Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic … - Full text - MIT Libraries
DM Langenau, H Feng, S Berghmans, JP Kanki, JL … - Proceedings of the National Academy of Sciences, 2005 - pnas.org
... that normal thymocytes from lck-GFP and rag2-GFP stable transgenic fish express
lower levels of scl and similar levels of lmo2 when compared with Myc-induced T ...
Web Search - dx.doi.org - pnas.org - ncbi.nlm.nih.gov

T-ALL: smoking guns and genes of interest - Full text - MIT Libraries
PD Aplan - Blood, 2004 - bloodjournal.org
... regulatory regions of antigen receptor genes (immunoglobulin or T-cell receptor
genes) and commonly involves transcription factors such as MYC, LMO2, or SCL ...
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… of human damage-specific DNA-binding protein genes DDB 1 and DDB 2 by Sp 1, E 2 F, N-myc and NF 1 … - Full text - MIT Libraries
AF Nichols, T Itoh, F Zolezzi, S Hutsell, S Linn - Nucleic Acids Research, 2003 - nar.oupjournals.org
... was approximately the same effect as seen with double mutation of the Sp1#1 and
N-myc sites. Although the TRANSFAC search found a potential Lmo2 element in ...
Cited by 3 - Web Search - pubmedcentral.nih.gov - nar.oxfordjournals.org - ehscenter.berkeley.edu - all 8 versions »

Research Article
S Hacein-Bey-Abina, C Von Kalle, M Schmidt, MP … - mail.med.upenn.edu
... As controls, pro- teins were made from 1 10 5 CHO cells or CHO cells transfected
with pEF-BOS-LMO2- myc or from 5 10 5 RPMI-8402 (LMO2 nonexpressor), MEL-F4N ...
View as HTML - Web Search - medicine.ucsd.edu - ugr.es - media.eurekalert.org - all 8 versions »

Cytogenetics and molecular genetics of childhood leukemia
SK Ma, TSK Wan, LC Chan - Hematological Oncology, 1999 - doi.wiley.com
... 1 t(7;9)(q34;q32) TAL2-TCRb T <1 t(7;9)(q34;q34) TAN1-TCRb T <1 t(8;14)(q24;q11)
myc-TCRa/d T <1 t(11;14)(p15;q11) LMO1-TCRd T <1 t(11;14)(p13;q11) LMO2-TCRd T ...
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Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization - Full text - MIT Libraries
BB Zeisig, T Milne, MP Garcia-Cuellar, S Schreiner … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... Two other genes implicated in malignant transformation, Lmo2 and N-myc, were also
upregulated by MLL-ENL-ERtm and are likely to contribute to transformation. ...
Cited by 12 - Web Search - dx.doi.org - mcb.asm.org - ncbi.nlm.nih.gov - all 6 versions »

The LIM Domain Protein LMO 4 Interacts with the Cofactor CtIP and the Tumor Suppressor BRCA 1 and … - Full text - MIT Libraries
EYM Sum, B Peng, X Yu, J Chen, J Byrne, GJ … - J Biol Chem, 2002 - jbc.org
... Expression vectors encoding LMO4, LMO2, or heterologous LIM domain proteins, each
carrying a FLAG or Myc epitope at the N terminus, together with an expression ...
Cited by 34 - Web Search - yurim.skku.ac.kr - skku.ac.kr - ncbi.nlm.nih.gov - all 6 versions »

The hepatitis C virus internal ribosome entry site facilitates efficient protein synthesis in blood … - Full text - MIT Libraries
GTY Chung, Y Yamada, R Pannell, A Forster, TH … - Nucleic Acids Research, 2003 - nar.oupjournals.org
... Mercier,P., Prats,AC and Morello,D. (2001) c-myc internal ribosome ... Rabbitts,TH (2000)
The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis ...
Web Search - pubmedcentral.nih.gov - nar.oxfordjournals.org - ingentaconnect.com - all 8 versions »

Progress in Hematology
Y Hayashi - cardenjennings.metapress.com
... whose expression pattern distinguishes t(4;11)-ALLs from other ALLs, including
overexpressed oncogene [HOXA9, MEIS1, HOXA10, LMO2(RMBT2), MYC, LGALSI, PDGFR ...
Web Search

Dissertation Summaries
MI from a Morpholino-Based, V Screen - dx.doi.org
... Because I used a chimeric transgene encoding Myc fused to the green fluorescent
protein ... most common molecular subclass of T-ALL in humans in which LMO2 and SCL ...
Web Search - liebertonline.com - liebertonline.com

