematopoietic Lineage-Specific Expression of the Gata2
Gene. ... We previously showed that the mouse Gata2 gene has two first exons (28). ...
Web Search - mcb.asm.org

SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage … - Full text - MIT Libraries
M Endoh, M Ogawa, S Orkin, S Nishikawa - The EMBO Journal, 2002 - embojournal.npgjournals.com
... On the other hand, SCL, LMO2 and GATA2, which are essential for HPC differentiation,
are also expressed in some ECs (Dorfman et al., 1992; Hwang et al., 1993 ...
Cited by 15 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 7 versions »

Lineage analysis of the hemangioblast as defined by FLK 1 and SCL expression - Full text - MIT Libraries
YS Chung, WJ Zhang, E Arentson, PD Kingsley, J … - Development, 2002 - dev.biologists.org
... to a nylon membrane, and hybridized with 32 P randomly primed cDNA probe corresponding
to the 3' end of the L32, Flk1, Scl, Gata1, Gata2 and Lmo2 genes. ...
Cited by 28 - Web Search - dev.biologists.org - dx.doi.org - ncbi.nlm.nih.gov

The pu. 1 promoter drives myeloid gene expression in zebrafish - Full text - MIT Libraries
K Hsu, D Traver, JL Kutok, A Hagen, TX Liu, BH Paw … - Blood, 2004 - bloodjournal.org
... The zpu.1-expressing cells appear later in development than those expressing scl,
lmo2, and gata2, which is consistent with findings in mammals, suggesting ...
Cited by 4 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov - all 5 versions »

Non-cell autonomous requirement for the bloodless gene in primitive hematopoiesis of zebrafish - Full text - MIT Libraries
EC Liao, NS Trede, D Ransom, A Zapata, M Kieran, … - Development, 2002 - dev.biologists.org
... Factors important for the development of both primitive and definitive hematopoiesis
such as Scl, Lmo2, Gata1, Gata2 and Flk1 (Kdr) have been described (Pevny ...
Cited by 12 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Zebrafish: An emerging genetic model for the study of cytokines and hematopoiesis in the era of …
GJ Lieschke - Int. J. Hematol, 2001 - cardenjennings.metapress.com
... here,15 of 18 show only 36% to 65% overall amino acid iden- tity with their murine
orthologues (the exceptions are lmo2, ferrochelatase, and gata2 with 90%, >80 ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Differences in the chromatin structure and cis-element organization of the human and mouse GATA1 … - Full text - MIT Libraries
V Valverde-Garduno, B Guyot, E Anguita, I Hamlett, … - Blood, 2004 - bloodjournal.org
... 69. In the specific case of transcriptional control of GATA1, SCL, LMO2, and GATA2
all act upstream of GATA1 (reviewed in Orkin 15 ) and are candidate GATA1 ...
Cited by 3 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

Expression of alpha4-integrin defines the earliest precursor of hematopoietic cell lineage diverged … - Full text - MIT Libraries
M Ogawa, M Kizumoto, S Nishikawa, T Fujimoto, H … - Blood, 1999 - bloodjournal.org
... in mouse embryos. Loss of either Gata2, Lmo2, or Tal1 profoundly affects
development of all hematopoietic cell lineages. 47-50 It ...
Cited by 35 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

A complex linkage in the developmental pathway of endothelial and hematopoietic cells
SI Nishikawa - Curr Opin Cell Biol, 2001 - cbi.pku.edu.cn
... The finding that tal1 (–/–) and lmo2 (–/–) ... and vascular remodelling Runt related
transcription factor 1 (Runx1), GATA-binding protein 2 (GATA2) and c ...
Cited by 19 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem … - Full text - MIT Libraries
S Gerecht-Nir, JE Dazard, M Golan-Mashiach, S … - Developmental Dynamics, 2005 - doi.wiley.com
... 2003), CD45 (Mikkola et al., 2003; Ferkowicz et al., 2003), and transcrip- tion
factors TAL1, LMO2, GATA1, GATA2, and GATA3, although up-reg- ulation of the ...
Cited by 2 - Web Search - weizmann.ac.il - weizmann.ac.il - ncbi.nlm.nih.gov

Identification of novel vascular endothelial–specific genes by the microarray analysis of the … - Full text - MIT Libraries
S Sumanas, T Jorniak, S Lin - Blood, 2005 - bloodjournal.org
... Expression of all known blood or endothelial cell–specific genes, including scl,
lmo2, gata1, gata2, flt1, and flt4, is almost completely lost in cloche ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Development of primitive and definitive hematopoiesis from nonhuman primate embryonic stem cells in … - Full text - MIT Libraries
K Umeda, T Heike, M Yoshimoto, M Shiota, H Suemori … - Development, 2004 - mphywww.tamu.edu
... 7). Brachyury, an early mesodermal marker, was expressed on day 4 but its expression
declined on day 6. The expression of FLK1, LMO2, MYB and GATA2, which were ...
Cited by 2 - View as HTML - Web Search - dev.biologists.org - dev.biologists.org - ncbi.nlm.nih.gov

