Application of fluorescence in situ hybridization to detect N-myc(MYCN) gene amplification on …
Y Hachitanda, M Saito, T Mori, M Hamazaki - Medical and Pediatric Oncology, 1997 - doi.wiley.com
Page 1. Application of Fluorescence in Situ Hybridization to Detect N-myc (MYCN)
Gene Amplification on Paraffin-Embedded Tissue Sections of Neuroblastomas ...
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… 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN - Full text - MIT Libraries
T Teitz, T Wei, MB Valentine, EF Vanin, J Grenet, … - Nat Med, 2000 - nature.com
... | Article | PubMed | ISI | ChemPort | Fulda, S., Lutz, W., Schwab, M. & Debatin,
KM Myc-N sensitizes neuroblastoma cells for drug-induced apoptosis. ...
Cited by 218 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Enhanced Expression of the Human Gene N-myc Consequent to Amplification of DNA May Contribute to … - Full text - MIT Libraries
M Schwab, J Ellison, M Busch, W Rosenau, HE Varmus … - Cancer Res, 2004 - pnas.org
... K. Kawamura, T. Etoh, and N. Ohnuma Enhanced Expression of N-myc Messenger RNA in ...
Res Home page AK Sarkar and JG Nuchtern Lysis of MYCN-amplified Neuroblastoma ...
Cited by 70 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Amplification of cellular oncogenes: a predictor of clinical outcome in human cancer
M Schwab, LC Amler - Genes Chromosomes Cancer, 1990 - ncbi.nlm.nih.gov
... Non-US Gov't. Gene Symbols: ABL; EGFR; ERBB2; HER-2/neu; HST; KRAS2; MYB; MYC; MYCL;
MYCN; NRAS; RAS1. Substances: DNA, Neoplasm; Proto-Oncogene ...
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Detection of gene amplification by genomic hybridization to cDNA microarrays - Full text - MIT Libraries
MA Heiskanen, ML Bittner, Y Chen, J Khan, KE Adler … - Cancer Res, 2000 - cancerres.aacrjournals.org
... The technique was validated using cancer cell lines with several known gene
amplifications, such as those affecting MYC, MYCN, ERBB2, and CDK4. ...
Cited by 48 - Web Search - ccr.cancer.gov - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - all 5 versions »

Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent …
K Ichimura, EE Schmidt, HM Goike, VP Collins - Oncogene, 1996 - ncbi.nlm.nih.gov
... In the glioblastomas with no alterations of CDKN2A, CDK4 or RB1, several other genes
(CCND1, CCND2, CCND3, CDK6, E2F, CDK7, MYC and MYCN) whose products take ...
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Matrix-based comparative genomic hybridization: Biochips to screen for genomic imbalances
S Solinas-Toldo, S Lampel, S Stilgenbauer, J … - Genes Chromosomes and Cancer, 1997 - doi.wiley.com
... Therefore, we used cosmids containing sequences of the amplified genes,
MYC or MYCN, as well as 402 SOLINAS-TOLDO ET AL. Page 5. ...
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MYCN is retained in single copy at chromosome 2 band p23–24 during amplification in human … - Full text - MIT Libraries
R Corvi, LC Amler, L Savelyeva, M Gehring, M … - Proc Natl Acad Sci US, 1994 - pubmedcentral.nih.gov
... Amplification of the human N-myc protooncogene, MYCN, is frequently seen either
in extrachromosomal double minutes or in homogeneously staining regions of ...
Cited by 22 - Web Search - pnas.org - ncbi.nlm.nih.gov

Enhanced MYCN expression and isochromosome 17q in pineoblastoma cell lines
UR Kees, JA Biegel, J Ford, PR Ranford, SE Peroni, … - Genes Chromosomes Cancer, 1994 - ncbi.nlm.nih.gov
... Characterization of these lines revealed that the proto-oncogenes MYC and MYCN were
not amplified, but both cell lines showed MYCN expression comparable to a ...
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Gene amplification in PNETs/medulloblastomas: mapping of a novel amplified gene within the MYCN … - Full text - MIT Libraries
MC Fruhwald, MS O'Dorisio, LJ Rush, JL Reiter, DJ … - Journal of Medical Genetics, 2000 - jmedgenet.com
... Fuller et al 9 pooled data from five independent studies and found that amplification
of the genes for MYC, MYCN, and the epidermal growth factor receptor (EGFR ...
Cited by 18 - Cached - Web Search - dx.doi.org - jmg.bmjjournals.com - ncbi.nlm.nih.gov - all 7 versions »

MYCN gene amplification in rhabdomyosarcoma
D Driman, PS Thorner, ML Greenberg, S Chilton- … - Cancer, 1994 - ncbi.nlm.nih.gov
... Rhabdomyosarcoma, Embryonal/genetics*; Rhabdomyosarcoma, Embryonal/pathology. Gene
Symbols: M-myc; MYCN. PMID: 8156531 [PubMed - indexed for MEDLINE]
Cited by 21 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

… and concomitant high levels of expression of a DEAD box gene with MYCN in human neuroblastoma
CF Manohar, HR Salwen, GM Brodeur, SL Cohn - Genes Chromosomes Cancer, 1995 - ncbi.nlm.nih.gov
... expression was observed in tumors or cell lines that lacked MYCN amplification. ... Genes,
myc*; Human; Infant; Molecular Sequence Data; Neoplasm Proteins/biosynthesis ...
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Comparative genomic hybridization detects many recurrent imbalances in central nervous system … - Full text - MIT Libraries
H Avet-Loiseau, AM Venuat, MJ Terrier-Lacombe, A … - British Journal of Cancer, 1999 - nature.com
... 1992; Neumann et al, 1993; Fujii et al, 1994). Few gene amplifica- tions
have been reported, involving MYC, MYCN or EGFR (Rouah ...
Cited by 18 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Localization of regulatory elements controlling human MYCN expression
S Hiller, S Breit, ZQ Wang, EF Wagner, M Schwab - Oncogene, 1991 - ncbi.nlm.nih.gov
... Teratoma/pathology; Transfection. Gene Symbols: MYCN. Substances: DNA, Neoplasm;
Proto-Oncogene Proteins c-myc. PMID: 2067849 [PubMed - indexed for MEDLINE]
Cited by 13 - Web Search - Get it from MIT Libraries

MYCC and MYCN oncogene amplification in medulloblastoma
N Aldosari, SH Bigner, PC Burger, L Becker, JL … - Arch Pathol Lab Med, 2002 - arpa.allenpress.com
... Cytogenetic abnormalities that have been described in childhood medulloblastoma
include loss of 17p, amplification of MYCC (c-myc), amplification of MYCN (N-myc ...
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Sustained expression of the human protooncogene MYCN rescues rat embryo cells from senescence. - Full text - MIT Libraries
M Schwab, JM Bishop - Proc Natl Acad Sci US A, 1988 - pubmedcentral.nih.gov
... an additional biological activity that can be used in the characterization of MYCN. ...
M, Trent J. Amplified DNA with limited homology to myc cellular oncogene is ...
Cited by 9 - Web Search - pnas.org - ncbi.nlm.nih.gov - adsabs.harvard.edu

… is not prognostic of adverse outcome in advanced-stage neuroblastoma with nonamplified MYCN - Full text - MIT Libraries
SL Cohn, WB London, D Huang, HM Katzenstein, HR … - J Clin Oncol, 2000 - jco.org
... 62 Thus, the apparently better prognosis of patients with high-level MYC- or
MYCN-expressing tumors may result from either higher rates of apoptosis or higher ...
Cited by 20 - Web Search - jco.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

ID2 expression is not associated with MYCN amplification or expression in human neuroblastomas - Full text - MIT Libraries
Q Wang, G Hii, S Shusterman, Y Mosse, CL Winter, C … - Cancer Res, 2003 - cancerres.aacrjournals.org
... Because MYC and MYCN are rather promiscuous, albeit relatively weak, transactivators,
and additional studies such as chromatin immunoprecipitation assays will ...
Cited by 8 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The mycN/max protein complex in neuroblastoma. Short review - Full text - MIT Libraries
A Wenzel, M Schwab - Eur J Cancer, 1995 - ncbi.nlm.nih.gov
... This principle structure is conserved among all members of the MYC gene family.
The resulting dimers can bind to the DNA sequence CACGTG. The mycN protein, but ...
Cited by 11 - Web Search - ncbi.nlm.nih.gov

