… and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary … - Full text - MIT Libraries
DW Kim, L Gazourian, SA Quadri, R Romieu-Mourez, … - Oncogene, 2000 - nature.com
... Keywords: NF-kB; RelA; AhR; c-myc oncogene; breast cancer Introduction ... Furthermore,
RelA and AhR enhanced endogenous c-Myc protein levels in MCF- 10F cells. ...
Cited by 27 - Web Search - ncbi.nlm.nih.gov

The Aryl Hydrocarbon Receptor Nuclear Transporter Is Modulated by the SUMO-1 Conjugation System - Full text - MIT Libraries
M Tojo, K Matsuzaki, T Minami, Y Honda, H Yasuda, … - J Biol Chem, 2002 - jbc.org
... To generate pcDNA3-Myc-AHR, the full-length cDNA for murine AHR was PCR-amplified
from pBOS-AHR by primers 5'-CCGGTGCCTCGAG AATATTTAATGAGCAGCGGCGCCAACATC-3 ...
Cited by 10 - Web Search - imeg.kumamoto-u.ac.jp - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Transactivation of Gene Expression by Myc is Inhibited by Mutation at the Phosphorylation Sites Thr- … - Full text - MIT Libraries
S Gupta, A Seth, RJ Davis - Proceedings of the National Academy of Sciences - pnas.org
... Mol Pharmacol Home page SL Levine and GH Perdew Aryl Hydrocarbon Receptor
(AhR)/AhR Nuclear Translocator ... and PC Singhal Role of 14-3-3{epsilon}, c-Myc/Max, ...
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[CITATION] … factor (AhR) and the Rel A nuclear factor-κB subunit cooperate to transactivate the c-myc promoter
DW Kim, L Gazourian, SA Quadri, DH Sherr, GE … - Submitted for publication, 2000
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… and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary …
NPG Contact - nature.com
... Oncogene (2000) 19, 5498-5506. Keywords. NF- B; RelA; AhR; c-myc oncogene; breast
cancer. Introduction. ... RelA and AhR activate the c-myc promoter in Hs578T cells. ...
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… and the aryl hydrocarbon receptor(AhR) cooperate to transactivate the c-myc promoter in mammary … - Full text - MIT Libraries
DW Kim, L Gazourian, SA Quadri, DHS Raphaelle, GE … - Oncogene, 2000 - nature.com
Nature.com
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Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene … - Full text - MIT Libraries
AF Trombino, RI Near, RA Matulka, S Yang, LJ Hafer … - Breast Cancer Res. Treat, 2000 - springerlink.com
... Interestingly, dimeriza- tion of the AhR with NF-κB/Rel [44, 45] and tran- scriptional
activation of the c-myc promoter by an AhR/Rel-A complex in human ...
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Analysis of the Murine AhR Gene Promoter
PM Garrison, MS Denison - J Biochem Toxicol, 2000 - doi.wiley.com
... The presence of this c- myc binding site in the human AhR gene promoter [41], which
share only 50% sequence homology with the 5 - flanking region of the C57 ...
Cited by 5 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

… AhR) by the Ubiquitin-Proteasome Pathway. ROLE OF THE TRANSCRIPTION ACTIVATON AND DNA BINDING OF AhR - Full text - MIT Libraries
Q Ma, KT Baldwin - Journal of Biological Chemistry, 2000 - jbc.org
... TA domain of AhR, is required for AhR degradation by TCDD, suggesting that the TA
domain functions as a degron. Other transcription factors, such as Myc and E2F ...
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… not 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, alters cell proliferation and c-myc and growth factor … - Full text - MIT Libraries
L Zhang, KT Shiverick - Biochem Biophys Res Commun, 1997 - ingentaconnect.com
... 8-tetrachlorodibenzo- p -dioxin (TCDD), two aryl hydrocarbon receptor (AhR) agonists,
on ... of transforming growth factor (TGF)-beta1, while the c-myc mRNA levels ...
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Molecular characterization of the murine Ahr gene - Full text - MIT Libraries
JV Schmidt, LA Carver, CA Bradfield - J Biol Chem, 1993 - mcardle.oncology.wisc.edu
... Printed in USA Molecular Characterization of the Murine Ahr Gene ... Interestingly, little
splicing homol- ogy was observed between the Ahr and per genes. ...
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Structure and Expression of the Mouse AhR Nuclear Translocator(mArnt) Gene - Full text - MIT Libraries
F Wang, J Gao, J Mimura, A Kobayashi, K Sogawa, Y … - J Biol Chem, 1998 - intl.jbc.org
... whose structure consists of 22 exons and is more complex than that of AhR, and
elucidated ... EBP, CREB-1, c-Jun, E-12, E-47, human bHLH factor, c-Myc (Santa Cruz ...
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Induction of CYP1A1. The AhR/DRE paradigm: transcription, receptor regulation, and expanding …
Q Ma - Curr Drug Metab, 2001 - ingentaconnect.com
... In mam- mary cells, AhR and the RelA NF-κB subunit cooperate to bind to
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Modulation of hepatocyte gene expression by the carcinogen benzo [a] pyrene
W Zhao, KS Ramos - Toxicology In Vitro, 1998 - ingentaconnect.com
... p-dioxin (TCDD) (1 nm), an aryl hydrocarbon receptor (AhR) agonist, elicited responses
comparable to BaP for c-jun and c-Ha-ras, but not for c-fos or c-myc. ...
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Specificity of DNA binding of the c-Myc/Max and ARNT/ARNT dimers at the CACGTG recognition site - Full text - MIT Libraries
H Swanson, JH Yang - Nucleic Acids Research, 1999 - nar.oupjournals.org
... a 3[prime]-A (eg TCACGTGA) inhibits DNA binding of the c-Myc/Max heterodimer ... that
is involved in regulating xenobiotic metabolism [the Ah receptor (AHR) and Ah ...
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Effect of transforming growth factor-beta1 on expression of aryl hydrocarbon receptor and genes of … - Full text - MIT Libraries
O Doehr, R Sinning, C Vogel, P Muenzel, J Abel - MOLECULAR PHARMACOLOGY, 1997 - molpharm.org
... effect of TGF- 1 on these cells may be due to a common action of TGF- 1 on expression
of several cell cycle-regulating genes like c-myc and possibly AHR. ...
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TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accident - Full text - MIT Libraries
MT Landi, PA Bertazzi, A Baccarelli, D Consonni, S … - Carcinogenesis, 2003 - carcin.oupjournals.org
... R., Sherr,DH and Sonenshein,GE (2000) The RelA NF-kappaB subunit and the aryl
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From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer … - Full text - MIT Libraries
… Daskalakis, M Granzow, A Ahr, TJF Blankenstein, M … - Clin. Cancer Res, 2004 - dx.doi.org
... Kittler * , Thomas Ragg , Angela Daskalakis , Martin Granzow , Andre Ahr ¶ , Thomas
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Aryl hydrocarbon receptor(AhR) agonists suppress interleukin-6 expression by bone marrow stromal … - Full text - MIT Libraries
B Jensen, R Leeman, J Schlezinger, D Sherr - Environmental Health: A Global Access Science Source, 2003 - dx.doi.org
... 46,47,53,54], it was important to determine if activation of the AhR influenced
NF ... of the NF-κB-binding upstream regulatory element of the c-myc promoter [29]. ...
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Aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) activity is unaltered by … - Full text - MIT Libraries
SL Levine, GH Perdew - Mol. Pharmacol, 2001 - molpharm.org
... threonine 58 could play an important role in the regulation of c-MYC activity ... shift
in ARNT charge heterogeneity after heterodimerization with the AhR is unknown ...
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Oligo GEArray® Rat Toxicology & Drug Resistance Microarray
S Conditions - search.cosmobio.co.jp
... genes: Induction of apoptosis: Atm, Bax, Gpx1, Il18, Mlh1, Myc, Tnf, Tradd ... Other
genes involved in apoptosis: Ahr, Akt1, Bag1, Clu, Dnaja3, E2f1, Gadd45b, Nfkb1 ...
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Heterodimers of bHLH-PAS Protein Fragments Derived from AhR, AhRR, and Arnt Prepared by Co- … - Full text - MIT Libraries
Y Kikuchi, S Ohsawa, J Mimura, M Ema, C Takasaki, … - Journal of Biochemistry, 2003 - jb.oupjournals.org
... (A) Schematic representation of the structures of human AhR, AhRR and ... The bHLH motif
is also found in other transcription factors, such as MyoD, Myc and E47. ...
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Aryl Hydrocarbon Receptor (AhR) Agonists Suppress Interleukin-6 Expression by Bone Marrow Stromal …
BA Jensen, RJ Leeman, JJ Schlezinger, DH Sherr - biomedcentral.com
... pathways (46, 47, 52, 53), it was important to determine if activation
of the AhR influenced ... element of the c-myc promoter (29). ...
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Activation of arylhydrocarbon receptor (AhR) in T lineage cells inhibits cellular growth
K Nohara, I Tomohiro, T Chiharu - ORGANOHALOGEN COMPOUNDS, 2004 - dioxin2004.abstract-management.de
... CA-AhR also upregulated the genes involved in both apoptosis and cell cycle arrest ...
On the other hand, protooncogene c-myc, which plays an important role in the ...
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Oligo GEArray® Mouse Toxicology & Drug Resistance Microarray
S Conditions - search.cosmobio.co.jp
... GADD45A, MYC, RB1, TP53. Negative regulation of cell cycle: APC, ATM, BAX, BRCA1,
CDKN2A, CDKN2D, MLH1, MSH2, RB1, TP53. Other cell cycle genes: ABL1, AHR, BCL2 ...
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Oligo GEArray® Human Toxicology & Drug Resistance Microarray
S Conditions - search.cosmobio.co.jp
... GADD45A, MYC, RB1, TP53. Negative regulation of cell cycle: APC, ATM, BAX, BRCA1,
CDKN2A, CDKN2D, MLH1, MSH2, RB1, TP53. Other cell cycle genes: ABL1, AHR, BCL2 ...
View as HTML - Web Search

Environmental Chemical-Induced Pro/Pre-B Cell Apoptosis: Analysis of c-Myc, p27 Kip1, and p21 WAF1 … - Full text - MIT Libraries
HY Ryu, KK Mann, JJ Schlezinger, B Jensen, DH … - J. Immunol, 2003 - jimmunol.org
... of the p27 Kip1 cyclin-dependent kinase inhibitor gene by c-Myc. ... The bioflavonoid
galangin blocks aryl hydrocarbon receptor (AhR) activation and polycyclic ...
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… in Ornithine Decarboxylase and Protein Tyrosine Kinase Activities, Polyamines and c-Myc, c-Fos and … - Full text - MIT Libraries
AS Randi, S Hernandez, L Alvarez, M Sanchez, M … - Toxicological Sciences, 2003 - toxsci.oupjournals.org
... The time-course of c-Myc, c-Fos, and c-Jun protein levels was different for ... type"
chemical and a weak agonist of the aryl hydrocarbon receptor (Ahr) (Hahn et al ...
Web Search - toxsci.oxfordjournals.org - ingentaconnect.com - csa.com - all 6 versions »

In silico identification of transcriptional regulators associated with c-Myc - Full text - MIT Libraries
R Elkon, KI Zeller, C Linhart, CV Dang, R Shamir, … - Nucleic Acids Research, 2004 - nar.oupjournals.org
... signatures were enriched in the cell-cycle-dependent promoter set were also enriched
in the c-Myc/Max target set (E2F, NF-Y, Sp1, Nrf1, ETF, CREB and AhR/Arnt ...
