Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias
HJ Lawrence, S Rozenfeld, C Cruz, K Matsukuma, A … - Leukemia, 1999 - nature.com
... 1996 Table 1 HOXA9 and MEIS1 expression in myeloid leukemic samples Sample No.
Diagnosis HOXA9 MEIS1 ... FAB Patient No. HOXA9 Meis1 M0 06–08 3+ 2+ 06–09 3+ 1+ ...
Cited by 47 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells - Full text - MIT Libraries
WF Shen, S Rozenfeld, A Kwong, LG Koemueves, HJ … - Mol Cell Biol, 1999 - mcb.asm.org
... In a similar manner, the binding of MEIS1 to HOXA9 was increased fivefold
in the presence of PBX2 (compare lane 15 with lane 14). ...
Cited by 19 - Web Search - mcb.asm.org - pubmedcentral.nih.gov

[CITATION] Kom ves LG, Lawrence HJ, Largman C. HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid … - Full text - MIT Libraries
WF Shen, S Rozenfeld, A Kwong, LG Komuves - Mol Cell Biol, 1999
Cited by 40 - Web Search

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia - Full text - MIT Libraries
SA Armstrong, JE Staunton, LB Silverman, R Pieters … - Nature Genetics, 2002 - nature.com
... al. Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the
t(4:11) abnormality. Oncogene 20, 874-878 (2001). | Article ...
Cited by 268 - Web Search - ciml.univ-mrs.fr - ncbi.nlm.nih.gov - all 5 versions »

Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia - Full text - MIT Libraries
U Thorsteinsdottir, E Kroon, L Jerome, F Blasi, G … - Mol Cell Biol, 2001 - dx.doi.org
... JL, Slany, RK (2004). Hoxa9 and Meis1 Are Key Targets for MLL-ENL-Mediated
Cellular Immortalization. Mol. Cell. Biol. 24: 617-628 ...
Cited by 44 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization - Full text - MIT Libraries
BB Zeisig, T Milne, MP Garcia-Cuellar, S Schreiner … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... Notably, however, MLL-ENL-ERtm cells that had been transduced with a combination
of Meis1 and Hoxa9 remained proliferative (>3 months in continuous culture ...
Cited by 12 - Web Search - dx.doi.org - mcb.asm.org - ncbi.nlm.nih.gov - all 6 versions »

Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: Potential mechanisms … - Full text - MIT Libraries
KR Calvo, PS Knoepfler, DB Sykes, MP Pasillas, MP … - Blood, 2005 - dx.doi.org
... U. Fuchs, A. Borkhardt, SK Chanda, J. Walker, R. Soden, JL Hess, and RK Slany Hoxa9
and Meis1 Are Key Targets for MLL-ENL-Mediated Cellular Immortalization Mol ...
Cited by 22 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Cooperative activation of Hoxa and Pbx 1-related genes in murine myeloid leukaemias
T Nakamura, DA Largaespada, JD Shaughnessy, NA … - Nature Genetics, 1996 - ncbi.nlm.nih.gov
... Proviral activation of Hoxa7 or Hoxa9 is strongly correlated with proviral activation
of Meis1 implying that Hoxa7 and Hoxa9 cooperate with Meis1 in leukaemia ...
Cited by 117 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

NUP 98-HOXA 9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in … - Full text - MIT Libraries
E Kroon, U Thorsteinsdottir, N Mayotte, T Nakamura … - The EMBO Journal, 2001 - embojournal.npgjournals.com
... post-BMT), Meis1 plus NUP98–HOXA9 (142 ± 52 days), Hoxa9 (BMT dose, 700 transduced
CFC per mouse, AML onset 128 ± 15 days) and Meis1 plus Hoxa9 (100 doubly ...
Cited by 47 - Web Search - emboj.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

SHORT REPORT Frequent co-expression of HoxA9 and Meis1 genes in infant acute lymphoblastic leukaemia … - Full text - MIT Libraries
T Imamura, A Morimoto, M Takanashi, S Hibi, T … - British Journal of Haematology, 2002 - blackwell-synergy.com
... J., Nakamura, T., Croce, CM, Cimino, G. & Canaani, E. (2001) Upregulation of Meis1
and HoxA9 in acute lymphocytic leukemias with the t(4;11) abnormality. ... Meis1. ...
Cited by 6 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable … - Full text - MIT Libraries
KR Calvo, DB Sykes, M Pasillas, MP Kamps - Mol Cell Biol, 2000 - dx.doi.org
... The genes encoding Hoxa9 and Meis1 are transcriptionally coactivated in
a subset of acute myeloid leukemia (AML) in mice. In marrow ...
Cited by 33 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Induction of acute myeloid leukemia (AML) in mice by the human leukemia-specific fusion gene NUP98- … - Full text - MIT Libraries
N Pineault, C Buske, M Feuring-Buske, C Abramovich … - Mol. Cell. Biol, 2004 - bloodjournal.org
... 6 WBC/ml), anemia (1.5- 4.6x10 9 RBC/ml) and splenomegaly (0.2- 0.5g). The expression
of Hoxa7 and Hoxa9 but not Meis1 is upregulated in NUP98-HOXD13 BM cells. ...
Cited by 14 - Web Search - dx.doi.org - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

MEIS1 and HOXA7 genes in human acute myeloid leukemia
O Afonja, JE Smith Jr, DM Cheng, AS Goldenberg, E … - Leuk Res, 2000 - ncbi.nlm.nih.gov
... In this study we determined their expression in human leukemia. Most human myeloid
leukemia cell lines co-expressed MEIS1 with HOXA7 and HOXA9. ...
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Expression of HOX genes in acute leukemia cell lines with and without MLL translocations
H Quentmeier, WG Dirks, RAF MacLeod, J Reinhardt, … - Leuk Lymphoma, 2004 - dx.doi.org
... Meis1 Meis1 HoxA9 HoxA9 HoxA9 FLT3 FLT3 FLT3 ... Of the 4 genes tested, MEIS1 and HOXA9
seemed to be most promising for distinguishing between MLL mu ...
Cited by 3 - Web Search - taylorandfrancis.metapress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa 7 and Hoxa 9 - Full text - MIT Libraries
PM Ayton, ML Cleary - Genes & Development, 2003 - genesdev.org
... Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4:
11) abnormality. Oncogene 20: 874-878.[CrossRef][Medline]. ...
Cited by 27 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Meis1-mediated apoptosis is caspase-dependent and can be suppressed by coexpression of HoxA9 in … - Full text - MIT Libraries
PJ Wermuth, AM Buchberg - Blood, 2005 - bloodjournal.org
... Meis1-HoxA9 cooperation suppresses several myeloid differentiation pathways. ... Hoxa9
and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. ...
Cited by 3 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t (12; 13 … - Full text - MIT Libraries
VPS Rawat, M Cusan, A Deshpande, W Hiddemann, L … - Proc Natl Acad Sci US A, 2004 - pubmedcentral.nih.gov
... The annealing temperatures were 58°C and 60°Cfor Meis1 and Hoxa9, respectively.
The number of PCR cycles for each gene was chosen ...
Cited by 6 - Web Search - dx.doi.org - intl.pnas.org - pnas.org - all 8 versions »

Hematopoietic, angiogenic and eye defects in Meis 1 mutant animals - Full text - MIT Libraries
T Hisa, SE Spence, RA Rachel, M Fujita, T Nakamura … - The EMBO Journal, 2004 - embojournal.npgjournals.com
... Meis1 and Hoxa9 expression is upregulated by retroviral integration in murine myeloid
leukemias and in human leukemias carrying MLL translocations. ...
Cited by 9 - Web Search - nature.com - embojournal.npgjournals.com - ncbi.nlm.nih.gov

Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in … - Full text - MIT Libraries
PS Knoepfler, KR Calvo, H Chen, SE Antonarakis, MP … - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... proliferation by SCF: Potential mechanisms of cooperativity with Hoxa9 in myeloid ...
Yin, and FB Hillgartner The Homeodomain Proteins PBX and MEIS1 Are Accessory ...
Cited by 64 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 7 versions »

Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism … - Full text - MIT Libraries
K Kirito, N Fox, K Kaushansky - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... colleagues (7). These investigators introduced a MEIS1 cDNA into HOXA9-transformed
murine bone marrow cells and analyzed intracellular localization of HOXA9. ...
Cited by 5 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

HOX and Non-HOX Homeobox Genes in Leukemic Hematopoiesis - Full text - MIT Libraries
BM Owens, RG Hawley - Stem Cells, 2002 - stemcells.alphamedpress.org
... of Hoxa9 alone [9]. Coexpression of HOXA9/HOXA7 and MEIS1 has been observed in human
AML, suggesting that collaboration between HOXA9 and MEIS1 is relevant to ...
Cited by 32 - Web Search - stemcells.alphamedpress.org - dx.doi.org - ncbi.nlm.nih.gov

[CITATION] ves Kom, LG; Lawrence, HJ; Largman, C.," HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid …
WF Shen, S Rozenfeld, A Kwong - Mol. Cell. Biol, 1999
Cited by 2 - Web Search - Get it from MIT Libraries

