The diabetes-linked transcription factor PAX4 promotes ß-cell proliferation and survival in rat and … - Full text - MIT Libraries
T Brun, I Franklin, L St-Onge, A Biason-Lauber, EJ … - The Journal of Cell Biology - jcb.org
... Thus, by modulating apoptosis through Bcl-xL expression and proliferation via
c-myc levels, Pax4 may regulate the total population of ß-cells and ultimately ...
Cited by 1 - Web Search - jcb.org - jem.org - ncbi.nlm.nih.gov

Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell … - Full text - MIT Libraries
BR Gauthier, TBCB Wollheim, EJ Schoenle - Diabetologia, 2005 - springerlink.com
... that Pax4 operates as a key regulator of adult beta cell mass by converging the
replicating effect of several signal transduction pathways towards the Myc-Id2 ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

An International Journal Home Help [Feedback][For Subscribers][Archive][Search][Contents] - Full text - MIT Libraries
SB Smith, R Gasa, H Watada, J Wang, SC Griffen, MS … - J. Biol. Chem, 2003 - pnas.org
... Hepatic Nuclear Factor 1 Cooperate in Activating Pancreatic Expression of Pax4 J.
Biol ... Xu, S. Bonner-Weir, and GC Weir Induction of c-Myc Expression Suppresses ...
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A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured … - Full text - MIT Libraries
M Sander, SC Griffen, J Huang, MS German - Biochemistry, 1998 - dx.doi.org
... Hepatic Nuclear Factor 1 Cooperate in Activating Pancreatic Expression of Pax4 J.
Biol ... Xu, S. Bonner-Weir, and GC Weir Induction of c-Myc Expression Suppresses ...
Cited by 16 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Gene Expression Profiling to Identify Oncogenic Determinants of Autocrine Human Growth Hormone in … - Full text - MIT Libraries
XQ Xu, BS Emerald, ELK Goh, N Kannan, LD Miller, … - J. Biol. Chem, 2005 - jbc.org
... 5'-GGCATACTAGGAGCTTGACTG-3'; PAX4 (sense), 5'-CTGGCGCATCACCTGATTGG-3'; PAX4 (antisense),
5 ... TFF3 cDNA inserts were reamplified with primers TFF3 cDNA-myc Top (5 ...
Web Search - jbc.org - ncbi.nlm.nih.gov

In vivo proliferation of differentiated pancreatic islet beta cells in transgenic mice expressing … - Full text - MIT Libraries
S Hino, T Yamaoka, Y Yamashita, T Yamada, J Hata, … - Diabetologia, 2004 - springerlink.com
... Tu- mourigenesis of pancreatic islets was examined by insulin con- tent, expression
of GLUT1, GLUT2, Pax4, c-myc and amylin, with an SV-40-transformed ...
Web Search - ncbi.nlm.nih.gov

Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4 alpha … - Full text - MIT Libraries
H Thomas, S Senkel, S Erdmann, T Arndt, G Turan, L … - Nucleic Acids Res, 2004 - pubmedcentral.nih.gov
... 9E10) and the anti-His tag antibody (27) was used for myc and histidine ... and TCF1
(HNF1α), whereas the genes encoding Foxa1 (HNF3α), Ngn3, Pax4, Ptf1a and ...
Cited by 1 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov

Neurogenin3 activates the islet differentiation program while repressing its own expression - Full text - MIT Libraries
SB Smith, H Watada, MS German - Mol Endocrinol, 2004 - mend.endojournals.org
... expression of Pax4. J Biol Chem 22. ... Biochem J 354:431-8 27. Swanson HI, Yang
JH 1999 Specificity of DNA binding of the c-Myc/Max and ...
Cited by 7 - Web Search - mend.endojournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

ASB TransScript
TF Antibodies, P Array, N Antibodies, N Antibodies - avivasysbio.com
... No. AVARP04004 ) 6 Anti-c-myc(Ab-2) Rabbit Polyclonal Cat No. ... ARP32062 Anti-PAWR
50 µg, 100 µg $180/$250 ARP32064 Anti-PAX4 50 µg, 100 µg $180/$250 ...
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Functional Modules in Ribosomal Protein L 5 for Ribonucleoprotein Complex Formation and … - Full text - MIT Libraries
M Claussen, F Rudt, T Pieler - J Biol Chem, 1999 - jbc.org
... vector (85). For in vitro expression of the fusion proteins, L5 was fused
to six N-terminal Myc epitopes in pCS2+MT (86). The control ...
Cited by 27 - Web Search - dx.doi.org - jbc.org - ncbi.nlm.nih.gov

Direct autoregulation and gene dosage compensation by POU-domain transcription factor Brn 3 a - Full text - MIT Libraries
M Trieu, A Ma, SR Eng, N Fedtsova, EE Turner - Development, 2003 - dev.biologists.org
... Brn3a-myc transgene, 5' GAAGAGGACTTGAGATCTATGAACAG; Brn3a common 3' oligonucleotide ...
in the mouse and human PAX6 (Kammandel et al., 1999 ), PAX4 (Brink et al ...
Cited by 8 - Web Search - ericonic.tripod.com - dev.biologists.org - ncbi.nlm.nih.gov - all 5 versions »

Fundamentals of Transcription Factors and Their Impact on Pancreatic Development and Cancer
JAKR Urrutia - Pancreatology, 2003 - content.karger.com
... 26, 27 Pax4 repressor beta and delta cell development 28, 29 Pax6 ... 52–55
c-myc activator cell proliferation, differentiation 56–58 c ...
Web Search - content.karger.com

Bio-engineering insulin-secreting cells from embryonic stem cells: a review of progress
E Roche, MP Sepulcre, R Ensenat-Waser, I Maestre, … - Med Biol Eng Comput, 2003 - iee.org
... or several endocrine pancreas precursor markers, such as the specific transcription
factors Neurogenin3, NeuroD=Beta2, Isl-1, Nkx2.2, Nkx6.1, Pax6, Pax4, Pdx-1 ...
Cited by 4 - View as HTML - Web Search - conferences.iee.org.uk - ncbi.nlm.nih.gov - link.aip.org - Get it from MIT Libraries

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... 01 N-Myc OCT1 02 Octamer factor 1 OCT1 03 Octamer factor 1 OCT1 04 Octamer factor
1 OCT1 Q6 Octamer factor 1 P300 01 p300 PAX3 B Pax3 binding sites PAX4 01 Pax ...
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Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4 {alpha … - Full text - MIT Libraries
H Thomas, S Senkel, S Erdmann, T Arndt, G Turan, L … - Nucleic Acids Research, 2004 - nar.oupjournals.org
... 9E10) and the anti-His tag antibody (27) was used for myc and histidine ... IPF1) and
TCF1 (HNF1 ), whereas the genes encoding Foxa1 (HNF3 ), Ngn3, Pax4, Ptf1a and ...
Web Search - nar.oupjournals.org

Contrasting patterns of expression of transcription factors in pancreatic alpha and beta cells - Full text - MIT Libraries
J Wang, G Webb, Y Cao, DF Steiner - Proc. Natl. Acad. Sci. USA, 2003 - pnas.org
... Thus, the higher levels of Id1, Id2, Id3, N-myc, and Mxi1 in the cell type ... Pax4,
which is restricted to pancreatic progenitors and is very low in adult cells ...
Cited by 6 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

The t (9; 14)(p13; q32) Chromosomal Translocation Associated With Lymphoplasmacytoid Lymphoma …
V Dyomin, H Ohno, RSK Chaganti, R Dalla-Favera - bloodjournal.org
... l), and t(2;8)(p12;q24) lead to the deregulated expression of the c-MYC proto-onco ...
YACa L OR 8Y*b Fig 2. Mapping of three 9p13 breakpoints and PAX4 gene within ...
Web Search - gis.a-star.edu.sg

Phosphorylation of the Transactivation Domain of Pax 6 by Extracellular Signal-regulated Kinase and … - Full text - MIT Libraries
I Mikkola, JA Bruun, G Bjoerkoey, T Holm, T … - J Biol Chem, 1999 - jbc.org
... Pax6, like Pax3, Pax4, and Pax7, also harbors a second DNA-binding domain, the paired ...
Thus, c-Myc (36), Spi-B (37), BCL-6 (38), Microphthalmia (39), and several ...
Cited by 19 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

In vitro cultivation of human islets from expanded ductal tissue - Full text - MIT Libraries
S Bonner-Weir, M Taneja, GC Weir, K Tatarkiewicz, … - Stem Cells, 2004 - dx.doi.org
... Kania, M. Wagner, U. Roll, L. St-Onge, and AM Wobus Expression of Pax4 in embryonic ...
G. Xu, S. Bonner-Weir, and GC Weir Induction of c-Myc Expression Suppresses ...
Cited by 215 - Web Search - pnas.org - pubmedcentral.nih.gov - joplink.net - all 7 versions »