Adult and embryonic blood and endothelium derive from distinct precursor populations which are … - Full text - MIT Libraries
M Walmsley, A Ciau-Uitz, R Patient - Development, 2002 - dev.biologists.org
... stages of blood cell and blood vessel development, including Flk1, cloche, SCL,
QH1, Ets, Runx1, Fli1, TGF-ß1, VEGF, CD34, Flt1, Tie2, GATA2, LMO2 and PECAM1 ...
Cited by 13 - Web Search - dx.doi.org - dev.biologists.org - ncbi.nlm.nih.gov - all 5 versions »

The GATA-E box-GATA motif in the EKLF promoter is required for in vivo expression - Full text - MIT Libraries
KP Anderson, SC Crable, JB Lingrel - Blood, 2000 - bloodjournal.org
... The identification of a multiprotein complex in which Lmo2 acts as a ... 38 One explanation
for this apparent inconsistency is compensation by GATA2 because the ...
Cited by 8 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

A human Mix-like homeobox gene MIXL shows functional similarity to Xenopus Mix. - Full text - MIT Libraries
W Guo, AP Chan, H Liang, ED Wieder, JJ Molldrem, … - Blood, 2002 - bloodjournal.org
... Mammalian hematopoiesis requires many factors, including SCL, LMO2, and GATA2, that
regulate the differentiation of uncommitted progenitors with high precision ...
Web Search - bloodjournal.org - bloodjournal.org - ncbi.nlm.nih.gov - all 5 versions »

Unchain my heart: the scientific foundations of cardiac repair - Full text - MIT Libraries
S Dimmeler, AM Zeiher, MD Schneider - J Clin Invest, 2005 - jci.org
... Cardiac-resident Sca-1 + cells lack the HSC markers CD45 and CD34 (also a marker
of EPCs), lack hematopoietic transcription factors (Lmo2, Gata2, Tal), and ...
Cited by 6 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Functional Analysis of Human Hematopoietic Stem Cell Gene Expression Using Zebrafish - Full text - MIT Libraries
CE Eckfeldt, EM Mendenhall, CM Flynn, TF Wang, MA … - PLoS Biol, 2005 - medicine.plosjournals.org
... For instance, LMO2 [21] and GATA2 [22], known to be involved in HSC development
and self-renewal, were expressed significantly higher in BM Rho lo than in Rho ...
Cached - Web Search - plme.allenpress.com - biology.plosjournals.org - pubmedcentral.nih.gov

Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression … - Full text - MIT Libraries
AC Oates, A Brownlie, SJ Pratt, DV Irvine, EC Liao … - Blood, 1999 - bloodjournal.org
... animals with a jak2a mutation would initially express markers for hematopoietic
stem cells (HSCs) and progenitor cells such as scl, lmo2, 73 and gata2 in an ...
Cited by 27 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Analysis of the relationship between Scl transcription factor complex protein expression patterns …
AM Rice, KM Holtz, J Karp, S Rollins, AC … - Leuk Res, 2004 - ncbi.nlm.nih.gov
... Scl and its transcription complex partners [ie, Rbtn1 (LMO1), Rbtn2 (LMO2), Ldb1,
and ... and APL blasts, while the levels of expression of Rbtn1, GATA2, and GATA3 ...
Web Search - Get it from MIT Libraries

Oligo GEArray® Human Hematopoietic Stem Cells and Hematopoiesis Microarray
S Conditions - search.cosmobio.co.jp
... CSF1, DLL1, ERAF, FEZ2, FUT10, IFI16, IL10, IL20, IL31RA, JAG1, LMO2, MLF1, MMP9 ...
CBFB, CD80, CD86, CEBPE, CEBPG, EGR1, ETS1, ETV6, GATA1, GATA2, GFI1, HDAC4 ...
View as HTML - Web Search

A nonsense mutation in zebrafish gata 1 causes the bloodless phenotype in vlad tepes - Full text - MIT Libraries
SE Lyons, ND Lawson, L Lei, PE Bennett, BM … - Proceedings of the National Academy of Sciences, 2002 - pnas.org
... Expression of lmo2, scl, and cbfb (20), all markers of hematopoietic stem cells ...
Expression of gata2, a marker of hematopoietic progenitors, was normal in the ...
Cited by 12 - Web Search - med.umich.edu - pubmedcentral.gov - dx.doi.org - all 8 versions »

Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA … - Full text - MIT Libraries
B Heavey, C Charalambous, C Cobaleda, M Busslinger - EMBO J, 2003 - embojournal.npgjournals.com
... Here we demonstrate that ectopic expression of the transcription factors C/EBP ,
GATA1, GATA2 and GATA3 strongly promoted in vitro macrophage differentiation ...
Cited by 10 - Web Search - nature.com - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

LMO3 Interacts with Neuronal Transcription Factor, HEN2, and Acts as an Oncogene in Neuroblastoma - Full text - MIT Libraries
M Aoyama, T Ozaki, H Inuzuka, D Tomotsune, J … - Cancer Research, 2005 - cancerres.aacrjournals.org
... On the other hand, a stable complex comprising LMO2, TAL1, and GATA1 was ... Our preliminary
data have suggested that GATA2, GATA3, GATA4, and GATA6 are highly ...
Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

GATA1 Function, a Paradigm for Transcription Factors in Hematopoiesis - Full text - MIT Libraries
R Ferreira, K Ohneda, M Yamamoto, S Philipsen - Mol Cell Biol, 2005 - mcb.asm.org
... When GATA1 is activated, GATA2 is repressed and GATA1 levels increase, possibly
through cross-talk between GATA1 and GATA2. ... Lmo2/Ldb1/Tal-1/E2A. ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell … - Full text - MIT Libraries
Y Ono, N Fukuhara, O Yoshie - Mol. Cell. Biol, 1998 - mcb.asm.org
... Thus, although it has been reported that LMO1 and LMO2 contain transactivation ...
regulation of endothelin-1 gene expression in endothelial cells, GATA2 and AP1 ...
Cited by 39 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... 1 GATA1 03 GATA-binding factor 1 GATA1 04 GATA-binding factor 1 GATA2 01 GATA ... LMO2COM
01 Complex of Lmo2 bound to Tal-1, E2A proteins, and GATA-1, half-site 1 ...
View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Original Research Report
T TSANG, DT HARRIS - dx.doi.org
... Cell growth and maintenance INHBC AI239905 Inhibin, beta C LMO2 AA464544 LIM domain
only 2 (rhombotin-like 1) MAD4 AA16970 Mad4 homolog PHB R60946 Prohibitin ...
Web Search - liebertonline.com - liebertonline.com

Hematopoietic Stem Cell Enrichment From the AGM Region of the Mouse Embryo
C Robin, E Dzierzak - Methods Mol Med, 2005 - biomed.humanapress.com
... domains 2, + + angiopoietin 1 receptor, TEK LMO2 — + +/– SMA
Smooth-muscle actin, tenascin C – – GATA2 — + + AML-1 Acute ...
Web Search - journals.humanapress.com - neurosci.humanapress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Mutant-specific gene programs in the zebrafish - Full text - MIT Libraries
GJ Weber, SE Choe, KA Dooley, NN Paffett-Lugassy, … - Blood, 2005 - bloodjournal.org
... stage- and lineage-specific regulation of the hematopoietic genetic program, since
we detect early critical transcription factors, such as scl, lmo2, and gata1 ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Hematopoietic differentiation of human embryonic stem cells progresses through sequential … - Full text - MIT Libraries
ET Zambidis, B Peault, TS Park, F Bunz, CI Civin - Blood, 2005 - bloodjournal.org
... hematopoietic transcriptional regulators, including SCL/TAL1, CDX4, GATA1, GATA2,
EKLF, and ... regulating HSPC development in MESCs and embryos (eg, LMO2, AML1, C ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Modeling Human Hematopoietic and Cardiovascular Diseases in Zebrafish
TE North, LI Zon - Key words, 2003 - doi.wiley.com
... genes demonstrated to be impor- tant in mouse and human develop- ment have been
isolated, including cmyb, gata1, gata2, globin, hhex, ikaros, lmo2, pu1, rag1 ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

GATA-1- and FOG-dependent Activation of Megakaryocytic alpha IIB Gene Expression - Full text - MIT Libraries
P Gaines, JN Geiger, G Knudsen, D Seshasayee, DM … - J Biol Chem, 2000 - jbc.org
... and/or FOG-GATA-2) complexes via its potential to bind Tal1-Lmo2 complexes (11 ... We
thank Dr. Stuart Orkin for pEFNeoFOG and pUC-GATA2, Dr. Barbara Graves for pKS ...
Cited by 18 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Hematopoietic regulatory domain of gata1 gene is positively regulated by GATA1 protein in zebrafish … - Full text - MIT Libraries
M Kobayashi, K Nishikawa, M Yamamoto - Development, 2001 - dev.biologists.org
... Alternative first exons/ promoters have also been identified in the gata2, gata5
and ... a multi-protein complex including GATA1, SCL/Tal-1, E2A, Lmo2 and Ldb1 ...
Cited by 17 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Report A Dynamic Switch in the Replication Timing of Key Regulator Genes in Embryonic Stem Cells …
P Perry, S Sauer, N Billon, WD Richardson, M … - landesbioscience.com
... B3) Lmo2 (2; E2) Sox2 (3; B) Nanog (6; F2) Gata1 (X; A1.1) Sox3 (X; A5) Utf1
(7; F2) Gata2 (6; D2) Irx3 (8; C5) Rex1 (8; B1.3) Gata3 ...
Web Search - landesbioscience.com