Identification of subsets of neuroblastomas by combined histopathologic and N-myc analysis - Full text - MIT Libraries
H Shimada, DO Stram, J Chatten, VV Joshi, Y … - J Natl Cancer Inst, 1995 - ncbi.nlm.nih.gov
... Neuroblastomas show different histopathologic phenotypes, and the tumor cells can
carry normal or multiple copies of the N-myc proto-oncogene (MYCN). ...
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… MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN - Full text - MIT Libraries
D Bannasch, I Weis, M Schwab - Oncogene, 1999 - nature.com
Nature.com
Cited by 6 - Web Search - nature.com - ncbi.nlm.nih.gov

New insights into testicular germ cell tumorigenesis from gene expression profiling - Full text - MIT Libraries
RI Skotheim, O Monni, S Mousses, SD Fossa, OP … - Cancer Res, 2002 - cancerres.aacrjournals.org
... growth factor receptor-bound protein 7; JUP, junction plakoglobin; LLGL2, lethal
giant larvae (Drosophila) homolog 2; MYBL2, B-Myb; MYCL1, L-Myc; MYCN, N-Myc ...
Cited by 38 - Web Search - folk.uio.no - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - all 5 versions »

Chromosome 1 alterations in breast cancer: allelic loss on 1p and 1q is related to lymphogenic …
A Borg, QX Zhang, H Olsson, E Wenngren - Genes Chromosomes Cancer, 1992 - ncbi.nlm.nih.gov
... genetics. Gene Symbols: CMM; MUC1; MYC; MYCL; MYCN; PEM. Substances: CA-15-3
Antigen; DNA Probes; Genetic Markers; Membrane Glycoproteins; ...
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Retinoic-acid-resistant neuroblastoma cell lines show alteredMYC regulation and high sensitivity to …
CP Reynolds, Y Wang, LJ Melton, PA Einhorn, DJ … - Medical and Pediatric Oncology, 2000 - doi.wiley.com
... Here we show that RA resistance in neu- roblastoma cell lines is associated with
a lack of down- regulation of total myc (MYCN and/or c-myc) gene ex- pression ...
Cited by 11 - Web Search - nant.org - reprints.nant.org - ncbi.nlm.nih.gov - all 7 versions » - Get it from MIT Libraries

Cell lineage and differentiation state are primary determinants of MYCN gene expression and …
BA Spengler, DL Lazarova, RA Ross, JL Biedler - Oncol Res, 1997 - ncbi.nlm.nih.gov
... relationship suggested by our data is that MYCN expression, regulated by cell ... Female;
Gene Expression Regulation, Neoplastic/genetics; Genes, myc/genetics*; Human ...
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Gene amplification and gene dosage in cell lines derived from squamous cell carcinoma of the head …
XY Yin, M Donovan-Peluso, TL Whiteside, JT Johnson … - Genes Chromosomes Cancer, 1991 - ncbi.nlm.nih.gov
... Tumor Cells, Cultured/pathology. Gene Symbols: ALB; EGF; EGFR; ERBB2; HBB; IGF2;
IGKC; IL2; INT2; MET; MOS; MYC; MYCL; MYCN; RARA; RASN; TG. Substances: DNA Probes ...
Cited by 9 - Web Search - Get it from MIT Libraries

Targeted expression of MYCN causes neuroblastoma in transgenic mice - Full text - MIT Libraries
WA Weiss, K Aldape, G Mohapatra, BG Feuerstein, JM … - The EMBO Journal, 1997 - embojournal.npgjournals.com
... of neuroblastoma. Keywords: comparative genomic hybridization/MYCN/
neuroblastoma/N-myc /transgenic. Introduction. Neuroblastoma is ...
Cited by 93 - Web Search - nature.com - emboj.org - ingentaconnect.com - all 11 versions »

… of Heterozygosity for the Short Arm of Chromosome 1 in Human Neuroblastomas: Correlation with N-myc … - Full text - MIT Libraries
CT Fong, NC Dracopoli, PS White, PT Merrill, RC … - Oncologist, 2003 - pnas.org
... the short arm of chromosome 1 correlates significantly with N-myc amplification,
suggesting ... page, Annals NYAS Online Home page M. SCHWAB Amplified MYCN in Human ...
Cited by 88 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Activation of MYCN in a case of non-Hodgkin’s lymphoma
MC Finnegan, DW Hammond, BW Hancock, MH Goyns - Leuk Lymphoma, 1995 - ncbi.nlm.nih.gov
... blot analysis of RNA samples derived from 11 non-malignant reactive lymphoid tissues
and 33 NHL was used to investigate expression of MYC, MYCL and MYCN. ...
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MycN and IFNg cooperate in apoptosis of human neuroblastoma cells - Full text - MIT Libraries
W Lutz, S Fulda, I Jeremias, KM Debatin, M Schwab - Oncogene, 1998 - nature.com
... Induction of genes in response to IFNg and MycN Several IFNg and Myc activated genes
play a role in the induction and/or execution of apoptosis including the ...
Cited by 45 - Web Search - ncbi.nlm.nih.gov

BIN 1 inhibits colony formation and induces apoptosis in neuroblastoma cell lines with MYCN …
MD Hogarty, X Liu, PM Thompson, PS White, EP … - Medical and Pediatric Oncology, 2000 - doi.wiley.com
... regulator of genes critical to cell cycle entry and progression [3]. Interestingly
however, the MYC family of oncogenes (which includes MYC, MYCN, and MYCL ...
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Detection of N-myc amplification by FISH in immature areas of fixed neuroblastomas: more efficient … - Full text - MIT Libraries
H Sartelet, L Grossi, D Pasquier, V Combaret, R … - The Journal of Pathology, 2002 - doi.wiley.com
... Original Paper Detection of N-myc amplification by FISH in immature ... Keywords:
N-myc; amplification; FISH; fixed; neuroblastoma Introduction ...
Cited by 6 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Cytogenetics and DNA amplification in colorectal cancers
S Bruederlein, K van der Bosch, P Schlag, M Schwab - Genes Chromosomes Cancer, 1990 - ncbi.nlm.nih.gov
... ERBB2; FOS; KRAS; MYB; MYC; MYCL; MYCN; RAS. Substances: Proto-Oncogene Proteins;
Receptor, erbB-2. PMID: 1980607 [PubMed - indexed for MEDLINE]
Cited by 9 - Web Search - Get it from MIT Libraries

Expression of a MYCN-interacting isoform of the tumor suppressor BIN1 is reduced in neuroblastomas … - Full text - MIT Libraries
T Tajiri, X Liu, PM Thompson, S Tanaka, S Suita, H … - Clin. Cancer Res, 2003 - clincancerres.aacrjournals.org
... that BIN1 may function as a suppressor gene in NB, because Bin1 is highly expressed
in neural tissues and binds the Myc Box motifs that are conserved in MycN. ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

E 2 F Proteins Regulate MYCN Expression in Neuroblastomas - Full text - MIT Libraries
V Strieder, W Lutz - Journal of Biological Chemistry, 2003 - jbc.org
... The conservation of E2F-binding sites in the proximal promoter regions of both MYC
and MYCN and the shared role of these E2F-binding sites in repressing ...
Cited by 4 - Web Search - jbc.org - imt.uni-marburg.de - ncbi.nlm.nih.gov - all 5 versions »

MYCN in neuronal tumours - Full text - MIT Libraries
M Schwab - Cancer Lett, 2004 - ingentaconnect.com
... full text options. Abstract: MYCN is a member of the MYC family of oncogenes
that encode nuclear proteins serving as transcription factors. ...
Cited by 5 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

MycN sensitizes neuroblastoma cells for drug-triggered apoptosis
S Fulda, W Lutz, M Schwab, KM Debatin - Medical and Pediatric Oncology, 2000 - doi.wiley.com
... MYCN is a member of the family of MYC genes, which encode transcription factors
that participate in the regu- lation of both cell growth and apoptosis [3,4]. ...
Cited by 6 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

M OLECULAR G ENETICS OF L UNG C ANCER - Full text - MIT Libraries
Y Sekido, KM Fong, JD Minna - Annual Review of Medicine, 2003 - med.annualreviews.org
... The three major MYC family members (MYC, MYCN, and MYCL) comprise yet another
important positive growth-regulatory system for lung cancer. ...
Cited by 21 - Web Search - med.annualreviews.org - intl-med.annualreviews.org - ncbi.nlm.nih.gov

Ability of circular extrachromosomal DNA molecules to carry amplified MYCN proto-oncogenes in human … - Full text - MIT Libraries
DR VanDevanter, VD Piaskowski, JT Casper, EC … - J Natl Cancer Inst, 1990 - ncbi.nlm.nih.gov
... Amplification of the proto-oncogene MYCN (also known as N-myc) in neuroblastomas
has been shown to correlate with both disease stage and prognosis, yet little ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov

MYCN amplification by differential PCR
SN Huddart, JR Mann, AG McGukin, R Corbett - Pediatr Hematol Oncol, 1993 - ncbi.nlm.nih.gov
... A method is described to estimate MYCN (N-myc) oncogene amplification in neuroblastoma
by the technique of differential polymerase chain reaction (PCR). ...
Cited by 5 - Web Search - Get it from MIT Libraries

N-myc gene amplification in rhabdomyosarcoma detected by fluorescence in situ hybridization: its …
Y Hachitanda, S Toyoshima, K Akazawa, M Tsuneyoshi - Mod Pathol, 1998 - ncbi.nlm.nih.gov
... FISH) was applied to 15 alveolar rhabdomyosarcomas (A-RMSs) and 14 embryonal RMSs
(E-RMSs) to detect N-myc (also called MYCN) oncogene amplification. ...
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PPM1D is a potential target for 17q gain in neuroblastoma - Full text - MIT Libraries
F Saito-Ohara, I Imoto, J Inoue, H Hosoi, A … - Cancer Res, 2003 - cancerres.aacrjournals.org
... Our experiments using combinations of antisense OPTs for PPM1D and c-MYC or MYCN
indicated additive inhibitory effects on cell growth (c-MYC; Fig. ...
Cited by 15 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Degradation of MYCN oncoprotein by the ubiquitin system
A Ciechanover, JA DiGiuseppe, AL Schwartz, GM … - Prog Clin Biol Res, 1991 - ncbi.nlm.nih.gov
... by other mechanisms in aggressive tumors with a single copy of MYCN. ... MeSH Terms:
Animals; Cloning, Molecular; Genes, myc*; Human; Kinetics; Neuroblastoma/genetics ...
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MYCN oncogene and angiogenesis: down-regulation of endothelial growth inhibitors in human …
E Hatzi, S Breit, A Zoephel, K Ashman, U Tontsch, … - Adv Exp Med Biol, 2000 - ncbi.nlm.nih.gov
MYCN oncogene and angiogenesis: down-regulation of endothelial growth inhibitors
in human ... We report here that enhanced expression of the N-myc oncogene in ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

The MYCN oncoprotein as a drug development target - Full text - MIT Libraries
X Lu, A Pearson, J Lunec - Cancer Lett, 2003 - ingentaconnect.com
... MYCN is a member of the myc family of proto-oncogenes which encode nuclear proteins
that form heterodimers with MAX protein through their conserved HLHZip ...
Cited by 2 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Concomitant p 53 mutation and MYCN amplification in neuroblastoma
R Manhani, LM Cristofani, V Filho, I Bendit - Medical and Pediatric Oncology, 1997 - doi.wiley.com
... While other studies confirm the frequency of MYCN amplification and infrequency
of p53 ... GM, Sather H: Association of multiple copies of N-myc oncogene with ...
Cited by 6 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Intratumoural heterogeneity of 1 p deletions and MYCN amplification in neuroblastomas
PF Ambros, IM Ambros, R Kerbl, A Luegmayr, S … - Medical and Pediatric Oncology, 2001 - doi.wiley.com
... Corvi R, Savelyeva L, Schwab M. Duplication of N-MYC at its ... Heterogeneity of MYCN
amplification in a child with stroma-rich neuroblastoma (ganglioneuroblastoma ...
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Establishment and characterization of a serous papillary adenocarcinoma cell line of the human ovary …
M Emoto, K Oshima, M Ishiguro, H Iwasaki, T … - Pathol. Res. Pract, 1990 - ncbi.nlm.nih.gov
... We also evaluated c-myc, MYCN and c-erbB2 gene amplification in the cultured cells,
and the xenografts, as well as in these four primary tissue specimens by a ...
Cited by 2 - Web Search - Get it from MIT Libraries

Genetic analysis of mediastinal nonseminomatous germ cell tumors in children and adolescents
DT Schneider, AE Schuster, MK Fritsch, G Calaminus … - Genes Chromosomes and Cancer, 2002 - doi.wiley.com
... Therefore, FISH analysis of MYC and MYCN was performed and revealed more than six
bold and irregular sig- nals for both MYC and MYCN, compared to the two small ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/ … - Full text - MIT Libraries
MA Grotzer, MD Hogarty, AJ Janss, X Liu, H Zhao, A … - Clin Cancer Res, 2001 - clincancerres.aacrjournals.org
... In childhood NB, amplification of MYCN, a MYC family member, occurs in about 25%
of primary tumors and is strongly associated with advanced-stage disease ...
Cited by 39 - Web Search - clincancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov