Joint analysis of two microarray gene-expression data sets to select lung adenocarcinoma marker … - Full text - MIT Libraries
H Jiang, Y Deng, HS Chen, L Tao, Q Sha, J Chen, CJ … - BMC Bioinformatics, 2004 - biomedcentral.com
... Deng 2+ , Huann-Sheng Chen 3 , Lin Tao 3 , Qiuying Sha 3 , Jun Chen 2 , ... genes or
their family members (EDNRB, EMP2, FABP4, GPC3, LMO2, TEK) were found in the ...
Cited by 7 - View as HTML - Web Search - dx.doi.org - pubmedcentral.nih.gov - citebase.eprints.org - all 7 versions »

Transcriptional control of fetal liver hematopoiesis: dominant negative effect of the overexpression …
T Terano, Y Zhong, S Toyokuni, H Hiai, Y Yamada - Exp Hematol, 2005 - ncbi.nlm.nih.gov
2005 Jun;33(6):641-51. ... Transcriptional control of fetal liver hematopoiesis: dominant
negative effect of the overexpression of the LIM domain mutants of LMO2. ...
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Activation of the T-Cell Oncogene LMO2 after Gene Therapy for X-Linked Severe Combined …
R Letters - nejm.org
... LMO2 and Gene Therapy for Severe Combined Immunodeficiency Fischer A., Abina SHB,
Thrasher A ... Full Text | PDF N Engl J Med 2004; 350:2526-2527, Jun 10, 2004. ...
Cached - Web Search - content.nejm.org

LMO2 and gene therapy for severe combined immunodeficiency. - Full text - MIT Libraries
BD Stone - N Engl J Med, 2004 - ncbi.nlm.nih.gov
2004 Jun 10;350(24):2526-7; author reply 2526-7. ... Comment on: N Engl J Med. 2004 Feb
26;350(9):913-22. LMO2 and gene therapy for severe combined immunodeficiency ...
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Progress in Hematology
JK Yamashita - Int J Hematol, 2004 - cardenjennings.metapress.com
... Correspondence and reprint requests: Jun K. Yamashita, MD, PhD, Laboratory of Stem
Cell ... among these molecules and others (ie, RUNX-1, LMO2, GATA families, and ...
Web Search

Combination of hTERT and bmi-1, E6, or E7 Induces Prolongation of the Life Span of Bone Marrow … - Full text - MIT Libraries
T Mori, T Kiyono, H Imabayashi, Y Takeda, K … - Mol Cell Biol, 2005 - mcb.asm.org
... Matsumoto, 7 Hirohisa Saito, 7 Satoshi Ogawa, 5 Michiie Sakamoto, 2 Jun-Ichi Hata ...
account (3). The infected virus genome was integrated into the LMO2 locus in ...
Cited by 1 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov

Kaposi’s sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as … - Full text - MIT Libraries
AV Moses, MA Jarvis, C Raggo, YC Bell, R Ruhl, BG … - J Virol, 2002 - jvi.asm.org
... with known functions in tumor development: c-kit, jun-D, and c-mer and the genes
coding for inhibitor of DNA binding 1 (ID1) and LIM domain protein (LMO2). ...
Cited by 22 - Web Search - pubmedcentral.nih.gov - ohsu.edu - dx.doi.org - all 6 versions »

Sustained transgene expression by human cord blood derived CD34 cells transduced with simian … - Full text - MIT Libraries
J Kikuchi, J Mimuro, K Ogata, T Tabata, Y Ueda, A … - J Gene Med, 2004 - doi.wiley.com
... Jiro Kikuchi 1 Jun Mimuro 1,2 * Kyoichi Ogata 1 Toshiaki Tabata 3 Yasuji Ueda 3
Akira Ishiwata 1 Konzoh Kimura 1 Katsuhiro Takano 1 Seiji Madoiwa 1,2 Hiroaki ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Retroviral Vectors: A Double-Edged Sword - Full text - MIT Libraries
M ST LOUIS - Science, 2005 - sciencemag.org
... The leukemias also apparently stem from an interaction between LMO2 and gc, so trials
for ADA-SCID, which ... Volume 308, Number 5729, Issue of 17 Jun 2005, pp. ...
Web Search - sciencemag.org

