XBP1 Is Essential for Survival under Hypoxic Conditions and Is Required for Tumor Growth - Full text - MIT Libraries
L Romero-Ramirez, H Cao, D Nelson, E Hammond, AH … - Cancer Res, 2004 - cancerres.aacrjournals.org
... HIF-1 wild-type and knockout mouse embryonic fibroblasts, XBP1 wild-type and ... In brief,
total RNA from ras/c-myc–transformed mouse embryonic fibroblasts ...
Cited by 3 - Web Search - cancerres.aacrjournals.org - cbrl.stanford.edu - ncbi.nlm.nih.gov

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases … - Full text - MIT Libraries
AL Shaffer, M Shapiro-Shelef, NN Iwakoshi, AH Lee, … - Immunity, 2004 - lymphochip.nih.gov
... cell differentiation: Blimp-1, a transcriptional re- pressor encoded by the prdm1
gene, and XBP1, a b ... such as c-myc, cIIta, pax5, spiB, and id3 (Lin et al., 1997 ...
Cited by 11 - View as HTML - Web Search - pathology.wustl.edu - ncbi.nlm.nih.gov

Breast cancer oestrogen independence mediated by BCAR 1 or BCAR 3 genes is transmitted through … - Full text - MIT Libraries
L Dorssers, T van Agthoven, A Brinkman, J … - Breast Cancer Res, 2004 - dx.doi.org
... Differences between the various cell line models might explain individual
differences (see Fig. 1, for example MYC, XBP1 and MGP). ...
Web Search - pubmedcentral.nih.gov - bmc.ub.uni-potsdam.de - breast-cancer-research.com - all 7 versions »

GeneInfoViz: Constructing and visualizing gene relation networks - Full text - MIT Libraries
M Zhou, Y Cui - In Silico Biol, 2004 - iospress.metapress.com
... not ANG CRABP2 CSF1 EGFR ERBB2 GA T A 3 GZMB IGF2 MST1 MYBL2 MYC PLA T S O X 4 S
O X 9 SRF T OP2B VIL2 XBP1 KIA A0427 SUI1 RN A catabolism 1 0 0 0 0 0 0 0 0 0 ...
Web Search - bioinfo.de - bioinfo.de - ncbi.nlm.nih.gov - all 5 versions »

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor … - Full text - MIT Libraries
NN Iwakoshi, AH Lee, P Vallabhajosyula, KL Otipoby … - Nature Immunology, 2003 - nature.com
... Yoshida, H., Matsui, T., Yamamoto, A., Okada, T. & Mori, K. XBP1 mRNA is induced
by ... Lin, Y., Wong, K. & Calame, K. Repression of c-myc transcription by Blimp-1 ...
Cited by 50 - Web Search - mcb.berkeley.edu - medicine.skku.ac.kr - lbcm.iib.uba.ar - all 6 versions »

Cancer: Negative feedback for B cells - Full text - MIT Libraries
LM Staudt - Nature, 2004 - nature.com
... Conversely, they no longer expressed Blimp-1 or XBP1 (a key regulator of the ... This
is because they express c-myc, owing to a chromosomal translocation — an ...
Web Search - nature.com - ncbi.nlm.nih.gov

Restraint of B Cell Activation by Foxj1-Mediated Antagonism of NF-{kappa} B and IL-6 - Full text - MIT Libraries
L Lin, SL Brody, SL Peng - The Journal of Immunology, 2005 - jimmunol.org
... Real-time PCR detection of Foxj1, IL-6, CD80, CD86, ICOS, ICOSL, CD40, CD154,
bcl-6, Blimp-1, IRF-4, Mitf, c-myc, Pax5, and Xbp1 were performed as described ...
Web Search - jimmunol.org - jimmunol.org - jimmunol.org

Regulation of plasma-cell development - Full text - MIT Libraries
M Shapiro-Shelef, K Calame - Nature Reviews Immunology, 2005 - nature.com
... repression of expression of X-box-binding protein 1 (XBP1) 34 , the IgH, the IgL
and the immunoglobulin joining (J) chain 35–37 provides a mechanism for how ...
Cited by 1 - Web Search - immuneweb.xxmc.edu.cn - ncbi.nlm.nih.gov

Effect on Tumor Cells of Blocking Survival Response to Glucose Deprivation - Full text - MIT Libraries
HR Park, A Tomida, S Sato, Y Tsukumo, J Yun, T … - Journal of the National Cancer Institute, 2004 - jncicancerspectrum.oupjournals.org
... GRP78 and GRP94; StressGen, Victoria, British Columbia, Canada); anti-FLAG M2 (for
detection of FLAG- tagged ATF6 and XBP1 proteins; Sigma); anti-Myc tag (for ...
Cited by 1 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov

The N-terminal Truncated Isoform of SOCS 3 Translated from an Alternative Initiation AUG Codon under … - Full text - MIT Libraries
A Sasaki, K Inagaki-Ohara, T Yoshida, A Yamanaka, … - J Biol Chem, 2003 - jbc.org
... The UPR also activates transcription factors ATF6 and XBP1, which induce the ER
stress ... Anti-GFP (FL) and anti-Myc (A-14 and 9E10) antibodies were purchased from ...
Cited by 9 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

A trip to the ER: coping with stress - Full text - MIT Libraries
DT Rutkowski, RJ Kaufman - Trends Cell Biol, 2004 - biochem.wisc.edu
... domain of the activated IRE1 molecule catalyzes the removal of a small (26-nucleotide)
intron from the mRNA of the gene encoding X-box-binding protein (XBP1). ...
Cited by 56 - View as HTML - Web Search - lbcm.iib.uba.ar - ncbi.nlm.nih.gov - all 4 versions »

Transcriptional control of B-cell development - Full text - MIT Libraries
M Schebesta, B Heavey, M Busslinger - Curr Opin Immunol, 2002 - inv.his.se
... Although the function of XBP1 has been genetically analyzed by gene targeting (see ...
the genes coding for the transcription factors CIITA and c-Myc, which in ...
Cited by 45 - View as HTML - Web Search - unb.br - ingentaconnect.com - all 6 versions »

Negative feedback for B cells
LM Staudt - nature.com
... Conversely, they no longer expressed Blimp-1 or XBP1 (a key regulator of the ...
are,abnormally,still dividing 10 .This is because they express c-myc, owing to a ...
Web Search

MINI REVIEW BREAST CANCER REVISITED USING DNA ARRAY-BASED GENE EXPRESSION PROFILING - Full text - MIT Libraries
F Bertucci, P Viens, P Hingamp, V Nasser, R … - Int. J. Cancer, 2003 - doi.wiley.com
... MYC Myelocytomatosis viral oncogene homolog nd Poor Poor nt PLAT Plasminogen activator,
tissue nd Good Good nt ... XBP1 X-box binding protein 1 nd Good Good nt ...
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Expression profiling and breast cancer biology.
L Miller, ET Liu - Breast Disease, 2004 - iospress.metapress.com
... expression of ER alpha and as- sociated genes such as GATA3, XBP1, TFF3 and ... each
of six initiating onco- transgenes in the mammary gland: MMTV-myc, C3T- SV40 ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus … - Full text - MIT Libraries
N Pavio, PR Romano, TM Graczyk, SM Feinstone, DR … - J. Virol, 2003 - jvi.asm.org
... activity in cells transfected with CAT-pcDNA3 (0.3 µg), PERK-c-Myc (0 to ... Hepatitis
C Virus Suppresses the IRE1-XBP1 Pathway of the Unfolded Protein Response. ...
Cited by 8 - Web Search - pubmedcentral.nih.gov - jvi.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Building an antibody factory: a job for the unfolded protein response - Full text - MIT Libraries
JW Brewer, LM Hendershot - Nature Immunology, 2005 - nature.com
... for UPR analysis, current data indicate that this active form of ATF6 enters the
nucleus and can upregulate transcription of ER chaperone genes 12 and Xbp1 (ref ...
Web Search - nature.com - ncbi.nlm.nih.gov

Wider connections for El Nino - Full text - MIT Libraries
WJ Randel - Mol. Cell. Biol, 1988 - nature.com
... Conversely, they no longer expressed Blimp-1 or XBP1 (a key regulator of the ...
are,abnormally,still dividing 10 .This is because they express c-myc, owing to a ...
Web Search - acd.ucar.edu - nature.com

Global Expression Profiling of Fibroblast Responses to Transforming Growth Factor-ß Reveals the … - Full text - MIT Libraries
RC Chambers, P Leoni, N Kaminski, GJ Laurent, RA … - American Journal of Pathology, 2003 - ajp.amjpathol.org
... response to TGF-ß 1 at the earliest time point examined (eg, C-MYC, ID1, ID3 ... first
report to suggest that TGF-ß 1 up-regulates TCF8 and XBP1, associated with ...
Cited by 23 - Web Search - ajp.amjpathol.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Cleavage of the Hepatitis C Virus NS5A Protein by Caspase-3 in the Interferon Sensitivity- … - Full text - MIT Libraries
R HIDAJAT, M NAGANO-FUJII, LIN DENG, HAK HOTTA - Kobe J. Med. Sci, 2004 - med.kobe-u.ac.jp
... FL cells transiently expressing FLAG-ns5a-Jk- Myc-His were treated with 40 ... Hepatitis
C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. ...
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Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis - Full text - MIT Libraries
FE Davies, AM Dring, C Li, AC Rawstron, MA Shammas … - Blood, 2003 - bloodjournal.org
... important in this process was used to determine genes that co-regulate with XBP1. ...
Identification of c-myc promoter-binding protein and X-box binding protein 1 ...
Cited by 15 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 8 versions »

