Runx1, c-Myb, and C/EBPa Couple Differentiation to Proliferation or Growth Arrest During … - Full text - MIT Libraries
AD Friedman - Journal of Cellular Biochemistry, 2002 - doi.wiley.com
... Notably, c-Myb and Runx1 co-operate to induce the T-cell receptor d gene in T-cells,
the MPO and neutrophil elast- ase (NE)genesin myeloblasts,andtheFlt3 gene ...
Cited by 11 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis - Full text - MIT Libraries
R Shimizu, S Takahashi, K Ohneda, JD Engel, M … - The EMBO Journal, 2001 - embojournal.npgjournals.com
... lineage-restricted transcription factors have been identified, including GATA-1,
GATA-2, EKLF (erythroid Krüppel-like factor), Myb and Runx1 (reviewed in ...
Cited by 33 - Web Search - nature.com - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk … - Full text - MIT Libraries
I Nobuhisa, M Takizawa, S Takaki, H Inoue, K Okita … - Mol. Cell. Biol, 2003 - pubmedcentral.nih.gov
... In the culture of the AGM region from mouse embryos lacking the transcription factor
c-Myb and Runx1 (AML1, Cbfa2, and Pebp2αB), which are known to be ...
Cited by 3 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov

Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 … - Full text - MIT Libraries
ML Kalev-Zylinska, JA Horsfield, MV Flores, JH … - Development, 2002 - dev.biologists.org
... with delayed maturation compared with normal in K,L. (O,P) Reduction in myb expression
in the aorta of runx1-mo embryo compared with control (arrowheads). ...
Cited by 30 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Regulation of the Murine D {delta} 2 Promoter by Upstream Stimulatory Factor 1, Runx1, and c-Myb - Full text - MIT Libraries
J Carabana, E Ortigoza, MS Krangel - The Journal of Immunology, 2005 - jimmunol.org
... We show that c-Myb, Runx1, and upstream stimulatory factor 1 (USF1) interact with
this promoter both in vitro and in vivo, and that all three factors appear ...
Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

PU. 1 regulates the expression of the vav proto-oncogene - Full text - MIT Libraries
DJ Denkinger, TQ Lambrecht, AM Cushman-Vokoun, RS … - J. Cell. Biochem, 2002 - doi.wiley.com
... mutations [Denkinger et al., 2000] myb (deletion of the sequence within the c-myb
box), myb-cbf (deletion of the sequences within the c-myb and Runx1/AML-1 ...
Cited by 2 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Potential roles for RUNX1 and its orthologs in determining hematopoietic cell fate - Full text - MIT Libraries
WD Tracey, NA Speck - Semin. Cell Dev. Biol, 2000 - benzerserver.caltech.edu
... Runx1 and Cbfb thus join a small group of genes (β1-integrin, c-myb, c-kit and Tie2)
that upon mutation cause widespread defects in definitive hematopoiesis ...
Cited by 16 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma - Full text - MIT Libraries
S Wotton, M Stewart, K Blyth, F Vaillant, A Kilbey … - Cancer Res, 2002 - cancerres.aacrjournals.org
... of human (H) and murine (M) genomic sequences at the Runx1 P1 promoter ... CCAAT box
and putative transcription factor-binding sites (CRE, Myb) are indicated. ...
Cited by 11 - Web Search - intl-cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

RUNX1/AML1: a central player in hematopoiesis
T Okuda, M Nishimura, M Nakao, Y Fujita - Int J Hematol, 2001 - cardenjennings.metapress.com
... Tal1/SCL and LMO2/ rbtn2, and other factors, including RUNX1/AML1 (runt- related
transcription factor 1/acute myeloid leukemia 1), CBF (PEBP2 ), c-Myb, Pu.1 ...
Cited by 11 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar - Full text - MIT Libraries
K Ogata, K Sato, T Tahirov, T Tahirov - Curr Opin Struct Biol, 2003 - cm.utexas.edu
... With an emphasis on the Runx1±CBFb±DNA and c-Myb±C/ EBPb±DNA complexes, we discuss
here the regulatory mechanisms for modulating the DNA-binding activity ...
Cited by 17 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Functional Domains of Runx1 Are Differentially Required for CD4 Repression, TCR {beta} Expression, … - Full text - MIT Libraries
M Kawazu, T Asai, M Ichikawa, G Yamamoto, T Saito, … - The Journal of Immunology, 2005 - jimmunol.org
... of the T-cell receptor enhancer by functional cooperation between c-Myb and core ...
Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis. ...
Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Protein–nucleic acid interactions - Full text - MIT Libraries
AK Aggarwal, JA Doudna - Current Opinion in Structural Biology, 2003 - rna.berkeley.edu
... Ogata, Sato and Tahirov review recent structures of Runx1±CBFb±DNA and c-Myb±C/
EBPb±DNA complexes that offer insights into cases in which one ...
Cited by 2 - View as HTML - Web Search - ingentaconnect.com - ingentaconnect.com