Arteriovenous malformations in mice lacking activin receptor-like kinase-1 - Full text - MIT Libraries
LD Urness, LK Sorensen, DY Li - Nat Genet, 2000 - nature.com
... C., McCoy, J. & Rosenquist, TH Expression of elastin, smooth muscle actin and
c-Jun as a ... Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites ...
Cited by 66 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Establishment of Modified Retroviral Vector Targeting X-Linked Severe Combined Immunodeficiency
CL Zhi, M Migita, J Hayakawa, Y Fukunaga - Infection - nms.ac.jp
... Cai Ling Zhi 1 , Makoto Migita 1―3 , Jun Hayakawa 1 and Yoshitaka ... Yamada Y: The effect
of chromosomal translocations in acute leukemia: the LMO2 paradigm in ...
Web Search - ghr.nlm.nih.gov - ghr.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

A transcription factor party during blood cell differentiation
MH Sieweke, T Graf - Curr. Opin. Genet. Dev, 1998 - ciml.univ-mrs.fr
... Finally, distinct functions of c-Jun during the regulation of cell growth could
be ... Westphal H, •• Forster A, Rabbitts TH: The LIM-only protein Lmo2 is a ...
Cited by 62 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

New insights into erythropoiesis
MJ Koury, ST Sawyer, SJ Brandt - Curr Opin Hematol, 2002 - co-hematology.com
... factors GATA-1 and TAL1 (or SCL) and the LIM domain protein LMO2 [2]. This ... SCF does
not activate JAK2/STAT5, but it activates MAP kinase, c-Jun NH 2 -terminal ...
Cited by 24 - Web Search - co-hematology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Occurrence of leukaemia following gene therapy of X-linked SCID - Full text - MIT Libraries
DB Kohn, M Sadelain, JC Glorioso - Nature Reviews Cancer, 2003 - nature.com
... Nature Genet. 1 Jun 2003 (doi:10.1038/ng1179). ... The effect of chromosomal translocations
in acute leukemias: the LMO2 paradigm in transcription and development. ...
Cited by 43 - Web Search - nature.com - ncbi.nlm.nih.gov - csa.com

Recurrent retroviral vector integration at the MDS1-EVI1 locus in non-human primate hematopoietic … - Full text - MIT Libraries
B Calmels, C Ferguson, MO Laukkanen, R Adler, M … - Blood, 2005 - ncbi.nlm.nih.gov
2005 Jun 2; [Epub ahead of print ... Recent reports linking insertional activiation of
LMO2 following gene therapy for X-SCID have led to a re-evaluation of risks ...
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Progress in Hematology
Y Hayashi - cardenjennings.metapress.com
... including overexpressed oncogene [HOXA9, MEIS1, HOXA10, LMO2(RMBT2), MYC ... MAP3K5),
underexpressed proapoptotic genes (ITPR3, IGFBP3, JUN), underexpressed tumor ...
Web Search

Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements - Full text - MIT Libraries
T Rozovskaia, O Ravid-Amir, S Tillib, G Getz, E … - Proceedings of the National Academy of Sciences, 2003 - pnas.org
... AML (16)]; (ii) HOX A10, which induces AML in mice (17); (iii) LMO2 (RMBT2), whose ...
activity both dependent and independent of p53 (30); and (iii) JUN, which is ...
Cited by 23 - Web Search - 171.66.122.165 - santafe.edu - weizmann.ac.il - all 10 versions »

Prolonged expression of c-fos suppresses cell cycle entry of dormant hematopoietic stem cells - Full text - MIT Libraries
S Okada, T Fukuda, K Inada, T Tokuhisa - Blood, 1999 - bloodjournal.org
... Although lineage-restricted transcription factors such as tal-1/SCL and rtbn2/LMO2
may be ... forms a complex with the product of another proto-oncogene c-jun (AP-1 ...
Cited by 10 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Differential regulation of coproporphyrinogen oxidase gene between erythroid and nonerythroid cells - Full text - MIT Libraries
S Takahashi, S Taketani, J Akasaka, A Kobayashi, N … - Blood, 1998 - bloodjournal.org
... By Shinichiro Takahashi, Shigeru Taketani, Jun-etsu Akasaka, Akira Kobayashi, Norio
Hayashi, Masayuki ... H, Forster A, Rabbitts TH: The LIM-only protein Lmo2 is a ...
Cited by 12 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The Human Artificial Chromosome
T Mota - undergraduatestudies.ucdavis.edu
... deficiency (SCID), the “bubble boy” disease, devel- oped leukemia (3). The delivered
DNA integrated into the host LMO2 gene, which ... 2002 Jun;18(6):313-319. ...
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Molecular genetics of childhood leukemias
JE Rubnitz, AT Look - J Pediat Hematol Oncol, 1998 - jpho-online.com
... to involve multiple signaling pathways, including RAS-mediated activation of Jun
(44,45 ... members of the LIM family of transcription factors (LMO1, LMO2)(122-124 ...
Cited by 28 - Web Search - jpho-online.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Cloning LiteratureWatch
A Romer-Oberdorfer, E Mundt, T Mebatsion… - CLONING, 2000 - dx.doi.org
... Manaia A, Lemarchandel V, Klaine M, et al. Lmo2 and GATA-3 associated expression
in intraembry- onic hemogenic sites. ... Nature 2000 Jun 29;405(6790):1066–1069. ...
Web Search - liebertonline.com - liebertonline.com

Cell adhesion-related gene expression by Helicobacter pylori in gastric epithelial AGS cells - Full text - MIT Libraries
JW Lim, H Kim, KH Kim - Int. J. Biochem. Cell Biol, 2003 - ncu.edu.tw
... the ex- pression of proto-oncogenes such as c-fos and c-jun, and cyclooxygenase ... Some
evidences show that LMO1, LMO2, and LMO4 led to leukemia and breast cancer ...
Cited by 5 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Dynamic changes in transcription factor complexes during erythroid differentiation revealed by … - Full text - MIT Libraries
M Brand, JA Ranish, NT Kummer, J Hamilton, K … - Nature Structural & Molecular Biology, 2004 - nature.com
... The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding ...
box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription ...
Cited by 26 - Web Search - chemistry.montana.edu - crablab.stanford.edu - gims.tcu.edu.tw - all 11 versions »

Critical Review - Full text - MIT Libraries
E Ingley, PA Tilbrook, SP Klinken - IUBMB Life, 2004 - dx.doi.org
... leads to activation of the transcription factors c- fos and c-jun (60). ... factors required
for commitment to the erythroid lineage, including SCL, LMO2, GATA-2 ...
Web Search - taylorandfrancis.metapress.com

Isolation and characterization of zebrafish NFE2 - Full text - MIT Libraries
SJ Pratt, A Drejer, H Foott, B Barut, A Brownlie, … - Physiological Genomics, 2002 - intl-physiolgenomics.physiology.org
... we have isolated the genes encoding GATA-1, -2, and -3, SCL, LMO2, fli1, and c ... sequences
related to an AP-1 site and forms heterodimers with both Fos and Jun. ...
Cited by 3 - Web Search - intl-physiolgenomics.physiology.org - physiolgenomics.physiology.org - ncbi.nlm.nih.gov

TRANSCRIPTION FACTORS
OFB CELLS - doi.wiley.com
... 27 The LMO2 Master Gene; Its Role as a Transcription Regulator Determining
Cell Fate in Leukemogenesis and in Hematopoiesis 483 ...
Web Search

Heterogeneous Transforming Growth Factor (TGF)-ß Unresponsiveness and Loss of TGF-ß Receptor Type … - Full text - MIT Libraries
H Osada, Y Tatematsu, A Masuda, T Saito, M … - Cancer Research, 2001 - cancerres.aacrjournals.org
... AD, Westphal H., Forster A., Rabbitts TH The LIM-only protein Lmo2 is a ... Hai T., Curran
T. Cross-family dimerization of transcription factors Fos/Jun and ATF ...
Cited by 4 - Web Search - cancerres.aacrjournals.org

Progress in Hematology
T Yamagata, K Maki, K Mitani - Int J Hematol, 2005 - cardenjennings.metapress.com
... ETO has been reported to enhance the expression of genes such as C/EBP , c-Jun,
and TRKA ... expres- sion of the PU.1 gene and down-regulation of the LMO2 and SCL ...
Web Search

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... not CAGG LMO2COM 01 Complex of Lmo2 bound to Tal-1, E2A proteins, and
GATA-1, half-site 1 Core should be CAGGTG not CAGG E47 01 ...
View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and …
I Bach, SJ Rhodes, RV Pearse 2nd, T Heinzel, B … - pnas.org
... Home page D. Harris, D. Chuderland, D. Bonfil, S. Kraus, R. Seger, and Z. Naor
Extracellular Signal-Regulated Kinase and c-Src, But Not Jun N-Terminal Kinase ...
Cited by 101 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu - all 5 versions » - Get it from MIT Libraries