Combined Proteomics and Pathways Analysis of Collecting Duct Reveals a Protein Regulatory Network …
EJ Hoorn, JD Hoffert, MA Knepper - J Am Soc Nephrol, 2005 - jasn.asnjournals.org
... IPA MYC Myelocytomatosis oncogen (c-myc) IPA NCOA1 Steroid receptor co-activator
1 (SRC-1) IPA ... IPA TP53 Tumor protein 53 IPA XBP1 X-box binding protein 1 IPA ...
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Stable Binding of ATF6 to BiP in the Endoplasmic Reticulum Stress Response - Full text - MIT Libraries
J Shen, EL Snapp, J Lippincott-Schwartz, R Prywes - Mol Cell Biol, 2005 - mcb.asm.org
... These results demonstrate the redundancy of the XBP1, ATF6, and additional pathways
for ER ... pBiP-myc was constructed by cloning human BiP cDNA into the vector ...
Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

TRB 3, a novel ER stress-inducible gene, is induced via ATF 4–CHOP pathway and is involved in cell … - Full text - MIT Libraries
N Ohoka, S Yoshii, T Hattori, K Onozaki, H Hayashi - The EMBO Journal, 2005 - embojournal.npgjournals.com
... pcDNA3.1-Myc-CHOP N9, N18, 19–26 and N70 lacking the amino-terminus of human CHOP ...
pcDNA3.1-Flag-ATF4, pcDNA3.1-Flag-XBP1, pcDNA3.1-Flag-NF-YA and pcDNA3.1 ...
Web Search - nature.com - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein … - Full text - MIT Libraries
I Nagamori, N Yabuta, T Fujii, H Tanaka, K … - Genes to Cells, 2005 - blackwell-synergy.com
... 4A; middle panel, lane 4). In contrast, the anti-Myc antibody did not ... with a previous
report that showed overproduced ATF6 and XBP1 activate transcription not ...
Web Search - ingentaconnect.com - genestocellsonline.org - ncbi.nlm.nih.gov

Global Expression Profiling of Fibroblast Responses to Transforming Growth Factor-
P Switching - J Pathol, 2003 - ajp.amjpathol.org
... response to TGF- 1 at the earliest time point examined (eg, C-MYC, ID1, ID3 ... the first
report to suggest that TGF- 1 up-regulates TCF8 and XBP1, associated with ...
Web Search - Get it from MIT Libraries

INSIGHTS INTO THE MULTISTEP TRANSFORMATION OF MGUS TO MYELOMA USING MICROARRAY EXPRESSION ANALYSIS
KC Anderson, AF Building - bloodjournal.org
... factor genes (XBP1, zinc finger proteins, forkhead box and ring finger proteins),
and developmental genes (WNT and SHH pathways). ... XBP1 was decreased in ...
Web Search

The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the … - Full text - MIT Libraries
NN Iwakoshi, AH Lee, LH Glimcher - Immunological Reviews, 2003 - blackwell-synergy.com
... control B cells, demonstrating lower amounts of J-chain mRNA, which is required
for IgM and IgA assembly in plasma cells, and higher levels of c-myc mRNA which ...
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Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation - Full text - MIT Libraries
R Sciammas, MM Davis - J. Immunol, 2004 - jimmunol.org
... arrest and apoptosis, a phenotype most likely downstream of c-myc repression. ... In
fact, Xbp1, a critical UPR transcription factor, is necessary for Ig secretion ...
Cited by 6 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Molecular Classifiers for Gastric Cancer and Nonmalignant Diseases of the Gastric Mucosa - Full text - MIT Libraries
WK Martins, MD Begnami, C Zitron, AL Montagnini, … - CANCER RESEARCH, 2004 - cancerres.aacrjournals.org
... HS.327751 16.6 11.7 – – – XBP1 14.3 8.93 14.6 – – POLR21 13.3 10.8
10.3 – – ... TIMP3 7.83 8.26 8.43 – – MYC 7.94 – – – – ...
Web Search - doccancers.info - %20www.hcanc.org.br - hcanc.org.br - all 6 versions »

