Overexpression of c-myc in diabetic mice restores altered expression of the transcription factor … - Full text - MIT Libraries
RIU Efren, T FERRE, MAS Alex, A HIDALGO, S … - Biochem. J, 2002 - biochemj.org
... Keywords: transgenic mice, c-myc, diabetes, liver, glucose metabolism, PPARa, ... Thus,
c-Myc might also repress the expression of PPARa by binding to this E-box. ...
Cited by 1 - View as HTML - Web Search - biochemj.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Hepatic expression of acute-phase protein genes during carcinogenesis induced by peroxisome … - Full text - MIT Libraries
SP Anderson, RC Cattley, JC Corton, NC Raleigh - Molecular Carcinogenesis, 1999 - doi.wiley.com
... Previously, we showed that mRNA levels for the hepatocyte growth factor receptor
c-met, as well as the transcription factors c- myc and PPARa, are increased in ...
Cited by 20 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - csa.com

Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and … - Full text - MIT Libraries
A Chawla, MA Lazar - Proc. Natl. Acad. Sci. USA, 1994 - pnas.org
... formed as described (25) with cDNA probes for aP2 (26); C/EBPa (27); PPARa (11);
RXRa, -(3, and -y (28); Nuc-1 (29); c-myc; and ,3actin labeled with 32p using ...
Cited by 77 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Peroxisome Proliferator–Activated Receptor a in the Human Breast Cancer Cell Lines MCF-7 and MDA- … - Full text - MIT Libraries
KM Suchanek, FJ May, JA Robinson, WJ Lee, NA … - MOLECULAR CARCINOGENESIS, 2002 - doi.wiley.com
... acid catabolism, PPARa has been linked to the regulation of genes important in cell-
cycle modulation, including cyclin-dependent kinases 1 and 4 and c-myc [13 ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

17 b-Hydroxysteroid dehydrogenase type 11 is a major peroxisome
K Motojima - ingentaconnect.com
... types of 17b-HSDs were identified as the most remarkably increased proteins in the
intestine by PPARa ligand in ... 20] recently reported that the myc-tagged human ...
Web Search

GEArray Q Series Human Cancer Drug Resistance & Metabolism Gene Array: AR-SAHS-019
FG Grouping - eurogentec.com
... ER-beta-cx), PPARA, PPARD, PPARG, PPARGC1, RARA, RARB, RARG, RXRA, RXRB, RXRG, SRD5A2.
Transcription Factors: AHR, AP1S1, ELK1, FOS (c-fos), HIF1A, MAFB, MYC (c ...
View as HTML - Web Search - eurogentec.be

GEArray Q Series Mouse Cancer Drug Resistance & Metabolism Gene Array: AR-SAMM-019
FG Grouping - eurogentec.com
... Ppara, Ppard, Pparg, Ppargc1, Rara, Rarb, Rxra, Rxrb, Rxrg, Srd5a2. Transcription
Factors: Ahr, Ap1s1, Ap1s2, Elk1, Fos (c-fos), Gabpa, Hif1a, Mafb, Myc (c-myc ...
View as HTML - Web Search - eurogentec.be

PPARd status and Apc-mediated tumourigenesis in the mouse intestine - Full text - MIT Libraries
KR Reed, OJ Sansom, AJ Hayes, AJ Gescher, DJ … - Oncogene, 2004 - nature.com
... confirmed by semiquantitative RT–PCR analysis, as expression ofc-MYC, a confirmed ...
Apc recombination, whereas similar upregulation of PPARd and PPARa was not ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

Oxidation-Sensitive Transcription Factors and Molecular Mechanisms in the Arterial Wall
F de Nigris, LO Lerman, M Condorelli, A Lerman, C … - Antioxidants & Redox Signaling, 2001 - dx.doi.org
... High-shear stress induces priming of NFkB and c-Myc and their target ... Although PPARa
is responsible for the PP- induced pleiotropic responses, PPARg seems to be ...
Cited by 18 - Web Search - liebertonline.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Stimulation of adipogenesis in fibroblasts by PPAR 2, a lipid-activated transcription factor
P Tontonoz, E Hu, BM Spiegelman - Cell, 1994 - umaryland.edu
... Two other murine PPARS, PPARA and @s 3 NUC-1, have also been reported to be expressed
at some E level in adipose tissue (Chawla and Lazar, 1994; ... PPARA ...
Cited by 645 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