MLL, Hox genes, and leukemia: the plot thickens - Full text - MIT Libraries
JL Hess - Blood, 2004 - bloodjournal.org
... study by Zeisig et al, 4 MLL fusion proteins up-regulated a number of putative
oncogenes outside the Hox genes, such as Lmo2, Flt3, and N-Myc, that possibly ...
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A Search for Human Insulators
R Blekhman, Y Mutsafi, T Pupko, E Bacharach - kimura.tau.ac.il
... The gene regions we studied contain the following: MHC, LMO2, p53, polR2A, Rb1,
Top1 and KHK. ... the c-myc insulator, however it is not conserved. - 13 - Page 14. ...
View as HTML - Web Search

Oligo GEArray® Human Hematopoietic Stem Cells and Hematopoiesis Microarray
S Conditions - search.cosmobio.co.jp
... CSF1, DLL1, ERAF, FEZ2, FUT10, IFI16, IL10, IL20, IL31RA, JAG1, LMO2, MLF1, MMP9 ...
HDAC9, HOXB4, IFI16, IL31RA, IRF4, IRF8, KLF6, LEF1, MAFB, MYC, NCOA6, NFYA ...
View as HTML - Web Search

Akt Phosphorylates Tal1 Oncoprotein and Inhibits Its Repressor Activity - Full text - MIT Libraries
A Palamarchuk, A Efanov, V Maximov, RI Aqeilan, CM … - Cancer Research, 2005 - cancerres.aacrjournals.org
... coimmunoprecipitated with Tal1 as shown by Western blotting with an anti-Myc antibody
(Fig. ... parts of a larger complex that also contains GATA-1, LMO2, and Ldb1 ...
Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

Acute Lymphoblastic Leukemia in the Adult
C Translocations - Hematology, 1999 - hematology.org
... Although SCL/tal, LMO1, and LMO2 are either not expressed or expressed ... B-cell
malignancies, which often display chro- mosomal translocations involving c-myc. ...
View as HTML - Web Search - doe.unimo.it - Get it from MIT Libraries

HLS 7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF 1 - Full text - MIT Libraries
JH Williams, LN Daly, E Ingley, JG Beaumont, PA … - The EMBO Journal, 1999 - embojournal.npgjournals.com
... Thus, HLS7 behaves like transcription factors PU.1, myc, myb, mafB and LMO2 (Coppola
and Cole, 1986 ; Todokoro et al., 1988 ; Sieweke et al., 1996 ; Visvader ...
Cited by 14 - Web Search - emboj.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Role of PU. 1 in hematopoiesis - Full text - MIT Libraries
RC Fisher, EW Scott - Stem Cells, 1998 - stemcells.alphamedpress.org
... pathway is evidenced by the ability of ecotopically expressed c-myc or c ... of a
transcription factor hierarchy in Figure 1. Transcription factors rbt2/LMO2 and ...
Cited by 51 - Web Search - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

Offizielles Protokoll der Gesellschaft der Aerzte in Wien
W Wintertagung - springer.at
... media (I/M) ratio was significantly reduced by 63% in Ad5- TFPI-c-myc treated arteries ...
mature B-NHL; TCR[beta]/TAL2 fusion in t(7;9) (q34;q32), LMO2/TCR[delta ...
View as HTML - Web Search

neoplasms. Evidence for a transcriptional activation function of hPTTG - Full text - MIT Libraries
AA frica DomoAnguez, F Ramos-Morales, F Romero, RM … - Oncogene, 1998 - nature.com
... Activation of transcription factors such as myc, hox11, lmo1, lmo2, tall, lyl1,
tal2, aml1, cbfb, mll and pbx is involved in acute leukemias (reviewed in Hwang ...
Web Search

Dysregulation of lymphocyte proliferation by chromosomal translocations and sequential genetic … - Full text - MIT Libraries
G Klein - BioEssays, 2000 - doi.wiley.com
... BCR/ABL Myeloid CML low t(9;22)(q34;q11) MYC/TCR , T ALL high t(8;14)(q24;q11)
LMO1/TCR T ALL high t(11;14)(p15;q11) TCR /LMO2 T ALL high t(7;11)(q35;p13) ...
Cited by 4 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

