The cardiac homeobox gene Csx/Nkx2. 5 lies genetically upstream of multiple genes essential for … - Full text - MIT Libraries
CT Basson, W Pease, GM Silberbach, JP Moak, M … - Development, 1999 - dev.biologists.org
... Selective downregulation of N-myc, HAND1 and MEF2C suggested that Csx/Nkx2.5 might
control later differentiation of cardiac myocytes through essential ...
Cited by 102 - Web Search - cardiogenomics.med.harvard.edu - cardiogenomics.med.harvard.edu - ncbi.nlm.nih.gov - all 6 versions »

Altered Twist 1 and Hand 2 dimerization is associated with Saethre-Chotzen syndrome and limb … - Full text - MIT Libraries
BA Firulli, D Krawchuk, VE Centonze, N Vargesson, … - Nature Genetics, 2005 - uni-marburg.de
... antibody Hand1 Myc Flag-T w ist1 – Myc-Hand2 Flag-T w ist1 – Myc-Hand1 Flag-Hand1 –
Myc-Hand2 Flag-Hand1 – Myc-Hand1 Flag-T w ist1 Flag-Hand1 Mar k e r ...
Web Search - ncbi.nlm.nih.gov

Differential Regulation of Hand1 Homodimer and Hand1-E12 Heterodimer Activity by the Cofactor FHL2 - Full text - MIT Libraries
AA Hill, PR Riley - Mol. Cell. Biol, 2004 - mcb.asm.org
... 2B, lane 5), or a combination of vectors for FLAG-Hand1 and MYC-FHL2 (lane 7). Extracts
from the transfected cells, along with untransfected controls, were ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

Role of Hand1/eHAND in the Dorso-Ventral Patterning and Interventricular Septum Formation in the … - Full text - MIT Libraries
K Togi, T Kawamoto, R Yamauchi, Y Yoshida, T Kita, … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... N-myc, TEF-1, and p57 were normally expressed in Hand1/eHAND KI embryos, suggesting
that there may be other mechanism(s). At E11.5, Hand1/eHAND expression was ...
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Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction … - Full text - MIT Libraries
SJ KIMBER, P HUSSLEIN - Biochem. J, 2002 - biochemj.org
... 641 Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic
expression ... cells. In contrast, Hand1 diminished INTRODUCTION ...
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Fluorescence Resonance Energy Transfer (FRET) as a method to calculate the dimerization strength of … - Full text - MIT Libraries
VE Centonze, BA Firulli, AB Firulli - Biological Procedures Online, 2004 - biologicalprocedures.com
... affect HAND1 dimerization (6). Our initial efforts focused on immunoprecipitation
of myc- and Flag-tagged HAND1 and E- proteins coexpressed in HEK293 cells. ...
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Methods Article - Full text - MIT Libraries
VE Centonze, BA Firulli, AB Firulli - Biol. Proced. Online, 2004 - dx.doi.org
... affect HAND1 dimerization (6). Our initial efforts focused on immunoprecipitation
of myc- and Flag-tagged HAND1 and E-proteins coexpressed in HEK293 cells. ...
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Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb … - Full text - MIT Libraries
N Genetics - Nature Genetics, 2005 - nature.com
... 4a). Expression of Flag-tagged Twist1 with Myc-tagged Hand1 or Hand2 resulted in
specific coimmunoprecipitation of Twist1 with either Hand protein. ...
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Functional Analyses of Three Csx/Nkx-2. 5 Mutations That Cause Human Congenital Heart Disease - Full text - MIT Libraries
W Zhu, I Shiojima, Y Hiroi, Y Zou, H Akazawa, M … - J Biol Chem, 2000 - jbc.org
... Csx/Nkx-2.5 regulates expression of various cardiac genes in the developing
heart, such as ANP, BNP, N-myc, MEF2C, HAND1, and Msx2 (22). ...
Cited by 13 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Methods Article - Full text - MIT Libraries
BA Firulli, DM Virshup, AB Firulli - Biol. Proced. Online, 2004 - dx.doi.org
... The HAND1 basic helix-loop-helix transcription factor regulates trophobblast
differentiation via ... Triplex forming Ability of a c-myc Promoter element Predicts ...
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Phosphopeptide mapping of proteins ectopically expressed in tissue culture cell lines - Full text - MIT Libraries
BA Firulli, DM Virshup, AB Firulli - Biological Procedures Online, 2004 - biologicalprocedures.com
... The HAND1 basic helix-loop-helix transcription factor regulates trophobblast
differentiation via ... Triplex forming Ability of a c-myc Promoter element Predicts ...
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Generation of neurons by transient expression of neural bHLH proteins in mammalian cells - Full text - MIT Libraries
MH Farah, JM Olson, HB Sucic, RI Hume, SJ Tapscott … - Development, 2000 - dev.biologists.org
... into pCS2+ or pCS2+MT (for myc epitope tag fusions; Rupp et al., 1994; Turner and
Weintraub, 1994). Details are available upon request. pCS2+ Hand1/Thing1, pCS2 ...
Cited by 86 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac … - Full text - MIT Libraries
YS Dai, P Cserjesi, BE Markham, JD Molkentin - J. Biol. Chem, 2002 - jbc.org
... The blot was incubated with mouse anti-Myc (Sigma ... transcription factors GATA5 and
GATA6 synergized with dHAND on the ANF promoter, whereas eHAND (HAND1) did not ...
Cited by 35 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Csx/Nkx 2-5 Is Required for Homeostasis and Survival of Cardiac Myocytes in the Adult Heart - Full text - MIT Libraries
H Toko, W Zhu, E Takimoto, I Shiojima, Y Hiroi, Y … - J Biol Chem, 2002 - jbc.org
... Knockout experiments have suggested that many genes such as Hand1, myocyte enhancer ...
cardiac -actin, cardiac ankyrin repeat protein (CARP), N-myc, and MSX2 are ...
Cited by 10 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

JAB 1 enhances HAND 2 transcriptional activity by regulating HAND 2 DNA binding - Full text - MIT Libraries
YS Dai, J Hao, C Bonin, Y Morikawa, P Cserjesi - Journal of Neuroscience Research, 2004 - doi.wiley.com
... Coimmunoprecipitation Assay 293T cells were cotransfected with Myc-tagged HAND2,
HAND2 HLH ... shown), overlapping with the pattern re- ported for HAND1 and Mash1 ...
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Inhibitor of Myogenic Family, a Novel Suppressor of Store-operated Currents through an Interaction … - Full text - MIT Libraries
R Ma, D Rundle, J Jacks, M Koch, T Downs, L … - J Biol Chem, 2003 - jbc.org
... helix (bHLH) transcription factors such as myogenin, Myf5, Mash2, and Hand1 by
preventing ... HEK293T cells were co-transfected with myc-tagged TRPC1 (M-TRPC1) and ...
Cited by 4 - Web Search - w3.ouhsc.edu - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic … - Full text - MIT Libraries
H Chen, SA Detmer, AJ Ewald, EE Griffin, SE Fraser … - J. Cell Biol, 2003 - intl.jcb.org
... additional giant cell markers, proliferin (Lee et al., 1988) and Hand1 (Riley et
al ... mutant cultures were infected with a retrovirus expressing Mfn1-Myc >90% of ...
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Life and death in the placenta: new peptides and genes regulating human syncytiotrophoblast and …
DW Morrish, J Dakour, H Li - Curr Prot Peptide Sci, 2001 - ingentaconnect.com
... Transcription factors such as TEF-5, Hand1, HEB, HASH-2 and two genes ... Interestingly,
EGF continues to elicit junB and c-myc responsiveness in mature syncytium ...
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Roles of cardiac transcription factors in cardiac hypertrophy - Full text - MIT Libraries
H Akazawa, I Komuro - Circ Res, 2003 - circres.ahajournals.org
... of several cardiac genes in the heart of Csx/Nkx2-5–deficient embryos (including
MLC2v, ANP, BNP, CARP, MEF2-C, eHAND/HAND1, N-myc, Iroquois homeobox gene 4 ...
Cited by 14 - Web Search - ahavj.ahajournals.org - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin- … - Full text - MIT Libraries
S Palmer, N Groves, A Schindeler, T Yeoh, C Biben, … - J. Cell Biol, 2001 - jcb.org
... However, in knockout mice genes encoding the regionally expressed transcription
factors Hand1/eHand, Irx4, Msx-2, and N-myc and the actin cross-linking protein ...
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JBC Papers in Press. Published on March 11, 2002 as Manuscript M107669200
R Title - jbc.org
... Knockout experiments have suggested that many genes such as Hand1, myocyte ... cardiac
α -actin, cardiac ankyrin repeat protein (CARP), N-myc and MSX2 were ...
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Requirement of the mouse I-mfa gene for placental development and skeletal patterning - Full text - MIT Libraries
N Kraut, L Snider, CMA Chen, SJ Tapscott, M … - The EMBO Journal, 1998 - embojournal.npgjournals.com
... In contrast, I-mfa did not interfere with the activity of the bHLH protein
Hand1, a positive regulator of giant cell differentiation. ...
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T-box genes coordinate regional rates of proliferation and regional specification during … - Full text - MIT Libraries
CL Cai, W Zhou, L Yang, L Bu, Y Qyang, X Zhang, X … - Development, 2005 - rosenfeldlab.ucsd.edu
... can immortalize mouse embryo fibroblasts and cooperate with the oncogenes Myc or
Ras ... of Nkx2-5. Two other genes downregulated in Nkx2-5 mutants, Hand1 and Irx4 ...
View as HTML - Web Search - dev.biologists.org - dev.biologists.org - ncbi.nlm.nih.gov

Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct … - Full text - MIT Libraries
DG McFadden, J McAnally, JA Richardson, J Charite, … - Development, 2002 - dev.biologists.org
... dHAND and the closely related bHLH protein eHAND (HAND1 – Mouse Genome Informatics)
are ... A 1:1000 dilution of rabbit polyclonal anti-Myc (Santa Cruz) antibody ...
Cited by 14 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis … - Full text - MIT Libraries
L Wei, K Imanaka-Yoshida, L Wang, S Zhan, MD … - Development, 2002 - dev.biologists.org
... Generation of transgenic mice Myc-tagged bovine Rho GDI cDNA (0.7 kb ... forward
5'-TACAGTATGGCCCTGTCCTA-3', reverse 5'-TCCAGGGCCCAGACGTGCTG-3'; eHAND (Hand1; 23 ...
Cited by 14 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Molecular Embryogenesis of the Heart - Full text - MIT Libraries
ML Kirby, KL Waldo - Pediatric and Developmental Pathology, 2002 - springerlink.com
Page 1. PERSPECTIVES IN PEDIATRIC PATHOLOGY Molecular Embryogenesis of the Heart
M ARGARET L. K IRBY , * AND WITH ILLUSTRATIONS BY K AREN L. W ALDO ...
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Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms - Full text - MIT Libraries
ME Massari, C Murre, R Articles - Mol. Cell. Biol, 2000 - dx.doi.org
... homology with the Drosophila Daughterless protein, the myogenic differentiation
factor MyoD, members of the achaete-scute gene complex, and the Myc family of ...
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Tbx 20 dose-dependently regulates transcription factor networks required for mouse heart and … - Full text - MIT Libraries
JK Takeuchi, M Mileikovskaia, K Koshiba-Takeuchi, … - Development, 2005 - cvri-server2.ucsf.edu
... with an Isl1 expression construct together with FLAG-Gata4, Myc-Tbx20, Myc-Tbx1
or ... Expression of Hand1 and Hand2, which mark the LV and RV, respectively, was ...
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APOPTOSIS, MOLECULAR AND GENETIC CONTRIBUTIONS
M Knoefler, R Vasicek, M Schreiber - harcourt-international.com
... Another bHLH protein which plays a fundamental role in murine trophoblast development
is Hand1. Contrary ... expression. Additionally, Hand1 / mice ...
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Roles of LIM proteins in cardiac hypertrophy
M Han, JK Wen, B Zheng - futuremedicine.com
... of imme- diate-early genes such as c-jun, c-fos, c-myc, erg-1 ... FHL2, sLIM3, DRAL
AP-1, CREB, CREM, Hand1, titin integrin-associated proteins, ERK2, Alzheimer’s ...
Web Search - futuremedicine.com

exclusive licence allowing the National Library of Canada to reproduce, loan, distribute or sell …
OON KlAON - collectionscanada.ca
... Figure 1 1 : Fm mRNA Expression in the Placenta (cork) Figure 12: Immunolocalization
of Myc-tagged Fzr ... In contrast to Mash2 mutants, Hand1 null embryos die ...
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ORIGINAL ARTICLE PTHrP promotes murine secondary trophoblast giant cell differentiation through … - Full text - MIT Libraries
AHK El-Hashash, P Esbrit, SJ Kimber - Differentiation, 2005 - blackwell-synergy.com
... The formation of TGCs depends on Hand1 (Riley et al., 1998; Scott et al., 2000 ... C.
Cooper, University of Texas, USA), c-Myc (1:200 mouse anti-human IgG; Oncogene ...
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Transcriptional regulation of vertebrate cardiac morphogenesis - Full text - MIT Libraries
BG Bruneau - Circ. Res, 2002 - circres.ahajournals.org
... roles of the bHLH transcription factors dHand (Hand2) and eHand (Hand1) and the
T ... 1. Mice deficient in the proto-oncogene transcription factor N-myc also have ...
Cited by 44 - Web Search - cardiogene.org - tagc.univ-mrs.fr - dx.doi.org - all 9 versions »

STRUCTURAL AND FUNCTIONAL SIMILARITIES AND DIFFERENCES BETWEEN THE GPS PROTEINS - Full text - MIT Libraries
H Jafar-Nejad, HJ Bellen - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... The Myc oncoprotein: a critical evaluation of transactivation and target gene ... mesodermal
defects in mouse embryos lacking the bHLH transcription factor Hand1. ...
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Implications for Congenital Heart Disease - Full text - MIT Libraries
D Srivastava - Annu. Rev. Physiol, 2001 - physiol.annualreviews.org
... 62). A similar phenotype is seen in mice carrying mutations in the N-myc,
TEF-1 and neurofibromatosis (NF-1) genes (63–65). Deficiencies ...
Cited by 31 - Web Search - phyto.annualreviews.org - ncbi.nlm.nih.gov

tt. Col. Prank P. Dyke United States 4ir Force Los A9qelea Air Porce Station, California Vslter 4. …
C El Sequnh - pdf.aiaa.org
... space of thc intrinsicallv flexible, software- proqrannable digital coanuter to
cope with th ?rowing 3emands for control sophistication and data hand1 iol in ...
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Akt-dependent phosphorylation negatively regulates the transcriptional activity of dHAND by … - Full text - MIT Libraries
M Murakami, K Kataoka, S Fukuhara, O Nakagawa, H … - European Journal of Biochemistry, 2004 - content.febsjournal.org
... P., Anson-Cartwright, L. & Cross, JC (1998) The Hand1 bHLH transcription ... H. & Lassar,
AB (1988) MyoD1: a nuclear phosphoprotein requiring a Myc homology region ...
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Mutations in the cardiac transcription factor NKX2. 5 affect diverse cardiac developmental pathways - Full text - MIT Libraries
DW Benson, GM Silberbach, A Kavanaugh-McHugh, C … - J Clin Invest, 1999 - jci.org
... activator of other genes expressed during cardiac development including Hand1 (eHand)
(9, 11 ... gene (14), cardiac ankyrin repeat protein gene (15), N-myc (9), and ...
Cited by 100 - Web Search - jci.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

The highly conserved cardiogenic bHLH factor Hand is specifically expressed in circular visceral … - Full text - MIT Libraries
V Koelsch, A Paululat - Dev. Genes Evol, 2002 - springerlink.com
... Humans, mice and other higher vertebrates have two related genes, dHand (also known
as Hand2, Hed, Thing2) and eHand (also known as Hand1, Hxt, Thing1 ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov

Gene expression profile of human endothelial cells exposed to sustained fluid shear stress - Full text - MIT Libraries
SM Wasserman, F Mehraban, LG Komuves, RB Yang, JE … - Physiol Genomics, 2002 - intl-physiolgenomics.physiology.org
... whereas pregnancy-induced growth inhibitor OKL38 and N-myc downstream regulated
gene ... of bHLH transcription factors that includes MyoD, NeuroD, Hand1, and Hand2 ...
Cited by 21 - Web Search - intl-physiolgenomics.physiology.org - physiolgenomics.physiology.org - ncbi.nlm.nih.gov

A novel stable polyalanine[poly (A)] expansion in the HOXA 13 gene associated with hand-foot-genital … - Full text - MIT Libraries
B Utsch, K Becker, D Brock, M Lentze, F … - Human Genetics, 2002 - springerlink.com
... 1996), HAND1 (Russell et al ... Monatsschr Kinderh 150 (in press) Bossone SA, Asselin
C, Patel AJ, Marcu KB (1992) MAZ, a zinc finger protein, binds to c-MYC and C2 ...
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Physiol. Genomics Articles in PresS. Published on November 5, 2002 as DOI 10.1152/physiolgenomics. …
SM Wasserman, F Mehraban, LG Komuves, RB Yang, JE … - physiolgenomics.physiology.org
... growth inhibitor OKL38 and N-myc downstream regulated gene-1/Cap43 are ... tissue-restricted
class of bHLH transcription factors that includes MyoD, NeuroD, Hand1 ...
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Annual Review of Physiology - Full text - MIT Libraries
D Srivastava - Annual Review of Physiology, 2001 - physiol.annualreviews.org
... 62). A similar phenotype is seen in mice carrying mutations in the N-myc,
TEF-1 and neurofibromatosis (NF-1) genes (63, 64, 65). ...
Web Search - physiol.annualreviews.org - phyto.annualreviews.org - phyto.annualreviews.org

A Genetic Screen for Candidate Tumor Suppressors Identifies REST. - Full text - MIT Libraries
TF Westbrook, ES Martin, IMR Schlabach, Y Leng, AC … - Cell, 2005 - biocat.de
... bors promise in more complex experimental designs. endogenous c-myc gene resulting
from extended cul- ... HAND1 Transcriptional regulation; cardiac morphogenesis ...
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Fluid shear stress induces endothelial KLF2 gene expression through a defined promoter region
JP Huddleson, S Srinivasan, N Ahmad, JB Lingrel - Biol. Chem, 2004 - degruyter.com
... These are loosely defined consensus sequences for Hand1/E47, Oct1, Pax4, and Pax6. ...
LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway ...
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Upregulation of embryonic transcription factors in right ventricular hypertrophy - Full text - MIT Libraries
A Cojoc, L Jahn - Basic Research in Cardiology, 2003 - springerlink.com
... of myosin light chain 2 (MLC2v), eHAND, MEF-2C and N-myc (32 ... extra-embryonic mesodermal
defects in mouse embryos lacking the bHLH tran- scription factor Hand1. ...
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m-Bop, a Repressor Protein Essential for Cardiogenesis, Interacts with skNAC, a Heart- and Muscle- … - Full text - MIT Libraries
RJ Sims III, EK Weihe, L Zhu, S O'Malley, JV … - J Biol Chem, 2002 - jbc.org
... The discovery of chamber-specific transcription factors, such as the Hand1 and Hand2 ...
Bra-1 and Bra-2, with viral oncoproteins and the Myc-related cellular ...
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Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed …
Y Xie, Y Wang, T Sun, F Wang, A Trostinskaia, E … - Molecular Reproduction and Development, 2005 - doi.wiley.com
... sulin like growth factor-II (IGFII), mammalian achaete scutehomologue2(MASH2),HAND1,
estrogenreceptor orphan ... that regulate cell cycle, DP-1, Rb, c-Myc, and max ...
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Conserved transcription factor binding sites of cancer markers derived from primary lung … - Full text - MIT Libraries
YL Yap, MP Wong, XW Zhang, D Hernandez, R Gras, DK … - Nucleic Acids Research, 2005 - nar.oupjournals.org
Page 1. Conserved transcription factor binding sites of cancer markers derived
from primary lung adenocarcinoma microarrays Yee Leng ...
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Endogenous retroviral syncytin: compilation of experimental research on syncytin and its possible … - Full text - MIT Libraries
I Knerr, B Huppertz, C Weigel, J Doetsch, C Wich, … - Molecular Human Reproduction, 2004 - molehr.oupjournals.org
... Dakour J, Li H, Chen H and Morrish DW (1999) EGF promotes development of a
differentiated trophoblast phenotype having c-myc and junB proto-oncogen activation. ...
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