Expression of HOX genes in acute leukemia cell lines with and without MLL translocations
H Quentmeier, WG Dirks, RAF MacLeod, J Reinhardt, … - Leuk Lymphoma, 2004 - dx.doi.org
... In primary cells from acute leukemia patients, expression of the genes MEIS1, HOXA5,
HOXA7 and HOXA9 has been reported to be correlated with the occurrence of ...
Cited by 3 - Web Search - taylorandfrancis.metapress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Expression of HOX Genes in Acute Leukemia Cell Lines with and without MLL Translocations
R Macleod, J Reinhardt, M Zaborski, H Quentmeier, … - Leukemia and Lymphoma, 2004 - ingentaconnect.com
... In primary cells from acute leukemia patients, expression of the genes MEIS1, HOXA5,
HOXA7 and HOXA9 has been reported to be correlated with the occurrence of ...
Web Search

Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with … - Full text - MIT Libraries
N Pineault, C Abramovich, H Ohta, RK Humphries - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1. ...
Compromised HOXA5 function can limit p53 expression in human breast tumours ...
Cited by 11 - Web Search - dx.doi.org - mcb.asm.org - ncbi.nlm.nih.gov - all 6 versions »

Meis1-mediated apoptosis is caspase-dependent and can be suppressed by coexpression of HoxA9 in … - Full text - MIT Libraries
PJ Wermuth, AM Buchberg - Blood, 2005 - bloodjournal.org
... NEOPLASIA Meis1-mediated apoptosis is caspase dependent and can be suppressed
by coexpression of HoxA9 in murine and human cell lines. ...
Cited by 3 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

MLL, Hox genes, and leukemia: the plot thickens - Full text - MIT Libraries
JL Hess - Blood, 2004 - bloodjournal.org
... genes still are the critical targets; however, MLL fusion proteins up-regulate multiple
Hox genes (including Hoxa5, Hoxa7, Hoxa9, Hoxa10, and Meis1 among others ...
Web Search

Rapid Generation of de novo Biological Pathways from Large-Scale Gene Expression Data Using the …
DC Siu - ingenuity.com
... TR ALPHA, HOXB7,TCF3, HOXB8, HOXC8, HOXA5, HOXD10, REN, HOXB3, HOXA3, HOXD3, CREBBP,
MEIS1, NCOR1, HDAC1 PKNOX1, PDGFRA, PBXIP1, IPF1, COL5A2, PLAU ...
View as HTML - Web Search

Analysis of HOX Homeodomain Proteins and Gene Transcripts in the Epidermis
LG Koemueves, C Largman - now.humanapress.com
... antibodies available from Santa Cruz Biotechnology (scbt@scbt.com): HOXA1 (N-20,
C-20); HOXA2 (N-20, P-20); HOXA5 (N-20 ... 1. MEIS1: guinea pig anti-protein. ...
Web Search - journals.humanapress.com - biomed.humanapress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Differences in Gene Expression between Wild Type and Hoxa 1 Knockout Embryonic Stem Cells after … - Full text - MIT Libraries
E Martinez-Ceballos, P Chambon, LJ Gudas - Journal of Biological Chemistry - jbc.org
... a 637-bp fragment was excised with EcoRI-BglII from pUC18-Hoxa5 (formerly known ...
Similarly, a 1.6-kb cDNA fragment of Meis1 was excised from the EcoRI site of ...
Web Search - jbc.org - ncbi.nlm.nih.gov

Functional and Cooperative Interactions between the Homeodomain PDX 1, Pbx, and Prep 1 Factors on … - Full text - MIT Libraries
G Goudet, S Delhalle, F Biemar, JA Martial, B … - J Biol Chem, 1999 - jbc.org
... Competitions with the Hoxa5 peptide (QPQIYPWMRKLH) were carried out by preincubating
the ... and Expression of Proteins-- The cDNAs coding for Meis1 (28) (generous ...
Cited by 33 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Gene expression profiling of pediatric acute myelogenous leukemia - Full text - MIT Libraries
ME Ross, R Mahfouz, M Onciu, HC Liu, X Zhou, G … - Blood, 2004 - bloodjournal.org
... Among these are genes that are expressed in the majority of MLL chimeric fusion
gene–containing cases, including MBNL1, MEIS1, HOXA4, HOXA5, HOXA9 HOXA10 ...
Cited by 8 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov

Homeodomain Sequences
SD Subsets, V Plots - pnas.org
... HB9, HB24, HD1, Hesx1, HEX, HOX11L1, HOX11L2, HOXA1, HOXA2, HOXA3, HOXA4, HOXA5,
HOXA6, HOXA7 ... 2, LH-2, Lhx3, Lhx4, Lhx5, Lim-1, LMX1, MBH1, MEIS1, Meis2, Meis3 ...
Web Search

Hox regulation of normal and leukemic hematopoietic stem cells.
C Abramovich, RK Humphries - Current Opinion in Hematology, 2005 - co-hematology.com
... and propose that the 'Hox code' minimally defined by the Hoxa5-a9 cluster is ... with
NUP98-Hox fusion genes undergo leukemic progression by Meis1 independent of ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of …
S Debernardi, DM Lillington, T Chaplin, S … - Genes Chromosomes and Cancer, 2003 - doi.wiley.com
... and HOXA5, jointly overexpressed in conjunction with five HOXB family members, HOXB2,
HOXB3, HOXB5, HOXB6, and HOXB7 (Giampaolo et al., 1994), and MEIS1 and ...
Cited by 27 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Differential Expression of Homeobox Genes in Functionally Distinct CD34 Subpopulations of Human Bone … - Full text - MIT Libraries
G Sauvageau, PM Lansdorp, CJ Eaves, DE Hogge, WH … - Proceedings of the National Academy of Sciences - pnas.org
... Pineault, C. Abramovich, H. Ohta, and RK Humphries Differential and Common Leukemogenic
Potentials of Multiple NUP98-Hox Fusion Proteins Alone or with Meis1 Mol ...
Cited by 174 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Progress in Hematology
Y Hayashi - cardenjennings.metapress.com
... con- sistent differences in expression [13].The genes HOXA9 and HOXA5 were not ... The
gene MEIS1, encoding a cofactor for HOX proteins that could accelerate Hoxa9 ...
Web Search

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa 7 and Hoxa 9 - Full text - MIT Libraries
PM Ayton, ML Cleary - Genes & Development, 2003 - genesdev.org
... evidenced by low levels of Hoxa1, higher levels of Hoxa3 and Hoxa5, and complete ...
Meis1, but not Meis2 or Meis3 was expressed in all MPMP lines immortalized by ...
Cited by 27 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and …
MC Center - Leukemia, 2003 - nature.com
... expression of Pbx2 and Pbx3, respectively (Table 1). The expression of Meis1 was
similar ... 4.0) Expressed only in t(4;11) samples HoxA4 M74297 HoxA5 M26679 HoxA7 ...
Web Search - ecu.edu

HOX genes: not just myeloid oncogenes any more.
HJ Lawrence, NA Fischbach, C Largman - Leukemia, 2005 - nature.com
... with NUP98-Hox fusion genes undergo leukemic progression by Meis1 independent of ...
Compromised HOXA5 function can limit p53 expression in human breast tumours. ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

A Conserved C-terminal Domain in PBX Increases DNA Binding by the PBX Homeodomain and Is Not a … - Full text - MIT Libraries
NC Green, I Rambaldi, J Teakles, MS Featherstone - J Biol Chem, 1998 - jbc.org
... combined misexpression of Hox genes and the PBX-related gene Meis1 causes leukemia ...
The second model is supported by data showing that HOXA5 can weakly interact ...
Cited by 13 - Web Search - dx.doi.org - jbc.org - ncbi.nlm.nih.gov

HOX and Non-HOX Homeobox Genes in Leukemic Hematopoiesis - Full text - MIT Libraries
BM Owens, RG Hawley - Stem Cells, 2002 - stemcells.alphamedpress.org
... differentiation, while the use of antisense oligonucleotides targeting HOXA5 results
in a ... Meis1 was found to be routinely coactivated with Hoxa7 and Hoxa9 ...
Cited by 32 - Web Search - stemcells.alphamedpress.org - dx.doi.org - ncbi.nlm.nih.gov

MOLECULAR TARGETS FOR THERAPY (MTT)
J Roche, C Zeng, A Baron, S Gadgil, RM Gemmill, I … - Leukemia, 2004 - nature.com
... Constitutive HOXA5 expression inhibits erythropoiesis and increases myelopoiesis
from human ... L, Blasi F, Sauvageau G. Defining roles for HOX and MEIS1 genes in ...
Web Search

HOXC 13 Is Involved in the Regulation of Human Hair Keratin Gene Expression - Full text - MIT Libraries
LF Jave-Suarez, H Winter, L Langbein, MA Rogers, J … - J Biol Chem, 2002 - jbc.org
... both the Hoxc8-mediated repression of the osteopontin gene and the HOXA5-controlled
activation ... associate with members of Exd/Pbx (25, 26) or Meis1 (27) family ...
Cited by 23 - Web Search - dx.doi.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

Human Homeobox HOXA 7 Regulates Keratinocyte Transglutaminase Type 1 and Inhibits Differentiation - Full text - MIT Libraries
PT La Celle, RR Polakowska - J Biol Chem, 2001 - jbc.org
... report establishes that keratinocyte expression of HOX genes HOXA7, HOXA5, and possibly ...
physically interact with the homeodomain cofactor PBX or MEIS1, or both ...
Cited by 9 - Web Search - jbc.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Proliferation of primitive myeloid progenitors can be reversibly induced by HOXA10 - Full text - MIT Libraries
JM Bjornsson, E Andersson, P Lundstrom, N Larsson, … - Blood, 2001 - bloodjournal.org
... of Hox transcription factors in various other pathways; that is, HoxA5 affects
expression of p53 ... studies on the role of cofactors of Hox proteins, Meis1 and PBX ...
Cited by 15 - Web Search - dx.doi.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Deregulated homeobox gene expression in cancer: cause or consequence? - Full text - MIT Libraries
C Abate-Shen - Nature Reviews Cancer, 2002 - nature.com
... | PubMed | ISI | ChemPort |. 50. Raman, V. et al. Compromised HOXA5 function can
limit p53 expression in human breast tumours. Nature 405, 974-978 (2000). ...
Cited by 38 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The Kinetic Status of Hematopoietic Stem Cell Subpopulations Underlies a Differential Expression of … - Full text - MIT Libraries
R Manfredini, R Zini, S Salati, M Siena, E … - Stem Cells, 2005 - stemcells.alphamedpress.org
... cells (Fig. 5A ). Among them, HOXA5, HOXA9, HOXA10, HOXB2, HOXB5, Meis1,
and PBX2 are preferentially expressed by CD34 + cells. ...
Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells - Full text - MIT Libraries
C Buske, M Feuring-Buske, C Abramovich, K … - Blood, 2002 - bloodjournal.org
... interact directly with Meis1 but only with Pbx1 in contrast to HOXA10, which can
interact directly with both proteins. 13 , 18 HOXA5 overexpression, also in ...
Cited by 23 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

The pathophysiology of HOX genes and their role in cancer - Full text - MIT Libraries
DG Grier, A Thompson, A Kwasniewska, GJ McGonigle, … - J Pathol, 2005 - doi.wiley.com
... Hoxa5 does not decrease significantly during lung development and remains highly
expressed in the lungs of newborn animals, suggesting that Hox genes have ...
Cited by 1 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Full Article - Full text - MIT Libraries
FR Goodman, PJ Scambler - Clinical Genetics, 2001 - blackwell-synergy.com
... implicated in leukaemogenesis [59,60], and co-activation of MEIS1 and HOXA9 ...
Interestingly, HOXA5 has recently been shown to activate transcription of the key ...
Web Search - blackwell-synergy.com

HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and … - Full text - MIT Libraries
NA Fischbach, S Rozenfeld, W Shen, S Fong, D … - Blood, 2005 - bloodjournal.org
... reports, mice that received transplants of marrow transduced with MEIS1 alone remained ...
of HOX genes, including impaired erythropoiesis with HOXA5, impaired B ...
Cited by 1 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

Molecular Cytogenetics A new recurrent inversion, inv (7)(p15q34), leads to transcriptional …
F Speleman, B Cauwelier, N Dastugue, J Cools, B … - Leukemia, 2005 - nature.com
... kb genomic region containing all HOXA genes, most probably distal to HOXA5 and proximal ...
levels of a subset of HOX genes (HOXA9, HOXA10, HOXC6 and MEIS1) in MLL ...
Web Search - nature.com

Proliferation of primitive myeloid progenitors can be reversibly induced by HOXA10 - Full text - MIT Libraries
R studies show that several Hox - Blood, 2001 - bloodjournal.org
... This latency period can be shortened dramatically if the Hox cofactors,
Pbx1 or Meis1, are co-overexpressed with their Hox partner. ...
Web Search

Supplementary Data ‘Stemness’: Transcriptional Profiling of Embryonic and Adult Stem Cells
M Ramalho-Santos, S Yoon, Y Matsuzaki, RC Mulligan … - intl.sciencemag.org
... p21, the Ap-1 components Fos, FosB, Jun and JunB, Myc, N-Myc, Meis1, and
Yes. Strikingly, ... th , LCB=6.9) and HoxA5 (172 nd , LCB=4.4). ...
Web Search

Effects of HOX homeobox genes in blood cell differentiation - Full text - MIT Libraries
MC Magli, C Largman, HJ Lawrence - J Cell Physiol, 1997 - doi.wiley.com
... Interestingly, human bone marrow cells exposed to antisense HOXA5 oligonucleotides
also displayed a de ... made homo- a novel pbx-like homeobox gene, Meis1, in the ...
Cited by 57 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Protein Kinase C-Mediated Phosphorylation of the Leukemia-Associated HOXA9 Protein Impairs Its DNA … - Full text - MIT Libraries
U Vijapurkar, N Fischbach, W Shen, C Brandts, D … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... The Drosophila SCR protein, which is homologous to HOXA5, is both activated and ... HOXA9
DNA binding capacity, as well as being potentiated by the MEIS1 HD protein ...
Cited by 1 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

A new recurrent inversion, inv (7)(p15q34), leads to transcriptional activation of
F Speleman, B Cauwelier, N Dastugue, J Cools, B … - Leukemia, 2005 - nature.com
... 15 and correlated to the mean expression level of each gene. Primers for HOXA1,
HOXA4, HOXA5, HOXA7, HOXA11 were designed according to Thompson et al. ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Modulation of the Human Homeobox Genes PRX-2 and HOXB 13 in Scarless Fetal Wounds - Full text - MIT Libraries
EJ Stelnicki, J Arbeit, DL Cass, C Saner, M … - Journal of Investigative Dermatology, 1998 - blackwell-synergy.com
... the expression patterns of the many HOX genes (HOXA4, HOXA5, HOXA6, HOXA7 ... protein
forms complexes with the non HOX homeodomain protein Meis1 and stabilizes the ...
Cited by 25 - Web Search - jidonline.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Targeted down-regulation of MLL-AF9 with antisense oligodeoxyribonucleotide reduces the expression …
H Kawagoe, R Kawagoe, K Sano - nature.com
... and -A9 32 were made by RT-PCR with the following primers: HOXA5: forward primer ...
leukemia that outgrew in BXH-2 mouse together with Hoxa9 and Meis1, a binding ...
Web Search - nature.com

PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins - Full text - MIT Libraries
K Shanmugam, NC Green, I Rambaldi, HU Saragovi, MS … - Mol Cell Biol, 1999 - mcb.asm.org
... this been observed by other groups with HOXB7 (16) and HOXA5 (26 ... Meis1 and pKnox1
bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in ...
Cited by 42 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

[CITATION] The HOX homeodomain proteins block CBP histone acetyltransferase activity - Full text - MIT Libraries
WF Shen, K Krishnan, HJ Lawrence, C Largman - Mol. Cell. Biol, 2001
... Louis, Mo.). 35 S-labeled HOX, MEIS1, and PBX1a proteins were synthesized as previously
described (44) using the TNT system (Promega, Madison, Wis.). ...
Cited by 21 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - dx.doi.org - all 6 versions »

Activation of Stem-Cell Specific Genes by HOXA9 and HOXA10 Homeodomain Proteins in CD34 Human Cord …
CM Ferrell, ST Dorsam, H Ohta, RK Humphries, MK … - stemcells.alphamedpress.org
... of multiple NUP98-Hox fusion proteins alone or with Meis1. ... Constitutive HOXA5 expression
inhibits erythropoiesis and increases myelopoiesis from human ...
Web Search - dx.doi.org - stemcells.alphamedpress.org

Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be … - Full text - MIT Libraries
DB Sykes, MP Kamps - Blood, 2001 - bloodjournal.org
... are implicated in myeloid differentiation, 33 no expression of Hoxa5, Hoxa7, or ...
Furthermore, expression of Meis1, Meis2, and Meis3 was not detected in the ...
Cited by 10 - Web Search - bloodjournal.org - bloodjournal.org - ncbi.nlm.nih.gov - all 5 versions »

Acute Leukemias New insights into MLL gene rearranged acute leukemias using gene expression …
A Kohlmann, C Schoch, M Dugas, S Schnittger, W … - Leukemia, 2005 - nature.com
... As given in Figure 3, HOXA9 as well as MEIS1 show up as genes ... relationship with
t(11q23)/MLL leukemias, for example, HOXA cluster genes (HOXA5, HOXA10), as ...
Web Search - nature.com

Progress in Hematology
M Eguchi, M Eguchi-Ishimae, M Greaves - Int J Hematol, 2005 - cardenjennings.metapress.com
... lineage, have shown ele- vated expression of some Hox genes,such as HoxA4,HoxA5,
HoxA7, HoxA9, and HoxA10, and of a cofactor for Hox pro- teins, Meis1 [88-90,94 ...
Web Search

Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias - Full text - MIT Libraries
CW So, M Lin, PM Ayton, EH Chen, ML Cleary - Cancer Cell, 2003 - rkblab.biochem.uci.edu
... required genes (including HoxA5, A7, A9, and A10) and Hox cofactors Meis1
and Meis3. Expression of these genes was maintained by ...
Cited by 24 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Human HOX gene mutations - Full text - MIT Libraries
FR Goodman, PJ Scambler - Clinical Genetics, 2001 - ingentaconnect.com
Page 1. Clin Genet 2001: 59: 1–11 Printed in Ireland. All rights reser6ed Mini
Review Human HOX gene mutations Goodman FR, Scambler PJ. ...
Cited by 31 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Hox in hair growth and development - Full text - MIT Libraries
A Awgulewitsch - Naturwissenschaften, 2003 - springerlink.com
Page 1. Naturwissenschaften (2003) 90:193–211 DOI 10.1007/s00114-003-0417-4 REVIEW
ARTI CLE Alexander Awgulewitsch Hox in hair growth and development ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - adsabs.harvard.edu

Identification of Cis-Element Regulating Expression of the Mouse Fgf10 Gene during Inner Ear …
H Ohuchi, A Yasue, K Ono, S Sasaoka, S Tomonari, A … - Key words, 2005 - doi.wiley.com
Page 1. PATTERNS & PHENOTYPES Identification of Cis-Element Regulating Expression
of the Mouse Fgf10 Gene during Inner Ear Development ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Changes in HOXB 6 homeodomain protein structure and localization during human epidermal development … - Full text - MIT Libraries
LG Koemueves, WF Shen, A Kwong, E Stelnicki, S … - Developmental Dynamics, 2000 - doi.wiley.com
... The HOXA1 and HOXA5 genes are also expressed as alternative tran- scripts which
would ... de- tect binding of the HOX proteins below paralog 8 to MEIS1 (Shen et al ...
Cited by 15 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with … - Full text - MIT Libraries
E Hedlund, SL Karsten, L Kudo, DH Geschwind, EM … - Journal of Neuroscience Research, 2004 - doi.wiley.com
... Thorensteinsdottir et al., 1997). Additionally, Hoxa5 in- activates the tumor
suppressor gene p53, while Hoxa10 Contract grant sponsor ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov