RUNX1/AML1: a central player in hematopoiesis
T Okuda, M Nishimura, M Nakao, Y Fujita - Int J Hematol, 2001 - cardenjennings.metapress.com
... 2 groups: factors that regulate both primitive and definitive hematopoiesis,including
Tal1/SCL and LMO2/ rbtn2, and other factors, including RUNX1/AML1 (runt ...
Cited by 11 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

A complex linkage in the developmental pathway of endothelial and hematopoietic cells
SI Nishikawa - Curr Opin Cell Biol, 2001 - cbi.pku.edu.cn
... V, Klaine M, Max-Audit I, Romeo P, Dieterlen-Lievre F, Godin I: Lmo2 and GATA-3 ... S,
Nishikawa S, Okada H, Satake M et al.: Requirement of Runx1/AML1/PEBP2alphaB ...
Cited by 19 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Modeling Human Hematopoietic and Cardiovascular Diseases in Zebrafish
TE North, LI Zon - Key words, 2003 - doi.wiley.com
... to be impor- tant in mouse and human develop- ment have been isolated, including
cmyb, gata1, gata2, globin, hhex, ikaros, lmo2, pu1, rag1, runx1, scl, and ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Adult and embryonic blood and endothelium derive from distinct precursor populations which are … - Full text - MIT Libraries
M Walmsley, A Ciau-Uitz, R Patient - Development, 2002 - dev.biologists.org
... stages of blood cell and blood vessel development, including Flk1, cloche, SCL,
QH1, Ets, Runx1, Fli1, TGF-ß1, VEGF, CD34, Flt1, Tie2, GATA2, LMO2 and PECAM1 ...
Cited by 13 - Web Search - dx.doi.org - dev.biologists.org - ncbi.nlm.nih.gov - all 5 versions »

Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid … - Full text - MIT Libraries
L Garcon, C Lacout, F Svinartchouk, JP Le Couedic, … - Blood, 2005 - bloodjournal.org
... Many genes coding for transcription factors have been reported to be mutated
(Scl/Tal-1, Lmo2, Tel, E2A, Runx1) 1 or their expression modified (Scl, 2 Pu.1, ...
Cited by 1 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants - Full text - MIT Libraries
D Traver, BH Paw, KD Poss, WT Penberthy, S Lin, LI … - Nature Immunology, 2003 - nature.com
... The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis ... Runx1
is required for zebrafish blood and vessel development and expression of a ...
Cited by 14 - Web Search - zfblasta.tch.harvard.edu - eanimal.snu.ac.kr - ncbi.nlm.nih.gov - all 6 versions »

Progress in Hematology
T Yamagata, K Maki, K Mitani - Int J Hematol, 2005 - cardenjennings.metapress.com
... Maintained expres- sion of the PU.1 gene and down-regulation of the LMO2 and SCL
genes in Runx1-Evi1 knock-in cells might be the under- lying causes for such a ...
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Leukaemia- a developmental perspective - Full text - MIT Libraries
S Izraeli - British Journal of Haematology, 2004 - blackwell-synergy.com
... paradigm of leukaemogenesis: RUNX1 abnormalities in acute leukaemias, GATA1 mutations
in the leukaemias of Down syndrome, and SCL and LMO2 ectopic expression ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Non-cell autonomous requirement for the bloodless gene in primitive hematopoiesis of zebrafish - Full text - MIT Libraries
EC Liao, NS Trede, D Ransom, A Zapata, M Kieran, … - Development, 2002 - dev.biologists.org
... of both primitive and definitive hematopoiesis such as Scl, Lmo2, Gata1, Gata2 and ...
hematopoiesis, such as Myb, Kit, Slf (Pou3f4), Tel, Aml1 (Runx1), Cbfb and ...
Cited by 12 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

The‘definitive’(and‘primitive’) guide to zebrafish hematopoiesis - Full text - MIT Libraries
AJ Davidson, LI Zon - Oncogene, 2004 - nature.com
... a wide range of HSC and angioblast genes including scl (Liao et al., 1998), lmo2
(Thompson et al., 1998), gata2 (Thompson et al., 1998), runx1 (Kalev-Zylinska ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