The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32 - Full text - MIT Libraries
N Spieker, P van Sluis, M Beitsma, K Boon, BD van … - Genomics, 2001 - ingentaconnect.com
... cases. The MEIS1 homeobox protein forms a complex with the HOXA9 and PBX
proteins that are implicated in human leukemia. MEIS1 is ...
Cited by 19 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with … - Full text - MIT Libraries
N Pineault, C Abramovich, H Ohta, RK Humphries - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in
a manner similar to that induced by retroviral coexpression of Hoxa9 and Meis1. ...
Cited by 11 - Web Search - dx.doi.org - mcb.asm.org - ncbi.nlm.nih.gov - all 6 versions »

Protein Kinase C-Mediated Phosphorylation of the Leukemia-Associated HOXA9 Protein Impairs Its DNA … - Full text - MIT Libraries
U Vijapurkar, N Fischbach, W Shen, C Brandts, D … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... vitro-synthesized HOXA9 also reduced its capacity to form a heterodimeric complex
with MEIS1 on an oligonucleotide target containing a MEIS1-HOXA9 site (data ...
Cited by 1 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and … - Full text - MIT Libraries
LH Kasper, PK Brindle, CA Schnabel, CE Pritchard, … - Mol Cell Biol, 1999 - mcb.asm.org
... Transformation driven by cooverexpression of HOXA9 and MEIS1 does not seem to require
a gain of transactivation function of HOXA9, suggesting that the ...
Cited by 67 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

The Role of NUP98 Gene Fusions in Hematologic Malignancy
C SLAPE, PD APLAN - therapy - dx.doi.org
... In mice, overexpression of Meis1 and HoxA9 leads to leukemic transformation
more rapidly than does over- expression of HoxA9 alone [31]. ...
Cited by 4 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity - Full text - MIT Libraries
Y Jacobs, CA Schnabel, ML Cleary - Mol. Cell. Biol, 1999 - mcb.asm.org
... Recent retroviral gene transfer experiments provide more direct genetic evidence
that Meis1 and Hoxa9 collaborate in myeloid oncogenesis (18), and Hoxa9 and ...
Cited by 74 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Transplantable cell lines generated with NUP98–Hox fusion genes undergo leukemic progression by …
V Columbia, C BC - Leukemia, 2005 - nature.com
... HOXA9. 16 However, in their experimental settings, HOXA9- immortalized cells
did not produce AML upon expression of Meis1. A conceivable ...
Cited by 1 - Web Search - nature.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Meis and Hox: a mighty pair defeats apoptosis - Full text - MIT Libraries
T Nakamura - Blood, 2005 - bloodjournal.org
... 2,3 The cooperative leukemogenic activity of Meis1 and HoxA9 has been further confirmed
by the fact that Meis1 overexpression significantly accelerates disease ...
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The HOX-MEIS connection in AML - Full text - MIT Libraries
HJ Lawrence, C Largman - Blood, 2005 - bloodjournal.org
... Previous studies have shown that Meis1 and Hoxa9 form dimeric cooperative DNA binding
complexes, as well as triple complexes containing the PBX protein. ...
Web Search

[CITATION] Hoxa9 and Meis1 Are Key Targets for MLL-ENL-Mediated Cellular Immortalization
S In, S Up
Web Search

Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires … - Full text - MIT Libraries
GG Wang, MP Pasillas, MP Kamps - Blood, 2005 - bloodjournal.org
... 5,6 The cooperating nature of Meis1 and Hoxa9 in leukemia was verified by using
retrovirus to express these genes in primary bone marrow and then using the ...
Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

Expression of HOX Genes in Acute Leukemia Cell Lines with and without MLL Translocations
R Macleod, J Reinhardt, M Zaborski, H Quentmeier, … - Leukemia and Lymphoma, 2004 - ingentaconnect.com
... These results suggest that MLL aberrations may regulate MEIS1 and HOXA9 gene expression
in ALL-derived cell lines, while AML-derived cell lines express these ...
Web Search

The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin - Full text - MIT Libraries
DT Zeisig, CB Bittner, BB Zeisig, MP Garcia- … - Oncogene, 2005 - nature.com
... Among the identified targets, the homeobox transcription factors Meis1 and Hoxa9
are two critical downstream effectors for MLL fusion mediated transformation ( ...
Web Search - nature.com - ncbi.nlm.nih.gov

Retroviral insertional mutagenesis identifies oncogene cooperation. - Full text - MIT Libraries
T Nakamura - Cancer Science, 2005 - blackwell-synergy.com
... reported that overexpression of Meis1 accelerates Hoxa9-induced AML, (12) and also
its chimeric form of NUP98-HOXA9-induced AML, (13) which was identified in ...
Web Search - ncbi.nlm.nih.gov

HOXA 9 Activates Transcription of the Gene Encoding gp 91 Phox during Myeloid Differentiation - Full text - MIT Libraries
L Bei, YF Lu, EA Eklund - J Biol Chem, 2005 - jbc.org
... Although this latency is longer than in experiments with Nup98-A9 or Meis1 plus
HoxA9 overexpression, it is rapid and reproducible in comparison to HoxA9 ...
Web Search - jbc.org - ncbi.nlm.nih.gov

Original Research Report
T TSANG, DT HARRIS - dx.doi.org
... antigen CD34 AA434387 CD34 angtigen Transcription factor/activity HOXA9
AA496921 Homeo box A9 HOXB2 AA911661 Homeo box B2 MEIS1
Web Search - liebertonline.com - liebertonline.com

Hox Genes: From Leukemia to Hematopoietic Stem Cell Expansion - Full text - MIT Libraries
C ABRAMOVICH, N PINEAULT, H OHTA, RK HUMPHRIES - Ann. NY Acad. Sci, 2005 - annalsnyas.org
... T. et al. 2001. Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias
with the t(4 : 11) abnormality. Oncogene 20: 874-878 ...
Web Search - annalsnyas.org - ncbi.nlm.nih.gov

Hox regulation of normal and leukemic hematopoietic stem cells.
C Abramovich, RK Humphries - Current Opinion in Hematology, 2005 - co-hematology.com
... al. Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the
t(4: 11) abnormality. Oncogene 2001; 20:874-878. [Context ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Meis1 (C-17): sc-10599
S CRUZ - cosmobio.co.jp
... C. 1999. Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human
myeloid leukemias. Leukemia 13: 1993-1999. 3. Shanmugam ...
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MLL, Hox genes, and leukemia: the plot thickens - Full text - MIT Libraries
JL Hess - Blood, 2004 - bloodjournal.org
... using a conditionally transforming version of MLL-ENL, collaborator Robert Slany's
laboratory and mine found that expression of Hoxa9 plus Meis1 was sufficient ...
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Fusion Genes Transplantable cell lines generated with NUP98− Hox fusion genes undergo leukemic …
N Pineault, C Abramovich, RK Humphries - Leukemia, 2005 - nature.com
... seem to block differentiation and only slightly increased self-renewal, consistent
with the reported lack of effect of Meis1 on NUP98−HOXA9 immortalized lines ...
Web Search

Identification of a new family of Pbx-related homeobox genes
T Nakamura, NA Jenkins, NG Copeland - Oncogene, 1996 - ncbi.nlm.nih.gov
... modulate the otherwise similar DNA bind specificities of Hox proteins, these results
suggested that Meis1 may function as a cofactor for Hoxa7 and Hoxa9 in the ...
Cited by 45 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Expression of BEX1 in acute myeloid leukemia with MLL rearrangements.
H Quentmeier, R Tonelli, R Geffers, A Pession, CC … - Leukemia, 2005 - nature.com
... of the 'mixed lineage leukemia' (MLL) gene: like the respective primary tumor cells,
these cell lines can be classified on the basis of MEIS1, HOXA9 and FLT3 ...
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Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model - Full text - MIT Libraries
M Iwasaki, T Kuwata, Y Yamazaki, NA Jenkins, NG … - Blood, 2005 - bloodjournal.org
... Retroviral constructs. Retroviral constructs encoding NUP98-HOXA9 and Meis1
were described previously. 19,26 Hemagglutinin (HA) epitope ...
Cited by 2 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Rapid Generation of de novo Biological Pathways from Large-Scale Gene Expression Data Using the …
DC Siu - ingenuity.com
... Application RBBP7 MST4 SH3BP2 FLI1 SYK HDAC6 (In Network 1.Data not shown)
MBP MEIS1 HOXA9 PBX1 PBX2 LGALS1 CD44 CD4 regulates MBP ...
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Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell … - Full text - MIT Libraries
U Thorsteinsdottir, A Mamo, E Kroon, L Jerome, J … - Blood, 2002 - bloodjournal.org
... U. Fuchs, A. Borkhardt, SK Chanda, J. Walker, R. Soden, JL Hess, and RK Slany Hoxa9
and Meis1 Are Key Targets for MLL-ENL-Mediated Cellular Immortalization Mol ...
Cited by 34 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov

AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins - Full text - MIT Libraries
WF Shen, JC Montgomery, S Rozenfeld, JJ Moskow, HJ … - Mol Cell Biol, 1997 - mcb.asm.org
... AbdB-Like Hox Proteins Stabilize DNA Binding by the Meis1 Homeodomain Proteins ...
These integrations result in constitutive activation of Meis1. ...
Cited by 86 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging … - Full text - MIT Libraries
N Mayotte, DC Roy, J Yao, E Kroon, G Sauvageau - Blood, 2002 - bloodjournal.org
... supported the ex vivo expansion of leukemia-repopulating cells (the myeloid leukemia
was generated from BM cells overexpressing HOXA9 plus Meis1 as described 5 ...
Cited by 6 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov