Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable … - Full text - MIT Libraries
KR Calvo, DB Sykes, M Pasillas, MP Kamps - Mol Cell Biol, 2000 - dx.doi.org
... The Hoxa9-immortalized progenitor exhibited a promyelocytic transcriptional profile,
expressing PU.1, AML1, c-Myb, C/EBP alpha, and C/EBP epsilon as well as ...
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Research Paper Routine expression profiling of microarray gene signatures in acute leukaemia by real … - Full text - MIT Libraries
E Sakhinia, M Faranghpour, JAL Yin, G Brady, JA … - British Journal of Haematology, 2005 - blackwell-synergy.com
... between the two groups, the difference in expression for each single gene was only
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Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a … - Full text - MIT Libraries
JD Shaughnessy Jr, DA Largaespada, E Tian, CF … - Oncogene, 1999 - nature.com
... al., 1996). As expected, nearly all of the viral integrations at Myb, Hoxa7,
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Estrogen-regulated Conditional Oncoproteins: Tools to Address Open Questions in Normal Myeloid Cell …
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... Myb [42], Hoxa9 [27] and E2a-Pbx1 [30,43] are oncoproteins that immortalize primary
GM-CSF or IL-3-dependent myeloblasts and have been rendered estrogen ...
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A transcription-factor-binding surface of coactivator p 300 is required for haematopoiesis - Full text - MIT Libraries
LH Kasper, F Boussouar, PA Ney, CW Jackson, J Rehg … - Nature, 2002 - nature.com
... that activate transcription and mediate NUP98-HOXA9 oncogenicity. Mol. Cell. Biol.
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Application of Ingenuity Pathways Analysis to Identify Putative Biomarkers of Childhood Leukemia …
IA Spectrum - Cancer - ingenuity.com
... Sst, TR ALPHA CHD4,CPSF3, Creb,CREB1, CREBBP,HDAC1, HDAC2,HOXA9, HOXC8, KIAA0601,
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Myeloid Leukemia: Disease Genes and Mouse Models
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Transcriptional regulation during myelopoiesis
N Lenny, JJ Westendorf, SW Hiebert - Mol Biol Rep, 1997 - springerlink.com
... Thus, c-Myb is a crucial determinant for myeloid cell proliferation and ... HOXA9 is
expressed in normal CD34 + marrow cells, particularly fractions enriched for ...
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Evi9 encodes a novel zinc finger protein that physically interacts with BCL6, a known human B-cell … - Full text - MIT Libraries
T Nakamura, Y Yamazaki, Y Saiki, M Moriyama, DA … - Mol. Cell. Biol, 2000 - mcb.asm.org
... encoding a hematopoietic cell growth and differentiation factor, Myb (myeloblastosis
oncogene); three homeobox genes, Hoxa7 (homeobox A7), Hoxa9 (homeobox A9 ...
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Molecular phenotyping of the immune system by microarray analysis.
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Activation of the Rap 1 Guanine Nucleotide Exchange Gene, CalDAG-GEF I, in BXH-2 Murine Myeloid … - Full text - MIT Libraries
AJ Dupuy, K Morgan, FC von Lintig, H Shen, H Acar, … - J Biol Chem, 2001 - jbc.org
... cell growth and differentiation factor, myeloblastosis oncogene (Myb); three homeobox
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Evi27 encodes a novel membrane protein with homology to the IL17 - Full text - MIT Libraries
J D Shaughnessy Jr - Oncogene, 2000 - nature.com
... cell growth and di€erentiation factor, myeloblastosis oncogene (Myb); three homeobox
genes, homeobox A7 (Hoxa7), homeobox A9 (Hoxa9), and myeloid ecotropic ...
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Applying machine learning techniques to analysis of gene expression data: cancer diagnosis
KB Hwang, DY Cho, SW Park, SD Kim, BY Zhang - Proceedings of the First Conference on Critical Assessment …, 2000 - bi.snu.ac.kr
... the cancer, the conditional probability P(Leukemia class | C- myb, MB-1 ... the 16 genes,
only “Zyxin” and “GB DEF = Homeodomain protein HoxA9 mRNA” were ...
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Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias
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... correlated with proviral activation of Meis1 implying that Hoxal and Hoxa9 cooperate
with ... DM, Smith, HR & Mushinski, JF Autoimmunity and c-myb transcription. ...
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Role of secondary structure in discrimination between constitutive and inducible activators - Full text - MIT Libraries
D Parker, M Rivera, T Zor, A Henrion-Caude, I … - Mol. Cell. Biol, 1999 - mcb.asm.org
... FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity ... interaction
between retinoic acid receptor and the oncoprotein Myb inhibits retinoic ...
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The Role of C/EBP {varepsilon} in the Terminal Stages of Granulocyte Differentiation - Full text - MIT Libraries
JA Lekstrom-Himes - Stem Cells, 2001 - stemcells.alphamedpress.org
... Deletional analysis of c-Myb shows loss of myeloid lineages with the ... HoxA9, HoxA10,
and HoxA5 are expressed early during myelopoiesis, with aberrant expression ...
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Retroviral insertional mutagenesis identifies oncogene cooperation. - Full text - MIT Libraries
T Nakamura - Cancer Science, 2005 - blackwell-synergy.com
... The use of genetically engineered mice such as NUP98-HOXA9 transgenic mice enabled
efficient identification of cooperative genes, which provides important ...
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S tem C ells - Full text - MIT Libraries
JA Lekstrom-Himes - Stem Cells, 2001 - immuneweb.xxmc.edu.cn
... Deletional analysis of c-Myb shows loss of myeloid lineages with the ... HoxA9, HoxA10,
and HoxA5 are expressed early during myelopoiesis, with aberrant expression ...
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An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation - Full text - MIT Libraries
GW Klappacher, VV Lunyak, DB Sykes, D Sawka- … - Cell, 2002 - rosenfeldlab.ucsd.edu
... DNA Synthesis (A) Northern blot analysis of mRNA derived from Hoxa9-immortalized
bone ... of METS results in significant repression of the c-Myc, c-Myb, and Cdc2 ...
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Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be … - Full text - MIT Libraries
DB Sykes, MP Kamps - Blood, 2001 - bloodjournal.org
... by transfection of E2a/Pbx1 and Hoxc8 (Figure 1E) or Hoxa9 (Figure 1F ... 28 , 29 c-Myb
and c-Myc showed characteristic down-regulation late in differentiation ...
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Demonstration of Permanent Factor-Dependent Multipotential (Erythroid/Neutrophil/Basophil) … - Full text - MIT Libraries
JS Greenberger, MA Sakakeeny, RK Humphries, CJ … - J. Biol. Chem, 2004 - pnas.org
... P. Zhou CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain
protein ... Reddy c-Myc Is Essential but Not Sufficient for c-Myb-mediated Block ...
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Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires … - Full text - MIT Libraries
GG Wang, MP Pasillas, MP Kamps - Blood, 2005 - bloodjournal.org
... immortalized by Hoxa9 plus Meis1 versus 3 others immortalized by Hoxa9 alone. This
analysis considered genes expressed as low as 1/30 that of c-Myb and one ...
Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

[PS] Analysis of an associative memory neural network for pattern identification in gene expression data
S Bicciato, M Pandin, G Didone, CD Bello - BIOKDD, 2001 - cs.rpi.edu
Page 1. BIOKDD01: Workshop on Data Mining in Bioinformatics (with SIGKDD01,
Conference) page 22 ANALYSIS OF AN ASSOCIATIVE MEMORY NEURAL ...
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E2a/Pbx1 induces the rapid proliferation of stem cell factor-dependent murine pro-T cells that cause … - Full text - MIT Libraries
DB Sykes, MP Kamps - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... B progenitors, and infection with retrovirus encoding Hoxb8, Hoxa9, or Nup98-HoxA9
did not ... 2). E2a/Pbx1 pro-T-cell proliferations also expressed c-myb and Egr2 ...
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Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin - Full text - MIT Libraries
K KAUSHANSKY, I LEMISCHKA - J. Immunol, 2005 - dx.doi.org
... K. Kirito, N. Fox, and K. Kaushansky Thrombopoietin Induces HOXA9 Nuclear Transport
in ... From The Cover: Suppressor screen in Mpl-/- mice: c-Myb mutation causes ...
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Identification of CCR2, flotillin, and gp49B genes as new G-CSF targets during neutrophilic …
S Iida, T Kohro, T Kodama, S Nagata, R Fukunaga - Journal of Leukocyte Biology, 2005 - jleukbio.org
... Key Words: DNA microarray • GM-CSF • M-CSF • SOCS • HoxA9. ... 1a (AML-1a), myeloid zinc
finger protein-1 or -2A (MZF-1/2A), PU.1, NF-Y, and c-Myb [ 13 14 ...