Model the Relationship Between Gene Expression and TFBSs Using a Simplified Neural Network with …
X Zhou, KY Liu, G Li, S Wong - springerlink.com
... Condition 1 Condition 2 Index Transcriptional-Factor Frequency Transcriptional-Factor
Frequency 1 NFKB 0.5421 Myc 0.6637 2 E2F1 0.4334 NFKB 0.5634 ...
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Quantitative Assessment of Gene Targeting in Vitro and in Vivo by the Pancreatic Transcription …
SK Chakrabarti, JC James, RG Mirmira - jbc.org
... Our results show that in all cells Pdx1 binds strongly to the insulin, islet amyloid
polypeptide, glucagon, Pdx1, and Pax4 promoters, whereas it does not bind ...
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The Pax 3-FKHR oncoprotein is unresponsive to the Pax 3-associated repressor hDaxx - Full text - MIT Libraries
AD Hollenbach, JE Sublett, CJ McPherson, G … - The EMBO Journal, 1999 - embojournal.npgjournals.com
... Pax4, which does not contain an octapeptide domain and is only 45% identical to
Pax3 ... of the co-repressors Sin3a and Sin3b on Ume6 and Myc respectively (Allend ...
Cited by 82 - Web Search - nature.com - emboj.org - ncbi.nlm.nih.gov - all 7 versions »

Quantitative Assessment of Gene Targeting in Vitro and in Vivo by the Pancreatic Transcription … - Full text - MIT Libraries
IOFCSIN DIRECTING, P BINDING - J. Biol. Chem, 2002 - jbc.org
... over controls) and moderately associates with the glucagon and Pax4 promoters (about ...
ChIP assay in studying the mammalian transcription factors c-Myc, p53, and ...
Web Search - jbc.org

Identification of A Pax Paired Domain Recognition Sequence and Evidence for DNA-dependent …
N Genet - uphs.upenn.edu
... CD spectra of the I'm-ti paired domain were identical when the protein was prepared
and analyzed in either buffer, and the Pax4 paired domain was able to hind ...
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Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific … - Full text - MIT Libraries
MB Breslin, M Zhu, AL Notkins, MS Lan - Nucleic Acids Research, 2002 - nar.oupjournals.org
... Both Pax4 and Pax6 sequences are in the reverse orientation with respect to the
NeuroD ... and Weintraub,H. (1990) Sequence-specific DNA binding by the c-myc protein ...
Cited by 5 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

p48 subunit of mouse PTF1 binds to RBP-Jk/CBF-1, the intracellular mediator of Notch signalling, and … - Full text - MIT Libraries
J Obata, M Yano, H Mimura, T Goto, R Nakayama, Y … - Genes to Cells, 2001 - genestocellsonline.org
... Other homeodomain proteins, Pax4 and Pax6, are required for the normal differentiation
of insulin ... at the N-terminus and p48 was tagged with the c-myc epitope at ...
Cited by 11 - Web Search - blackwell-synergy.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Global expression analysis of gene regulatory pathways during endocrine pancreatic development - Full text - MIT Libraries
G Gu, JM Wells, D Dombkowski, F Preffer, B Aronow, … - Development, 2004 - dev.biologists.org
... for several transcription factors in the developing pancreas including, HNF1α (Tcf1α),
HNF1β (Tcf1β), HNF4α (Tcf4α), Pdx1, NeuroD1, Ngn3, Pax4, Pax6 and ...
Cited by 13 - Web Search - biology.missouri.edu - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Genes expressed in the developing endocrine pancreas and their importance for stem cell and diabetes …
JM Wells - Diabetes/Metabolism Research and Reviews, 2003 - doi.wiley.com
... transcription factor, LIM/homeodomain (AJ132765) Lmyc1 Lung carcinoma myc–related
oncogene ... 2 K2 transcription factor related, locus 2 (U31566) Pax4, 6 Paired ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

The NeuroD1/BETA2 sequences essential for insulin gene transcription colocalize with those necessary … - Full text - MIT Libraries
A Sharma, M Moore, E Marcora, JE Lee, Y Qiu, S … - Mol Cell Biol, 1999 - mcb.asm.org
... cells on the injected side of the embryo expressed the myc-tagged BETA2 ... 1997. The
Pax4 gene is essential for differentiation of insulin-producing -cells in the ...
Cited by 21 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