FGF-20 and DKK1 are transcriptional targets of ß-catenin and FGF-20 is implicated in cancer and … - Full text - MIT Libraries
MN Chamorro, DR Schwartz, A Vonica, AH Brivanlou, … - The EMBO Journal, 2005 - embojournal.npgjournals.com
... as FGF20 (Jeffers et al, 2001), ETV5 (Ets-5) (Dhulipal, 1997), LMO2 (Rabbitts et
al ... regulated by Bmp signaling and the AP-1 family member c-jun (Grotewold and ...
Cited by 3 - Web Search - nature.com - courses.washington.edu - pubmedcentral.nih.gov - all 8 versions »

Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1 - Full text - MIT Libraries
VC Foletta, MA Lim, J Soosairajah, AP Kelly, EG … - J. Cell Biol, 2003 - jcb.org
... with LIMK1 but did not interact with two negative control baits (Jun and Lck) or ...
analysis with overexpressed BMPR-II and the LIM domain protein LMO2 (Larson et ...
Cited by 25 - Web Search - jcb.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

PMA-induced phenotypic changes in K 562 cells: MAPK-dependent and-independent events
C Shelly, L Petruzzelli, R Herrera - Leukemia, 1998 - nature.com
... 16 PMA treatment also leads to the induction of transcription factors such as
jun/fos 17 and egr-1 18 and of protooncogenes such as c-ski 19 and c-sis. 11 ...
Cited by 13 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Microarray Analysis of B-Cell Lymphoma Cell Lines with the t (14; 18)
RS Robetorye, SD Bohling, JW Morgan, GC Fillmore, … - Mol. Diagn, 2004 - jmd.amjpathol.org
Page 1. Microarray Analysis of B-Cell Lymphoma Cell Lines with the
t(14;18) Ryan S. Robetorye,* Sandra D. Bohling, † John W. Morgan ...
Cited by 6 - Web Search - jmd.amjpathol.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Final Accepted Version
SJ Pratt, A Drejer, H Foott, B Barut, A Brownlie, … - physiolgenomics.physiology.org
... have isolated the genes encoding GATA-1, 2, and 3, SCL, LMO2, fli1, and c-myb ... sequences
related to an AP-1 site and forms heterodimers with both Fos and Jun. ...
Web Search

Picking the Right Spot - Full text - MIT Libraries
D Trono, X Wu, Y Li, B Crise, SM Burgess - Science, 2003 - sciencemag.org
... the vector DNA integrated in the immediate vicinity of the promoter of the
growth-promoting LMO2 gene (13). ... Volume 300, Number 5626, Issue of 13 Jun 2003, pp. ...
Cited by 2 - Web Search - sciencemag.org - dx.doi.org

Role of PU. 1 in hematopoiesis - Full text - MIT Libraries
RC Fisher, EW Scott - Stem Cells, 1998 - stemcells.alphamedpress.org
... the form of a transcription factor hierarchy in Figure 1. Transcription factors
rbt2/LMO2 and SCL ... partner), followed by the binding of c-fos and c-jun to form a ...
Cited by 51 - Web Search - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

Comparative Analysis of the Genetic Structure and Chromosomal Mapping of the Murine Gadd45g/CR6 Gene
B HOFFMAN, D LIEBERMANN - DNA AND CELL BIOLOGY, 2003 - dx.doi.org
... Smad elements were also found to meet the criteria for the for- mation of enhanceosomes
with DNA elements for Lmo2 at 2583 to 2480 in the human, and between ...
Web Search - liebertonline.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Development of herpesvirus-based episomally maintained gene delivery vectors
MA Calderwood, RE White, A Whitehouse - Expert Opinion on Biological Therapy, 2004 - dx.doi.org
... 4-6] . Using lin- ear amplification-mediated polymerase chain reaction (PCR) the
site of retroviral integration was mapped to the LMO2 oncogene, mutations of ...
Cited by 2 - Web Search - extenza-eps.com - ashley-pub.com - ingentaconnect.com - all 9 versions »

GATA-1: Friends, Brothers, and Coworkers - Full text - MIT Libraries
F MORCEAU, M SCHNEKENBURGER, M DICATO, M DIEDERICH - Ann. NY Acad. Sci, 2004 - annalsnyas.org
... CBP)/p300, Friend leukemia integration 1 (Fli-1), Lim domain only 2 (Lmo2), and
PU ... GATA-1 inhibits PU.1 function by displacing the PU.1 coactivator c-Jun 75 (Fig ...
Web Search - annalsnyas.org - ncbi.nlm.nih.gov

Dimerization of CtIP, a BRCA 1- and CtBP-interacting Protein, Is Mediated by an N-terminal Coiled- … - Full text - MIT Libraries
MJ Dubin, PH Stokes, EYM Sum, RS Williams, VA … - J Biol Chem, 2004 - jbc.org
... 4). More recently, CtIP has been shown to bind LMO4 and LMO2 (5), LIM ... per and basic
helix-loop-helix/zipper proteins such as GCN4 and c-Jun, respectively, must ...
Cited by 2 - Web Search - gloverlab.biochem.ualberta.ca - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

Current Status and Future Prospects of Gene Therapy
KD Lewis, TN Humes, R Gonzalez - Am J Cancer, 2005 - ingentaconnect.com
... carrying the γc gene inserted near the LMO2 gene, which is a T- 2005 Adis Data
Information BV. ... for overexpression of the LMO2 protein, which blocks T-cell ...
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Supplementary Data ‘Stemness’: Transcriptional Profiling of Embryonic and Adult Stem Cells
M Ramalho-Santos, S Yoon, Y Matsuzaki, RC Mulligan … - intl.sciencemag.org
... cycle/oncogenesis (70) eg Mapk 12/14, Mapkk3, K-Ras2, H-Ras, RhoB, All1, Fos, FosB,
Jun, JunB, Myc, N-Myc, Elf1, Ext2, Meis1, PU.1, Tal1 (Scl), Lmo2, Yes, ski ...
Web Search

MAPK-mediated Phosphorylation of GATA-1 Promotes Bcl-X L Expression and Cell Survival - Full text - MIT Libraries
YL Yu, YJ Chiang, YC Chen, M Papetti, CG Juo, AI … - J. Biol. Chem, 2005 - jbc.org
... The c-Jun N-terminal kinase inhibitor JIP-I had no effect (Fig. ... of the transcription
complexes, including p300/CREB-binding protein, E2A, SCL, LMO2, and Ldb-1 ...
Web Search - jbc.org

Transcriptional Control of T Lymphocyte Differentiation - Full text - MIT Libraries
FJT Staal, F Weerkamp, AW Langerak, RW Hendriks, … - Stem Cells, 2001 - stemcells.alphamedpress.org
... in erythroid cells containing TAL1-E2A heterodimers as well as LMO1 and LMO2 proteins
[57 ... NF-AT complex is AP1, consisting of dimers of Fos and Jun proteins. ...
Cited by 17 - Web Search - dx.doi.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition - Full text - MIT Libraries
P Savagner - BioEssays, 2001 - doi.wiley.com
... MDCK cells HGF met, MAPK, PI 3-K, 1, 2, 29 Ras, Rho, Rac, Src, Snail 8 - Mammary
epithelial cells TGFb Fos/Jun 1, 2 Stromelysin-1 53 In vitro In vivo: ...
Cited by 97 - Web Search - doi.wiley.com - jexpclinassistreprod.com - ncbi.nlm.nih.gov

GATA1 Function, a Paradigm for Transcription Factors in Hematopoiesis - Full text - MIT Libraries
R Ferreira, K Ohneda, M Yamamoto, S Philipsen - Mol Cell Biol, 2005 - mcb.asm.org
... Lmo2 makes the bridge between the transcription factors, either as a single molecule ...
1 by preventing it from interacting with its cofactor c-Jun (134), while PU ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Tlag 2, an N-Methyl-N-Nitrosourea Susceptibility Locus, Maps to Mouse Chromosome 4 - Full text - MIT Libraries
JM Angel, ER Richie - Molecular Carcinogenesis, 2002 - doi.wiley.com
... and susceptibility loci Pctr1, Pctr2, and Pcts [20,27,71]; the receptor tyrosine
kinase genes Tie1 and Tek [79,80]; and the onco- genes Jun, Lmyc1, Lck, and ...
Cited by 5 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - csa.com

Coordinated Changes in Classes of Ribosomal Protein Gene Expression Is Associated with Light-Induced … - Full text - MIT Libraries
R Grewal, J Stepczynski, R Kelln, T Erickson, R … - Investigative Ophthalmology & Visual Science, 2004 - iovs.org
... 15 16 17 These genes include clusterin, hemeoxygenase1, IRBP, c-fos, c-jun, the
caspases, and ... USF, Oct-1, HNF-3b, CDP CR1, HNF-4, FoxJ2, Evi-1, Lmo2 complex, c ...
Cited by 1 - Web Search - dx.doi.org - iovs.org - ncbi.nlm.nih.gov