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HOX and Non-HOX Homeobox Genes in Leukemic Hematopoiesis - Full text - MIT Libraries
BM Owens, RG Hawley - Stem Cells, 2002 - stemcells.alphamedpress.org
... provided by experimental data showing that combining E2A-PBX1 with HOXA9 resulted
in ... also been identified as a downstream target of the Myb oncogene; therefore ...
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Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to … - Full text - MIT Libraries
A Yokoyama, Z Wang, J Wysocka, M Sanyal, DJ … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... proteins, both of which are implicated in maintenance of HoxA9 gene expression ... Manak
for generously providing a rabbit polyclonal anti-Drosophila Myb antibody, P ...
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The role of homeobox genes in hematopoiesis
MC Magli - Biotherapy, 1998 - ingentaconnect.com
... viral integration site 1), often in concomitance with Hoxa7 or Hoxa9 [65, 66 ... might
be mediated by nuclear proto- oncogenes (c-myc, c-myb), or, alternatively, by ...
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Tissue Classification Through Analysis of Gene Expression Data Using A New Family of ART …
I INTRODUCTION - ieeexplore.ieee.org
Page 1 0-7803-7278-6/02/$ 10.00 ©2002 IEEE 300 Tissue Classification Through Analysis
of Gene Expression Data Using A New Family of ART Architectures Rui Xu1 ...
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Control of Self-Renewal and Differentiation of Hematopoietic Stem Cells: HOXB4 on the Threshold - Full text - MIT Libraries
H KLUMP, B SCHIEDLMEIER, C BAUM - Ann. NY Acad. Sci, 2005 - annalsnyas.org
... key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. ...
CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein ...
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Bioconductor’s multtest package
S Dudoit, Y Ge - mssm.edu
... homolog (HU-K5) mRNA" [23] "GB DEF = Homeodomain protein HoxA9 mRNA" [24 ... receptor"
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Transcriptional Profiling During the Early Differentiation of Granulocyte and Monocyte Progenitors …
DB Sykes, J Scheele, M Pasillas, MP Kamps - Leukemia & Lymphoma, 2003 - dx.doi.org
... b-actin were expressed at relative levels of 125,000 to 200,000, and a spectrum
of transcription factors important in myeloid cell function (CBFb, c-Myb, c/EBPa ...
Cited by 2 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Bmi1, stem cells, and senescence regulation - Full text - MIT Libraries
IK Park, SJ Morrison, MF Clarke - J. Clin. Invest, 2004 - jci.org
... Enforced expression of Hoxa9/Meis-1 in both normal and Bmi1-deficient mouse ... G1/S
transition, such as DNA polymerase II, cyclin E, p19, myb, and dihydrofolate ...
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Interaction of AF 4 wild-type and AF 4· MLL fusion protein with SIAH proteins: indication for t (4; … - Full text - MIT Libraries
A Bursen, S Moritz, A Gaussmann, S Moritz, T … - Oncogene, 2004 - nature.com
... particular MLL fusion leads to leukemia, even in a Hoxa7- or Hoxa9-deficient genetic ...
corepressor N-CoR (Zhang et al., 1998), and the c-Myb protein (Tanikawa et ...
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Cancer Genomics and Molecular Pattern Recognition
C Genomics, BD Analysis - broad.mit.edu
Page 1. Cancer Genomics and Molecular Pattern Recognition Pablo Tamayo ∗
& Sridhar Ramaswamy ∗ † ∗ Cancer Genomics Group, Whitehead ...
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Novel therapies for chronic myelogenous leukemia
BN Jahagirdar, JS Miller, A Shet, CM Verfaillie - Exp Hematol, 2001 - cmlsupport.com
... m-RNA of c-myb gene has been the target of several preclinical and clinical studies. ...
Data from early clinical studies of c-myb AS-ODNs are now emerging. ...
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Defects in yolk sac hematopoiesis in Mll-null embryos - Full text - MIT Libraries
JL Hess, BD Yu, B Li, R Hanson, SJ Korsmeyer - Blood, 1997 - bloodjournal.org
... myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein
HOXA9. ... expression of the hematopoietic stem cell antigen CD34: role of c-myb. ...
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S tem C ells
RA Shivdasani - immuneweb.xxmc.edu.cn
... gene in rare cases of acute myeloid leukemia (AML) [85], and HoxA9 –/– mice show ...
