The homeodomain protein Meis 1 is essential for definitive hematopoiesis and vascular patterning in … - Full text - MIT Libraries
V AZCOITIA, M ARACIL, C MARTINEZA, M TORRES - Developmental Biology, 2005 - ncbi.nlm.nih.gov
... Homeodomain Proteins; Meis1 protein; Neoplasm Proteins; Platelet Membrane Glycoprotein
IIb; Proto-Oncogene Proteins; Runx1 protein; Transcription Factors. PMID ...
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Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t (11; 12)(p …
R La Starza, M Trubia, B Crescenzi, C Matteucci, M … - Genes Chromosomes Cancer, 2003 - doi.wiley.com
... NUP98/HOXD13 requires co-expression of other genes, such as the human MEIS1 (an ... by
Dr. M. Rocchi, University of Bari, Italy), which spans the RUNX1 gene at ...
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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and … - Full text - MIT Libraries
Q Wang, T Stacy, M Binder, M Marin-Padilla, AH … - Developmental Biology, 1996 - dx.doi.org
... T. Stacy, CJ Matheny, NA Speck, and M. FTR de Bruijn Runx1 Is Expressed in ... and N.
G Copeland Hematopoietic, angiogenic and eye defects in Meis1 mutant animals ...
Cited by 368 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 7 versions »

Gene Expression Profiling and Microarrays Gene expression profiling of leukemic cell lines reveals …
A Andersson, P Eden, D Lindgren, J Nilsson, C … - Leukemia, 2005 - nature.com
... 28 In our data set, two cell lines harbored RUNX1/CBFA2T1 and CBFA2T1 was ... Hoxa9 and
Meis1 are key targets for MLL-ENL-mediated cellular immortalization. ...
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Hematopoietic, angiogenic and eye defects in Meis 1 mutant animals - Full text - MIT Libraries
T Hisa, SE Spence, RA Rachel, M Fujita, T Nakamura … - The EMBO Journal, 2004 - embojournal.npgjournals.com
... Meis1 appears to act later in embryonic development than other transcription factors
such as GATA3 (Pandolfi et al, 1995), RUNX1 (Okuda et al, 1996; Wang et al ...
Cited by 9 - Web Search - nature.com - embojournal.npgjournals.com - ncbi.nlm.nih.gov

Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of …
S Debernardi, DM Lillington, T Chaplin, S … - Genes Chromosomes and Cancer, 2003 - doi.wiley.com
... M2 (LSI BCR-ABL ES; Vysis), t(8;21) in M2 (LSI RUNX1-CBFA2T1 dual ... members, HOXB2,
HOXB3, HOXB5, HOXB6, and HOXB7 (Giampaolo et al., 1994), and MEIS1 and PBX3 ...
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Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling
BJ Quade, TY Wang, K Sornberger, PD Cin, GL Mutter … - Genes Chromosomes and Cancer, 2004 - doi.wiley.com
Page 1. Molecular Pathogenesis of Uterine Smooth Muscle Tumors from
Transcriptional Profiling Bradley J. Quade, 1* Tao-Yeuan Wang ...
Cited by 7 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genetic programs regulating HSC specification, maintenance and expansion - Full text - MIT Libraries
J Lessard, A Faubert, G Sauvageau - Oncogene, 2004 - nature.com
... et al., 1996; Lacaud et al., 2002) (also known as RUNX1/CBFA2 and ... Meis1 Embryonic
lethality, absence of megakaryocytes, reduced fetal liver CFCs (Hisa et al ...
Web Search - ncbi.nlm.nih.gov

Design Principle of Gene Expression Used by Human Stem Cells; Implication for Pluripotency
R Title - arxiv.org
... The common genes include CD34, AC133, BMI1, TIE, HOXA10, FZD6, SOX4, TCF3, RUNX1,
FLT3, LMO2, SCA1, MEIS1, MPL, TEK, SCA1, MDR1 and others. Theses genes ...
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BIO-TECHNICAL METHODS (BTS)
J Qiu, P Gunaratne, LE Peterson, D Khurana, N … - Leukemia, 2003 - nature.com
... DAD1 and MEIS1 expression was consistently elevated in the t(4;11) subgroup but
HOXA9 expression was ... 12 21–30 AML1, RUNX1 Acute myeloid leukemia 1 gene 21 ...
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The Molecular Basis of Leukemia - Full text - MIT Libraries
DG Gilliland, CT Jordan, CA Felix, CT Jordan - Hematology, 2004 - asheducationbook.org
... When mutations such as RUNX1-ETO are expressed alone, they impair differentiation ...
translocations, it recently was observed that the Hoxa9 and Meis1 genes are ...
Cited by 1 - Web Search - neuroscienzemolecolari.it - asheducationbook.org - ncbi.nlm.nih.gov

Children and adults with acute lymphoblastic leukaemia have similar gene expression profiles. - Full text - MIT Libraries
E Kuchinskaya, M Heyman, D Grander, M Linderholm, … - European Journal Of Haematology, 2005 - blackwell-synergy.com
... included into the study: 7 with MLL rearrangement, 8 with ETV6/RUNX1, 5 with ... which
corresponded to T-lineage leukaemia (p<0.0001), rearrangements of ETV6/RUNX1 ...
Web Search - blackwell-synergy.com - ejh.dk - ncbi.nlm.nih.gov

The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t (2; 11)(q31; p15) - Full text - MIT Libraries
T Taketani, T Taki, N Shibuya, E Ito, J Kitazawa, … - Cancer Res, 2002 - cancerres.aacrjournals.org
... specific subtypes of hematological malignancies (1, 2, 3) . The AML1 (RUNX1), MLL,
MOZ ... Hoxb8 with interleukin-3, Hoxa10, Hoxb3, and Hoxa9, with Meis1 in murine ...
Cited by 26 - Web Search - intl-cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Progress in Hematology
M Eguchi, M Eguchi-Ishimae, M Greaves - Int J Hematol, 2005 - cardenjennings.metapress.com
... of HoxA9 and other Hox proteins in which the Hox cofactor Meis1 can accelerate ... rule,
as, for example, in childhood ALL with TEL-AML1 (ETV6- RUNX1) fusion or in ...
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The Kinetic Status of Hematopoietic Stem Cell Subpopulations Underlies a Differential Expression of … - Full text - MIT Libraries
R Manfredini, R Zini, S Salati, M Siena, E … - Stem Cells, 2005 - stemcells.alphamedpress.org
... CD34 + cells, because TPO response genes, such as HOXB4, CBFß, Runx1, Nfe-2 ... Among
them, HOXA5, HOXA9, HOXA10, HOXB2, HOXB5, Meis1, and PBX2 are preferentially ...
Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

Gene Expression Profile in AML Gene expression profile reveals deregulation of genes with relevant …
NC Gutierrez, R Lopez-Perez, JM Hernandez, I … - Leukemia, 2005 - nature.com
... A5, A6, A7, A9, A10, B2, B5 and B7) and the TALE proteins (MEIS1 and PBX3 ... However,
RUNX1 (at 21q22) expression levels had similar intensity in all AML cases and ...
Web Search - nature.com

TRANSCRIPTION FACTORS
OFB CELLS - doi.wiley.com
... II TRANSCRIPTION FACTORS AND THE MYELOID LINEAGE 85 6 RUNX1(AML1) and CBFB: Genes
Required for the Development of All Definitive Hematopoietic Lineages 87 ...
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Analysis of translocations that involve the NUP98 gene in patients with 11p15 chromosomal …
YN Kobzev, J Martinez-Climent, S Lee, J Chen, JD … - GENES, CHROMOSOMES & CANCER, 2004 - doi.wiley.com
... Thus, NUP98, along with MLL, ETV6 (TEL), and RUNX1 (AML1), is one of the rare genes
that have numerous genetic partners with vastly different functions. ...
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Gene expression profile reveals deregulation of genes with relevant functions in the different …
S Salamanca-CSIC - Leukemia, 2005 - nature.com
... A5, A6, A7, A9, A10, B2, B5 and B7) and the TALE proteins (MEIS1 and PBX3 ... However,
RUNX1 (at 21q22) expression levels had similar intensity in all AML cases and ...
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Gene expression profiling of pediatric acute myelogenous leukemia - Full text - MIT Libraries
ME Ross, R Mahfouz, M Onciu, HC Liu, X Zhou, G … - Blood, 2004 - bloodjournal.org
... Among these are genes that are expressed in the majority of MLL chimeric fusion
gene–containing cases, including MBNL1, MEIS1, HOXA4, HOXA5, HOXA9 HOXA10 ...
Cited by 8 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov

The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice - Full text - MIT Libraries
C Schessl, VPS Rawat, M Cusan, A Deshpande, TM … - J. Clin. Invest, 2005 - jci.org
... of genetic alterations in patients with AML have demonstrated that genetic lesions
of more than 1 transcriptional regulator, such as AML1-ETO (RUNX1-MTG8), HOX ...
Web Search - pubmedcentral.nih.gov - jci.org

SUPPLEMENTARY DATA FOR CLASSIFICATION, SUBTYPE DISCOVERY, AND PREDICTION OF OUTCOME IN PEDIATRIC …
I Section, E Methods, II Section, P Dataset - stjuderesearch.org
Page 1. SUPPLEMENTARY DATA FOR CLASSIFICATION, SUBTYPE DISCOVERY, AND PREDICTION
OF OUTCOME IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA ...
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Animal models of acute myelogenous leukaemia– development, application and future perspectives
E Mc Cormack, O Bruserud, BT Gjertsen - Leukemia, 2005 - nature.com
... Firstly, the AML1(Cbfa2, Runx1, Pebp2 B) 84 oncogene targeted by chromosomal ...
Co-expression and interaction of NUP98−HOX9 with Meis1 has been shown to ...
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Transcriptional Profiling During the Early Differentiation of Granulocyte and Monocyte Progenitors …
DB Sykes, J Scheele, M Pasillas, MP Kamps - Leukemia & Lymphoma, 2003 - dx.doi.org
... E2a–Pbx1 can heterodimerize with Hox proteins but cannot heterodimerize with Meis1
because the first 89 residues of Pbx1 contain a portion of the Meis ...
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Bibliography Current World Literature
JY Bertrand, S Giroux, R Golub… - Current Opinion in Hematology, 2005 - co-hematology.com
... R, Gao H, et al.: Early B cell factor cooperates with Runx1 and mediates ... Rachel RA,
et al.: Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. ...
Web Search - co-gastroenterology.com - co-ophthalmology.com - coronary-artery.com

[BOOK] Cytogenetic and molecular genetic changes in childhood acute leukaemias
T Niini - 2002 - ethesis.helsinki.fi
Page 1. Department of Medical Genetics Haartman Institute University of Helsinki
Finland Cytogenetic and Molecular Genetic Changes in Childhood Acute Leukaemias ...
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