ERK5 is targeted to myocyte enhancer factor 2A (MEF2A) through a MAPK docking motif - Full text - MIT Libraries
D BARSYTE-LOVEJOY, A GALANIS, A CLANCY, AD … - Biochem. J, 2004 - biochemj.org
... proteins. GAL4-MEF2-Jun and GAL4-MEF2-Elk1 have the D-domain of MEF2A
and C-terminal TAD of Jun and Elk-1 respectively. Numbers ...
View as HTML - Web Search - biochemj.org

Dealing with osmostress through MAP kinase activation - Full text - MIT Libraries
E de Nadal, PM Alepuz, F Posas, S transduction by … - EMBO Reports, 2002 - emboreports.npgjournals.com
... JNK and p38 target several transcription factors directly, enhancing their
ability to activate transcription (eg MEF2A/C, Elk1/Sap1a). ...
Cited by 24 - Web Search - nature.com - embo.org - ncbi.nlm.nih.gov - all 6 versions »

Activation of the p 38 MAP kinase pathway is required for foam cell formation from macrophages … - Full text - MIT Libraries
M Zhao, Y Liu, X Wang, L New, J Han, UT Brunk - Apmis, 2002 - blackwell-synergy.com
... The plasmids pcDNA3-MKK6b(E), pcDNA3-MKK7(D), and pcDNA3-MKK1(E), GAL4-ELK1,
GAL4-MEF2A, GAL4-ATF2 were described previously (34). ...
Cited by 5 - Web Search - ingentaconnect.com

Regulation of the MEF2 family of transcription factors by p38 - Full text - MIT Libraries
M Zhao, L New, VV Kravchenko, Y Kato, H Gram, F di … - Mol. Cell. Biol, 1999 - pubmedcentral.nih.gov
... the p38 pathway by dominant active MKK6 dramatically enhanced MEF2A-dependent reporter ...
we tested the responsiveness of GAL4-ATF2 and GAL4-ELK1 fusion proteins ...
Cited by 122 - Web Search - ncbi.nlm.nih.gov

Activation and signaling of the p38 MAP kinase pathway - Full text - MIT Libraries
T ZARUBIN, J Han - Cell Res, 2005 - cell-research.com
... CHOP (growth arrest and DNA damage inducible gene 153, or GADD153), p53, C/EBPβ,
myocyte enhance factor 2C (MEF2C), MEF2A, MITF1, DDIT3, ELK1, NFAT, and high ...
View as HTML - Web Search - cell-research.com - ncbi.nlm.nih.gov

Post-translational control of the MEF 2 A transcriptional regulatory protein - Full text - MIT Libraries
O Ornatsky, DM Cox, P Tangirala, JJ Andreucci, ZA … - Nucleic Acids Research, 1999 - nar.oupjournals.org
... SRF), requires the phopshorylation of an accesory protein (Elk1) for full
responsiveness to MAP kinase signalling (29,30). Even though MEF2A is phosphorylated ...
Cited by 34 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Role of p 38 and p 44/42 mitogen-activated protein kinases in microglia - Full text - MIT Libraries
M Koistinaho, J Koistinaho - Glia, 2002 - doi.wiley.com
... regulated/activated kinase; ATF2, activating transcrip- tion factor 2; MEF2A/C,
myocyte ... clear target of p44/42 MAPK is transcription factor Elk1, leading to ...
Cited by 19 - Web Search - ncbi.nlm.nih.gov

Regulation of the MEF2 Family of Transcription Factors by p38 dagger
M Zhao, L New, VV Kravchenko, Y Kato, H Gram, F di … - mcb.asm.org
... the p38 pathway by dominant active MKK6 dramatically enhanced MEF2A-dependent reporter ...
we tested the responsiveness of GAL4-ATF2 and GAL4-ELK1 fusion proteins ...
Web Search - mcb.asm.org

Downregulation of c-fos gene transcription in cells transformed by E1A and - Full text - MIT Libraries
TV Pospelova, VA Pospelov - Oncogene, 2002 - nature.com
... of ERK, JNK and p38 kinases towards speci®c substrates, we performed an in vitro
kinase assay with GST-Elk1-C, GST-Jun-N, GST-ATF2-N and GST-MEF2A as speci®c ...
Web Search

In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance
Y Shi, M Gaestel - Biol. Chem, 2002 - degruyter.com
... Among the four p38 iso- forms, p38α is the most potent kinase for MEF2A (Zhao et
al ... The FXF motif is conserved between SAP1 and Elk1 (Galanis et al., 2001). ...
Cited by 15 - Web Search - extenza-eps.com - mh-hannover.de - degruyter.de - all 10 versions »

Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry - Full text - MIT Libraries
T Lee, AN Hoofnagle, Y Kabuyama, J Stroud, X Min, … - Mol. Cell, 2004 - www-jackson.ch.cam.ac.uk
... kinases protected from solvent by docking motif inter- tides containing the DEJL
motif from MEF2A or MAP ... the dependence of Elk1 and nucleoporin binding on ...
Cited by 8 - View as HTML - Web Search - ncbi.nlm.nih.gov

GEArray S Series Human Immunology Signaling Pathways Gene Array: AR-SAHS-605
FG Grouping, A Molecules, I ICAM, CS Molecules, C … - eurogentec.com
... Factors: ATF2, CEBPB, CREB1, CREBBP, EGFR, EGR1, EGR2, EGR3, ELK1, ELK3, ELK4 ... ICOS,
IRF1, ISGF3G, JUN, JUNB, MADH4, MAPKAPK2, MAPKAPK3, MAX, MEF2A, MEF2B, MEF2C ...
View as HTML - Web Search - eurogentec.be

GEArray S Series Human Autoimmune and Inflammatory Response Gene Array: AR-SAHS-602
FG Grouping, A Proteins, CS Receptors, ST Proteins … - eurogentec.be
... EGR2, EGR3, ELK1, ELK3, EP300, FKBP1B, FLJ14639 (NIP45), FOS, FOSL1, FOSL2, FOXP3,
GATA3, GATA4, GRLF1, ICOS, IRF1, JUN, JUNB, JUND, MAF, MAX, MEF2A, MEF2B ...
View as HTML - Web Search - eurogentec.com

Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, … - Full text - MIT Libraries
JE Cavanaugh, J Ham, M Hetman, S Poser, C Yan, Z … - J. Neurosci, 2001 - jneurosci.org
... However, MEF2A and MEF2C are phosphorylated and activated by ERK5 but not by
ERK1/2, whereas Elk1 is phosphorylated and activated by ERK1/2 but not by ERK5 ...
Cited by 54 - Web Search - jneurosci.org - jneurosci.org - ncbi.nlm.nih.gov - all 5 versions »

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and … - Full text - MIT Libraries
JM Kyriakis, J Avruch, JM Kyriakis, J Avruch - Physiol Rev, 2001 - intl-physrev.physiology.org
... not p38, can phosphorylate two critical residues in the Elk1 COOH terminus ... MEF2s
(MEF2A-D) were originally identified as transcription factors that bound to AT ...
Cited by 398 - Web Search - physrev.physiology.org - zeck.floop.org.uk - ncbi.nlm.nih.gov

Id helix–loop–helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain … - Full text - MIT Libraries
PR Yates, GT Atherton, RW Deed, JD Norton, AD … - The EMBO Journal, 1999 - embojournal.npgjournals.com
... (C) Gel-retardation analysis of binary (2°) complex formation by Elk1-93 and ... affect
DNA binding by the MADS-box proteins SRF (Figure 4) and MEF2A (EC.Roberts ...
Cited by 53 - Web Search - nature.com - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

ERK (MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38 (SAPK) - Full text - MIT Libraries
JA Aguirre-Ghiso, Y Estrada, D Liu, L Ossowski - Cancer Res, 2003 - cancerres.aacrjournals.org
... protein GAL4-Elk1 (pFA-Elk, Stratagene; ERK phosphorylation target) or expression
plasmids coding for GAL4-CHOP (pFA-CHOP, Stratagene) or GAL4-MEF2A (p38 ...
Cited by 39 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - all 4 versions »

The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex - Full text - MIT Libraries
M Hassler, TJ Richmond - The EMBO Journal, 2001 - embojournal.npgjournals.com
... of transcription factors, and the X-ray structure of its core domain (amino acids
140–223) and those for the related yeast MCM1 and human MEF2A bound to DNA ...
Cited by 34 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 6 versions »

Regulation of TNF expression by multiple mitogen-activated protein kinase pathways - Full text - MIT Libraries
W Zhu, JS Downey, J Gu, F Di Padova, H Gram, J Han - J. Immunol, 2000 - jimmunol.org
... Recombinant His-MEF2C, GST-ELK1(307–428), GST-ATF2(1–109), and GST-ATF2(1–109 ... There
are a number of transcription factors, such as c-Jun, MEF2A/2C, ELK-1 ...
Cited by 36 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions - Full text - MIT Libraries
RM Biondi, AR Nebreda - Biochem. J, 2003 - bj.portlandpress.com
... Figure 3 MAPK docking interactions with substrates, activators and regulators The
docking groove for MEF2A (1LEW) and MKK3b (1LEZ) on p38α MAPK is equivalent ...
Cited by 38 - View as HTML - Web Search - biochemj.org - safar.pitt.edu - dx.doi.org - all 7 versions »

Novel transcription factors in human CD34 antigen-positive hematopoietic cells - Full text - MIT Libraries
I Gomes, TT Sharma, S Edassery, N Fulton, BG Mar, … - Blood, 2002 - bloodjournal.org
... I PC Hs.182280 MEF2A MADS box transcription enhancer factor 2, polypeptide
A (myocyte enhancer factor 2A) 15q26 21.5 I W Hs.26703 ...
Cited by 3 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Docking Sites on MEKs, MAP Kinase Phosphatases, and the Elk-1 Transcription Factor Compete for … - Full text - MIT Libraries
AJ BARDWELL, M ABDOLLAHI, L BARDWELL - Biochem J, 2003 - biochemj.org
... Also, the hydrophobic residues in the docking sites of both MKK3b and MEF2A have
been shown to bind to a hydrophobic docking groove in p38 MAPK [45]. ...
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The Molecular Mechanism of MAPK/ERK Inactivation
Z Yao, R Seger - Current Genomics, 2004 - ingentaconnect.com
... regulation of ERK1b by MEK1 and PTP-SL.; and modified Elk1-phosphorylation by ... p38
complexed to the docking sites on its nuclear substrate MEF2A and activator ...
Web Search

Hydrogen Peroxide Stimulates c-Src-mediated Big Mitogen-activated Protein Kinase 1 (BMK1) and the … - Full text - MIT Libraries
PRINCS FOLLOWING, O INSULTS - J. Biol. Chem, 2002 - jbc.org
... from ERK1/2-induced activation of Elk1 and CREB transcription factors (30). The
MEF2 proteins constitute a family of transcription factors: MEF2A, MEF2B, MEF2C ...
Web Search - jbc.org

Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 … - Full text - MIT Libraries
AJ Bardwell, M Abdollahi, L Bardwell - Biochem. J, 2003 - imb-jena.de
... Also, the hydrophobic residues in the docking sites of both MKK3b and MEF2A have
been shown to bind to a hydrophobic docking groove in p38 MAPK [45]. ...
Cited by 17 - View as HTML - Web Search - biochemj.org - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated … - Full text - MIT Libraries
BJ Wilkins, LJ De Windt, OF Bueno, JC Braz, BJ … - Mol Cell Biol, 2002 - mcb.asm.org
... Specifically, the phosphorylation status of MEF2A and its DNA-binding
efficiency were shown to be Cs sensitive (32). Calcineurin ...
Cited by 37 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

MAP kinases - Full text - MIT Libraries
Z Chen, TB Gibson, F Robinson, L Silvestro, G … - Chem. Rev, 2001 - audreyli.com
Page 1. MAP Kinases Zhu Chen, † Tara Beers Gibson, Fred Robinson, Loraine
Silvestro, Gray Pearson, Bing-e Xu, Angelique Wright, Colleen ...
Cited by 70 - View as HTML - Web Search - ncbi.nlm.nih.gov

Marathon running increases ERK 1/2 and p 38 MAP kinase signalling to downstream targets in human … - Full text - MIT Libraries
M Yu, E Blomstrand, AV Chibalin, A Krook, JR … - The Journal of Physiology, 2001 - jphysiol.org
... Activated p90rsk phosphorylates several transcription factors, including Elk1 and
cAMP ... The MEF2A isoform is required for striated muscle-specific expression of ...
Cited by 19 - Web Search - blackwell-synergy.com - ingentaconnect.com - jp.physoc.org - all 5 versions »

Negative Regulation of Growth Hormone (GH) Signaling
K Institutet, S Stockholm - diss.kib.ki.se
... 2, 3 NM_010234 FBJ osteosarcoma oncogene (c-fos) 2, 3 NM_013597 myocyte enhancer
factor 2A (Mef2a) 2 AK018370 Bcl6 interacting corepressor 3 ...
Web Search

Functional Cross-Antagonism between Transcription Factors FLI-1 and EKLF - Full text - MIT Libraries
J Starck, N Cohet, C Gonnet, S Sarrazin, Z … - Mol Cell Biol, 2003 - mcb.asm.org
... pCMV Gal4 Elk 1-205 encoding a fusion protein between the ETS domain of Elk1 and
the DNA binding domain of Gal4 (a gift from A. Sharrocks) has already been ...
Cited by 4 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Regulation of the Human c-fos Gene: X-ray Structure of the SAP-1, SRF, DNA Ternary Complex
DN ETH - e-collection.ethbib.ethz.ch
... 24 Figure 6: X-ray structure MEF2a/DNA..... 25 ...
View as HTML - Web Search - e-collection.ethbib.ethz.ch