Tal 1/SCL Binding to Pericentromeric DNA Represses Transcription - Full text - MIT Libraries
J Wen, S Huang, SD Pack, X Yu, SJ Brandt, CT … - J Biol Chem, 2005 - jbc.org
... antibodies specific for GATA-1 ( -GATA1, lane 10) and GATA-2 ( -GATA2, lane 11 ... is
known to interact with GATA-1 through the transcription factor LMO2 that acts ...
Web Search - dx.doi.org - jbc.org - ncbi.nlm.nih.gov

Supplementary Data ‘Stemness’: Transcriptional Profiling of Embryonic and Adult Stem Cells
M Ramalho-Santos, S Yoon, Y Matsuzaki, RC Mulligan … - intl.sciencemag.org
... numerous HSC markers (including Notch1, Abcg2, Tie1, Tie2, Vla5, Flp, Tal1/Scl,
Gata2, Mll ... JunB, Myc, N-Myc, Elf1, Ext2, Meis1, PU.1, Tal1 (Scl), Lmo2, Yes, ski ...
Web Search

GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei - Full text - MIT Libraries
JH van Doorninck, J van der Wees, A Karis, E … - J. Neurosci, 1999 - jneurosci.org
... Orkin SH (1994) An early haematopoietic defect in mice lacking the transcription
factor GATA2. ... H, Forster A, Rabbitts TH (1997) The LIM-only protein Lmo2 is a ...
Cited by 29 - Web Search - jneurosci.org - ncbi.nlm.nih.gov

Hhex and scl function in parallel to regulate early endothelial and blood differentiation in … - Full text - MIT Libraries
W Liao, CY Ho, YL Yan, J Postlethwait, DY Stainier - Development, 2000 - dev.biologists.org
... et al., 1998). Cells in these bilateral regions also express the hematopoietic
gene lmo2 (Thompson et al., 1998). The pattern of ...
Cited by 41 - Web Search - amherst.edu - ucsf.edu - ncbi.nlm.nih.gov - all 5 versions »

A novel E 2 box-GATA element modulates Cdc 6 transcription during human cells polyploidization - Full text - MIT Libraries
N Vilaboa, R Bermejo, P Martinez, R Bornstein, C … - Nucleic Acids Research, 2004 - nar.oupjournals.org
... non-immune goat serum (Goat NI), rabbit anti-GATA-2 antibody ( -GATA2) or non ... The
formation of a multimeric complex formed by GATA-1, Tal1, E47, Lmo2 and Ldb1A ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Coexpression of SCL and GATA 3 in the V 2 interneurons of the developing mouse spinal cord - Full text - MIT Libraries
E Smith, M Hargrave, T Yamada, CG Begley, MH … - Developmental Dynamics, 2002 - doi.wiley.com
... The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding
complex which ... GATA2 is required for the generation of V2 interneurons. ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov

Leukemia Cells and the Cytokine Network: Therapeutic Prospects - Full text - MIT Libraries
S Moqattash, JD Lutton - Experimental Biology and Medicine, 2004 - ebmonline.org
... The mechanism of commitment of erythropoiesis by activin A and BMP2 was thought
to involve two key events: increase in Epo-R and decrease in GATA2 expression. ...
Cited by 1 - Web Search - ebmonline.org - ebmonline.org - ncbi.nlm.nih.gov

Genetics of mouse growth
A Efstratiadis - Int. J. Dev. Biol, 1998 - ijdb.ehu.es
... slight GR e9.5; death e10.5 Flt1 (5) FMS-like tyrosine kinase 1 GR e8.5; death
e9.5 Lmo2 (2) Lim only 2 (Rbtn2; rhombotin 2) GR by e9.75; death by e11.5 ...
Cited by 88 - View as HTML - Web Search - ncbi.nlm.nih.gov - ijdb.ehu.es - Get it from MIT Libraries

BMC Biotechnology - Full text - MIT Libraries
BMC Biotechnology - BMC Biotechnology, 2005 - biomedcentral.com
... transcription factors (GATA2, Fli1, Trp53, Mdm2, JUN, FOS, MAD, MAX). Over ... fusions.
These included CDK2, FLI1, CDKN-1B, mdm2, GATA2, Ephb2(LB) and ...
View as HTML - Web Search - dx.doi.org - gdrs-intranet.ath.cx - botany.sinica.edu.tw - all 6 versions »