Phenotyping of Evi1, Evi11/Cb2, and Evi12 transformed leukemias isolated from a novel panel of cas- … - Full text - MIT Libraries
M Joosten, PJ Valk, Y Vankan, N de Both, B … - Virology, 2000 - ingentaconnect.com
... as well as the incidence of known common virus integration sites (VISs) in
MuLV-induced myeloid malignancies (ie, Evi1, Evi11/Cb2, Evi12, Fli1, and c-Myb). ...
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How can oncogenic transcription factors cause cancer: a critical review of the myb story
M Introna, J Golay - Space, 1999 - nature.com
... transcription factors cause cancer: a critical review of the myb story. ... Activation
of EVI1 transcripts with chromosomal translocation joining the TCRV locus and ...
Cited by 7 - Cached - Web Search - nature.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 … - Full text - MIT Libraries
H Yuasa, Y Oike, A Iwama, I Nishikata, D Sugiyama, … - EMBO J, 2005 - embojournal.npgjournals.com
... are phenotypes commonly seen in mice lacking SCL, Runx1 or c-Myb, in which ... Ang-1
and its cognate receptor, Tie2, significantly decreased in Evi1 –/– embryos ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - embojournal.npgjournals.com - ncbi.nlm.nih.gov

Sint1, a common integration site in SL3-3-induced T-cell lymphomas, harbors a putative proto- … - Full text - MIT Libraries
AB Sorensen, AH Lund, S Ethelberg, NG Copeland, NA … - J Virol, 2000 - jvi.asm.org
... For example, c-myb, Evi1, and Evi2 are genes/common integration sites which mainly
are correlated with MLV-induced myeloid leukemias (4, 23, 33, 39), while c ...
Cited by 14 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Transcriptional regulation during myelopoiesis
N Lenny, JJ Westendorf, SW Hiebert - Mol Biol Rep, 1997 - springerlink.com
... 1B and contains putative sites for PU.1, C/EBP, and c-Myb (JJW & SWH ... of AML-1 fused
to several alternate transcripts, including the Evi1 transcription regulator ...
Cited by 41 - Web Search - kluweronline.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking. - Full text - MIT Libraries
O Kustikova, B Fehse, U Modlich, M Yang, J … - Science, 2005 - sciencemag.org
... Evi1 (hit #5), 14013, 3A3, Znf TF, murine and human leukemia, -547816, F, ND,
fl.MS1. ... Mybbp1a, 18432, 11B4, Myb-binding protein, 46577, R, r1, r4, r1.1, r4.1, ...
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Evi27 encodes a novel membrane protein with homology to the IL17 - Full text - MIT Libraries
J D Shaughnessy Jr - Oncogene, 2000 - nature.com
... Myb); three homeobox genes, homeobox A7 (Hoxa7), homeobox A9 (Hoxa9), and myeloid
ecotropic viral integration site 1 (Meis1); a zinc-®nger protein (Evi1); and ...
Web Search

PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, … - Full text - MIT Libraries
I Nuchprayoon, S Meyers, LM Scott, J Suzow, S … - Mol. Cell. Biol, 1994 - mcb.asm.org
... elements, including potential binding sites for PU.1, C/EBP, c-Myb, and PEBP2 ... speculate
that the resulting oncoproteins, AML1-ETO, AML1-EAP, AML1-Evi1, and CBF ...
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Posttranslational modification of TEL and TEL/AML1 by SUMO-1 and cell-cycle-dependent assembly into … - Full text - MIT Libraries
SR Chakrabarti, R Sood, S Nandi, G Nucifora - Blood, 2004 - dx.doi.org
... SUMO-1 Protein to the Negative Regulatory Domain of the c-Myb Transcription Factor ...
V. Senyuk, S. Sitailo, Y. Chi, and G. Nucifora Interaction of EVI1 with cAMP ...
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The role of the AML1 transcription factor in leukemogenesis
RB Lorsbach, JR Downing - Int J Hematol, 2001 - cardenjennings.metapress.com
... well, including the t(16;21) [AML1-MTG16],t(3;21) [AML1-EVI1],and t ... sites for other
transcription factors are often present, including C/EBP , Myb, Ets family ...
Cited by 7 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Identification of cis-elements regulating expression of Fgf10 during limb development
H Sasaki, T Yamaoka, H Ohuchi, A Yasue, T Nohno, H … - Int. J. Dev. Biol, 2002 - ijdb.ehu.es
... contain three conserved DNA-binding motifs: RREB, GKLF, IRFF, and EVI1 (see Table ...
by direct protein - protein interaction with HNF-4 CMYB c-Myb, important in ...
Cited by 2 - View as HTML - Web Search - ijdb.ehu.es - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

The B-lymphocyte maturation promoting transcription factor BLIMP1/PRDI-BF1 maps to D6S447 on human … - Full text - MIT Libraries
BA Mock, L Liu, D LePaslier, S Huang - Genomics, 1996 - ncbi.nlm.nih.gov
... that includes the retinoblastoma interacting zinc finger gene RIZ and the MDS1-EVI1
leukemia cancer ... to mouse Chromosome 10 at 14 cM distal to the Myb locus and ...
Cited by 20 - Web Search - ncbi.nlm.nih.gov

EVI 1 Abrogates Interferon-{alpha} Response by Selectively Blocking PML Induction - Full text - MIT Libraries
S Buonamici, D Li, FM Mikhail, A Sassano, LC … - J Biol Chem, 2005 - jbc.org
... and that the activity of a reporter gene driven by a c-MYB promoter containing ... in
PML these putative genes are also unresponsive to IFN- when EVI1 is expressed ...
Cited by 1 - Web Search - jbc.org - ncbi.nlm.nih.gov

Point mutations of the Runt domain as a means to improve solubility and enable structure …
M HAMMARSTROeM - ibg.uu.se
... Leukemia Virus and TCR-δ, CBF binds DNA co- operatively with the Myb transcription
factor 22 . ... The t(3;21) fusion of one of the EAP, MDSI or EVI1 proteins to ...
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The role of TEL fusion genes in pediatric leukemias
JE Rubnitz, CH Pui, JR Downing - Leukemia, 1999 - nature.com
... of adjacent binding sites for lineage-restricted transcription factors including
myb, CEBP , and ... inv(16) (CBF - MYH11), 48 and the t(3;21) (AML1-EVI1) 49–51 ...
Cited by 45 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Transcription Factors: Normal and Malignant Development of Blood Cells
IJ Hematol - Int J Hematol, 2001 - cardenjennings.metapress.com
... translocation and targets nine factors: retinoic acid receptor (RAR) , inv(16),
EVI1, t(8 ... is relatively short,with two chapters,one for myc and myb and another ...
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Role of B-lymphocyte-induced Maturation Protein-1 in Terminal Differentiation of B Cells and Other …
C ANGELIN-DUCLOS, G CATTORETTI, DH CHANG, KI LIN, … - Cold Spring Harbor Symposia on Quantitative Biology, 1999 - dx.doi.org
... the retinoblastoma interacting zinc finger protein RIZ and the leukemia oncoprotein
MDS1-EVI1 (Mock et ... PU.1 BSAP PU.1 VBcl-6 BSAP A-Myb Some characteristics of ...
Cited by 7 - Web Search - cshl-symposium.org - cshl-symposium.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Leukemogenesis by CBF oncoproteins
AD Friedman - Leukemia, 1999 - nature.com
... zinc finger clusters (ZF1-7 and ZF8-10) and a repression domain, within the EVI1
segment ... potently to trans-activation in cooperation with Ets-1, PU.1, c-Myb or C ...
Cited by 45 - Web Search - nature.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Estrogen-regulated Conditional Oncoproteins: Tools to Address Open Questions in Normal Myeloid Cell …
DB Sykes, MP Kamps - Leukemia & Lymphoma, 2003 - dx.doi.org
... N. and Perkins, AS (1996) “Retroviral insertional activation of the EVI1 oncogene
does ... JM and Gonda, TJ (1997) “Inactivation of a c-Myb/estrogen receptor ...
Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Progress in Hematology
T Yamagata, K Maki, K Mitani - Int J Hematol, 2005 - cardenjennings.metapress.com
... Runx1-ETO/MTG8), t(16;21) (Runx1-MTG16), t(3;21) (Runx1-Evi1), t(12;21 ... and requires
synergistic aid from another transcription factor, such as AP-1, Myb, C/EBP ...
Web Search

Overexpression of AML 1 renders a T hybridoma resistant to T cell receptor-mediated apoptosis - Full text - MIT Libraries
M Fujii, K Hayashi, M Niki, N Chiba, K Meguro, K … - Oncogene, 1998 - nature.com
... MTG8/ETO, EVI1 or TEL genes (Erickson et al., 1992; Golub et al., 1995; Mitani ...
PEBP2/CBF and c-Myb independently bind to their adjacent sites in the enhancer ...
Cited by 9 - Web Search - nature.com - ncbi.nlm.nih.gov

Lysine acetylation and the bromodomain: a new partnership for signaling - Full text - MIT Libraries
XJ Yang - BioEssays, 2004 - doi.wiley.com
... Block u biquitination (74) Helix-turn-helix (HTH) c-Myb K471, 480, 485 p300 Increase ...
227 PCAF Potentiate transcription (83) EVI1 PCAF, CBP Stimulate transport ...
Cited by 15 - Web Search - ncbi.nlm.nih.gov

Sox4 blocks cytokine-induced differentiation of 32Dcl3 cells and is a possible cooperating partner …
KE Boyd, A Poholek, O Mironenko, NG Copeland, NA … - yalepath.org
... Myeloid leukemias arising in AKXD23 mice contain proviral insertions at Evi1, which ...
Evi1 can induce leukemia, arguing that cooperating events are necessary. ...
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MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with at … - Full text - MIT Libraries
OM Sobulo, J Borrow, R Tomek, S Reshmi, A Harden, … - Proc Natl Acad Sci USA, 1997 - dx.doi.org
... associated Factor (P/CAF) Results in Reversible Acetylation of EVI1 and in ... 1 Oncoprotein
Tax Inhibits the Transcriptional Activity of c-Myb through Competition ...
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A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... VMYB 02 v-Myb Core should be AACGG not AACG ... EVI1 06 Ectopic viral integration
site 1 encoded factor Core should be ACAAGAT not AGAT ...
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Rearrangements of Chromosome Band 3 q 21 in Myeloid Leukemia
R Wieser - Leukemia & Lymphoma, 2002 - dx.doi.org
... levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low ... their clinical
implications of the GATA family, stem cell leukemia gene, and EVI1 in leukemia ...
Cited by 4 - Web Search - taylorandfrancis.metapress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Core binding factor genes and human leukemia - Full text - MIT Libraries
SM Hart, L Foroni - Haematologica, 2002 - haematologica.it
... binding of CBF to the core sequence is important for gene expression, adjacent binding
sites for lineage-restricted transcription factors, such as c-MYB, C/EBP ...
Cited by 9 - View as HTML - Web Search - haematologica.org - ncbi.nlm.nih.gov - haematologica.org - all 8 versions »

Transcription factor GATA-2 gene is located near 3q21 breakpoints in myeloid leukemia - Full text - MIT Libraries
R Wieser, A Volz, U Vinatzer, K Gardiner, U Jager, … - Biochem Biophys Res Commun, 2000 - charite.de
... HNT-34) with t(3;3) (q21; q26), t(9;22) (q34;q11) and the expression of EVI1 gene,
p210 ... high lev- els of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low ...
Cited by 5 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

TRANSCRIPTION FACTORS
OFB CELLS - doi.wiley.com
... transcription and, 328—329 Acute lymphoblastic leukemia (ALL) c-myb oncogene and ...
background, 379—380 transgenic mouse models, 384—385 EVI1 gene involvement ...
Web Search

The diverse role of the ETS family of transcription factors in cancer - Full text - MIT Libraries
DG Gilliland - Clin. Cancer Res, 2001 - clincancerres.aacrjournals.org
... v-ets was discovered as an oncoprotein fusion with gag and myb in the E26 ... to
transcription factor partners such as AML1 (27, 28, 29, 30, 31) , EVI1 (32) , and ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov

Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice - Full text - MIT Libraries
JJ Moskow, F Bullrich, K Huebner, IO Daar, AM … - Mol. Cell. Biol, 1995 - mcb.asm.org
... be involved in neoplastic disease in humans, as in the case of Evi1, making murine ...
revealed that of the known onco- genes tested, the c-myb locus exhibited ...
Cited by 96 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Sequence analysis of porcine endogenous retrovirus long terminal repeats and identification of … - Full text - MIT Libraries
CA Wilson, S Laeeq, A Ritzhaupt, W Colon-Moran, FK … - J Virol, 2003 - jvi.asm.org
... responsible for this difference. These binding sites include those for the
transcription factors SOX5, Ets-1, Evi1, GATA, v-Myb, and CEBP. ...
Cited by 6 - Web Search - pubmedcentral.nih.gov - jvi.asm.org - ncbi.nlm.nih.gov

G ENETIC P ROFILE OF A CUTE M YELOID L EUKEMIA - Full text - MIT Libraries
C Mecucci, R Rosati, R La Starza - Reviews in Clinical & Experimental Hematology, 2002 - blackwell-synergy.com
... I gene is involved at 3q21 as in the inv(3). Both EVI1 and MEL1 ... intronic
hematopoietic-specific enhancer comprising recognition sites for GATA-1 and c-myb ( ...
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Translocation Breakpoints in Cancer
AM Oliveira, JA Fletcher - ehgonline.net
... also cooperates with other transcription factors, such as Myb, ETS and C ... preleukemic)
syndromes, RUNX1±ecotropic viral integration site 1 (EVI1) in chronic ...
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AML1 interconnected pathways of leukemogenesis
J Michaud, HS Scott, R Escher - Cancer Invest, 2003 - taylorandfrancis.metapress.com
... TCRg T-cell receptor g T cells Experimental [30] Gene rearrange- ment [218]
c-myb [219] TCRd T-cell receptor d T cells Experimental ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 … - Full text - MIT Libraries
ML Kalev-Zylinska, JA Horsfield, MV Flores, JH … - Development, 2002 - dev.biologists.org
... leukemias, of which TEL-RUNX1 in t(12;21) and RUNX1-EVI1 in t(3 ... labeled riboprobes
for zebrafish scl, flk-1 (kdr – Zebrafish Information Network) myb and ßE ...
Cited by 30 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical … - Full text - MIT Libraries
JR Downing - Br. J. Haematol, 1999 - blackwell-synergy.com
... The AML1 gene is rearranged by t(3;21)[AML1-EVI1] in myelodysplasia and blast ... binding
sites for lineage-restricted transcription factors, such as c-Myb, C/EBP ...
Cited by 77 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Activation of a novel proto-oncogene, Frat 1, contributes to progression of mouse T-cell lymphomas - Full text - MIT Libraries
J Jonkers, HC Korswagen, D Acton, M Breuer, A … - The EMBO Journal, 1997 - embojournal.npgjournals.com
... and protein-protein interaction (Ma and Ptashne, 1987 ; Sigler, 1988 ), and several
proto-oncogenes, such as Evi1 (Perkins et al., 1991 ), c-myb (Weston and ...
Cited by 43 - Web Search - emboj.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

acquises de la cellule souche hematopoietique ou d’un precurseur deja commis vers les lignees …
S YNTHESE - MEDECINE/SCIENCES, 2003 - ist.inserm.fr
... famille Ras, Harvey et Kirsten Ras, des oncogènes nucléaires Myc, Myb, et de ... Dans
les leucémies myéloïdes, le gène EVI1 est surex- primé dans de rares ...
View as HTML - Web Search - erudit.org

Oncogenes et leucemies: historique et perspectives
S Gisselbrecht, BG Roussy - M e decine et Science, 2003 - erudit.org
... famille Ras, Harvey et Kirsten Ras, des oncogènes nucléaires Myc, Myb, et de ... 14Dans
les leucémies myéloïdes, le gène EVI1 est surexprimé dans de rares ...
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Strukturfunktionsanalyse des Translokationsprodukts AML1-ETO zur Entwicklung gezielter …
D Hildebrand - deposit.ddb.de
Page 1. Strukturfunktionsanalyse des Translokationsprodukts AML1- ETO zur
Entwicklung gezielter therapeutischer Ansätze Dissertation ...
Web Search - publikationen.ub.uni-frankfurt.de

A Novel Transcript Encoding an N-Terminally Truncated AML1/PEBP2 B Protein Interferes with …
Y ZHANG, SUKC BAE, G HUANG, YXIN FU, JIE LU, MEEY … - mcb.asm.org
... Third, PEBP2 appears to function in conjunction with several other transcription
factors, such as Ets-1 (15, 58, 70), Myb (18), and C/EBP (72). ...
Web Search

AML1-MTG8 leukemic protein induces the expression of granulocyte colony-stimulating factor (G-CSF) … - Full text - MIT Libraries
K Shimizu, I Kitabayashi, N Kamada, T Abe, N … - Blood, 2000 - bloodjournal.org
... of those known to be important for hematopoiesis, including ETS1, c-MYB, ALY,
PU.1 ... transcription factors such as AML1-MTG8/ETO, TEL-AML1, AML1-EVI1, AML1-MTG16 ...
Cited by 22 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

CONSEQUENCES OF CHROMOSOMAL ABNORMALITIES IN TUMOR DEVELOPMENT - Full text - MIT Libraries
I Sanchez-Garcia - Annual Review of Genetics, 1997 - dx.doi.org
... Studies carried out with AML1-ETO (68), AML1-EVI1 (87), and CBFB-MYHI1 (77 ... Other
examples of this phenomenon are illustrated by v-Myb, which up-regulates BCL-2 ...
Cited by 25 - Web Search - wwwlib.bionet.nsc.ru - genet.annualreviews.org - ncbi.nlm.nih.gov - all 6 versions »

De la cytogenetique a la cytogenomique des tumeurs: le point en 2004
A Bernheim, JL Huret, M Guillaud-Bataille, O … - Bull Cancer, 2004 - john-libbey-eurotext.fr
... LAM, myélodysplasies t(3;3)(q21;q26) RPN1-EVI1 ou inv(3)(q21;q26) ou ins(3;3)(q26;
q21q26) t(3;5)(q25;q34) MLF1-NPM1 t(5;12)(q33;p13) PDGFRB-ETV6 -5 ou del(5q ...
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The use of retroviral vectors for gene therapy-what are the risks? A review of retroviral … - Full text - MIT Libraries
D Anson - Genetic Vaccines and Therapy, 2004 - dx.doi.org
... of any one of a number of different cellular genes (Ahi1, Bla1, Bmi1, Cyclin D2,
Dsi1, Emi1, Ets1, Evi1, Gfi1, c-Ha-ras, Lck, Mis2, Mlvi2, 3 and 4, c-myb, c-myc ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - gvt-journal.com - citebase.eprints.org - all 9 versions »

The runx genes: gain or loss of function in cancer - Full text - MIT Libraries
K Blyth, ER Cameron, JC Neil - Nature Reviews Cancer, 2005 - nature.com
... For exam- ple, RUNX1–ETO is particularly common in primary AML of the subtype M2,
whereas RUNX1–EVI1 and many of the ... RUNX CBFβ p300 C/EBP ETS MYB SMADs ...
Web Search - ncbi.nlm.nih.gov

Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, … - Full text - MIT Libraries
PJ Valk, Y Vankan, M Joosten, NA Jenkins, NG … - J Virol, 1999 - jvi.asm.org
... suppressor genes (7). Multiple human proto-oncogenes and tumor suppressors, eg,
EVI1 (34), NF1 ... Mml1 (24) and Mis2 (43), which both map close to c-Myb on mouse ...
Cited by 15 - Web Search - pubmedcentral.nih.gov - jvi.asm.org - ncbi.nlm.nih.gov

Genetic Vaccines and Therapy - Full text - MIT Libraries
DS Anson - Genetic Vaccines and Therapy, 2004 - immuneweb.xxmc.edu.cn
Page 1. ...
View as HTML - Web Search - bmc.ub.uni-potsdam.de

Recent acquisitions on functional properties of the p14/p19ARF tumor suppressor protein and its …
R Summary - john-libbey-eurotext.fr
... Myb lui permettant de lier des séquences d'ADN « myb » et « Ets ... générant les protéines
chimériques CBFbeta-SMMHC, AML1-ETO, AML1-EVI1 peuvent perturber ...
Cached - Web Search - john-libbey-eurotext.fr