This group includes the proto-oncogenes SCL/Tal-1, c-Myc, c-Myb, and the ...
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Conquering the Curse of Dimensionality in Gene Expression Cancer Diagnosis: Tough Problem, Simple …
M Mramor, G Leban, J Demsar, B Zupan - ailab.si
... 0 C U77948 KAI1 414 26 CR X85116 EPB72 42 62 CR M91592 ZNF76 578 112 N U22376 MYB
50 9 CR M62982 ALOX12 143 872 CR Y12556 PRKAB1 123 3082 CR U82759 HOXA9 9 25 ...
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EFFECTIVE USE OF WEB-BASED PUBLIC GENOMIC DATABANKS FOR AUTOMATIC AND UPDATED PERSONAL ANNOTATIONS …
M Masseroli, A Stella, GE Carrara, M Mazzarani, M … - bioinformatics.polimi.it
... D G protein-coupled receptor 65 GPR65 X D homeo box A9 HOXA9 X X X ... D
v-myb myeloblastosis viral oncog homolog (avian) ene MYB X ...
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MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein - Full text - MIT Libraries
P Ernst, J Wang, M Huang, RH Goodman, SJ Korsmeyer - Mol Cell Biol, 2001 - mcb.asm.org
... 1 oncoprotein Tax inhibits the transcriptional activity of c-Myb through competition ...
bearing a targeted interruption of the homeobox gene HOXA9 have defects in ...
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[PS] CITATIONS FOR PROTEIN/DNA (REGULATORY) - Full text - MIT Libraries
PDA White, X Ding, JC Vanderspek, JR Murphy, D … - J. Biol. Chem, 2004 - aist.go.jp
Page 1. CITATIONS FOR PROTEIN/DNA (REGULATORY) NDB ID Citation 1O4X
DC.Williams, M.Cai, GM.Clore Molecular basis for synergistic ...
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Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid … - Full text - MIT Libraries
U Thorsteinsdottir, G Sauvageau, MR Hough, W … - Mol Cell Biol, 1997 - mcb.asm.org
... in rare cases of chronic myeloid leukemias, the N-terminal half of the nucleoporin
gene NUP98 is fused in frame with most of the coding region of the HOXA9 gene ...
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The use of genetic microarray analysis to classify and predict prognosis in haematological … - Full text - MIT Libraries
AP Levene, GJ Morgan, FE Davies - Clinical and Laboratory Haematology, 2003 - blackwell-synergy.com
... Significantly, HOXA9 is deregulated by the t(7;11)(p15;p15) chromosomal translocation ...
germinal centre differentiation, such as the nuclear factor A-myb and BCL ...
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The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in … - Full text - MIT Libraries
JF DiMartino, L Selleri, D Traver, MT Firpo, J … - Blood, 2001 - bloodjournal.org
... 34-36 The presence of extensive hemorrhages in Aml1, c-Myb, and Rb knockout ... Accordingly,
while mice deficient for individual Hox genes such as HoxA9, HoxB6, or ...
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G ENETIC P ROFILE OF A CUTE M YELOID L EUKEMIA - Full text - MIT Libraries
C Mecucci, R Rosati, R La Starza - Reviews in Clinical & Experimental Hematology, 2002 - blackwell-synergy.com
... The leukemogenic potential of NUP98/HOXA9 protein was tested in vitro by transformation ...
specific enhancer comprising recognition sites for GATA-1 and c-myb (112 ...
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Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT … - Full text - MIT Libraries
DE Zhang, P Zhang, ND Wang, CJ Hetherington, GJ … - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
Full Text of this Article. PDF Version of this Article. Similar articles found
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Homeodomain Proteins - Full text - MIT Libraries
WJ Gehring, M Affolter, T Burglin - Annual Review of Biochemistry, 1994 - biochem.annualreviews.org
Page 1. Annu. Rev. Biochem. 1994. 63.’487-526 Copyright © 1994 by Annual
Reviews Inc. All rights reserved HOMEODOMAIN PROTEINS ...
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CONSEQUENCES OF CHROMOSOMAL ABNORMALITIES IN TUMOR DEVELOPMENT - Full text - MIT Libraries
I Sanchez-Garcia - Annual Review of Genetics, 1997 - dx.doi.org
... The NUP98-HOXA9 fusion (15, 91) may also be considered within this framework of ... Other
examples of this phenomenon are illustrated by v-Myb, which up-regulates ...
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