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Differential c-myc expression profiles in normal human bronchial epithelial cells following … - Full text - MIT Libraries
WR Fields, JG Desiderio, RM Leonard, EE Burger, BG … - Molecular Carcinogenesis, 2004 - doi.wiley.com
ARTICLES Differential c-myc Expression Profiles in ... Key words: benzo[a]pyrene; mRNA;
gene expression; c-myc; normal human bronchial epithelial cells; lung ...
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Topic 1.13 Transcriptional roles of AhR in expression of biological effects induced by endocrine …
Y Fujii-Kuriyama, J Mimura - iupac.org
... AhR and its partner molecule, Arnt, belong to a superfamily of structurally related ...
is shared by another family of tran- scription factors such as Myc and MyoD ...
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PDGF inducesc-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell …
RB Womer, K Frick, CD Mitchell, AH Ross, S … - Journal of Cellular Physiology, 1987 - doi.wiley.com
JOURNAL OF CELLULAR PHYSIOLOGY 13265-72 (1987) PDGF Induces c-myc mRNA Expression
in ... 3 h at 37OC induced a 7.5-fold increase in c-myc mRNA accumulation as ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation - Full text - MIT Libraries
N MATSUSHITA, Y FUJII-KURIYAMA - Proc. Natl. Acad. Sci. USA, 1995 - pnas.org
... shown that each component ofdimers of bHLH proteins such as MyoD and c-Myc specifically
recognize ... interesting to elucidate how Arnt and AhR interact with each ...
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Transforming growth factor-beta1 coregulates mRNA expression of aryl hydrocarbon receptor and cell- … - Full text - MIT Libraries
O Dohr, J Abel - Biochem Biophys Res Commun, 1997 - ingentaconnect.com
... reporter plasmid in both cell lines, a down-regulation of c-myc and cyclin ... The results
show a coregulation of mRNA expression of AhR and cell-cycle regulating ...
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Expression of the aryl hydrocarbon receptor is regulated by serum and mitogenic growth factors in … - Full text - MIT Libraries
C Vaziri, A Schneider, DH Sherr, DV Faller - J Biol Chem, 1996 - jbc.org
... It is noteworthy that, like the AhR, c-myc expression is elevated in exponentially
growing cultures of fibroblasts relative to growth-arrested cells (18, 19 ...
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Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor … - Full text - MIT Libraries
MR Campanero, EK Flemington - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... OF AhR J. Biol. Chem., March 17, 2000; 275(12): 8432 - 8438. [Abstract] [Full Text]
[PDF], Home page, Mol. Cell. Biol. Home page MA Gregory and SR Hann c-Myc ...
Cited by 69 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Identification of a novel mechanism of regulation of Ah (dioxin) receptor function - Full text - MIT Libraries
J Mimura, M Ema, K Sogawa, Y Fujii-Kuriyama, J … - Genes Dev, 1999 - genesdev.org
... 1996 ; Mimura et al. 1997 ). Structurally, AhR and Arnt belong to a superfamily
of bHLH transcription factors that include MyoD and Myc (Murre et al. 1989 ). ...
Cited by 63 - Web Search - genesdev.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

[CITATION] Inhibition of the MEK-1/p42 MAP kinase reduces aryl hydrocarbon receptorAAAAAADNA interactions
S Yim, M Oh, SM Choi, H Park
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2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin Blocks Androgen-Dependent Cell Proliferation of LNCaP Cells … - Full text - MIT Libraries
S Barnes-Ellerbe, KE Knudsen, A Puga - Molecular Pharmacology, 2004 - molpharm.org
... AHR indirectly induces c-Myc expression through an AHR/RelA DNA-binding complex
that binds to the nuclear factor- B–responsive element in the c-Myc gene ...
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Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a … - Full text - MIT Libraries
GD Carystinos, M Kandouz, MA Alaoui-Jamali, G … - Mol. Pharmacol, 2003 - molpharm.aspetjournals.org
... NIH3T3-Ras nuclear extracts (10 µg per lane) were incubated with radiolabeled Cx200
and antibodies to c-Myc, HSP90, AhR (negative control), and Sp1. ...
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Mapping the protein/DNA contact sites of the Ah receptor and Ah receptor nuclear translocator. - Full text - MIT Libraries
HI Swanson, J Yang - J Biol Chem, 1996 - jbc.org
... within basic region 2. The goal of our first substitution within this region was
to change the DNA binding specificity of the AHR to resemble that of Myc. ...
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[CITATION] Transforming Growth Factor-β Coregulates mRNA Expression of Aryl Hydrocarbon Receptor and Cell- …
O Doehr, J Abel
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FP Guengerich, CR Wolf - J Cancer Res Clin Oncol, 1996 - springerlink.com
... helix- loop-helix proteins, while the basic region of AHR diverges considerably
from ... Heidelberg, Germany) reported on amplifi- cation of the n-myc oncogene and ...
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The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization … - Full text - MIT Libraries
JM Rodriguez-Frade, AJ Vila-Coro, AM de Ana, JP … - Biochemistry, 1999 - dx.doi.org
... After MCP-1 stimulation, immunoprecipitation with Myc-specific antibodies revealed
YSK-tagged ... Home page, Blood Home page J. Roland, BJ Murphy, B. Ahr, V. Robert ...
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PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without … - Full text - MIT Libraries
C Lee, K Bae, I Edery - Mol. Cell. Biol, 1999 - mcb.asm.org
... 3 µl of an antibody against the HA epitope (12CA5), the myc epitope (9E10 ... that PER
can block the ability of an arylhydrocarbon receptor (AHR)-ARNT heterodimer ...
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Cell-Specific Regulation of Human Aryl Hydrocarbon Receptor Expression by Transforming Growth Factor …
S Wolff, PA Harper, JMY Wong, V Mostert, Y Wang, J … - Cell, 2001 - molpharm.org
... found to lack TGF- -induced effects on genes that in other cell lines are negatively
regulated by TGF- such as c-myc, cyclin A and AhR (Döhr and Abel, 1997 ). ...
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2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced down-regulation of glucose transporting …
H Nagashima, F Matsumura - J. ENVIRON. SCI. HEALTH, 2002 - taylorandfrancis.metapress.com
... However, it is clear that this process is also mediated by AhR. ... c-Ras-AP-1 pathway,
some groups reported that c-Src is closely related with c-Myc in platelet ...
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cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) … - Full text - MIT Libraries
K Hirose, M Morita, M Ema, J Mimura, H Hamada, H … - Mol Cell Biol, 1996 - mcb.asm.org
... bHLH or bHLH/ leucine zipper (LZ) structural motifs such as MyoD, myogenin, Myc,
and Max ... with segments of cDNAs coding for the bHLH/PAS domains of AhR and Arnt ...
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a protein related to human hypoxia-inducible factor la and Drosophila single-minded - Full text - MIT Libraries
JR Nambub, W Chenb, S Hubsa, ST Crewsa - Gene, 1996 - unc.edu
... Sima within the Sim-related gene family since it shows signifi- cantly lower identity
to other bHLH proteins: Ahr (28%), Arnt (28%), MyoD (20%) and Myc (15%). ...
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Evolution of bHLH transcription factors: modular evolution by domain shuffling - Full text - MIT Libraries
B Morgenstern, WR Atchley - Mol. Biol. Evol, 1999 - techfak.uni-bielefeld.de
... Tfeb-Hu- man; (3) Hairy-Fly with Sim-Fly; (4) Arnt-Human with Ahr-Human, Sim-Fly,
Sim1-Mouse, Sim2-Mouse, and Trh-Fly; (5) Usf2-Mouse with Myc-Chicken; and (6 ...
Cited by 22 - View as HTML - Web Search - gobics.de - atchleylab.org - gwdg.de - all 12 versions »