GENE MODULATION IN PEROXISOME PROLIFERATOR-INDUCED HEPATOCARCINOGENESIS
SP ANDERSON, A BY - lib.ncsu.edu
Page 1. GENE MODULATION IN PEROXISOME PROLIFERATOR-INDUCED HEPATOCARCINOGENESIS
By STEVEN PAUL ANDERSON A dissertation submitted to the Graduate Faculty of ...
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Receptor-Mediated Hepatocarcinogenesis: Role of Hepatocyte Proliferation and Apoptosis - Full text - MIT Libraries
JD Oliver, RA Roberts - Pharmacology and Toxicology, 2002 - ingentaconnect.com
... hepatocyte apoptosis and that these effects require the presence of PPARa (Hasmall
& ... 1998) and several immediate early genes including c-myc, c-fos, c-jun ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov

in Saccharomyces cerevisiae
AJ Hanspeter ROTTENSTEINER, HR Barbara HAMILTON - Eur. J. Biochem, 1997 - blackwell-synergy.com
... For expression of Oaflp and the variant tagged with nine Myc eptiopes, Oaflp-Myc,,
under control of the ADH2 promoter, in- tegrative plasmids pADH2-OAF and ...
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Electrophoretic mobility-shift assay (EMSA) - Full text - MIT Libraries
M Humphreys - Proc. Natl Acad. Sci. USA, 1998 - nature.com
... Activation of human aorta smooth-muscle cells is inhibited by PPARa but not by ... on
Yku70, we studied the subnuclear distribution of a Yku70±myc fusion protein ...
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The United States–Japan Workshop on: The Role of Nuclear Receptors in Carcinogenesis - Full text - MIT Libraries
M REPORT - MOLECULAR CARCINOGENESIS, 2004 - doi.wiley.com
... of CAR leads to induction of CYPs, mdm2, and c-myc, which results ... from a ‘‘humanized’’
mouse model to study the role of PPARa in hepatocarcinogenesis. ...
Web Search - ncbi.nlm.nih.gov

Identification of an extended half-site motif required for the function of peroxisome proliferator- … - Full text - MIT Libraries
S Osada, T Tsukamoto, M Takiguchi, M Mori, T Osumi - Genes to Cells, 1997 - genestocellsonline.org
... the peroxisome proliferator- responsive enhancer of the rat AOX gene, we analysed
the minimal sequence requirements for enhancer activity and PPARa/RXRa binding ...
Cited by 19 - Web Search - ingentaconnect.com - genestocellsonline.org - ncbi.nlm.nih.gov

IL-6-independent pathway - Full text - MIT Libraries
GM Ledda-Columbano, M Curto, R Piga, AI Zedda, M … - Oncogene, 1998 - nature.com
... immediate early genes (c-fos, c- jun, LRF-1, egr-1 and c-myc) (Coni et ... such as
cipro®brate, exert their mitogenic e€ect through activation of PPARa, a member ...
Cited by 32 - Web Search - nature.com - ncbi.nlm.nih.gov

Induction of differentiation and peroxisome proliferator-activated receptor c expression in colon … - Full text - MIT Libraries
M Kato, T Kusumi, S Tsuchida, M Tanaka, M Sasaki, … - J Cancer Res Clin Oncol, 2004 - springerlink.com
... different members in the PPAR family identified to date, encoded by sep- arate genes:
PPARa, PPARb, and ... 2002) and activate c-myc or caspase (Miyashita et al. ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

NF-kB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type - Full text - MIT Libraries
B Lin, C Williams-Skipp, Y Tao, MS Schleicher, LL … - Cell Death Differ, 1999 - nature.com
... been shown to play a role in apoptosis mediated by engagement of PPARa and PPARg ...
46 Here NF-kB functions to stimulate expression of c-myc, a factor necessary ...
Cited by 51 - Web Search - nature.com - ncbi.nlm.nih.gov

Repression of CAR-Mediated Transactivation of CYP 2 B Genes by the Orphan Nuclear Receptor, Short …
Y Bae, JK Kemper, B Kemper - DNA and Cell Biology, 2004 - dx.doi.org
... by adding antibodies for CAR (CAR and HIS), RXR, GRIP1, and SHP (c-myc), which was ...
SHP is also known to interactwith PPARa, TR, RXR, HNF- 4, ERa, and ERb in two ...
Cited by 4 - Web Search - liebertonline.com - liebertonline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

New Approaches to Mechanism Analysis for Drug Discovery Using DNA Microarray Data Combined with …
H Sato, S Ishida, K Toda, R Matsuda, Y Hayashi, M … - Current Drug Discovery Technologies, 2005 - ingentaconnect.com
... 1 APC = Adenomatous polyposis coli protein c-Myc = Myc proto-oncogene ... protein kinase
p38 PI3K = Phosphatidylinositol 3 kinase PPARa = Peroxisome proliferator ...
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Physiological functions of protein kinase B/Akt - Full text - MIT Libraries
ZZ Yang, O Tschopp, A Baudry, B Dummler, D Hynx, … - Biochem. Soc. Trans, 2004 - bst.portlandpress.com
... peroxisome proliferator-activated receptor g) co-activator-1 and PPARa suggest that ...
multiple onco-proteins and tumour suppressors such as Ras, Myc, PKB/Akt, Her ...
Cited by 2 - Cached - Web Search - bst.portlandpress.co.uk - biochemsoctrans.org - ncbi.nlm.nih.gov - all 7 versions »

Age-related phenotypes in the staggerer mouse expand the ROR· nuclear receptor’s role beyond the …
CI Jarvis, B Staels, B Brugg, Y Lemaigre-Dubreuil, … - Mol Cell Endocrinol, 2002 - npa.snv.jussieu.fr
... to bind the RORE site in the promoter region of the N-myc gene (Dussault ... receptors
such as the glucocorticoid receptor (Auphan et al., 1995), PPARa and PPARg ...
Cited by 16 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Genomic organization of the mouse peroxisome proliferator-activated receptor b/d gene: alternative … - Full text - MIT Libraries
LK LARSEN, EZ AMRI, S MANDRUP, C PACOT, K … - Biochem. J, 2002 - biochemj.org
... 1 and Figure 1A) and, in analogy with the genes encoding PPARa [ 21] and ... 45], the
max-binding protein (mnt) transcriptional repressor [ 46], c-Myc [ 47, 48 ...
Cited by 1 - Cached - Web Search - biochemj.org

Anti-Tumor Mechanisms ofValproate: ANovel Role foran Old Drug
RA Blaheta, J Cinatl Jr - Medicinal Research Reviews, 2002 - doi.wiley.com
... expression of cell surface glycoconjugates and/or decreased expression of N-myc
oncoprotein ... 77,78 Three forms are known, PPARa, PPARg, and PPARd, the latter of ...
Web Search

Nutrient and hormonal regulation of pyruvate kinase gene expression - Full text - MIT Libraries
K Yamada, T Noguchi - Biochem. J, 1999 - biochemj.org
... In this case, c-Myc might exert an indirect effect through the ChoRE of ... mediated
suppression of L-PK gene expression is observed even in PPARa-deficient mice ...
Cited by 28 - Cached - Web Search - biochemj.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Suppression of Vitamin D Receptor and Induction of Retinoid X Receptor a Expression During Squamous …
S Segaert, M Garmyn, H Degreef, R Bouillon - ingentaconnect.com
... Likewise, we observed a striking parallel between c-myc mRNA and VDR expression
as ... cytes might facilitate the action of nuclear receptors such as PPARa and FXR ...
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Nitric oxide stimulated vascular smooth muscle cells undergo apoptosis induced in part by … - Full text - MIT Libraries
CM Pilane, EF LaBelle - Journal of Cellular Physiology, 2005 - doi.wiley.com
... To date, three have been observed, namely, the -a, -b, and -g. LTB 4 acts via
PPARa (Devchand et al., 1996) while PGJ 2 acts via PPARg. ...
Web Search - ncbi.nlm.nih.gov

INDUCTION OF THE HUMAN NEURONAL NITRIC OXIDE SYNTHASE EXPRESSION BY EPIDERMAL GROWTH FACTOR IS …
H Dihazi, J Kappler, V Gieselmann, F Dietz, A … - wissenschaft-online.de
... potentiate its own expression in a positive feedback loop via PPARa activation ... conserved
between this sequence and a fragment from the human c-myc protein, for ...
View as HTML - Web Search - wissenschaft-online.de

Molecular Interaction Map of a Macrophage.
K Oda, T Kimura, Y Matsuoka, M Muramatsu, H Kitano - AfCS Research Reports, 2004 - signaling-gateway.org
... Two arrows originating from ERK to RSK and c-Myc (marked as 2 in Fig. 2) are
interpreted as activation of RSK and c-Myc by ERK. ... PDK-1 RSK CREB c-Myc PKC SOS ...
Cited by 3 - View as HTML - Web Search - celldesigner.org - signaling-gateway.org - celldesigner.org

A Novel Peroxisome Proliferator-activated Receptor Isoform with Dominant Negative Activity Generated …
L Sabatino, A Casamassimi, G Peluso, MV Barone, D … - jbc.org
... has been detected thus far only in thyroid follicular tumors (8); PPARA undergoes
an ... either alone or in association with the weak oncogene c-Myc, we examined ...
Web Search

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... NF1 Q6 Nuclear factor 1 NFAT Q6 Nuclear factor of activated T-cells NMYC 01 N-Myc
OCT1 02 Octamer ... PPARA 01 PPAR/RXR heterodimers Core should be AAAGGT not AAAG ...
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A novel peroxisome proliferator-activated receptor gamma isoform with dominant negative activity … - Full text - MIT Libraries
L Sabatino, A Casamassimi, G Peluso, MV Barone, D … - Journal of Biological Chemistry, 2005 - jbc.org
... has been detected thus far only in thyroid follicular tumors (8); PPARA undergoes
an ... either alone or in association with the weak oncogene c-Myc, we examined ...
Web Search - jbc.org - ncbi.nlm.nih.gov

Using Genetically Altered Mice in Toxicogenomic Analysis of Chemical Exposure
JC Corton, SP Anderson - doi.wiley.com
... In our laboratories, we compared transcript profiles generated from the livers of
wild-type and PPARa-null (peroxisome proliferator-activated re- ceptor a) mice ...
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Cyclopentenone Prostaglandins: New Insights on Biological Activities and CellularTargets
DS Straus, CK Glass - Key words, 2001 - doi.wiley.com
Page 1. Cyclopentenone Prostaglandins: New Insights on Biological Activities
and CellularTargets Daniel S. Straus, 1 Christopher K. Glass 2 ...
Cited by 105 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

SREBP-1 interacts with HNF-4a and interferes with PGC-1 recruitment to suppress hepatic …
T Yamamoto, H Shimano, Y Nakagawa, T Ide, TM … - jbc.org
... hormone) and transcriptional factors (CREB, C/EBPa, HNF-3, HNF-4a, and PPARa) ...
pcDNA3.1 (Invitrogen). The expression vector for c-myc-tagged SREBP-1a was ...
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Origin and evolution of avian microchromosomes - Full text - MIT Libraries
DW Burt, FTC Alert - Cytogenetic and Genome Research, 2002 - content.karger.com
... NAGA 1 22 15 Schmid et al. 2000 PPARA 1 22 15 Schmid et al. 2000 G22P1 1 22 15 Suzuki
et al. ... PENK 2 8 4 Schmid et al. 2000 MYC 2 8 15 24 Schmid et al. 2000 ...
Cited by 21 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

The e¡ ect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome …
JE Walgren, DT Kurtz, JM McMillan - Cell Biology and Toxicology, 2000 - springerlink.com
... Through activation of the steroidlike receptor peroxisome proliferator-activated
receptor a (PPARa), peroxisome proliferators regulate the transcription of ...
Cited by 4 - Web Search - kluweronline.com - ncbi.nlm.nih.gov - csa.com - Get it from MIT Libraries

Modulation of immune function by dietary fatty acids
EA Miles, PC Calder - Proc Nutr Soc, 1998 - ingentaconnect.com
Page 1. Proceedings of the Nutrition Society (1998), 57, 277-292 277 Modulation
of immune function by dietary fatty acids Elizabeth ...
Cited by 36 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Essential role of Smad3 in the inhibition of inflammation-induced PPARb/d expression
NS Tan, L Michalik, N Di-Poı1, CY Ng, N Mermod, … - nature.com
... Three closely related PPAR isotypes have been identified, PPARa (NR1C1), PPARb/
d (NR1C2; called PPARb below) and PPARg (NR1C3), which are encoded by separate ...
Web Search - nature.com

