In vivo amplification of the PAX3-FKHR and PAX7-FKHR fusion genes in alveolar rhabdomyosarcoma - Full text - MIT Libraries
FG Barr, LE Nauta, RJ Davis, BW Schaefer, LM Nycum … - J. Clin. Pathol, 2003 - hmg.oupjournals.org
... Case no. RT-PCR a. PAX-FKHR FISH b. FKHR Southern c. MYCN Southern d. MYCN FISH
e. 20. PAX3-FKHR. ND f. 0.8. 13.6. ND. 106. PAX3-FKHR. 1. 0.8. 2.8. 2. 144. PAX3 ...
Cited by 30 - Web Search - hmg.oupjournals.org - ncbi.nlm.nih.gov

… VARIANT OF ALVEOLAR RHABDOMYOSARCOMA WITH UNBALANCED t (2; 13) AND HYPOTETRAPLOIDY, WITHOUT MYCN …
A Smith, P Sharma, J Tomlinson, L Robson, A … - Pathology, 2001 - dx.doi.org
... The PAX3–FKHR fusion protein appears to be primarily involved in the pathogenesis
of AR. Inexplicably, MYCN gene amplifica- tion has been detected in some ...
Cited by 1 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Relationship Between MYCN Copy Number and Expression in Rhabdomyosarcomas and Correlation With … - Full text - MIT Libraries
D Williamson, YJ Lu, T Gordon, R Sciot, A Kelsey, … - Journal of Clinical Oncology, 2004 - jco.org
... PAX/FOXO1A (nine of 12), each ARMS showing high-level MYCN copy number changes also
tested positive for the presence of a PAX/FOXO1A fusion (8 x PAX3/FOX01A 1 ...
Cited by 2 - Web Search - dx.doi.org - jco.org - ncbi.nlm.nih.gov

Gene Expression Signatures Identify Rhabdomyosarcoma Subtypes and Detect a Novel t (2; 2)(q35; p23) … - Full text - MIT Libraries
M Wachtel, M Dettling, E Koscielniak, S Stegmaier, … - Cancer Research, 2004 - cancerres.aacrjournals.org
... to constitute targets for the PAX3/FKHR translocation product, among them NCAM
(16) , PDGFR- (17) , c-met (18) , bcl-xl (19) , as well as MYCN and arginino ...
Cited by 1 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

MYCN expression in human rhabdomyosarcoma cell lines and tumour samples
L Toffolatti, E Frascella, V Ninfo, C Gambini, M … - cancer - doi.wiley.com
... D, Thorner PS, Greenberg ML, Chilton MacNeill S, Squire J. MYCN gene amplification
in ... In vivo amplification of the PAX3–FKHR and PAX7–FKHR fusion genes in ...
Cited by 5 - Web Search - doi.wiley.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

A novel and consistent amplicon at 13 q 31 associated with alveolar rhabdomyosarcoma
AT Gordon, C Brinkschmidt, J Anderson, N Coleman, … - Genes Chromosomes and Cancer, 2000 - doi.wiley.com
... have been shown to result in the formation of the fusion genes PAX3- FKHR and ... Also,
a number of oncogenes, primarily MYCN at 2p24 and GLI1/SAS/MDM2/ CDK4 in ...
Cited by 16 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Soft tissue tumors: Rhabdomyosarcoma
C Morphological - caroll.vjf.cnrs.fr
... the 12q13-15 amplicon could involve genes: - CHOP, - MDM2, and - SAS; - MYCN gene
is ... of the fusion gene (and more frequently than cases with the PAX3-FKHR gene ...
Cached - Web Search

Diagnosis and classification of the small round-cell tumors of childhood - Full text - MIT Libraries
SL Cohn - Am J Pathol, 1999 - ajp.amjpathol.org
... in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. ...
Milanaccio C, Conte M, Bruzzi P, De Bernardi B: MYCN oncogene amplification ...
Cited by 7 - Web Search - ajp.amjpathol.org - ncbi.nlm.nih.gov

Clinically critical impact of molecular genetic studies in pediatric solid tumors
BH Kushner, MP LaQuaglia, NKV Cheung, K Kramer, AC … - Medical and Pediatric Oncology, 1999 - doi.wiley.com
... cence in situ hybridization demonstrated amplification of the MYCN gene (as previously
reported with ARMS [7]) and RT-PCR detected the PAX3-FKHR chimeric tran ...
Cited by 10 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecular cytogenetic characterization of rhabdomyosarcoma cell lines - Full text - MIT Libraries
S Rodriguez-Perales, A Martinez-Ramirez, SA de … - Cancer Genetics and Cytogenetics, 2004 - ingentaconnect.com
... The RH30 cell line, positive for the PAX3-FOXO1A fusion gene, was found ... gene copy
changes, confirming the previously reported high-level amplification of MYCN. ...
Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Identification of a commonly amplified 4. 3 Mb region with overexpression of C 8 FW, but not MYC in … - Full text - MIT Libraries
CT Storlazzi, T Fioretos, K Paulsson, B Stroembeck … - Human Molecular Genetics, 2004 - hmg.oupjournals.org
... amplification’ (8). Furthermore, in spite of the fact that several amplified genes
have been identified, for example MYCN, PAX7/PAX3-FOXO1A and MDM2 (9–13 ...
Web Search - hmg.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Comparative expressed sequence hybridization to chromosomes for tumor classification and … - Full text - MIT Libraries
YJ Lu, D Williamson, J Clark, R Wang, N Tiffin, L … - Proceedings of the National Academy of Sciences, 2001 - pnas.org
... 3). Alveolar cases with the PAX3-FKHR showed lack of expression from the 10q22 ...
Overexpression of MYCN at this location was demonstrated by quantitative reverse ...
Cited by 19 - Web Search - pubmedcentral.nih.gov - crukdmf.icr.ac.uk - dx.doi.org - all 7 versions »

Diagnostic Molecular Pathology-Lessons from the Small Round Cell Tumours of Childhood.
PHB Sorensen - Clinical Biochemistry, 1995 - ingentaconnect.com
... Similar RT-PCR strategies have now been applied to identify PAX3/FKHR andPAX7 /FKHR ...
In SRCTs, amplification of the MYCN gene is observed approximately 30% of NB ...
Web Search - ingentaconnect.com

A novel site of DNA amplification on chromosome 1 p 32-33 in a rhabdomyosarcoma revealed by … - Full text - MIT Libraries
H Steilen-Gimbel, K Remberger, N Graf, WI Steudel, … - Human Genetics, 1996 - springerlink.com
... Driman D, Thorner PS, Greenberg ML, Chilton-MacNeill S, Squire J (1994) MYCN gene
amplification ... Barr FG (1993) Fusion of a fork head domain gene to PAX3 in the ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov

Genetics for the paediatric surgeon
AD Lander, AD Lander - Surgery, 2004 - extenza-eps.com
... The status of MYCN gene amplification is measured using fluorescence in situ ... chromosomal
translocations led to the identification of the genes PAX3, PAX 7 and ...
Web Search - extenza-eps.com - dx.doi.org

MOLECULAR GENETIC CHANGES IN ALVEOLAR SOFT PART SARCOMA
T Children, C Ontario - Pediatric Pathology and Molecular Medicine, 2000 - taylorandfrancis.metapress.com
... translocations involve the fusion of similar DNA- binding domains, PAX3 on chromosome ...
in Ewing sarcoma and pPNET, including ampliücation of the MYCN gene and ...
Cited by 1 - Web Search

MOLECULAR GENETIC CHANGES IN ALVEOLAR SOFT PART SARCOMA
T Children, C Ontario - Pediatric Pathology and Molecular Medicine, 2000 - dx.doi.org
... translocations involve the fusion of similar DNA- binding domains, PAX3 on chromosome ...
in Ewing sarcoma and pPNET, including ampliücation of the MYCN gene and ...
Web Search

Murine models for experimental therapy of pediatric solid tumors with poor prognosis - Full text - MIT Libraries
C Beltinger, KM Debatin - International Journal of Cancer, 2001 - doi.wiley.com
... It remains to be shown that the response of the MYCN transgenics to chemotherapy ...
This fuses the DNA-binding domains of PAX3 and PAX7, respectively, with the ...
Cited by 3 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Pediatric genitourinary tumors.
D Herz, D McLellan, K Garrels, PA Merguerian - Current Opinion in Oncology, 2000 - co-oncology.com
... Only three of the 37 genes had been previously described to be overexpressed
in alveolar rhabdomyosarcoma (PAX3-FKHR, MYCN, and CDK4) [35]. ...
Web Search - co-oncology.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Update on childhood rhabdomyosarcoma - Full text - MIT Libraries
HP McDowell - Archives of Disease in Childhood, 2003 - adc.bmjjournals.com
... involving PAX3 and PAX7 and the forkhead gene on chromosome 13. Other genetic changes
presently under investigation in RMS include amplification of MYCN, MDM2 ...
Cited by 6 - Web Search - adc.bmjjournals.com - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Immunohistochemical Findings in Embryonal Small Round Cell Tumors With Molecular Diagnostic …
NJ Sebire, SMS Gibson, DMS Rampling, SMS Williams, … - Applied Immunohistochemistry & Molecular Morphology-, 2005 - appliedimmunohist.com
... 4), embryonal rhabdomyosarcoma without either the t(2;13) PAX3-FKHR or t ... with no
identifiable fusion products (n = 5), neuroblastoma with MYCN status assessment ...
Web Search - appliedimmunohist.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genes, chromosomes, and rhabdomyosarcoma
J Anderson, A Gordon, K Pritchard-Jones, J Shipley - Genes Chromosomes and Cancer, 1999 - doi.wiley.com
... The fusion genes are thought critically to affect downstream targets of PAX3 and
PAX7 ... Genomic amplification of such genes as MYCN, MDM2, CDK4, and PAX7-FKHR is ...
Cited by 39 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Congenital Neuroblastoma Arising in the Deltoid Muscle.
T Kang, J Dormans, J Maris, D Carpentieri, BR … - Journal of Pediatric Hematology/Oncology, 2004 - jpho-online.com
... tumors of childhood, including EWS-ERG and EWS-FLI1 (Ewing sarcoma), PAX3-FKHR and
PAX7 ... No stage 1 patient had MYCN amplification, diploid DNA index, or Shimada ...
Cited by 1 - Web Search - jpho-online.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecular genetics and pathogenesis of rhabdomyosarcoma
FG Barr, JA Biegel, R Raney, JWMD Herms, J Behnke, … - J Pediatr Hematol Oncol, 1997 - jpho-online.com
... Though the PAX3/PAX7-FKHR gene fusions and allelic loss at 11p15.5 are the ... This finding
correlates with reports of MYCN amplification in 3 of 7, 4 of 6, and 3 ...
Cited by 27 - Web Search - jpho-online.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Pathologic quiz case: Ovarian mass in a 2-year-old girl presenting with pleural effusions.
C Senger, L Diaz, H Katzenstein, PM Chou - Archives of Pathology and Laboratory Medicine - arpa.allenpress.com
... The t(2;13) involving the Pax3 gene is more frequently found in a group of ... fusion
gene on a subset of double minutes and multiple copies of the MYCN gene on ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

RECIENTES AVANCES EN EL DIAGNOSTICO Y PRONOSTICO DE LOS TUMORES DE CELULAS REDONDAS INFANTILES
S Navarro, JA Lopez-Guerrero, A Pellin, A Llombart … - conganat.sld.cu
... Resultado de estas translocaciones son los genes de fusión PAX3-FKHR en el caso
de la t(2;13 ... del locus 2q24 se asocian a la amplificación del gen MYCN, pero a ...
Cached - Web Search - conganat.sld.cu

The PAX5 oncogene is expressed in N-type neuroblastoma cells and increases tumorigenicity of a S- … - Full text - MIT Libraries
FBB Kubetzko, C di Paolo, C Maag, R Meier, BW … - Carcinogenesis, 2004 - carcin.oupjournals.org
... The difference in MYCN expression was observed in both MYCN amplified and non ... been
described in medulloblastoma and lymphomas (21,22) and of PAX3 in melanoma (23 ...
Cited by 2 - Web Search - carcin.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Analysis of the transforming and growth suppressive activities of the PAX 3-FKHR oncoprotein - Full text - MIT Libraries
SJ Xia, FG Barr - Oncogene, 2004 - nature.com
... the most frequently amplified chromosomal regions are 2p24 (involving MYCN) and
12q13 ... of proteins that increase the tolerance of cells for PAX3-FKHR toxicity ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Cytogenetics and tissue culture of small round cell tumors of bone and soft tissue
R Noguera - Semin Diagn Pathol, 1996 - ncbi.nlm.nih.gov
... is associated with a chimeric gene between PAX3 and FKHR. Specific genetic alterations
of the short arm of chromosome 1 and amplification of the MYCN gene are ...
Cited by 5 - Web Search - Get it from MIT Libraries

Cytogenetic abnormalities in 42 rhabdomyosarcoma: A United Kingdom cancer cytogenetics group study
T Gordon, A McManus, J Anderson, T Min, J … - Medical and Pediatric Oncology, 2001 - doi.wiley.com
... In vivo amplification of the PAX3-FKHR and PAX7-FKHR fusion genes in alveolar rhabdo-
myosarcoma. ... MYCN gene amplifi- cation in rhabdomyosarcoma. ...
Cited by 12 - Web Search - doi.wiley.com

Gene Amplification as Means for Determining Therapeutic Strategies in Human Cancers
GJ Tsongalis, RW Cartun, A Ricci Jr - Clin Chem Lab Med, 2000 - degruyter.com
... Neuroblastoma MYCN, Del1p, 17q ES/pPNET EWS/FLI-1, EWS/ERG NHL, B-cell IgH NHL,
T-cell TCR Wilm’s Tumor WT1 DSRCT EWS/WT1 Alveolar Rhabdo. Pax3/FKHR Synovial ...
Cited by 4 - Web Search - extenza-eps.com - degruyter.de - dx.doi.org - all 8 versions »

Disease outcome may be predicted by molecular detection of minimal residual disease in bone marrow …
M Fukuda, Y Miyajima, Y Miyashita, K Horibe - J Pediatr Hematol Oncol, 2001 - jpho-online.com
... All six patients, including two with MYCN amplification, whose BM samples became ...
In alveolar rhabdomyosarcoma, PAX3-FKHR or PAX7-FKHR transcripts in BM was ...
Cited by 14 - Web Search - jpho-online.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Cytogenetic and molecular findings related to rhabdomyosarcoma. An analysis of seven cases - Full text - MIT Libraries
R Gil-Benso, C Lopez-Gines, C Carda, JA Lopez- … - Cancer Genet Cytogenet, 2003 - ingentaconnect.com
... 13)(q35;q14) or its variant t(1;13)(p36;q14), which fuse PAX3 and PAX7 ... Overexpression
of MYCN oncogene was found in two ARMS; N-myc DNA probe detected oncogene ...
Cited by 2 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

ALK protein expression in rhabdomyosarcomas - Full text - MIT Libraries
K Pillay, D Govender, R Chetty - Histopathology, 2002 - ingentaconnect.com
... PAX3 gene is believed to regulate transcription during early neuromuscular development
and FKHR ... Genomic amplification of such genes as MYCN, MDM2, CDK4 and PAX7 ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

Pediatric Solid Tumors: Dose Intensity and Targeted Therapy
NKV Cheung - ishapd.org
... chromosomal aberrations (Table 1), cellular oncogenes (eg, MYCN in neuroblastoma),
(4) tumor suppressor genes (Table 2 ... PAX3-FKHR 95% t(1;13)(p36;q14) PAX7-FKHR 5 ...
View as HTML - Web Search - haem.nus.edu.sg

BRIEF REPORTS Prognostic Significance of Elevated Lactate Dehydrogenase and Creatine Kinase in …
H Moritake, S Kamimura, K Akiyoshi, Y Nagatoshi, H … - Med Pediatr Oncol, 2003 - doi.wiley.com
... analysis of the bone marrow blasts revealed the characteristic chimeric PAX3/FKHR
transcript ... 8], many prognostic markers of RMS, such as desmin [9], MYCN [10,11 ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

The Turkish Journal of Pediatrics 2004, Volume 46, Number 3, Page (s) 239-244 [Summary][PDF][Similar …
G Diniz, S Aktaþ, R Ortac, A Erbay, C Vergin, M … - tjp.dergisi.org
... of the pathogenesis of this disease[6]. The most investigated parameters in RMS
are PAX3-FKHR and PAX7-FKHR gene fusion[19,20], MYCN amplification[21], MAGE ...
Cached - Web Search - tjp.dergisi.org

TOPICAL TOPICS Recent Advances in the Diagnosis of Pediatric Soft-Tissue Tumors
SE Kilpatrick, AJ Garvin - Medical and Pediatric Oncology, 1999 - doi.wiley.com
... 1–5% Alveolar Myogenin t(2;13)(q35;q14), PAX3-FKHR fusion 80% ... EMA CD99 Neuroblastoma
SYN 1p36 deletion or MYCN amplification 70%–80% NB84 rearrangement ...
Cited by 4 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Second Israeli-German Bi-National Conference Current Concepts in Pediatric Oncology and Hematology
O Session - Monatsschrift Kinderheilkunde, 2002 - springerlink.com
Page 1. Abstracts | Monatsschrift Kinderheilkunde 10•2002 1278 Topic 1:
Stem cell therapy in malignant and non-malignant diseases ...
Web Search

De la cytogenetique a la cytogenomique oncologique
A Bernheim, J Couturier - medecine/sciences, 2000 - ist.inserm.fr
... Rhabdomyosarcome alvéolaire t(2;13)(q35;q14) PAX3/FKHR t(1;13)(p36;q14) PAX7 ... 2 %
à 4 % des cas sont observées aussi des amplifications de MYCN, sous forme de ...
View as HTML - Web Search

