… induce the expression of bone-specific isoforms of PEBP2 alpha A (CBFA1): evidence for a new myc … - Full text - MIT Libraries
M Stewart, A Terry, M Hu, M O'Hara, K Blyth, E … - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... AJ van Wijnen, YL Wang, and GS Stein Transcription factors RUNX1/AML1 and RUNX2 ... Is
Alleviated by Moloney Murine Leukemia Virus Infection in myc Transgenic Mice J ...
Cited by 45 - Web Search - pnas.org - pnas.org - pubmedcentral.nih.gov

Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma - Full text - MIT Libraries
S Wotton, M Stewart, K Blyth, F Vaillant, A Kilbey … - Cancer Res, 2002 - cancerres.aacrjournals.org
... 1. a, virus-induced rearrangements of the Runx1 gene in CD2-MYC lymphomas. ... b,
tumor-free survival of CD2-MYC/Runx2 transgenic mice on a Runx1 (+/-) background. ...
Cited by 11 - Web Search - intl-cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Interplay of RUNX1/MTG8 and DNA Methyltransferase 1 in Acute Myeloid Leukemia - Full text - MIT Libraries
S Liu, T Shen, L Huynh, MI Klisovic, LJ Rush, JL … - Cancer Research, 2005 - cancerres.aacrjournals.org
... with DNMT1. B, control for ectopic expression of RUNX1/MTG8 and Myc-tagged
DNMT1 by immunoblotting in 293T cells. C, association ...
Cited by 1 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

Gene Expression Profiling and Microarrays Gene expression profiling of leukemic cell lines reveals …
A Andersson, P Eden, D Lindgren, J Nilsson, C … - Leukemia, 2005 - nature.com
... Thus, cell lines harboring 11q23/MLL rearrangements, TCF3/PBX1, IGH@/MYC,
RUNX1/CBFA2T1, P210 BCR/ABL1, ETV6/RUNX1, or CBFB/MYH11, were shown to segregate ...
Web Search - nature.com

The Runx genes as dominant oncogenes - Full text - MIT Libraries
ER Cameron, K Blyth, L Hanlon, A Kilbey, N Mackay, … - Blood Cells Mol Dis, 2003 - ncbi.nlm.nih.gov
... effect in c-MYC expressing tumors in vivo while c-MYC may rescue cells from the
antiproliferative effects of Runx2. The oncogenic potential of Runx1 is also ...
Cited by 14 - Web Search - ncbi.nlm.nih.gov

Oligo GEArray® Mouse TGFβ BMP Signaling Pathway Microarray
S Conditions - search.cosmobio.co.jp
... Plat, Plau, Serpine1, Tdgf1, Tgfb3, Tgfbr1, Tgfbr3 Transcription Factors and Regulators:
Dlx2, Fos, Gsc, Idb1, Idb3, Jun, Junb, Myc, Nr0b1, Runx1, Runx2, Smad1 ...
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Oligo GEArray® Rat TGFβ BMP Signaling Pathway Microarray
S Conditions - search.cosmobio.co.jp
... Transcription Factors and Regulators: Dlx2, Fos, Gsc, Idb1, Idb3, Jun, Junb, Madh1,
Madh3, Madh4, Madh5, Madh7, Madh9, Myc, Nr0b1, Runx1, Runx2, Sox4, Stat1 ...
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c-Myc overcomes cell cycle inhibition by CBF beta-SMMHC, a myeloid leukemia oncoprotein
F Bernardin, Y Yang, CI Civin, AD Friedman - Cancer Biol Ther, 2002 - ncbi.nlm.nih.gov
... Factor (CBF) oncoprotein or harbor point mutations in one or both AML1 (RUNX1) genes. ...
c-Myc, a protein which stimulates S phase entry, is over-expressed in one ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Runx1, c-Myb, and C/EBPa Couple Differentiation to Proliferation or Growth Arrest During … - Full text - MIT Libraries
AD Friedman - Journal of Cellular Biochemistry, 2002 - doi.wiley.com
... In Ba/F3 cells, exogenous cdk4, cyclin D2, or c-Myc prevent cell cycle inhibition
by CBFB-SMMHC or KRAB-Runx1- ER [Lou et al., 2000; Bernardin et al., 2002a]. ...
Cited by 11 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Filamin A-Bound PEBP2ss/CBFss Is Retained in the Cytoplasm and Prevented from Functioning as a …
N Yoshida, T Ogata, K Tanabe, S Li, M Nakazato, K … - mcb.asm.org
... plasmids. The protein level of Runx1 in these cells was measured by immunoblot
(IB) analysis with an anti-Myc antibody. The bands ...
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Dimerization with PEBP2ss protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation - Full text - MIT Libraries
G Huang, K Shigesada, K Ito, HJ Wee, T Yokomizo, Y … - EMBO J, 2001 - embojournal.npgjournals.com
... PEBP2 by the ubiquitin–proteasome system We have shown here that RUNX1 is
proteolytically ... regulators (I B–NF B complex, Jun, Fos, p53, MyoD, Myc, E2F, etc ...
Cited by 53 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 8 versions »

Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear … - Full text - MIT Libraries
KS Harrington, A Javed, H Drissi, S McNeil, JB … - J Cell Sci, 2002 - jcs.biologists.org
... We find that both RUNX1 and RUNX2 proteins, which support development of ... specific
isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene ...
Cited by 18 - Web Search - dx.doi.org - jcs.biologists.org - ncbi.nlm.nih.gov

… aberrations, a recurring involvement of chromosome 21 and amplification of the MYC oncogene in acute … - Full text - MIT Libraries
E Hilgenfeld, H Padilla-Nash, N McNeil, T Knutsen, … - British Journal of Haematology, 2001 - blackwell-synergy.com
... for the t(8;21), which detects the first five exons of the AML1 (RUNX1) gene
(encompassing ... for 5p15.2/5q31, 7p11.1-q11.1/7q31, BCR/ABL, CYCLIN D1, MYC and TEL ...
Cited by 17 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Oligo GEArray® Human TGFβ BMP Signaling Pathway Microarray
S Conditions - search.cosmobio.co.jp
... INHBB, INHBC, PDGFB, PLAU, SERPINE1 Transcription Factors and Regulators: DLX2,
EVI1, FOS, GSC, HIPK2, ID1, ID3, ID4, JUN, JUNB, MYC, NR0B1, RUNX1, RUNX2, SMAD1 ...
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… proliferation and apoptotic cell death in the sensory lineage of mice overexpressing N-myc
M Kobayashi, JHLP Ernfors - springerlink.com
... Runx1 is expressed in small-diameter nociceptive neurons, whereas Runx3 is ex- pressed ...
In addition to the above transcription factors, N-myc has been reported ...
Web Search

Regulation of the Murine D {delta} 2 Promoter by Upstream Stimulatory Factor 1, Runx1, and c-Myb - Full text - MIT Libraries
J Carabana, E Ortigoza, MS Krangel - The Journal of Immunology, 2005 - jimmunol.org
... lanes 4 and 5). Protein-DNA complexes containing E47 and Runx1 are indicated ... E2 sequence
CACGTG can be recognized by bHLH-zipper proteins, including Myc/Mad/Max ...
Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Selection for c-myc integration sites in polyclonal T-cell lymphomas - Full text - MIT Libraries
DR Broussard, JA Mertz, M Lozano, JP Dudley - J. Virol, 2002 - jvi.asm.org
... Mutations in c-Myb, Ets, or AML-1 (RUNX1) binding sites that ... during lymphoma growth
frequently have insertions that activate c-myc transcription through the ...
Cited by 6 - Web Search - pubmedcentral.nih.gov - jvi.asm.org - ncbi.nlm.nih.gov

Identification of protein interaction between the Drosophila Runx1 transcription factor Lozenge and …
A Thesis, S Singh, T Advisor, JA Pollock, J Patton … - etd1.library.duq.edu
... Identification of protein interaction between the Drosophila Runx1 transcription
factor Lozenge and ETS-1 ... Runx1 proteins one such family of transcription ...
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The Novel ETS Factor TEL2 Cooperates with Myc in B Lymphomagenesis {dagger}
M Cardone, A Kandilci, C Carella, JA Nilsson, JA … - mcb.asm.org
... TEL1 is suggested by its loss during disease progression of TEL-RUNX1-expressing
childhood ... that TEL2 indeed is an oncogene that cooperates with Myc in lymphoma ...
Web Search - mcb.asm.org

Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis - Full text - MIT Libraries
L Waltzer, G Ferjoux, L Bataille, M Haenlin - The EMBO Journal, 2003 - embojournal.npgjournals.com
... shown in Figure 4D, a flag-tagged version of N-terminally deleted GATA1 expressed
in COS-7 cells was specifically co-immunoprecipitated with myc-tagged RUNX1. ...
Cited by 7 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 6 versions »

Transforming Growth Factor-{beta} Stimulates p 300-dependent RUNX 3 Acetylation, Which Inhibits … - Full text - MIT Libraries
YH Jin, EJ Jeon, QL Li, YH Lee, JK Choi, WJ Kim, … - J Biol Chem, 2004 - jbc.org
... Cell lysates were prepared from 293 cells transfected with plasmids expressing
Myc-tagged full-length RUNX cDNAs (RUNX1, RUNX2, and RUNX3), and ...
Cited by 6 - Web Search - jbc.org - ncbi.nlm.nih.gov

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among …
A Andersson, P Eden, D Lindgren, J Nilsson, C … - Leukemia, 2005 - ncbi.nlm.nih.gov
... as well as of primary leukemias harboring 11q23/MLL rearrangements, t(1;19)[TCF3/
PBX1], t(12;21)[ETV6/RUNX1], t(8;21)[RUNX1/CBFA2T1], t(8;14)[IGH@/MYC], t(8;14 ...
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The common retroviral insertion locus Dsi1 maps 30 kilobases upstream of the P1 promoter of the … - Full text - MIT Libraries
M Stewart, N MacKay, ER Cameron, JC Neil - J. Virol, 2002 - jvi.asm.org
... Conditional expression and oncogenicity of a human c-myc transgene linked to a ... Potential
role for RUNX1 and its orthologs in determining hematopoietic cell fate ...
Cited by 17 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Transcriptional cross-regulation of RUNX 1 by RUNX 3 in human B cells - Full text - MIT Libraries
LC Spender, HJ Whiteman, CE Karstegl, PJ Farrell - Oncogene, 2005 - nature.com
... In retrovirus insertional mutagenesis experiments in CD2-MYC trans- genic mice,
deregulated RUNX1, RUNX2 or RUNX3 (expressed from P1) were found to contribute ...
Cited by 2 - Web Search - nature.com - ncbi.nlm.nih.gov

Modeling first-hit functions of the t (12; 21) TEL-AML 1 translocation in mice - Full text - MIT Libraries
S Tsuzuki, M Seto, M Greaves, T Enver - Proceedings of the National Academy of Sciences, 2004 - pnas.org
... TEL (ETV6)-AML1 (RUNX1), generated by the chromosomal translocation t(12;21)(p13;
q22 ... cDNA for TEL-AML1 tagged with the myc-epitope at the carboxyl terminus was ...
Cited by 5 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Editorial Comment RUNX Genes, Neoplasia, and Cleidocranial Dysplasia - Full text - MIT Libraries
M Michael Cohen Jr - American Journal of Medical Genetics, 2001 - doi.wiley.com
... RUNX Genes and Oncogenesis Gene Species Effect RUNX1 Human Mutations showing haploinsuf ...
by Runx2 is synergistic with other oncogenes such as Myc RUNX3 Human One ...
Web Search - doi.wiley.com

Leukemia‐associated AML 1/ETO(8; 21) chromosomal translocation protein increases the cellular … - Full text - MIT Libraries
S McNeil, A Javed, KS Harrington, JB Lian, JL … - Journal of Cellular Biochemistry, 2000 - doi.wiley.com
... gle tumor related chromosomal translocation, (8;21), involving the AML1 (RUNX1)
1 and ETO ... Marrow cells transformed with v-myc (MLB13-myc clone 14 and MLB13-myc ...
Cited by 11 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid … - Full text - MIT Libraries
TJ Ley, PJ Minx, MJ Walter, RE Ries, H Sun, M … - Proc Natl Acad Sci US A, 2003 - pubmedcentral.nih.gov
... For three genes (HRAS, FLT3, and c-KIT), the frequency was significantly higher
in the AML pilot set, but for two others (c-MYC and AML-1/RUNX1), the frequency ...
Cited by 10 - Web Search - dx.doi.org - pnas.org - ncbi.nlm.nih.gov - all 6 versions »

Centromeric breakage and highly rearranged chromosome derivatives associated with mutations of TP53 …
MK Andersen, DH Christiansen, J Pedersen-Bjergaard - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
... The locus-specific probes (LSI)—MLL dual-color, p53, BCR/ABL, C-MYC, cyclin D1,
ETO/RUNX1, ETV6/RUNX1 extra signal, 5q EGR1/D5S23, 7q 7S486/CEP7—came from ...
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Transforming growth factor-β stimulates p300-dependent RUNX3 acetylation which inhibit …
S Korea - jbc.org
... Plasmids and Antibodies Myc-, HA- and GFP-tagged RUNX1, RUNX2, RUNX3 full length
and deletion ... Myc-tagged full-length RUNX cDNAs (RUNX1, RUNX2 and RUNX3) and ...
Web Search

A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease … - Full text - MIT Libraries
A Barbouti, M Hoglund, B Johansson, C Lassen, PG … - Cancer Res, 2003 - cancerres.aacrjournals.org
... genes (eg, TP53, CDKN2A, and RB1) and oncogenes (eg, RAS and MYC), but thus far ... of
AML-associated translocations/fusion genes, eg, t(3;21)(q26;q22)/RUNX1-EVI1, t ...
Cited by 8 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - lu-research.lub.lu.se - all 5 versions »

Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions - Full text - MIT Libraries
MC Ghozi, Y Bernstein, V Negreanu, D Levanon, Y … - Genetics, 1996 - dx.doi.org
... and Y. Groner Transcription-Coupled Translation Control of AML1/RUNX1 Is Mediated
by ... of PEBP2alpha A (CBFA1): Evidence for a new myc collaborating oncogene PNAS ...
Cited by 46 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Fine-tuning PU. - Full text - MIT Libraries
DL Stirewalt - Science, 1994 - nature.com
... with amplifica- tion of the chromosome 15 region harboring Myc observed in ... with the
creation of new chimeric proteins (Bcr-Abl, PML-RARα, RUNX1-CBFA2T1) that ...
Web Search - nature.com - ncbi.nlm.nih.gov

Chromosome band 16q22-linked familial AML: exclusion of candidate genes, and possible disease risk …
R Escher, A Jones, F Hagos, C Carmichael, M … - GENES, CHROMOSOMES & CANCER, 2004 - doi.wiley.com
... autosomal dominant trans- mission of AML in three generations excluded RUNX1 (Horwitz
et al ... as such also represses the promoter of the oncogenic MYC (Hoffman et ...
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Plzf pushes stem cells - Full text - MIT Libraries
N Kotaja, P Sassone-Corsi - Science, 1994 - nature.com
... with amplifica- tion of the chromosome 15 region harboring Myc observed in ... with the
creation of new chimeric proteins (Bcr-Abl, PML-RARα, RUNX1-CBFA2T1) that ...
Web Search - nature.com - ncbi.nlm.nih.gov

Innovation: Novel ChIP-based strategies to uncover transcription factor target genes in the immune … - Full text - MIT Libraries
AS Weinmann - Nature Reviews Immunology, 2004 - nature.com
... immunoprecipitation screen reveals protein kinase C as a direct RUNX1 target gene. ...
Analysis of Myc bound loci identified by CpG island arrays shows that Max is ...
Cited by 4 - Web Search - depts.washington.edu - zlab.bu.edu - ncbi.nlm.nih.gov - all 5 versions »

Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants - Full text - MIT Libraries
D Traver, BH Paw, KD Poss, WT Penberthy, S Lin, LI … - Nature Immunology, 2003 - nature.com
... is required for zebrafish blood and vessel development and expression of a human
RUNX1-CBF2T1 transgene ... Myc-induced T-cell leukemia in transgenic zebrafish. ...
Cited by 14 - Web Search - zfblasta.tch.harvard.edu - eanimal.snu.ac.kr - ncbi.nlm.nih.gov - all 6 versions »

Oligo GEArray® Human Hematopoietic Stem Cells and Hematopoiesis Microarray
S Conditions - search.cosmobio.co.jp
... HDAC5, HDAC7A, HDAC9, HOXB4, IFI16, IL31RA, IRF4, IRF8, KLF6, LEF1, MAFB, MYC, NCOA6,
NFYA, NOTCH1, NOTCH2, NOTCH4, PAX5, RBPSUH, RHOH, RUNX1, SCAND1, STAT1 ...
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Internal ribosome initiation of translation and the control of cell death
M Holcik, N Sonenberg, RG Korneluk, SG Karsh - Trends Genet, 2000 - pitt.edu
... known 34 VEGF Hypoxia 22 ODC Cell cycle 28 PITSLRE Cell cycle 29 c-Myc Apoptosis
28 ... Not known 12 BiP Not known 36 NRF Not known 37 AML1/RUNX1 Development 38 Kv1 ...
Cited by 77 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell … - Full text - MIT Libraries
B Lu, P Zagouras, JE Fischer, J Lu, B Li, RA … - Proc Natl Acad Sci US A, 2004 - pubmedcentral.nih.gov
... Based on previous studies that identify runx1 as a tumor suppressor (34) and affecting
T cell ... Myc is an important transcription factor in T cell activation (36 ...
Cited by 4 - Web Search - dx.doi.org - intl.pnas.org - pnas.org - all 6 versions »

CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of … - Full text - MIT Libraries
M Kochetkova, OL McKenzie, AJ Bais, JM Martin, GA … - Cancer Res, 2002 - cancerres.aacrjournals.org
... translocation t(8;21) that also results in a fusion protein with RUNX1. ... coding region
was amplified from fetal spleen total cDNA using myc-tag containing ...
Cited by 10 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - corbettresearch.com - all 5 versions »

AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t (8; 21) myeloid … - Full text - MIT Libraries
T Pabst, BU Mueller, N Harakawa, C Schoch, T … - Nat Med, 2001 - nature.com
... In addition, AML1–ETO was shown to completely inhibit C/EBP –dependent activation
as well as synergistic activation of RUNX1 and C/EBP (ref. ... 40) or MYC (ref ...
Cited by 89 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

A RUNX/AML-binding motif residing in a novel 13-bp DNA palindrome may determine the expression of … - Full text - MIT Libraries
E KOPF, R MISKIN - Journal of Thrombosis and Haemostasis - ingentaconnect.com
... The precedence of the c-Myc motif, the locations of the palindrome in the genes ... The
Ets factor, when bound to DNA in cis with respect to RUNX1, can cooperate ...
Web Search - ingentaconnect.com

Fusion genes in leukemia: an emerging network
SK Bohlander, FTC Alert - Cytogenet Cell Genet, 2000 - content.karger.com
... eg ETV6/RUNX1 (AML1), RUNX1/CBFA2T1 (ETO), ETV6/EVI1, RUNX1/EVI1, ETV6 ... the juxtaposition
of strong enhancers/promoters (eg overexpression of MYC in Burkitt's ...
Cited by 13 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Molecular cloning of a constitutional t (7; 22) translocation associated with risk of hematological …
AS Hill, PK MacCallum, BD Young, DM Lillington - Genes Chromosomes and Cancer, 2003 - doi.wiley.com
... that normal hematopoiesis can be dis- rupted by both increases or decreases of RUNX1 ...
hancer region 3 of the C and J regions and deregulation of MYC (Gerbitz et ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2
J Snaddon, ML Smith, M Neat, M Cambal-Parrales, A … - Genes Chromosomes Cancer, 2003 - doi.wiley.com
... factors during hematopoie- sis, for example, PU.1 and RUNX1 (Smith et al., 1996;
Zhang et al., 1996), as well as cellular onco- genes such as MYC (Johansen et ...
Cited by 15 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Core-binding factors in haematopoiesis and leukaemia - Full text - MIT Libraries
NA Speck, DG Gilliland - Nature Reviews Cancer, 2002 - nature.com
... In vitro analyses of known and novel RUNX1-AML1 mutations in dominant familial ... recurring
involvement of chromosome 21 and amplification of the MYC oncogene in ...
Cited by 60 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

AML 1/RUNX 1 Increases During G 1 to S Cell Cycle Progression Independent of Cytokine-dependent … - Full text - MIT Libraries
F Bernardin-Fried, T Kummalue, S Leijen, MI … - J Biol Chem, 2004 - jbc.org
... AML1/RUNX1, a member of the core binding factor (CBF) family stimulates ... Analysis
of exogenous Myc-AML1 or AML1-ER demonstrated a significant reduction in G 1 ...
Cited by 12 - Web Search - dx.doi.org - ncbi.nlm.nih.gov - peo.cshl.org - all 5 versions »

Divergence and convergence of TGF-b/BMP signaling - Full text - MIT Libraries
K Miyazono, K Kusanagi, H Inoue - J. Cell Physiol, 2001 - doi.wiley.com
... Runx1/2/3 Smad1,2,3,5 MH2, MH1? ... those induced by TGF-b. TGF-b induces growth inhibition
of various cells which is mediated by repression of c-myc, induction of ...
Cited by 135 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Translocation Breakpoints in Cancer
AM Oliveira, JA Fletcher - ehgonline.net
... encoding hematopoiesis- related transcription factors, including runt-related
transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) (RUNX1) and core ...
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