Identification and validation of novelERBB 2(HER 2, NEU) targets including genes involved in … - Full text - MIT Libraries
J Beckers, F Herrmann, S Rieger, AL Drobyshev, M … - International Journal of Cancer, 2005 - doi.wiley.com
... Some of these genes, such as Her2 (neu/Erbb2), T2, Myc, Ep300 (P300), Fra-2 (Fosl2),
c-fos (Fos) and JunD (Jund1 and Jund2), were not represented on the ...
Cited by 2 - Web Search

GEArray Q Series Human Wnt Signaling Pathway Gene Array: AR-SAHS-043
FG Grouping, R Ligand, R Molecules, I Molecules - eurogentec.com
... Target genes: Canonical (Wnt / beta-catenin) Pathway: Transcription factors: CDX1,
EP300, FOSL1 (Fra-1), ID2, ID3, JUN, MSX1, MSX2, MYC, PITX2, T (Brachyury ...
View as HTML - Web Search - eurogentec.be

A plethora of sites - Full text - MIT Libraries
G Euskirchen, M Snyder - Nature Genetics, 2004 - nature.com
... example, the Ewing sarcoma gene EWSR1, the tumor suppressor gene EP300 and the
mitogen-activated protein kinase gene MAPK1 each use Sp1 or c-Myc to regulate ...
Cited by 1 - Web Search - nature.com - cs.huji.ac.il - ncbi.nlm.nih.gov

GEArray Q series Human p53 Signaling Pathway Gene Array: AR-SAHS-027
FG Grouping - eurogentec.com
... CHEK2 (Chk2), CREBBP (CBP), CSNK1A1 (CK1), CSNK2A1, CSNK2A2, CSNK2B, EP300 (p300),
HIPK2 ... BRCA1, CDKN2A (p14ARF), E1B-AP5 (E1B55K), E2F1, MDM2, MYC, RASA1 (Ras ...
View as HTML - Web Search - eurogentec.be

GEArray Q series Human p53 Signaling Pathway Gene Array Cat. No.* Kit Size HS-027-2/HS-027N-2 2 …
FG Grouping - tebu-bio.com
... CHEK2 (Chk2), CREBBP (CBP), CSNK1A1 (CK1), CSNK2A1, CSNK2A2, CSNK2B, EP300 (p300),
HIPK2 ... BRCA1, CDKN2A (p14ARF), E1B- AP5 (E1B55K), E2F1, MDM2, MYC, RASA1 (Ras ...
View as HTML - Web Search

GEArray Q series Human p53 Signaling Pathway Gene Array
FG Grouping - superarray.com
... CHEK2 (Chk2), CREBBP (CBP), CSNK1A1 (CK1), CSNK2A1, CSNK2A2, CSNK2B, EP300 (p300),
HIPK2 ... BRCA1, CDKN2A (p14ARF), E1B-AP5 (E1B55K), E2F1, MDM2, MYC, RASA1 (Ras ...
View as HTML - Web Search - superarray.com - cosmobio.co.jp - cosmobio.co.jp - all 5 versions »

p 300 regulates p 53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation … - Full text - MIT Libraries
NG Iyer, SF Chin, H Ozdag, Y Daigo, DE Hu, M … - Proceedings of the National Academy of Sciences, 2004 - pnas.org
... been implicated as modulators of the p53 response, including ARF, c-myc, and ASPP ...
HCT116 is hemizygous for p300: EP300 is expressed from a single allele, with ...
Cited by 8 - Web Search - pubmedcentral.nih.gov - dx.doi.org - intl.pnas.org - all 8 versions »

Adenovirus-5 e 1 a: paradox and paradigm - Full text - MIT Libraries
SM Frisch, JS Mymryk - Nature Reviews Molecular Cell Biology, 2002 - nature.com
... 14. Evan, GI et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell
69, 119-128 (1992). | Article | PubMed | ISI | ChemPort |. 15. ...
Cited by 39 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The role of emerging genomics and proteomics technologies in cancer drug target discovery.
P Onyango - Current Cancer Drug Targets, 2004 - ingentaconnect.com
... EP300 E1A-binding protein (p300) gene Colorectal; breast and pancreatic cancers ... MYC
Homolog of v-myc avian myelocytomatosis viral oncogene Burkitt lymphoma ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to … - Full text - MIT Libraries
S Cawley, S Bekiranov, HH Ng, P Kapranov, EA … - Cell, 2004 - zi.ku.dk
... Factors Positions of 5 , 3 , and internal binding sites for Sp1 (red), c-Myc (green),
or p53 (blue) are shown for the EWSR1 (A and B), EP300 (C and D), and ...
Cited by 106 - View as HTML - Web Search - thep.lu.se - stanford.edu - zlab.bu.edu - all 11 versions »