A Computational Model to Define the Molecular Causes of Type 2 Diabetes Mellitus
M JOSHI, OIT SB, J LEVY, J PAPPO - DIABETES TECHNOLOGY & THERAPEUTICS, 2005 - dx.doi.org
Page 1. DIABETES TECHNOLOGY & THERAPEUTICS Volume 7, Number 2, 2005 © Mary Ann Liebert,
Inc. A Computational Model to Define the Molecular Causes ...
Web Search - liebertonline.com - liebertonline.com - smi-web.stanford.edu

Colon cancer: genomics and apoptotic events
C Rupnarain, Z Dlamini, S Naicker, K Bhoola - Biol. Chem, 2004 - degruyter.com
... APC (Figure 3) affects the expression of many genes, including the c- myc
oncogene and its antagonist Mad-1 (He et al., 1998). The ...
Cited by 1 - Web Search - extenza-eps.com - degruyter.de - dx.doi.org - all 8 versions »

Critical Review - Full text - MIT Libraries
A Ismail, Z Nawaz - IUBMB Life, 2005 - taylorandfrancis.metapress.com
... On the other hand VDR, AR and PPARa are targeted to the proteasome in their ... and several
other unstable transcription factors such as E2F-1, Jun, Myc, p53, Fos ...
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Workshop P Apoptosis and Cell Death
E Aga, DM Katschinski, W Solbach, T Laskay - ingentaconnect.com
... Consistent with these findings, the mRNA levels of the NF-ÍB-dependent genes c-myc
and A1 (an anti-apoptotic Bcl-2 family member) were not reduced after BCR ...
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PPAR gamma signaling exacerbates mammary gland tumor development - Full text - MIT Libraries
E Saez, J Rosenfeld, A Livolsi, P Olson, E … - Genes Dev, 2004 - genesdev.org
... The expression of cyclin D1 and c-myc, the canonical mammalian Wnt target genes,
was significantly up-regulated in multiple mammary tumors derived from bigenic ...
Cited by 17 - Web Search - belmonte.salk.edu - pubmedcentral.nih.gov - dx.doi.org - all 10 versions »

Molecular mechanisms and cellular biology of the steroid receptor coactivator (SRC) family in …
J Xu, BW O’Malley - Rev. Endocr. Metab. Disord, 2002 - springerlink.com
... assays on promoters of three estrogen target genes including cathepsin D, pS2 and
c-Myc in MCF-7 ... [56] have shown that expression of PPARa-regulated genes in ...
Cited by 11 - Web Search - kluweronline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Hepatic Gene Expression and Lipid Homeostasis in C 57 Bl/6 Mice Exposed to Hydrazine or … - Full text - MIT Libraries
VE Richards, B Chau, MR White, CA Mcqueen - Toxicological Sciences, 2004 - toxsci.oupjournals.org
... in expression of Mapk10 (MAP kinase 10) (0.44 ± 0.03), c-Myc (myelocytomatosis oncogene ...
an increase in free fatty acids, physiologic ligands of PPARa (Clark et ...
Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - csa.com - all 7 versions »

Therapies to Slow Polycystic Kidney Disease
VE Torres - Nephron Experimental Nephrology - content.karger.com
... c-Src inhibitor – – – yes 2 – – – – c-myc antisense – – – –
yes – – – PRARÁ agonist – – – – – yes ...
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Modulation of the Far-Upstream Enhancer of the Rat a-Fetoprotein Gene by Members of the RORa, Rev- …
B BOIS-JOYEUX, C CHAUVET, H NACER-CHERIF, W … - DNA AND CELL BIOLOGY, 2000 - dx.doi.org
Page 1. DNA AND CELL BIOLOGY Volume 19, Number 10, 2000 Mary Ann Liebert, Inc.
Pp. 589–599 Modulation of the Far-Upstream Enhancer of the Rat ...
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PPARgamma pathway activation results in apoptosis and COX-2 inhibition in HepG2 cells - Full text - MIT Libraries
MY Li, H Deng, JM Zhao, TXY Dai D, XY Tan - World J Gastroenterol, 2003 - wjgnet.com
Page 1. PO.Box 2345, Beijing 100023,China World J Gastroenterol 2003;9(6):1220-
1226 Fax: +86-10-85381893 World Journal of Gastroenterology ...
Cited by 7 - View as HTML - Web Search - wjgnet.com - wjgnet.com - ncbi.nlm.nih.gov - all 6 versions »