TRANSCRIPTION FACTORS
OFB CELLS - doi.wiley.com
... 85 6 RUNX1(AML1) and CBFB: Genes Required for the Development of All Definitive ... 27
The LMO2 Master Gene; Its Role as a Transcription Regulator Determining Cell ...
Web Search

Scl is required for dorsal aorta as well as blood formation in zebrafish embryos - Full text - MIT Libraries
LJ Patterson, M Gering, R Patient - Blood, 2005 - bloodjournal.org
... for the multiprotein complex containing Scl and Lmo2. 49 Our data show that initiation
of gata1 expression is Scl-dependent. Initially, runx1 expression is ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Endothelial progenitor cells: a source for therapeutic vasculogenesis - Full text - MIT Libraries
H Rumpold, D Wolf, R Koeck, E Gunsilius - J Cell Mol Med, 2004 - jcmm.ro
... the embryo • Markers and development of EC and HC • SCL/Tal • Aml1/Runx1 ... phenotype
of SCL -/- is similar to the phenotype of LMO2 -/-, which physically ...
Cited by 2 - View as HTML - Web Search - ncbi.nlm.nih.gov

SHORT REPORT Absence of SCL mutations in myeloid malignancies - Full text - MIT Libraries
E Delabesse, J Li, S Schnittger, W Hiddemann, AR … - British Journal of Haematology, 2003 - blackwell-synergy.com
... RUNX1 is essential for murine definitive haematopoiesis and mutations in its
DNA-binding (Runt ... binding and for the interaction of SCL with E2A and LMO2 proteins ...
Web Search - ncbi.nlm.nih.gov

Transcription Factors: Normal and Malignant Development of Blood Cells
IJ Hematol - Int J Hematol, 2001 - cardenjennings.metapress.com
... focuses on myeloid differentiation,consists of the topics RUNX1(AML1)/CBFB ... TEL/ETV6,
mixed lineage leukemia (MLL), coacti- vators, LMO2, and acetyltransferases ...
Web Search

Progress in Hematology
R Ono, T Nosaka, Y Hayashi - Int J Hematol, 2005 - cardenjennings.metapress.com
... 1,2]. The genes identified to date include Tal1/SCL and LMO2/rbtn2, which regulate
both primitive and definitive hematopoiesis, and AML1/RUNX1/CBF and CBF ...
Web Search

Absence of SCL mutations in myeloid malignancies - Full text - MIT Libraries
G Munich - British Journal of Haematology, 2003 - ingentaconnect.com
... RUNX1 is essential for murine definitive haematopoiesis and mutations in its
DNA-binding (Runt ... and for the inter- action of SCL with E2A and LMO2 proteins. ...
Web Search

Absence of Yolk sac Hematopoiesis from Mice with a Targeted Disruption of the scl Gene - Full text - MIT Libraries
L Robb, I Lyons, R Li, L Hartley, F Kontgen, RP … - Proceedings of the National Academy of Sciences - pnas.org
... Development Home page M. Gering, Y. Yamada, TH Rabbitts, and RK Patient Lmo2 and
Scl ... C. Hogan, L. Carlsson, N. Speck, J. Palis, and G. Keller Runx1 is essential ...
Cited by 181 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu

Oligo GEArray® Human Hematopoietic Stem Cells and Hematopoiesis Microarray
S Conditions - search.cosmobio.co.jp
... DLL1, ERAF, FEZ2, FUT10, IFI16, IL10, IL20, IL31RA, JAG1, LMO2, MLF1, MMP9 ... MYC, NCOA6,
NFYA, NOTCH1, NOTCH2, NOTCH4, PAX5, RBPSUH, RHOH, RUNX1, SCAND1, STAT1 ...
View as HTML - Web Search

The Gene SCL is Expressed during Early Hematopoiesis and Encodes a Differentiation-Related DNA- … - Full text - MIT Libraries
CG Begley, PD Aplan, SM Denning, BF Haynes, TA … - Blood, 2005 - pnas.org
... page MP McCormack and TH Rabbitts Activation of the T-Cell Oncogene LMO2 after Gene ...
C. Hogan, L. Carlsson, N. Speck, J. Palis, and G. Keller Runx1 is essential ...
Cited by 116 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Runx 3 is required for hematopoietic development in zebrafish - Full text - MIT Libraries
ML Kalev-Zylinska, JA Horsfield, MVC Flores, JH … - Developmental Dynamics, 2003 - doi.wiley.com
... through forced transient expression of runx3 but in contrast to runx1 (Kalev-Zylinska ...
Early Expression of scl, lmo2, and gata1 Is Preserved in runx3-Morpholino ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

Zebrafish as a model organism for blood diseases - Full text - MIT Libraries
J Berman, K Hsu, AT Look - British Journal of Haematology, 2003 - blackwell-synergy.com
... myb (Thompson et al, 1998) and runxa (orthologue of mammalian runx1) (Burns et ... These
cells appear later than those expressing scl, lmo2 and gata-2, consistent ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov

Design Principle of Gene Expression Used by Human Stem Cells; Implication for Pluripotency
R Title - arxiv.org
... The common genes include CD34, AC133, BMI1, TIE, HOXA10, FZD6, SOX4, TCF3, RUNX1,
FLT3, LMO2, SCA1, MEIS1, MPL, TEK, SCA1, MDR1 and others. Theses genes ...
View as HTML - Web Search - weizmann.ac.il - weizmann.ac.il

ORIGINAL PAPER ES02. 01 Transcriptional regulation of haematopoiesis - Full text - MIT Libraries
B Goettgens - Vox Sanguinis, 2004 - blackwell-synergy.com
... The knock-out phenotypes for runx1 and cbf are very similar, consistent with the ...
unlikely to be a coincidence that five transcription factors (SCL, LMO2, Runx-1 ...
Web Search - ncbi.nlm.nih.gov

The bloody fate of endothelial stem cells - Full text - MIT Libraries
H Kubo, K Alitalo - Development, 2003 - dx.doi.org
... Runx1 expression marks long-term repopulating hematopoietic stem cells in the
midgestation ... The T cell leukemia LIM protein Lmo2 is necessary for adult mouse ...
Cited by 10 - Web Search - genesdev.org - genesdev.org - ncbi.nlm.nih.gov - all 5 versions »

Pathways in blood and vessel development revealed through zebrafish genetics
PS Crosier, ML Kalev-Zylinska, CJ Hall, MV Flores, … - Int J Dev Biol, 2002 - ijdb.ehu.es
... shown that this system has potential for the study of Runx1-mediated leukemogenesis ...
The expression of several blood markers including scl, lmo2, and gata- 1, as ...
Cited by 5 - View as HTML - Web Search - ncbi.nlm.nih.gov - ijdb.ehu.es - Get it from MIT Libraries

Translocation Breakpoints in Cancer
AM Oliveira, JA Fletcher - ehgonline.net
... encoding hematopoiesis- related transcription factors, including runt-related
transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) (RUNX1) and core ...
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Transcriptional regulation of haematopoiesis - Full text - MIT Libraries
B Goettgens - Vox Sanguinis, 2004 - ingentaconnect.com
... The knock-out phenotypes for runx1 and cbfβ are very similar, consistent with ... unlikely
to be a coincidence that five transcription factors (SCL, LMO2, Runx-1 ...
Web Search

Putative intermediate precursor between hematogenic endothelial cells and blood cells in the … - Full text - MIT Libraries
ST Fraser, M Ogawa, T Yokomizo, Y Ito, S Nishikawa … - Development Growth and Differentiation, 2003 - blackwell-synergy.com
... Runx1 null mutant embryos lacked this novel population. ... 1998). Hematopoietic commitment
of endothelial cells is dependent upon Runx1 expression. ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

ZEBRAFISH AS A MODEL ORGANISM FOR BLOOD DISEASES - Full text - MIT Libraries
OFV EMBRYOGENSIS - British Journal of Haematology, 2003 - ingentaconnect.com
... myb (Thompson et al, 1998) and runxa (orthologue of mammalian runx1) (Burns et ... These
cells appear later than those expressing scl, lmo2 and gata-2, consistent ...
Web Search

Mechanisms regulating the origins of the vertebrate vascular system - Full text - MIT Libraries
MS Saha, EA Cox, CW Sipe - Journal of Cellular Biochemistry, 2004 - doi.wiley.com
... tothe BL- CFCs and to the hematopoietic lineages in EBs, with the runx1 À/À ... in its
absence the role is assumed by other factors such as Scl- Tal1 or Lmo2. ...
Web Search - ncbi.nlm.nih.gov