Loss of heterozygosity on long arm of chromosome 22 in sporadic colorectal carcinoma - Full text - MIT Libraries
CZ Zhou, ZH Peng, F Zhang, GQ Qiu, L He - World J Gastroenterol, 2002 - wjgnet.com
... Zhou CZ et al. LOH on 22q in colorectal cancer 669 D22s315 D22s280 D22s283 D22s423
D22s274 NF2 EP300 BIK ... [47] , c- myc expression and aneuploidy [48] . ...
Cited by 12 - View as HTML - Web Search - wjgnet.com - wjgnet.com - ncbi.nlm.nih.gov - all 5 versions »

GEArray S Series Human Immunology Signaling Pathways Gene Array: AR-SAHS-605
FG Grouping, A Molecules, I ICAM, CS Molecules, C … - eurogentec.com
... CREB1, CREBBP, EGFR, EGR1, EGR2, EGR3, ELK1, ELK3, ELK4, EP300, ETS1, ETS2 ... MAPKAPK3,
MAX, MEF2A, MEF2B, MEF2C, MEF2D, MHC2TA, MKNK1, MLLT7, MYC, MYF5, NFKB2 ...
View as HTML - Web Search - eurogentec.be

Identification of Transcriptional Networks during Liver Regeneration - Full text - MIT Libraries
P White, JE Brestelli, KH Kaestner, LE Greenbaum - J Biol Chem, 2005 - jbc.org
... The Myc targets that were differentially expressed encode proteins involved ... shown
are PCK1, phosphoenolpyruvate carboxykinase; CDKN1A, p21; EP300, E1A binding ...
Cited by 3 - Web Search - jbc.org - ncbi.nlm.nih.gov

GEArray S Series Human Autoimmune and Inflammatory Response Gene Array: AR-SAHS-602
FG Grouping, A Proteins, CS Receptors, ST Proteins … - eurogentec.be
... ELK3, EP300, FKBP1B, FLJ14639 (NIP45), FOS, FOSL1, FOSL2, FOXP3, GATA3, GATA4, GRLF1,
ICOS, IRF1, JUN, JUNB, JUND, MAF, MAX, MEF2A, MEF2B, MEF2D, MYC, NFAT5 ...
View as HTML - Web Search - eurogentec.com

The Ewing’s sarcoma gene product functions as a transcriptional activator - Full text - MIT Libraries
KL Rossow, R Janknecht - Cancer Res, 2001 - cancerres.aacrjournals.org
... a, 3 µg of the indicated Myc-tagged EWS expression vectors were coexpressed ... Ponder
BA, Kouzarides T., Caldas C. Mutations truncating the EP300 acetylase in ...
Cited by 25 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

Genomic Organization, Tissue Expression, and Cellular Localization of AF3p21, a Fusion Partner of …
A Hayakawa, Y Matsuda, M Daibata, H Nakamura, K … - GENES, CHROMOSOMES & CANCER, 2001 - doi.wiley.com
... We used a well-characterized anti-MYC tag mono- clonal antibody and showed that ... In
acute myeloid leukemia, the EP300 (E1A binding protein p300) gene on 22q13 ...
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Allelic losses of loci at 3p25. 1, 8p22, 13q12, 17p13. 3, and 22q13 correlate with postoperative … - Full text - MIT Libraries
A Hirano, M Emi, M Tsuneizumi, Y Utada, M … - Clin Cancer Res, 2001 - clincancerres.aacrjournals.org
... JL, Walker RA Alterations to either c-erbB2 or c-myc proto-oncogenes in ... JDA, Ponder
BAJ, Kouzarides T., Caldas C. Mutations truncating the EP300 acetylase in ...
Cited by 12 - Web Search - clincancerres.aacrjournals.org - ncbi.nlm.nih.gov

SHORT REPORT REDUCED EXPRESSION OF MYO18B, A CANDIDATE TUMOR-SUPPRESSOR GENE ON CHROMOSOME ARM 22Q, … - Full text - MIT Libraries
N Yanaihara, M Nishioka, T Kohno, A Otsuka, A … - Int. J. Cancer, 2004 - doi.wiley.com
... in sporadic ovarian cancers, somatic mutations of the c-erbB-2, c-myc and K-ras ... This
chromosome arm contains 3 known TSGs, NF2, EP300 and SNF5/INI1, which are ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Prevalence estimates of recurrent balanced cytogenetic aberrations and gene fusions in unselected …
F Mitelman, F Mertens, B Johansson - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
Page 1. Prevalence Estimates of Recurrent Balanced Cytogenetic Aberrations and
Gene Fusions in Unselected Patients with Neoplastic Disorders ...
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Notch1 oncoprotein antagonizes TGF-beta/Smad-mediated cell growth suppression via sequestration of … - Full text - MIT Libraries
S Masuda, K Kumano, K Shimizu, Y Imai, M Kurokawa, … - Cancer Science, 2005 - blackwell-synergy.com
... pcDNA3/myc-ICN1 (amino acids 1747 2531 of mouse Notch1), pME18Sneo/myc-ICN,
pTracerCMV/ICN1-Flag, pTracerCMV/ICN2-Flag and pTracerCMV/ICN3-Flag were described ...
Web Search - ncbi.nlm.nih.gov

High-resolution gene copy number and expression profiling of human chromosome 22 in ovarian …
M Benetkiewicz, Y Wang, M Schaner, P Wang, KK … - Genes Chromosomes and Cancer, 2005 - doi.wiley.com
... These genes are: RBX1, EP300, TCF20, and NUP50. The EP300 gene is considered
a tumor suppressor that encodes the interacting protein ...
Cited by 3 - Web Search - puffer.genpat.uu.se - ncbi.nlm.nih.gov - Get it from MIT Libraries

Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu - Full text - MIT Libraries
A Goel, R Janknecht - Mol Cell Biol, 2003 - mcb.asm.org
... were immunoprecipitated with antiacetyllysine antibodies and then detected by
anti-Myc Western blotting ... Mutations truncating the EP300 acetylase in human cancers ...
Cited by 6 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Emerging issues in genotoxicology
BJ Barclay - currentdrugdiscovery.com
... hydrolase organelles EP300 Histone acetyltransferase Regulation of transcription ...
protein-tyrosine kinase MYC Transcription factor, Activates expression of ...
View as HTML - Web Search - inpharm.com

Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3 - Full text - MIT Libraries
A Kumar, Y Zhao, G Meng, M Zeng, S Srinivasan, LM … - Mol. Cell. Biol, 2002 - mcb.asm.org
... Mutations truncating the EP300 acetylase in human cancers. ... Basal and human
papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin ...
Cited by 11 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Examples of the complex architecture of the human transcriptome revealed by RACE and high-density … - Full text - MIT Libraries
P Kapranov, J Drenkow, J Cheng, J Long, G Helt, S … - Genome Research, 2005 - genome.org
... Overall, six genes (DGCR14, CTCLC1, EP300, GTSE1, SEC14L2, and SHH) showed examples ...
2004 ) identified two prominent c-Myc transcription-factor-binding sites at ...
Web Search - dx.doi.org - genome.org - ncbi.nlm.nih.gov

HISTONE-DEACETYLASE INHIBITORS: NOVEL DRUGS FOR THE TREATMENT OF CANCER - Full text - MIT Libraries
RW Johnstone - Nature Reviews Drug Discovery, 2002 - nature.com
... | Article | PubMed | ISI | ChemPort |. 22. Gayther, SA et al. Mutations truncating
the EP300 acetylase in human cancers. Nature Genet. 24, 300-303 (2000). ...
Cited by 137 - Web Search - nature.com - ncbi.nlm.nih.gov

Genetic and cytogenetic analyses of breast cancer yield different perspectives of a complex disease - Full text - MIT Libraries
P O’Connell - Breast Cancer Res. Treat, 2003 - springerlink.com
... kinase MYC myc oncogene Oncogene, transcription 8q24.12 Gain [35] ... 22] EP300
E1A binding protein TSG, chromatin remodeling 22q13 Both [60] ...
Cited by 4 - Web Search - kluweronline.com - ingentaconnect.com - ncbi.nlm.nih.gov

Genes, chromatin, and breast cancer: an epigenetic tale
LM Mielnicki, HL Asch, BB Asch - J Mammary Gland Biol Neoplasia, 2001 - kluweronline.com
... The c-myc oncogene is amplified and overex- pressed in some human breast cancers
and these alter- ations correlate with survival in some studies (83, 84). ...
Cited by 10 - Web Search - springerlink.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Targeted histone deacetylase inhibition for cancer therapy
DM Vigushin, RC Coombes - Curr. Cancer Drug Targets, 2004 - ingentaconnect.com
... In proliferating cells, Myc/Max heterodimers activate transcription of genes that
stimulate proliferation and are regulated by E-box promoter elements such as ...
Cited by 7 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

[BOOK] Molecular biology of cancer
F Macdonald, CHJ Ford, AG Casson - 2004 - print.google.com
... 113 7.3. 1 MYC 11 3 7.3.2 RAS 1 13 7.3.3 Other oncogenes 115 ... 141 9.2 Genetic changes
in breast cancer 142 9.2.1 MYC 142 9.2.2 ERBB2 and RAS 144 92 3 p53 146 ...
Cited by 10 - Web Search - Get it from MIT Libraries - Library Search

Identification of Novel Candidate Oncogenes and Tumor Suppressors in Malignant Pleural Mesothelioma … - Full text - MIT Libraries
GJ Gordon, GN Rockwell, RV Jensen, JG Rheinwald, … - American Journal of Pathology, 2005 - ajp.amjpathol.org
... suppressors RASSF1A, NF2, and p16 as well as the growth factors/proto-oncogenes/
signaling molecules c- fos, c-jun, EGF, VEGF, MetAP2, c-Met, c-myc, and fra-1 ...
Web Search - ajp.amjpathol.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and … - Full text - MIT Libraries
EM Blalock, JW Geddes, KC Chen, NM Porter, WR … - Proceedings of the National Academy of Sciences, 2004 - intl.pnas.org
... included the cAMP response element-binding protein (CREB) cofactor (EP300), a calpain ...
for growth and proliferation, including several of the MYC family (MGA ...
Cited by 11 - Web Search - pubmedcentral.nih.gov - med.uni-marburg.de - dx.doi.org - all 8 versions »

A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease … - Full text - MIT Libraries
A Barbouti, M Hoglund, B Johansson, C Lassen, PG … - Cancer Res, 2003 - cancerres.aacrjournals.org
... eg, TP53, CDKN2A, and RB1) and oncogenes (eg, RAS and MYC), but thus ... for transformation
and also recruits the transcriptional coactivators CREBBP/EP300 (17) . ...
Cited by 8 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - lu-research.lub.lu.se - all 5 versions »

DNA methylation and chromatin modifications in cancer and development
I Kuzmin, L Geil - Int. Arch. Biosci.(2001) - iabs.us
... A smaller group of genes, including c- jun, c-myc, TCLI protooncogene, carboanhydrases
CA9 and CA12 may become hypomethylated and reactivated in a course of ...
Cited by 3 - View as HTML - Web Search

CBP/p300 in cell growth, transformation, and development - Full text - MIT Libraries
RH Goodman, S Smolik - Development, 2000 - genesdev.org
... see below). Because activation of the Wnt pathway induces c-myc and cyclin
D1 (at least in mammalian cells) (He et al. 1998 ; Tetsu ...
Cited by 393 - Web Search - genesdev.org - genesdev.org - ncbi.nlm.nih.gov - all 5 versions »

Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours - Full text - MIT Libraries
M Esteller, JG Herman - The Journal of Pathology, 2002 - doi.wiley.com
... cases of gamma-globin, gamma-cristallin, alpha-chorionic gonadotropin, H-Ras, and
the c-myc genes; and ... Mutations truncating the EP300 acetylase in human cancers ...
Cited by 115 - Web Search - ingentaconnect.com - bioinformatics.med.umich.edu - ncbi.nlm.nih.gov - all 5 versions »

pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in … - Full text - MIT Libraries
K Simin, H Wu, L Lu, D Pinkel, D Albertson, RD … - PLoS Biol, 2004 - dx.doi.org
... to the number of changes observed in myelocytomatosis oncogene (c-myc)-induced mouse ...
Furthermore, p53 and EP300 (E1A-binding protein p300), which map to the ...
Web Search - medicine.plosjournals.org - surrey.ac.uk - plosbiology.org - all 11 versions »

Histone acetylation and disease - Full text - MIT Libraries
S Timmermann, H Lehrmann, A Polesskaya, A Harel- … - Cell. Mol. Life Sci, 2001 - springerlink.com
... Disruption of this repressor complex by overexpression of c-Myc or v-Ski results
in reinduction of cell cycle ... (2000) Mutations truncating the EP300 acety- lase ...
Cited by 53 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Functional Genomic Analysis of the Wnt-Wingless Signaling Pathway - Full text - MIT Libraries
R DasGupta, A Kaykas, RT Moon, N Perrimon, SC Maps … - Science, 2005 - sciencemag.org
Page 1. Revised 5 May 05, see page 7 Science SOM DasGupta, p. 1 Science
Supporting Online Material Functional Genomic Analysis of ...
Cited by 6 - Web Search - flyrnai.org - ncbi.nlm.nih.gov - all 4 versions »

Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase … - Full text - MIT Libraries
CA Hobbs, BA Paul, SK Gilmour - Cancer Res, 2002 - cancerres.aacrjournals.org
... JD, Ponder BA, Kouzarides T., Caldas C. Mutations truncating the EP300 acetylase
in ... RE, Johnson LR Decreased expression of protooncogenes c-fos, c-myc, and c ...
Cited by 10 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

Gene Expression Profiles Reveal that DCN, DIO 1, and DIO 2 Are Underexpressed in Benign and …
LAT Arnaldi, RC Borra, RMB Maciel, JM Cerutti - Thyroid, 2005 - dx.doi.org
Page 1. 210 THYROID Volume 15, Number 3, 2005 © Mary Ann Liebert, Inc. Gene Expression
Profiles Reveal that DCN, DIO1, and DIO2 Are Underexpressed in ...
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Lamin A/C and emerin mutations in Emery-Dreifuss muscular dystrophy disrupt Rb-MyoD pathways.
C Author - jbpc.mbl.edu
Page 1. Lamin A/C and emerin mutations in Emery-Dreifuss muscular dystrophy
disrupt Rb-MyoD pathways. Marina Bakay 1 *, Gisela Melcon ...
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The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases - Full text - MIT Libraries
XJ Yang - Nucleic Acids Research, 2004 - nar.oupjournals.org
... Originally identified as an essential cofactor for the oncogenic transcription factors
c-Myc and E2F (143), TRRAP is an ATM/PI-3 kinase-like protein shared by ...
Cited by 14 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Epigenetics and cancer - Full text - MIT Libraries
AH Lund, M van Lohuizen - Genes & Development, 2004 - genesdev.org
... 2001 ; Vonlanthen et al. 2001 ; Leung et al. 2004 ). Originally identified as a
potent collaborator with Myc in mouse leukemia (van Lohuizen et al. ...
Cited by 11 - Web Search - dx.doi.org - genesdev.org - ncbi.nlm.nih.gov

The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA …
FY Diao, M Xu, Y Hu, J Li, Z Xu, M Lin, L Wang, Y … - J Mol Endocrinol, 2004 - njmu.edu.cn
... GenBank ID Gene name Abbreviation Unigene P/N Classification Cell division NM_014335
CREBBP/EP300 inhibitory protein 1 CR11 Hs. 381137 3·12 ...
Cited by 1 - Web Search - jme.endocrinology-journals.org - journals.endocrinology.org - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Hepatic Temporal Gene Expression Profiling in Helicobacter hepaticus-Infected A/JCr Mice
S BOUTIN, A ROGERS, Z SHEN, R FRY, J LOVE, P … - Toxicologic Pathology, 2004 - dx.doi.org
... Tubulin, beta 3 * * 2.68 Tubulin, beta 5 * * 2.67 CREBBP/EP300 inhibitory protein
1 * 2.24 2.63 Retinoic acid early transcript gamma * 1.69 2.63 ...
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Trichostatin A Inhibits b-Casein Expression in Mammary Epithelial Cells - Full text - MIT Libraries
P Pujuguet, D Radisky, D Levy, C Lacza, MJ Bissell - Journal of Cellular Biochemistry, 2001 - doi.wiley.com
... and is accompanied by the transcriptional repression of pro-growth genes, including
c-myc, cyclin D1 ... Mutations truncating the EP300 acetylase in human cancers. ...
Cited by 4 - Web Search - doi.wiley.com - www-library.lbl.gov - ncbi.nlm.nih.gov - all 5 versions »

Histone modification enzymes: novel targets for cancer drugs
R Kristeleit, L Stimson, P Workman, W Aherne - Expert Opinion on Emerging Drugs, 2004 - dx.doi.org
Page 1. Review 2004 © Ashley Publications Ltd ISSN 1472-8214
135 Ashley Publications www.ashley-pub.com ...
Web Search - extenza-eps.com - ashley-pub.com - ingentaconnect.com - all 8 versions »

Bibliography Current World Literature
E Tumors - Current Opinion in Oncology, 2005 - co-oncology.com
... Pession A, Tonelli R, Fronza R, et al: Targeted inhibition of NMYC by peptide nucleic
acid in N-myc amplified human neuroblastoma cells: cell-cycle inhibition ...
Web Search

Epigenetic and Chromatin Modifiers As Targeted Therapy of Hematologic Malignancies - Full text - MIT Libraries
KN Bhalla - J Clin Oncol, 2005 - jco.org
... 156-158 Induction of GADD45 and ß and upregulation of transforming growth factor
beta (TGF-ß), which inhibits c-myc, may also contribute to the cell cycle ...
Cited by 2 - Web Search - dx.doi.org - jco.org - ncbi.nlm.nih.gov