SHORT REPORT MUTATIONAL ANALYSIS OF THE LMO4 GENE, ENCODING A BRCA1-INTERACTING PROTEIN, IN BREAST …
KD Sutherland, JE Visvader, DYH Choong, EYM Sum, … - cancer patient - doi.wiley.com
... 11 The latter finding is reminiscent of the ability of LMO2 to act as a ... 3F10 (Boehringer
Mann- heim Biochemicals, Indianapolis, IN) and anti-c-myc 9E10 (Sigma ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels … - Full text - MIT Libraries
DS Chervinsky, XF Zhao, DH Lam, M Ellsworth, KW … - Mol Cell Biol, 1999 - mcb.asm.org
... Additionally, tumors from the SCL LMO1 mice overexpressed c-myc, similar to tumors
from E2A ... with T-ALL are SCL, LMO1 (or the closely related LMO2), HOX11, and ...
Cited by 34 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Perspective: chromosomal translocations can affect genes controlling gene expression and … - Full text - MIT Libraries
TH Rabbitts - The Journal of Pathology, 1999 - doi.wiley.com
... D, Iyer R, Magrath I. Point mutations in the c-Myc transactivation domain ... The T cell
leukaemia LIM protein Lmo2 is necessary for adult mouse haematopoiesis. ...
Cited by 9 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Zn finger proteins: Key ways for metalloregulation
AV Kudrin - The Journal of Trace Elements in Experimental Medicine, 2002 - doi.wiley.com
... LMO2 is required in erythropoiesis at an early stage, such that LMO2-deficient mice
die ... triple-helix-binding ZFP-1 (THZif-1) induced by antisense c-myc RNA in ...
Cited by 1 - Web Search

The Gene SCL is Expressed during Early Hematopoiesis and Encodes a Differentiation-Related DNA- … - Full text - MIT Libraries
CG Begley, PD Aplan, SM Denning, BF Haynes, TA … - Blood, 2005 - pnas.org
... page MP McCormack and TH Rabbitts Activation of the T-Cell Oncogene LMO2 after Gene ...
7 homeobox gene causes decreased expression of GATA-1 and c-myc genes and ...
Cited by 116 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Structure and function of the SCL/TAL-1 containing transcriptinal complexes in erythropoiesis and …
L Maouche-Chretien - john-libbey-eurotext.fr
... obtenus lors des activations ou des inactivations géniques de tal-1 et lmo2. ... motif
in immunoglobulin enhancer binding : daughterless, MyoD and Myc proteins. ...
Cached - Web Search - john-libbey-eurotext.fr

Differentiation Mechanisms and Malignancy
GI Abelev - BIOCHEMISTRY (Moscow), 2000 - protein.bio.msu.ru
... case, classical oncogenes directly induce autonomization of the cell cycle (MYC,
PRAD, BCL-3 ... For example, the Lmo2 protein controls the very first stages of hemo ...
Cited by 3 - View as HTML - Web Search - protein.bio.msu.su - ncbi.nlm.nih.gov - maik.rssi.ru - all 6 versions » - Get it from MIT Libraries

HOX11L2 expression defines a clinical subtype of pediatricT-ALLassociated with poor prognosis - Full text - MIT Libraries
LMO LYL - Blood, 2002 - bloodjournal.org
... q24;q11), expected to lead to transcriptional activation of the c-MYC gene. 21 No
cytogenetic abnormality of the LYL1(19p13), TAL1 (1p32), or LMO2 (11p13) loci ...
Cited by 21 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Retroviral insertional mutagenesis identifies oncogene cooperation. - Full text - MIT Libraries
T Nakamura - Cancer Science, 2005 - blackwell-synergy.com
... in the homozygous mutants, and there was frequent involvement of Myc, Jundp2 and ...
T-ALL, and integrations of the chain-bearing retrovirus in the LMO2 locus were ...
Web Search - ncbi.nlm.nih.gov

The Tal1 oncoprotein inhibits E47-mediated transcription - Full text - MIT Libraries
ST Park, XH Sun - J Biol Chem, 1998 - jbc.org
... possibly in cooperation with the zinc finger proteins LMO2 and GATA-1 ... EXPERIMENTAL
PROCEDURES Plasmids—The pTal1-myc (hereafter called pTal1), TalM1/pBS, and ...
Cited by 33 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements - Full text - MIT Libraries
T Rozovskaia, O Ravid-Amir, S Tillib, G Getz, E … - Proceedings of the National Academy of Sciences, 2003 - pnas.org
... This includes activation of oncogenes (MYC, HOX A9 and MEIS1, LMO2, etc.), inactivation
of tumor suppressor genes such as FHIT and DAPK1, suppression of ...
Cited by 23 - Web Search - 171.66.122.165 - santafe.edu - weizmann.ac.il - all 10 versions »

Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene - Full text - MIT Libraries
CL Dobson, AJ Warren, R Pannell, A Forster, TH … - The EMBO Journal, 2000 - embojournal.npgjournals.com
... mice or chimeric mice made by injecting E14 ES cells with a single Lmo2 null allele
(C320 cells; Yamada et al., 1998) ; and (ii) a cohort of Mll-myc tag mice. ...
Cited by 53 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 7 versions »

The LIM-only Protein DRAL/FHL 2 Interacts with and Is a Corepressor for the Promyelocytic Leukemia … - Full text - MIT Libraries
P McLoughlin, E Ehler, G Carlile, JD Licht, BW … - Journal of Biological Chemistry - jbc.org
... of LIM-only proteins are clearly implicated in transcriptional regulation: LMO2,
which interacts ... pcDNA3.1 myc/his-PLZF and deletion constructs of PLZF, delPOZ ...
Cited by 16 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Notch signaling in leukemia
JC Aster, WS Pear - Curr. Opin. Hematol, 2001 - co-hematology.com
... from other genes implicated in human T-ALL, such as TAL1, LMO1, and LMO2, which
are ... cooperates in the induction of T-ALL by E2A-PBX1 [35•] and c-MYC [36,37 ...
Cited by 27 - Web Search - co-hematology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Chance or necessity? Insertional mutagenesis in gene therapy and its consequences - Full text - MIT Libraries
C Baum, C von Kalle, FJ Staal, Z Li, B Fehse, M … - Mol Ther, 2004 - angt.net
... occurring in a normal or nonpermissive genetic environment, as shown for MYC [24 ...
or more) clones harboring a random transgene insertion in the vicinity of LMO2. ...
Cited by 20 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Chromosomal abnormalities and tumor development: from genes to therapeutic mechanisms - Full text - MIT Libraries
C Cobaleda, J Perez-Losada, I Sanchez-Garcia - BioEssays, 1998 - doi.wiley.com
... the mechanisms involved in transactivation and the identities of MYC-regulated genes ...
containing a zinc-finger LIM domain, (19) which include LMO1 and LMO2 in T ...
Cited by 13 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

SSBP 2, a candidate tumor suppressor gene, induces growth arrest and differentiation of myeloid … - Full text - MIT Libraries
H Liang, S Samanta, L Nagarajan - Oncogene, 2005 - nature.com
... screen expression profile in BP2−30 cells demonstrates loss of C-MYC expression
and ... LMO2, originally isolated due to its activation in T-cell leukemia, is a ...
Web Search - nature.com - ncbi.nlm.nih.gov

Modulation of the Interleukin-6 Receptor Subunit Glycoprotein 130 Complex and Its Signaling by LMO 4 …
V Novotny-Diermayr, B Lin, L Gu, X Cao - Journal of Biological Chemistry - jbc.org
... LMO1 and LMO2 were initially identified as T cell oncogenes by virtue of their ... into
the pXJ40-hemagglutinin (HA)-tagged vector or the pXJ40-Myc-tagged vector ...
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Differential gene expression of human stem progenitor cells derived from early stages of in utero … - Full text - MIT Libraries
F Shojaei, L Gallacher, M Bhatia - Blood, 2004 - dx.doi.org
... Candidate regulators, such as Lim only domain-2 (LMO2), nuclear factor–kappa B
(NF- B), tripartite motif 28 (Trim28), and N-myc protooncogene (MYCN), and a ...
Cited by 3 - Web Search - bloodjournal.org - bloodjournal.org - ncbi.nlm.nih.gov - all 5 versions »

Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity … - Full text - MIT Libraries
RK Goyal, P Lin, J Kanungo, AS Payne, AJ Muslin, … - Mol Cell Biol, 1999 - mcb.asm.org
... can be nuclear (eg, the erythrocyte protein rhombotin 2 or LMO2) (40), cytosolic
(eg ... Rabbit polyclonal anti-Myc antiserum was generated by A. Shaw (Washington ...
Cited by 24 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO 1 is blocked by O 6- … - Full text - MIT Libraries
E Allay, JS Reese, EA McGuire, ON Koc, N Sedransk, … - Oncogene, 1997 - nature.com
... Transgenic expression of either LMO1 or LMO2 in the mouse thymus results in T ... increases
lymphomagenesis in pim-1 transgenic mice through myc overexpression and ...
Cited by 9 - Web Search - nature.com - ncbi.nlm.nih.gov

The LIM-only protein Lmo 2 is a bridging molecule assembling an erythroid, DNA-binding complex which … - Full text - MIT Libraries
IA Wadman, H Osada, GG Grutz, AD Agulnick, H … - The EMBO Journal, 1997 - embojournal.npgjournals.com
... The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding
complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. ...
Cited by 161 - Web Search - emboj.org - nature.com - ncbi.nlm.nih.gov - all 7 versions »

Transcription Factors: Normal and Malignant Development of Blood Cells
IJ Hematol - Int J Hematol, 2001 - cardenjennings.metapress.com
... EVI1, t(8;21), TEL/ETV6, mixed lineage leukemia (MLL), coacti- vators, LMO2, and
acetyltransferases ... is relatively short,with two chapters,one for myc and myb ...
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TRANSCRIPTION FACTORS
OFB CELLS - doi.wiley.com
... 27 The LMO2 Master Gene; Its Role as a Transcription Regulator Determining Cell
Fate in ... 519 29 The Roles of the c-myc and c-myb Oncogenes in Hematopoiesis and ...
Web Search

An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates … - Full text - MIT Libraries
PD Aplan, CA Jones, DS Chervinsky, X Zhao, M … - The EMBO Journal, 1997 - embojournal.npgjournals.com
... Nottage, K. and Rabbitts, TH (1996) Protein dimerization between Lmo2 (Rbtn2) and ...
motif in immunoglobulin enhancer binding, daughterless, MyoD and myc proteins ...
Cited by 49 - Web Search - emboj.org - nature.com - ncbi.nlm.nih.gov - all 7 versions »

LMO3 Interacts with Neuronal Transcription Factor, HEN2, and Acts as an Oncogene in Neuroblastoma - Full text - MIT Libraries
M Aoyama, T Ozaki, H Inuzuka, D Tomotsune, J … - Cancer Research, 2005 - cancerres.aacrjournals.org
... Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development
and ... Amplification of N-myc in untreated human neuroblastomas correlates with ...
Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1 - Full text - MIT Libraries
VC Foletta, MA Lim, J Soosairajah, AP Kelly, EG … - J. Cell Biol, 2003 - jcb.org
... (A) GST–LIMK1 interaction with myc-tagged LAP ... after coimmunoprecipitation analysis
with overexpressed BMPR-II and the LIM domain protein LMO2 (Larson et al ...
Cited by 25 - Web Search - jcb.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Lhx 9 and Lhx 9: Differential Biochemical Properties and Effects on Neuronal Differentiation
B Molle, S Pere, V Failli, I Bach, S Retaux - DNA and Cell Biology, 2004 - dx.doi.org
... Immunofluorescence is directed against GFP (A,B) or the myc epitope-tag (C ... and Xenopus
LMO3 increases neurogenesis (Bao et al., 2000), whereas LMO2 and LMO4 ...
Web Search - liebertonline.com - liebertonline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants - Full text - MIT Libraries
D Traver, BH Paw, KD Poss, WT Penberthy, S Lin, LI … - Nature Immunology, 2003 - nature.com
... 7. Yamada, Y. et al. The T cell leukemia LIM protein Lmo2 is necessary for adult
mouse hematopoiesis. ... Myc-induced T-cell leukemia in transgenic zebrafish. ...
Cited by 14 - Web Search - zfblasta.tch.harvard.edu - eanimal.snu.ac.kr - ncbi.nlm.nih.gov - all 6 versions »

The zinc-finger proto-oncogene Gfi-1 b is essential for development of the erythroid and … - Full text - MIT Libraries
S Saleque, S Cameron, SH Orkin - Genes & Development, 2002 - genesdev.org
... The effect of chromosomal translocations in acute leukemias: The LMO2 paradigm in
transcription ... site in murine leukemia virus-induced lymphomas of c-myc and Pim ...
Cited by 22 - Web Search - genesdev.org - pubmedcentral.nih.gov - dx.doi.org - all 8 versions »