LMO2 and HOXA9 - Google Scholar

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization - Full text - MIT Libraries
BB Zeisig, T Milne, MP Garcia-Cuellar, S Schreiner … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... Seven of the putative target genes upregulated by MLL-ENL-ERtm (Flt-3, Meis-1, Hoxa9,
Ptprc, Lmo2, Adam10, and S100a4) have been previously found to be ...
Cited by 12 - Web Search - dx.doi.org - mcb.asm.org - ncbi.nlm.nih.gov - all 6 versions »

MLL, Hox genes, and leukemia: the plot thickens - Full text - MIT Libraries
JL Hess - Blood, 2004 - bloodjournal.org
... a number of putative oncogenes outside the Hox genes, such as Lmo2, Flt3, and ... very
similar to ENL, also develops leukemia in the absence of functional Hoxa9. 7. ...
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Progress in Hematology
Y Hayashi - cardenjennings.metapress.com
... reported on genes whose expression pattern distinguishes t(4;11)-ALLs from other
ALLs, including overexpressed oncogene [HOXA9, MEIS1, HOXA10, LMO2(RMBT2), MYC ...
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Retroviral insertional mutagenesis identifies oncogene cooperation. - Full text - MIT Libraries
T Nakamura - Cancer Science, 2005 - blackwell-synergy.com
... the cooperative oncogenes like the mating experiment between NUP98-HOXA9 transgenic
and ... and integrations of the chain-bearing retrovirus in the LMO2 locus were ...
Web Search - ncbi.nlm.nih.gov

Chromosomal abnormalities and tumor development: from genes to therapeutic mechanisms - Full text - MIT Libraries
C Cobaleda, J Perez-Losada, I Sanchez-Garcia - BioEssays, 1998 - doi.wiley.com
... p13;q11) T-ALL LMO2, TCR- /TCR- t(7;11)(q35;p13) T-ALL TCR- , LMO2 Homeodomain t ...
9)(p23;q34) ANLL DEK, CAN/NUP214 t(7;11)(p15;p15) ANLL (M2, M4) HOXA9, NUP98 (9 ...
Cited by 13 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Original Research Report
T TSANG, DT HARRIS - dx.doi.org
... Cell growth and maintenance INHBC AI239905 Inhibin, beta C LMO2 AA464544 LIM ...
Transcription factor/activity HOXA9 AA496921 Homeo box A9 HOXB2 AA911661 Homeo box ...
Web Search - liebertonline.com - liebertonline.com

Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid … - Full text - MIT Libraries
A Cozzio, E Passegue, PM Ayton, H Karsunky, ML … - Genes & Development, 2003 - genesdev.org
... Hence, Hoxa9 up-regulation in ME-transduced transient repopulating CMP and GMP ... the
expression of transcriptionally active loci, such as the LMO2 locus, which ...
Cited by 26 - Web Search - genesdev.org - pubmedcentral.nih.gov - dx.doi.org - all 9 versions »

The ubiquitous MLL gene and its multitude of chromosomal abnormalities - Full text - MIT Libraries
A Daser, TH Rabbitts - GENES & DEVELOPMENT, 2004 - dx.doi.org
... All MLL-associated leukemia subtypes had HOXA9 and MEIS1 expression (Armstrong et ...
expressed in stem cells and early progenitors from the Lmo2 promoter (Warren ...
Cited by 11 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Molecular Cytogenetics A new recurrent inversion, inv (7)(p15q34), leads to transcriptional …
F Speleman, B Cauwelier, N Dastugue, J Cools, B … - Leukemia, 2005 - nature.com
... consistently increased expression levels of a subset of HOX genes (HOXA9, HOXA10,
HOXC6 ... of certain T-cell oncogenes (HOX11, LYL1, TAL1, LMO1 and LMO2) in the ...
Web Search - nature.com

HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL … - Full text - MIT Libraries
J Soulier, E Clappier, JM Cayuela, A Regnault, M … - Blood, 2005 - bloodjournal.org
... The genes that mainly define this cluster are HOXA5, HOXA9, HOXA10, and LRIG1 ... expression
of genes expressed in immature cells (eg, CD34 or LMO2) and frequent ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

E2a/Pbx1 induces the rapid proliferation of stem cell factor-dependent murine pro-T cells that cause … - Full text - MIT Libraries
DB Sykes, MP Kamps - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development
and potentiates ... Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in ...
Cited by 4 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

A new recurrent inversion, inv (7)(p15q34), leads to transcriptional activation of
F Speleman, B Cauwelier, N Dastugue, J Cools, B … - Leukemia, 2005 - nature.com
... other T-cell leukemia specific genes (HOX11, LYL1, LMO1, LMO2, HOX11L2), initially ...
Primers for the other HOXA genes (HOXA2, HOXA3, HOXA6, HOXA9, HOXA10, HOXA13 ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecular phenotyping of the immune system by microarray analysis.
J Geliebter, A Mittelman, RK Tiwari - Cancer Invest, 2003 - taylorandfrancis.metapress.com
... CD33, zyxin leptin receptor, HOXA9 [56] “Germinal center B cell” DLBCL vs. “in vitro
activated B cell” DLBCL CD 10, CD 38, A-myb, LMO2, 8-oxoguanine ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