PAX genes in development and disease: The role of PAX2 in urogenital tract development
MR Eccles, S He, M Legge, R Kumar, J Fox, C Zhou, … - Int J Dev Biol, 2002 - ijdb.ehu.es
... hypopigmentation PAX4 - - Pax4 knockout (+/-) No abnormalities Pax4 knockout (-/-)
Absence of ... three promoter-luciferase expression constructs, N-myc, p53, and ...
Cited by 5 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - ijdb.ehu.es - Get it from MIT Libraries

Genetic and biochemical diversity in the Pax gene family - Full text - MIT Libraries
DA Underhill - Biochem Cell Biol, 2000 - article.pubs.nrc-cnrc.gc.ca
... gene in α-cells (Hussain and Habener 1999), in contrast with Pax4, which represses ...
gain-of-function experi- ments also identified LEF-1 and N-myc as targets ...
Cited by 11 - Web Search - dx.doi.org - pubs.nrc-cnrc.gc.ca - ncbi.nlm.nih.gov - all 6 versions »

Diabetes and stem cells according to: Timothy J. Kieffer et al. Harnessing the gut to treat diabetes - Full text - MIT Libraries
Y Fujita, AT Cheung - Pediatric Diabetes, 2004 - blackwell-synergy.com
... Additional homeodomain transcription factors important for the development of
enteroendocrine and pancreatic endocrine cells are Nkx2.2, Pax4, and Pax6. ...
Cited by 1 - Web Search - ingentaconnect.com - surgery.ubc.ca - ncbi.nlm.nih.gov

Molecular Mechanisms of PDX-1 Regulation
US Jhala, S Sharma, S Dutta, M Montminy - content.karger.com
... In addition to PDX-1, other homeobox proteins including Isl-1, Pax4, Pax6, nkx6 ... 1
gene expression is not clear, other nuclear factors, most notably myc and Max ...
Web Search - content.karger.com

Transcriptional regulation of the human PAX 6 gene promoter. - Full text - MIT Libraries
ZP Xu, GF Saunders - J Biol Chem, 1997 - jbc.org
... as in Pax1 and Pax9) or with a full-length (as in Pax3, Pax4, Pax6, and ... including
single binding sites for Sp1 protein (at bases 395 to 387), Myc protein (at ...
Cited by 13 - Web Search - jbc.org - ncbi.nlm.nih.gov

Genetic factors regulating experimental arthritis in mice and rats
RL Wilder, EF Remmers, Y Kawahito, PS Gulko, GW … - Current Directions in Autoimmunity, 1999 - content.karger.com
Page 1. Theofilopoulos AN (ed): Genes and Genetics of Autoimmunity. Curr
Dir Autoimmun. Basel, Karger, 1999, vol 1, pp 121–165 ..... ...
Cited by 10 - Web Search - content.karger.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Neogenesis y regeneracion de las celulas β pancreaticas
R de Haro-Hernandez, JD Mendez - Gac Med Mex, 2002 - medigraphic.com
Page 1. Otras secciones de este sitio: ...
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Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi 1 b and Gfi 1 … - Full text - MIT Libraries
L Vassen, K Fiolka, S Mahlmann, T Moeroey - Nucleic Acids Research, 2005 - nar.oupjournals.org
... Gel-shift analysis The Myc-tagged Gfi1 and Gfi1b proteins were produced with
the TNT(TM) Rabbit Reticulocyte Lysate System (Promega). ...
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Twists and turns in the development and maintenance of the mammalian small intestine epithelium
AL Hauck, KS Swanson, PJA Kenis, DE Leckband, HR … - Birth Defects Research Part C Embryo Today Reviews, 2005 - doi.wiley.com
... expression and apoptosis, increased expression of math1, nkx2- 2, Pax4, Pax6, Delta1 ...
and crypts, lack of proliferation, nuclear -catenin, c-myc, Enc1; loss of ...
Web Search - scs.uiuc.edu - swinegenomics.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

cAMP Response Element-Binding Protein, Activating Transcription Factor-4, and Upstream Stimulatory … - Full text - MIT Libraries
JL Steiger, S Bandyopadhyay, DH Farb, SJ Russek - J Neurosci, 2004 - jneurosci.org
... factor-1; GKLF, gut-enriched Krueppel-like binding factor; MAZ, Myc-associated zinc ...
zinc finger protein; MZF1, myeloid zinc finger protein-1; PAX4, paired box ...
Cited by 2 - Web Search - dx.doi.org - jneurosci.org - ncbi.nlm.nih.gov