Biochemistry and structural biology in the post-genome era: search for the underlying mechanisms of …
K Ogata - Seikagaku, 2004 - ncbi.nlm.nih.gov
... Binding Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myb;
Runx1 protein; Transcription Factors; transcription factor ...
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PEBP2 and c-myb sites crucial for oe 5 core enhancer activity in pre-B cells
A Maartensson, XQ Xie, C Persson, M Holm, T … - doi.wiley.com
... PEBP2 and c-myb sites crucial for ø 5 core ... Thus, c-myb may be involved in
determining the stage- specific expression of the Q 5 gene. ...
Web Search - doi.wiley.com

Molecular Mechanisms of Megakaryocyte Differentiation - Full text - MIT Libraries
H Schulze, RA Shivdasani - Seminars in Thrombosis and Hemostasis, 2004 - thieme-connect.com
... genes by GATA, Ets, and FOG proteins. Top of Page. GATA-1, Pu.1, c-Myb,
and Runx1. The commitment to single blood cell lineages is ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Cell cycle inhibition mediated by the outer surface of the C/EBP basic region is required but not … - Full text - MIT Libraries
Q Wang, R Cleaves, T Kummalue, C Nerlov, AD … - Oncogene, 2003 - nature.com
... is invariably associated with cell cycle arrest, and expression or downregulation
of transcriptional regulators such as MyoD, c-Myb, AML1/Runx1, and C/EBPa may ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

A complex linkage in the developmental pathway of endothelial and hematopoietic cells
SI Nishikawa - Curr Opin Cell Biol, 2001 - cbi.pku.edu.cn
... One shortcoming of this hypothesis is its inability to explain the differences in
the angiogenic defects between runx1 (–/–) myb (–/–) and gata2 ...
Cited by 19 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

CBF—A biophysical perspective - Full text - MIT Libraries
JH Bushweller - Semin Cell Dev Biol, 2000 - cs.dartmouth.edu
... a crystal structure of the nuclear matrix targeting signal (NMTS) of Runx1 fused
to ... Ets proteins (particularly Ets-1), C/EBP, TLE, PU.1, ALY, Myb, Ear2 and p300 ...
Cited by 5 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions - Full text - MIT Libraries
MC Ghozi, Y Bernstein, V Negreanu, D Levanon, Y … - Genetics, 1996 - dx.doi.org
... of a TATA motif and the presence of Sp1, PU.1, Oct, CRE, Myb, Ets, and ... Goldenberg,
O. Brenner, G. Berke, D. Levanon, and Y. Groner Runx3 and Runx1 are required ...
Cited by 46 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: The … - Full text - MIT Libraries
JC Bories, J Demengeot, L Davidson, FW Alt - Immunology, 1996 - dx.doi.org
... Home page J. Carabana, E. Ortigoza, and MS Krangel Regulation of the Murine
D{delta}2 Promoter by Upstream Stimulatory Factor 1, Runx1, and c-Myb J. Immunol ...
Cited by 62 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 7 versions »

Deletion of the mouse T-cell receptor beta gene enhancer blocks alpha beta T-cell development - Full text - MIT Libraries
G Bouvier, F Watrin, M Naspetti, C Verthuy, P … - Immunology, 1996 - dx.doi.org
... Home page J. Carabana, E. Ortigoza, and MS Krangel Regulation of the Murine
D{delta}2 Promoter by Upstream Stimulatory Factor 1, Runx1, and c-Myb J. Immunol ...
Cited by 58 - Web Search - pnas.org - ciml.univ-mrs.fr - ncbi.nlm.nih.gov - all 7 versions »

A RUNX/AML-binding motif residing in a novel 13-bp DNA palindrome may determine the expression of … - Full text - MIT Libraries
E KOPF, R MISKIN - Journal of Thrombosis and Haemostasis - ingentaconnect.com
... by recruiting into the complex additional co-factors that can bind in cis to adjacent
DNA sites, such as Ets or Myb. In addition, RUNX1 associates with ...
Web Search - ingentaconnect.com

Hemogenic and nonhemogenic endothelium can be distinguished by the activity of fetal liver kinase ( … - Full text - MIT Libraries
H Hirai, M Ogawa, N Suzuki, M Yamamoto, G Breier, … - Blood, 2003 - bloodjournal.org
... demonstrated that only GFP ECs could give rise to HPCs and preferentially expressed
Runx1 and c-Myb genes that are required for the definitive hematopoiesis. ...
Cited by 7 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov

Multigene Targeting with Antisense Oligodeoxynucleotides: An Exploratory Study Using Primary Human … - Full text - MIT Libraries
JB Opalinska, B Machalinski, J Ratajczak, MZ … - Clinical Cancer Research, 2005 - clincancerres.aacrjournals.org
... Oncogene 1999;18:3047–55.[Medline]; Friedman AD. Runx1, c-Myb, and C/EBP couple
differentiation to proliferation or growth arrest during hematopoiesis. ...
Web Search - clincancerres.aacrjournals.org

Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants - Full text - MIT Libraries
D Traver, BH Paw, KD Poss, WT Penberthy, S Lin, LI … - Nature Immunology, 2003 - nature.com
... A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis ...
Runx1 is required for zebrafish blood and vessel development and expression of ...
Cited by 14 - Web Search - zfblasta.tch.harvard.edu - eanimal.snu.ac.kr - ncbi.nlm.nih.gov - all 6 versions »

Runx 3 is required for hematopoietic development in zebrafish - Full text - MIT Libraries
ML Kalev-Zylinska, JA Horsfield, MVC Flores, JH … - Developmental Dynamics, 2003 - doi.wiley.com
... Furthermore, Runx3 depletion decreased runx1 expression in the ventral wall of the
dorsal aorta and reduced the number of spi1- and lyz-containing blood cells. ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia - Full text - MIT Libraries
LH Castilla, P Perrat, NJ Martinez, SF Landrette, … - Proc Natl Acad Sci US A, 2004 - pubmedcentral.nih.gov
... CBFb/RUNX1 heterodimer regulation of normal proliferation and differentiation of
myeloid and lymphoid lineages depend on the combined functions of Myb and CBF ...
Cited by 8 - Web Search - dx.doi.org - pnas.org - ncbi.nlm.nih.gov - all 5 versions »

Primitive erythropoiesis is regulated by Smad-dependent signaling in postgastrulation mesoderm - Full text - MIT Libraries
M Schmerer, T Evans - Blood, 2003 - bloodjournal.org
... are not known, and at least some of the regulatory factors that are required for
definitive erythropoiesis are not essential, including c-myb and runx1. ...
Cited by 2 - Web Search - bloodjournal.org - bloodjournal.org - ncbi.nlm.nih.gov

Identification and characterization of two types of erythroid progenitors that express GATA-1 at … - Full text - MIT Libraries
N Suzuki, N Suwabe, O Ohneda, N Obara, S Imagawa, … - Ann. NY Acad. Sci, 2005 - bloodjournal.org
Page 1. Suzuki et al . Identification and characterization of two types of
erythroid progenitors that express GATA-1 at distinct levels ...
Cited by 8 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov - all 5 versions »

Scl is required for dorsal aorta as well as blood formation in zebrafish embryos - Full text - MIT Libraries
LJ Patterson, M Gering, R Patient - Blood, 2005 - bloodjournal.org
... (FH) HSCs were lost in Scl-depleted embryos. Runx1 and c-myb expression at 26 hpf
associated with the DA was lost in scl morphants (F, G, arrows). ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Putting a Hex on blood and endothelium - Full text - MIT Libraries
J Palis - Blood, 2003 - bloodjournal.org
... A functional c-myb gene is required for normal murine fetal hepatic ... Runx1 is essential
for hematopoietic commitment at the hemangioblast stage of development ...
Web Search

Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a … - Full text - MIT Libraries
B Gottgens, A Nastos, S Kinston, S Piltz, EC … - The EMBO Journal, 2002 - embojournal.npgjournals.com
... Runx1 may therefore regulate production of blood progenitors from haemogenic
endothelium ... Sequences containing conserved Myb, Ets and GATA sites are essential ...
Cited by 34 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 7 versions »

Williams–Beuren syndrome critical region-5/non-T-cell activation linker: a novel target gene of … - Full text - MIT Libraries
M Fliegauf, M Stock, T Berg, M Luebbert - Oncogene, 2004 - nature.com
... The AML1/RUNX1 gene (acute myeloid leukemia gene 1/runt-related gene 1) belongs ...
lineage-restricted transcription factors such as C/EBP, Ets and Myb (Giese et al ...
Web Search - ncbi.nlm.nih.gov

Translocation Breakpoints in Cancer
AM Oliveira, JA Fletcher - ehgonline.net
... hematopoiesis (right). Runx1 also cooperates with other transcription factors,
such as Myb, ETS and C/EBP (bottom). Interactions with ...
View as HTML - Web Search

Upstream and downstream targets of RUNX proteins - Full text - MIT Libraries
F Otto, M Luebbert, M Stock - Journal of Cellular Biochemistry, 2003 - doi.wiley.com
... RUNX protein that regulates osteocalcin expression, the earlier experiments involving
RUNX1 point to ... proximal enhancer in immature myeloid cells without c-Myb. ...
Cited by 16 - Web Search - ncbi.nlm.nih.gov

In vivo drug discovery in the zebrafish - Full text - MIT Libraries
LI Zon, RT Peterson - Nature Reviews Drug Discovery, 2005 - nature.com
... and vessel development and expression of a human RUNX1-CBF2T1 transgene ... Suppressor
screen in Mpl -/- mice: c-Myb mutation causes supraphysiological production ...
Web Search - mcdb.ucla.edu - toxpathindia.tripod.com - ncbi.nlm.nih.gov - all 5 versions »

RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping … - Full text - MIT Libraries
A Puig-Kroger, T Sanchez-Elsner, N Ruiz, EJ Andreu … - Blood, 2003 - bloodjournal.org
... 58 M-CSF receptor, 29,30 and myeloperoxidase 27 is mainly controlled through the
concerted and synergistic action of RUNX1 with factors such as Myb, PU.1, and C ...
Cited by 1 - Web Search - weizmann.ac.il - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Transcriptional cross-regulation of RUNX 1 by RUNX 3 in human B cells - Full text - MIT Libraries
LC Spender, HJ Whiteman, CE Karstegl, PJ Farrell - Oncogene, 2005 - nature.com
... in RUNX1 regulation were identified between À139 and À12 relative to the transcription
start, including PU.1, CRE and a RUNX-like site upstream of an Myb ...
Cited by 2 - Web Search - nature.com - ncbi.nlm.nih.gov

Core binding factor genes and human leukemia - Full text - MIT Libraries
SM Hart, L Foroni - Haematologica, 2002 - haematologica.it
... involves the recruitment of specific factors which can co-operatively bind DNA,
transcriptional syn- ergy between RUNX1 and c-MYB appears to occur without co ...
Cited by 9 - View as HTML - Web Search - haematologica.org - ncbi.nlm.nih.gov - haematologica.org - all 8 versions »

Transcriptional regulation of the human MIP-1 alpha promoter by RUNX 1 and MOZ - Full text - MIT Libraries
CAP Bristow, P Shore - Nucleic Acids Research, 2003 - nar.oupjournals.org
... any co-activators, RUNX1 is a relatively weak transcriptional regulator but cooperates
effectively with other transcription factors such as Ets-1 and c-Myb, or ...
Cited by 6 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2
J Snaddon, ML Smith, M Neat, M Cambal-Parrales, A … - Genes Chromosomes Cancer, 2003 - doi.wiley.com
... For example, RUNX1 mutations have been reported in cases of both AML and
myelodysplastic ... C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase ...
Cited by 15 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila … - Full text - MIT Libraries
E Ogawa, M Maruyama, H Kagoshima, M Inuzuka, J Lu, … - Proceedings of the National Academy of Sciences - pnas.org
... Nakase, Y. Fujita, M. Nakao, S. Toda, N. Kitamura, T. Abe, and T. Okuda VWRPY
motif-dependent and -independent roles of AML1/Runx1 transcription factor in ...
Cited by 272 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

CD4/CD8-LINEAGE DIFFERENTIATION IN THE THYMUS: FROM NUCLEAR EFFECTORS TOMEMBRANE SIGNALS - Full text - MIT Libraries
R Bosselut - molecules - nature.com
Page 1. REVIEWS T cells meditate effective immune responses by recog- nizing
antigen through cell-surface receptors (T-cell receptors ...
Cited by 4 - Web Search - nature.com - ncbi.nlm.nih.gov

MOLECULAR GENETICS OF T CELL DEVELOPMENT - Full text - MIT Libraries
EV Rothenberg, T Taghon - Annual Review of Immunology, 2005 - arjournals.annualreviews.org
... Other factors, such as c-Myb, PU.1, and Runx1, are required to generate the multipotent
hematopoietic progenitors of T cells, in addition to playing specific ...
Cited by 2 - Web Search - arjournals.annualreviews.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T … - Full text - MIT Libraries
I Taniuchi, M Osato, T Egawa, MJ Sunshine, SC Bae, … - Cell, 2002 - imbt.ntou.edu.tw
... transfection assays in the mouse CD4 CD8 thymoma associated factor), and c-Myb
(Allen et al., 2001; Donda ... transcription factor Runx1. Two 5 -PuACCPuCA-3 con- ...
Cited by 90 - View as HTML - Web Search - mcb.berkeley.edu - saturn.med.nyu.edu - ncbi.nlm.nih.gov - all 6 versions »

Expression of the AML-1 Oncogene Shortens the G
DK Strom, J Nip, JJ Westendorf, B Linggi, B … - jbc.org
... 1 termed AML-1B (1) (also known as Runx1, CBFA2, or PEBP2 B1(2–4)), activates the ...
specific factors (eg C/EBP , AP-1, ets-1, PU.1, and c-Myb) that regulate ...
Web Search

Transcription Factors: Normal and Malignant Development of Blood Cells
IJ Hematol - Int J Hematol, 2001 - cardenjennings.metapress.com
... Two, which focuses on myeloid differentiation,consists of the topics RUNX1(AML1)/
CBFB ... is relatively short,with two chapters,one for myc and myb and another for ...
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Pathways in blood and vessel development revealed through zebrafish genetics
PS Crosier, ML Kalev-Zylinska, CJ Hall, MV Flores, … - Int J Dev Biol, 2002 - ijdb.ehu.es
... As with runx1, expression of runx3 is reduced in cloche embryos, placing the gene
in ... Analysis of c-myb expression at 48 hpf revealed a reduction in this marker ...
Cited by 5 - View as HTML - Web Search - ncbi.nlm.nih.gov - ijdb.ehu.es - Get it from MIT Libraries

Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell … - Full text - MIT Libraries
R Kim, A Trubetskoy, T Suzuki, NA Jenkins, NG … - J Virol, 2003 - jvi.asm.org
... One of its paralogs, Runx1/AML1, is important in human leukemias and was ... factors
targeted were the previously known retroviral insertion targets Myb, Myc, and ...
Cited by 18 - Web Search - liv.med.utoronto.ca - mstp.nwu.edu - mstp.northwestern.edu - all 10 versions »

Alan M. Gewirtz, Josef T. Prchal and Kenneth Kaushansky
D Actinomycin, PCR Allele-specific - asheducationbook.org
... AML1 Located on chromosome 21, AML1 (CBF 2, RUNX1) is the fusion partner of
ETO in t(8:21). ... c-myb This gene encodes a transcription factor. ...
Web Search - asheducationbook.org