Molecular Classifiers for Gastric Cancer and Nonmalignant Diseases of the Gastric Mucosa - Full text - MIT Libraries
R Articles - Cancer Research, 2004 - intl-cancerres.aacrjournals.org
... the tissue classes in which a higher expression of the c-Myc oncogene and a ... in part,
because four pair of genes (KIAA0106-COL4A1, CLTC-COL4A1, XBP1-COL4A1, and ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Identification of Genes Involved in Resistance to Interferon-in Cutaneous T-Cell Lymphoma - Full text - MIT Libraries
L Tracey, R Villuendas, P Ortiz, A Dopazo, I … - American Journal of Pathology, 2002 - ajp.amjpathol.org
... cell types. 5 Some of the recognized IFN- targets that explain its
anti-tumoral role are hTERT, 6 bcl2, 7 c-MYC, 8 and other cell ...
Cited by 22 - Web Search - cnio.es - ingentaconnect.com - ncbi.nlm.nih.gov - all 8 versions »

Transcriptional regulatory cascades controlling plasma cell differentiation - Full text - MIT Libraries
KI Lin, C Tunyaplin, K Calame - Immunological Reviews, 2003 - blackwell-synergy.com
... Blimp-1 represses a gene expression program associated with cell proliferation and
growth (66), including the previously identified direct target c-myc and c ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Human EDEM 2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of … - Full text - MIT Libraries
SW Mast, K Diekman, K Karaveg, A Davis, RN Sifers, … - Glycobiology, 2004 - glycob.oupjournals.org
... mannosidase activity, and is up-regulated by ER stress through XBP1 (Hosokawa et ...
This construct (EDEM2-Myc-HA-His/pEAK) contained the full-length EDEM2 coding ...
Web Search - glycob.oupjournals.org - ncbi.nlm.nih.gov

Progress in Hematology
JD Shaughnessy Jr - cardenjennings.metapress.com
... Only 2 genes, XBP1 and IRF4, were up-regulated transcription factors ... 1 proto- oncogene
originally discovered as cooperating with trans- genic c-Myc in inducing B ...
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Identification of genes modulated in multiple myeloma using genetically identical twin samples - Full text - MIT Libraries
NC Munshi, T Hideshima, D Carrasco, M Shammas, D … - Blood, 2004 - bloodjournal.org
... EEF1A1 J04617 29.9 XBP1 Z93930 26.8 KRT8 X74929 17.9 EIF4G2 U73824 5.8 ... (C) Normalized
expression values from gene chip Hu95av2 for oncogenes v-fos, c-myc, and v ...
Cited by 13 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... Nuclear factor 1 NFAT Q6 Nuclear factor of activated T-cells NMYC 01 N-Myc OCT1
02 ... factor Tst-1/Oct-6 USF 02 Upstream stimulating factor VMAF 01 v-Maf XBP1 01 X ...
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Dilated Cardiomyopathy Caused by Aberrant Endoplasmic Reticulum Quality Control in Mutant KDEL … - Full text - MIT Libraries
H Hamada, M Suzuki, S Yuasa, N Mimura, N Shinozuka … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... cells and cells stably expressing either wild-type or mutant Myc-tagged KDEL ... mRNA
splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling ...
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Structural organization and classification of the human mucin genes
N Moniaux, F Escande, N Porchet, JP Aubert, SK … - Front Biosci, 2001 - xylian.igh.cnrs.fr
... the TATA box-like sequence, are found potential binding sites for c-Myc/N-Myc/Max
transcription ... GMCSF, NF-mu-E1, NF-Y, Pu-box, SRY, TCF-1, TdT Inr, XBP1, and W ...
Cited by 57 - Cached - Web Search - bioscience.org - bioscience.org - ncbi.nlm.nih.gov - all 7 versions » - Get it from MIT Libraries

Gene Expression Profiles of HeLa Cells Impacted by Hepatitis C Virus Non-structural Protein NS4B - Full text - MIT Libraries
Y Zheng, L Ye, J Liu, W Jing, KA Timani, X Yang, F … - Journal of Biochemistry and Molecular Biology, 2005 - jbmb.or.kr
... On the other hand, N-myc downstream regulated gene1, v-fos, and TU3A were
down-regulated. ... Tumor associated NM006096 N-myc downstream regulated gene1 (NDRG1) ...
View as HTML - Web Search - jbmb.or.kr - jbmb.or.kr - ncbi.nlm.nih.gov