The Regulation of Amylin and Insulin Gene Expression and Secretion
ROFI SECRETION - Pancreas, 2005 - pancreasjournal.com
... through positive activity on PDX-1 and negative activity on c-Myc. ... Pax4, a highly
conserved transcription factor required for differentiation of β cells and ...
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TranSignal TM GR-TF Interaction Arrays
PU Manual - panomics.com
... SIE Stat5 Stat5 MRE MRE 12 CDP CDP FA S T -1 FA S T -1 Myc-Max Myc-Max
Pax-5 Pax-5 Smad SBE Smad SBE Stat6 Stat6 13 CDP CDP FA S
View as HTML - Web Search - biocat.de

Wnt signaling in the intestinal epithelium: from endoderm to cancer - Full text - MIT Libraries
A Gregorieff, H Clevers - Genes & Development, 2005 - genesdev.org
... 2003 ). Whether c-Myc performs similar functions in the intestine will need to be ...
For example, the activation of NGN3, BETA2, Pax4, and Pax6 is associated with ...
Web Search - dx.doi.org - genesdev.org - ncbi.nlm.nih.gov

Fluid shear stress induces endothelial KLF2 gene expression through a defined promoter region
JP Huddleson, S Srinivasan, N Ahmad, JB Lingrel - Biol. Chem, 2004 - degruyter.com
... These are loosely defined consensus sequences for Hand1/E47, Oct1, Pax4, and Pax6. ...
LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway ...
Cited by 1 - Web Search - extenza-eps.com - degruyter.de - ijp-online.com - all 10 versions »

TranSignal TM Protein/DNA Arrays
CS Version - panomics.com
... CDP CDP FA S T -1 FA S T -1 Myc-Max Myc-Max Pax-5 Pax-5 Smad SBE Smad SBE
Stat6 Stat6 13 CDP CDP FA S T -1 FA S T -1 Myc-Max Myc ...
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The PAX6 gene is activated by the basic helix–loop–helix transcription factor NeuroD/BETA2 - Full text - MIT Libraries
E Marsich, A Vetere, M Di Piazza, G Tell, S … - Biochem J, 2003 - bj.portlandpress.com
... 4]. During embryogenesis, PAX genes exhibit highly restricted temporal and spatial
expression patterns [4]. Two members of the PAX gene family, PAX4 and PAX6 ...
Cited by 4 - View as HTML - Web Search - biochemj.org - biochemj.org - ncbi.nlm.nih.gov - all 5 versions »

Stem-cell-based approaches for regenerative medicine - Full text - MIT Libraries
S Kume - Development, Growth and Differentiation, 2005 - blackwell-synergy.com
... mice with overexpression of mitogenic oncogenes such as TGF- , c-Myc and SV40T ...
Expression of Pax4 in embryonic stem cells promotes differentiation of nestin ...
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Genome-wide prediction and analysis of function-specific transcription factor binding sites - Full text - MIT Libraries
F Long, H Liu, C Hahn, P Sumazin, MQ Zhang, A … - In Silico Biology, 2004 - iospress.metapress.com
... PAX4 02(M00377) 34.19% NAAWAATTANS ... This agrees with the evidence that ZF5 is a
transcription repressor of c-myc proto-oncogene exhibiting growth-suppressive ...
Cited by 1 - Web Search - bioinfo.de - bioinfo.de - ncbi.nlm.nih.gov

TranSignal TM Protein/DNA Arrays
PU Manual, MA MA1014 - panomics.com
Page 1. TranSignal TM Protein/DNA Arrays Cat. # MA1010, MA1011, MA1012 Product User
Manual, MA1013 & MA1014, MA1015 Released 09/28/04 Panomics, Inc. ...
View as HTML - Web Search - biocat.de

Xenopus aristaless-related homeobox(xARX) gene product functions as both a transcriptional activator … - Full text - MIT Libraries
DW Seufert, NL Prescott, HM El-Hodiri - Developmental Dynamics, 2005 - doi.wiley.com
... xArx ASMO specifically inhibits translation of an xArx–green fluorescent protein
fusion (Arx- GFP) but not GFP lacking the xArx ASMO tar- get (myc-GFP) fusion ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

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