[CITATION] Acute Lymphoblastic Leukemia
MG Alterations
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Progress in Hematology
M Eguchi, M Eguchi-Ishimae, M Greaves - Int J Hematol, 2005 - cardenjennings.metapress.com
... mice displayed a more immature phenotype, suggesting that HoxA9 contributes to ... Lox
recombination, is introduced into the genomic locus of LMO2, the expression ...
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acquises de la cellule souche hematopoietique ou d’un precurseur deja commis vers les lignees …
S YNTHESE - MEDECINE/SCIENCES, 2003 - ist.inserm.fr
... LMO2(11p13) t(11;14)(p13;q11) TCR δ, TCR α, TCR β ... NUP98 (11p15) Nucléoporine LAM
secondaires (protéine associée au pore nucléaire) HOXA9 (7p15) Facteur ...
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The Kinetic Status of Hematopoietic Stem Cell Subpopulations Underlies a Differential Expression of … - Full text - MIT Libraries
R Manfredini, R Zini, S Salati, M Siena, E … - Stem Cells, 2005 - stemcells.alphamedpress.org
... Among them, HOXA5, HOXA9, HOXA10, HOXB2, HOXB5, Meis1, and PBX2 are preferentially
expressed by ... key factors for HSC self-renewal [29, 30], and LMO2, CBFß, and ...
Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that … - Full text - MIT Libraries
YW Lin, C Slape, Z Zhang, PD Aplan - Blood, 2005 - bloodjournal.org
... A large number of genes typically expressed in erythroid precursors (LMO2, Eraf,
HbbY ... those obtained using a similar NUP98 fusion gene, NUP98-HOXA9, which has ...
Cited by 1 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Disruption of the RanbBP17/Hox11L2 region by recombination with the TCRd locus in acute …
TE Hansen-Hagge, M Schaefer, H Kiyoi, SW Morris, … - Leukemia, 2002 - nature.com
Page 1. Leukemia (2002) 16, 2205–2212 2002 Nature Publishing Group All
rights reserved 0887-6924/02 $25.00 www.nature.com/leu ...
Cited by 9 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

CONSEQUENCES OF CHROMOSOMAL ABNORMALITIES IN TUMOR DEVELOPMENT - Full text - MIT Libraries
I Sanchez-Garcia - Annual Review of Genetics, 1997 - dx.doi.org
... involvement, especially breakpoints within the chromosome band 11p13 that activate
LMO2 (112 ... The NUP98-HOXA9 fusion (15, 91) may also be considered within this ...
Cited by 25 - Web Search - wwwlib.bionet.nsc.ru - genet.annualreviews.org - ncbi.nlm.nih.gov - all 6 versions »

Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4 - Full text - MIT Libraries
JM Bjornsson, N Larsson, AC Brun, M Magnusson, E … - Mol Cell Biol, 2003 - mcb.asm.org
... These include targeting of genes such as GATA-2, SCL/tal-1, Rbtn2/Lmo2, AML1,
PU.1/Spi1, Ikaros, Hoxb6, and Hoxa9 (reviewed in references 34 and 51). ...
Cited by 13 - Web Search - pubmedcentral.nih.gov - ask.lub.lu.se - dx.doi.org - all 7 versions »

Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements - Full text - MIT Libraries
T Rozovskaia, O Ravid-Amir, S Tillib, G Getz, E … - Proceedings of the National Academy of Sciences, 2003 - pnas.org
... This includes activation of oncogenes (MYC, HOX A9 and MEIS1, LMO2, etc.), inactivation ...
progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9 Blood, April 15 ...
Cited by 23 - Web Search - 171.66.122.165 - santafe.edu - weizmann.ac.il - all 10 versions »

DNA microarray analysis in malignant lymphomas - Full text - MIT Libraries
C Schwaenen, S Wessendorf, HA Kestler, H Doehner, … - Annals of Hematology, 2003 - springerlink.com
... GC-DLBCL a CD10, CD38, A-MYB, OGG1, BCL-6, BCL7A, LMO2 (TTG-2/RBTN2 ... SLAM, PRKCZ,
KIAA0655, KIAA0802, KIAA0922, FAT, GS3955, Nidogen2 MLL NKG2-D, HOXA9, S100 A10 ...
Cited by 6 - Web Search - utoronto.ca - ncbi.nlm.nih.gov

Genetic programs regulating HSC specification, maintenance and expansion - Full text - MIT Libraries
J Lessard, A Faubert, G Sauvageau - Oncogene, 2004 - nature.com
... À À Lmo2 Embryonic lethality, absence of primitive erythropoiesis, presence
of YS derived macrophages (Warren et al., 1994) ES ...
Web Search - ncbi.nlm.nih.gov

Exploitation of stem cell plasticity - Full text - MIT Libraries
E Martin-Rendon, SM Watt - Transfusion Medicine, 2003 - blackwell-synergy.com
... Overexpression of HoxA9 in HSCs induces stem cell expansion (Thorsteinsdottir et
al., 2002), whereas HoxA5 and HoxA10 perturb their differentiation activity ...
Cited by 4 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov

Dokumentation und Evaluation der Weiterbildung Abstracts
O Session - Onkologie, 2002 - content.karger.com
... The Hox gene regulatory network is implicated in human leukemogenesis at the level
of the Hox genes themselves (eg NUP98-HOXD13, NUP98-HOXA9, ETV6-CDX2), at ...
Web Search - content.karger.com

Gene expression profiling and its application in studies of haematological malignancy - Full text - MIT Libraries
M Hubank - British Journal of Haematology, 2004 - blackwell-synergy.com
... et al (2002) applied hierarchical clustering to T-ALL tumours and showed clustering
of tumours associated with dysregulation of HOX11, TAL1, LYL1, LMO1 and LMO2 ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

[BOOK] Cytogenetic and molecular genetic changes in childhood acute leukaemias
T Niini - 2002 - ethesis.helsinki.fi
... t(11;14)(p15;q11) LMO1 Relocation to TCRδ TF <1 T t(11;14)(p13;q11) LMO2 Relocation
to TCRδ TF <1 T ... t(7;11)(q34;p13) LMO2 Relocation to TCRβ TF <1 T ...
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