Comparison of gene expression changes induced in mouse and human cells treated with direct-acting … - Full text - MIT Libraries
M Islaih, B Li, IA Kadura, JL Reid-Hubbard, JT … - Environmental and Molecular Mutagenesis, 2004 - doi.wiley.com
... Nfe212 Transcription regulation 4.9 4.7 94821_at X-box binding protein 1 Xbp1
Transcription regulation 4.4 3.0 96192_at Transacting transcription factor 3 ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - csa.com

Regulation Of Major Histocompatibility Complex Class-Ii Genes: X, Y And Other Letters Of The … - Full text - MIT Libraries
C Benoist, D Mathis - Annual Review of Immunology, 1990 - immunol.annualreviews.org
... pathways that involve protein kinase C translocation and Ca++ influx followed by
a rapid induction of c-myc and c-fos (LPS, anti-Ig, TPA, calcium ionophores ...
Cited by 165 - Web Search - immunol.annualreviews.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Kuo-I Lin Chainarong Tunyaplin Kathryn Calame - Full text - MIT Libraries
KI Lin - Immunological Reviews, 2003 - ingentaconnect.com
... Blimp-1 represses a gene expression program associated with cell proliferation and
growth (66), including the pre- viously identified direct target c-myc and c ...
Web Search

The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth - Full text - MIT Libraries
H Santos-Rosa, J Leung, N Grimsey, S Peak-Chew, S … - The EMBO Journal, 2005 - embojournal.npgjournals.com
... was followed by Western blot with anti-PtA and anti-Myc antibodies respectively. ...
The transcription factor XBP1 has been shown recently to mediate the massive ...
Web Search - pubmedcentral.nih.gov - embojournal.npgjournals.com - ncbi.nlm.nih.gov

Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory … - Full text - MIT Libraries
M Shapiro-Shelef, KI Lin, LJ McHeyzer-Williams, J … - Immunity, 2003 - molbio.grad.uiowa.edu
... Functional Blimp-1 binding sites have been identified on several direct targets
including c-myc, CIITA promoter III, Pax5, SpiB, and Id3 (Lin et ...
Cited by 30 - View as HTML - Web Search - ncbi.nlm.nih.gov

Repression of gene expression by oxidative stress - Full text - MIT Libraries
Y Morel, R Barouki - Biochem J, 1999 - bj.portlandpress.com
... It reported that oxidative stress induced transcription of the XBP1 protein, a
transcription factor that is related to cell cycle regulatory factors. ...
Cited by 103 - View as HTML - Web Search - biochemj.org - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

The Mitotic Cyclins Clb2p and Clb4p Affect Morphogenesis in Candida albicans - Full text - MIT Libraries
ES Bensen, A Clemente-Blanco, KR Finley, J Correa- … - Mol Biol Cell, 2005 - molbiolcell.org
... To generate pMG2093, a HindIII-BglII fragment containing 13 myc epitopes from plasmid
pFA6a-13myc-TRP1 (Longtine et al., 1998 ) was ligated into pGFP-HIS1 ...
Web Search - molbiolcell.org - ncbi.nlm.nih.gov

Expression of the AID protein in normal and neoplastic B cells - Full text - MIT Libraries
L Pasqualucci, R Guglielmino, J Houldsworth, J … - Blood, 2004 - bloodjournal.org
... and up-regulation of post-GC markers such as IRF4 and XBP1, overall suggesting ...
c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in ...
Cited by 6 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

REGULATORY MECHANISMS THAT DETERMINE THE DEVELOPMENT AND FUNCTION OF PLASMA CELLS - Full text - MIT Libraries
KL Calame, KI Lin, C Tunyaplin - Annual Review of Immunology, 2003 - immunol.annualreviews.org
... In the mouse lymphoma cell line BCL1, where treatment with cytokines induces
plasmacytic differentiation, ectopic expression of either c-Myc or cyclin E to ...
Cited by 38 - Web Search - phyto.annualreviews.org - nutr.annualreviews.org - ncbi.nlm.nih.gov - all 6 versions »

Development of a murine hematopoietic progenitor complementary DNA microarray using a subtracted … - Full text - MIT Libraries
X Ma, T Husain, H Peng, S Lin, O Mironenko, N Maun … - Blood, 2002 - bloodjournal.org
... 3.1 0.22 Tal1 T-cell acute lymphocytic leukemia 1 — — Xbp1 Essential for plasma
cell differentiation, liver development 1.6 0.4 1.1 0.5 ...
Cited by 6 - Web Search - info.med.yale.edu - dx.doi.org - ncbi.nlm.nih.gov - all 8 versions »