The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, … - Full text - MIT Libraries
MA Hall, DJ Curtis, D Metcalf, AG Elefanty, K … - Blood, 2004 - dx.doi.org
... Kutok, K. Akashi, IR Williams, NA Speck, and DG Gilliland Loss of Runx1 perturbs
adult ... Home page M. Gering, Y. Yamada, TH Rabbitts, and RK Patient Lmo2 and Scl ...
Cited by 21 - Web Search - pnas.org - intl.pnas.org - pubmedcentral.nih.gov - all 7 versions »

Emergence of Multipotent Hemopoietic Cells in the Yolk Sac and Paraaortic Splanchnopleura in Mouse … - Full text - MIT Libraries
I Godin, F Dieterlen-Lievre, A Cumano - Proceedings of the National Academy of Sciences - pnas.org
... P. Kingsley, C. Hogan, L. Carlsson, N. Speck, J. Palis, and G. Keller Runx1 is
essential for ... I Max-Audit, P Romeo, F Dieterlen-Lievre, and I Godin Lmo2 and GATA ...
Cited by 105 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Mutant-specific gene programs in the zebrafish - Full text - MIT Libraries
GJ Weber, SE Choe, KA Dooley, NN Paffett-Lugassy, … - Blood, 2005 - bloodjournal.org
... not only of the earliest transcription factors, such as scl, lmo2, and gata1 ... slc22a4
is regulated by the hematopoietic transcription factor runx1 68 and has ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

RNA interference as a potential tool in the treatment of leukaemia
A Borkhardt, O Heidenreich - Expert Opinion on Biological Therapy, 2004 - extenza-eps.com
... 2.4 RUNX1–CBFA2T1 The translocation t(8;21) is one of the most frequent chromo-
somal aberrations involved in AML [26] . ... mut. p53 RUNX1 CBFA2T1 ...
Web Search - ashley-pub.com - dx.doi.org - ingentaconnect.com - all 8 versions »

Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell … - Full text - MIT Libraries
H Tagawa, M Suguro, S Tsuzuki, K Matsuo, S Karnan, … - Blood, 2005 - bloodjournal.org
... BARD1, PIK3CG, LRMP, Hs.1098, BCL6, HDAC1, MYBL2, MME (CD10), STAG3, LMO2, APS,
Hs ... PM5, PDIR, IGHM, CD22, Hs.296938, Hs.1565, Hs.83126, MAPKAPK3, RUNX1, Hs.55947 ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

acquises de la cellule souche hematopoietique ou d’un precurseur deja commis vers les lignees …
S YNTHESE - MEDECINE/SCIENCES, 2003 - ist.inserm.fr
... binding factor) qui comporte deux sous-unités CBFA2 (ou AML1, RUNX1) et CBFβ ...
transcriptionnels comme les protéines LYL1, TAL1/SCL, LMO1 et LMO2, HOX11 et ...
View as HTML - Web Search - erudit.org

SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage … - Full text - MIT Libraries
M Endoh, M Ogawa, S Orkin, S Nishikawa - The EMBO Journal, 2002 - embojournal.npgjournals.com
... On the other hand, SCL, LMO2 and GATA2, which are essential for HPC differentiation,
are also expressed in some ECs (Dorfman et al ... (2002) Runx1 is essential for ...
Cited by 15 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 7 versions »

Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute …
B Johansson, F Mertens, F Mitelman - Annals of Medicine, 2004 - dx.doi.org
Page 1. Clinical and biological importance of cytogenetic abnormalities
in childhood and adult acute lymphoblastic leukemia Bertil ...
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Expression of Galectin-3 in Skeletal Tissues Is Controlled by Runx 2 - Full text - MIT Libraries
M Stock, H Schaefer, S Stricker, G Gross, S … - J Biol Chem, 2003 - jbc.org
... other two members of the Runt family of transcription factors (Runx1 and Runx3 ...
c-Ets, CP2, c-Rel, GATA proteins, GFI1, HNF3b, Ikaros factors, Lmo2 complex, MyoD ...
Cited by 4 - Web Search - jbc.org - ncbi.nlm.nih.gov

Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem … - Full text - MIT Libraries
S Gerecht-Nir, JE Dazard, M Golan-Mashiach, S … - Developmental Dynamics, 2005 - doi.wiley.com
... 3 BMI1 B lymphoma insertion region 4 LMO2 LIM domain only 2 5 TIE Tyrosine kinase
6 GATA1 GATA binding protein 1 7 RUNX1 Runt-related transcription factor 1 ...
Cited by 2 - Web Search - weizmann.ac.il - weizmann.ac.il - ncbi.nlm.nih.gov

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor … - Full text - MIT Libraries
P Hematti, BK Hong, C Ferguson, R Adler, H Hanawa, … - PLoS Biol, 2004 - dx.doi.org
... in this paper are ARHGEF12 (23365), EVI1 (2122), HMGA2 (8091), LMO2 (4005), MDS1
(4197), MKL1 (57591), MSF (10801), RAD51L1 (5890), RUNX1 (861), andTRIM5α ...
Cited by 6 - Web Search - medicine.plosjournals.org - plme.allenpress.com - plosbiology.org - all 11 versions »

du Sud-Est porteur de la mutation S163R, qui serait peut-etre apparue par selection au traitement … - Full text - MIT Libraries
N Med, M Cell - Nat Med, 2004 - erudit.org
... Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites. ... Runx1
expression marks long-term repopulating hematopoietic stem cells in the ...
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The hare and the tortoise: an embryonic haematopoietic race - Full text - MIT Libraries
I Godin, A Cumano - Nat Rev Immunol, 2002 - nature.com
... The T-cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. ...
Lmo2 and GATA-3 associated expression in intra-embryonic hemogenic sites. ...
Cited by 26 - Web Search - nature.com - ncbi.nlm.nih.gov

Making waves in cancer research: new models in the zebrafish
S Berghmans, C Jette, D Langenau, K Hsu, R Stewart … - BioTechniques, 2005 - biotechniques.com
... are similar to a subtype of human T-ALL (38), expressing both scl and lmo2. ... The
transient expression of the human RUNX1-CBF2T1, a fusion gene product of the t(8 ...
View as HTML - Web Search - biotechniques.com

Oncogenes et leucemies: historique et perspectives
S Gisselbrecht, BG Roussy - M e decine et Science, 2003 - erudit.org
... binding factor) qui comporte deux sous-unités CBFA2 (ou AML1, RUNX1) et CBFβ ...
transcriptionnels comme les protéines LYL1, TAL1/SCL, LMO1 et LMO2, HOX11 et ...
Cited by 2 - Cached - Web Search

State-of-the-Art Review
HKA MIKKOLA, SH ORKIN - JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH, 2002 - dx.doi.org
... is identical to that resulting from the loss of LMO2, a LIM ... Aml1/runx1 separates
definitive hematopoiesis from embryonic erythropoiesis at the hemangioblast ...
Web Search - liebertonline.com - liebertonline.com

Hematopoietic Stem Cell Enrichment From the AGM Region of the Mouse Embryo
C Robin, E Dzierzak - Methods Mol Med, 2005 - biomed.humanapress.com
... angiopoietin 1 receptor, TEK LMO2 — + +/– SMA Smooth-muscle actin, tenascin C – –
GATA2 — + + AML-1 Acute myeloid leukaemia 1, Cbfa2, Runx1, PEBP2 ...
Web Search - journals.humanapress.com - neurosci.humanapress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Hematopoietic differentiation of human embryonic stem cells progresses through sequential … - Full text - MIT Libraries
ET Zambidis, B Peault, TS Park, F Bunz, CI Civin - Blood, 2005 - bloodjournal.org
... Interestingly, several genes important for regulating HSPC development in MESCs
and embryos (eg, LMO2, AML1, C-MYB [data not shown], KDR/flk-1 [VEGFR2], and FLT ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Gene Expression Profiling of Leiomyoma and Myometrial Smooth Muscle Cells In Response to TGF-β
X Luo, L Ding, J Xu, N Chegini - Endocrinology (submitted), 2004 - endo.endojournals.org
... dependent regulation of IL-11, TGIF, TIEG, EGR3, CITED2, Nur77, RUNX1, RUNX2,
p27, p57, Gas-1 ... in LSMC and MSMC are Runx1 and Runx2. ...
Cited by 1 - Web Search - endo.endojournals.org