Alternative prognostic factors in pediatric embryonal rhabdomyosarcoma: Nm23 expression, …
G Diniz, S Aktaþ, R Ortac, A Erbay, C Vergin, M … - tjp.dergisi.org
... of the pathogenesis of this disease 6 . The most investigated parameters in RMS
are PAX3-FKHR and PAX7-FKHR gene fusion 19,20 , MYCN amplification 21 , MAGE ...
View as HTML - Web Search - tjp.dergisi.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Cytogenetics and the surgeon: an invaluable tool in diagnosis, prognosis and counselling of patients … - Full text - MIT Libraries
GME Humphrey, R Squire, M Lansdown, A Markham, K … - Br J Surg, 1998 - doi.wiley.com
... which produce trans- criptionally active fusion proteins known respectively as
PAX3-FKHR and ... of chromosome 1p36·2–3 and amplification of the MYCN gene are ...
Cited by 1 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

alanek na vzvu–pfiehled
IPMMV AVZBROJ, AVFA PATHOLOGIST - linkos.cz
... diferenciální PCR pro detekci amplifikace genu MYCN (2q24.1) u dûtí s neurobla ...
4a,b) au alveolárních rabdomyosarkomÛ – t(2;13) sgeny PAX3/FKHR at(1;13 ...
View as HTML - Web Search - linkos.cz

Molecular genetics in the diagnosis and prognosis of solid pediatric tumors - Full text - MIT Libraries
PS Thorner, JA Squire - Pediatr Dev Pathol, 1998 - springerlink.com
... Alveolar rhabdo- myosarcoma t(2;13)(q35;q14) t(1;13)(p36;q14) PAX3/FKHR PAX7/FKHR
Synovial sar- coma t(X;18)(p11;q11) SYT/SSX1 ... Neuroblastoma 2p24 MYCN ...
Cited by 13 - Web Search - ncbi.nlm.nih.gov

De la cytogenetique a la cytogenomique des tumeurs: le point en 2004
A Bernheim, JL Huret, M Guillaud-Bataille, O … - Bull Cancer, 2004 - john-libbey-eurotext.fr
... thyroïdiens 19q13 Tumeurs pédiatriques Neuroblastomes del(1)(p32p36), + 17q21-qter
dm MYCN Rhabdomysarcomes (alvéolaires) t(2;13)(q37;q14) PAX3-FKHR t(1;13 ...
View as HTML - Web Search - john-libbey-eurotext.fr

TUMEURS DE LA VERGE
ICE ET, IPAR HPV - urofrance.org
... SCHAFER BW, NYCUM LM, BIEGEL JA In vivo amplification of the PAX3-FKHR and ... THORNER
PS, GREENBERG ML, CHI LTON-MACNEILL S., SQUIRE J. MYCN gene amplification in ...
View as HTML - Web Search

LEARNING OBJECTIVES - Full text - MIT Libraries
PP Breitfeld, WH Meyer - The Oncologist, 2005 - theoncologist.alphamedpress.org
... PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in ... Relationship between
MYCN copy number and expression in rhabdomyosarcomas and correlation ...
Web Search

Cytogenetics and molecular pathology in cancer diagnostics
S Knuutila - Annals of Medicine, 2004 - dx.doi.org
... large T-cell t(2;13)(q35;q14)/ PAX3;FOXO1A Alveolar rhabdomyosarcoma Small round
cell tumor t(2p12)/IGK@ NHLB-cell amp(2p)/MYCN Neuroblastoma Poor prognosis ...
Cited by 1 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization …
JA Bridge, J Liu, V Weibolt, KS Baker, D Perry, R … - Genes Chromosomes and Cancer, 2000 - doi.wiley.com
... Page 4. RT-PCR was negative for both the PAX3-FKHR and PAX7-FKHR ... in situ hybridization
analysis of chromosome 1p36 deletion in human MYCN amplified neuroblastoma ...
Cited by 31 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Allelotype of pediatric rhabdomyosarcoma - Full text - MIT Libraries
M Visser, C Sijmons, J Bras, RJ Arceci, M Godfried … - Oncogene, 1997 - nature.com
... which results in a chimaeric transcript encoding a fusion protein consisting of
the intact PAX3 or PAX7 ... 0/12 0/14 1/8 2p MYCN D2S123 2p24 2p15-p16 0/12 2/14 2q ...
Cited by 26 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov