H 2 O 2 sensing through oxidation of the Yap 1 transcription factor - Full text - MIT Libraries
A Delaunay, AD Isnard, MB Toledano - The EMBO Journal, 2000 - dx.doi.org
... yap1 strain cultures expressing Myc-Yap1, Yap1 C303A,C310A,C315A or Yap1
C598T,C620A,C629T before and 5 min after treatment with 400 µMH 2 O 2 were processed ...
Cited by 81 - Web Search - embojournal.npgjournals.com - emboj.org - pubmedcentral.nih.gov - all 6 versions »

[CITATION] sensing through oxidation of the Yap1 transcription factor
AA Delaunay, AD Isnard, MB Toledano
... D yap1 strain cultures expressing Myc-Yap1, Yap1 L619S,L623S or Yap1 C598T,C620A,
C629T , before and 20 min after H 2 O 2 treatment, were processed as in (C). ...
Web Search - nature.com

A Thiol Peroxidase Is an H 2 O 2 Receptor and Redox-Transducer in Gene Activation
MB Barrault, J Vinh, MB Toledano - pharmacology.cwru.edu
... Myc epitope-tagged Yap1 (Myc-Yap1) by Western blot with an anti-Myc antibody. ... This
mobility shift We purified H 2 O 2 -treated Myc-Yap1 C303A by one-step ...
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Signal Transduction Virtual Journal - Full text - MIT Libraries
A Delaunay, AD Isnard, MB Toledano - The EMBO Journal, 2000 - stke.org
... yap1 strain cultures expressing Myc-Yap1, Yap1 C303A,C310A,C315A or Yap1
C598T,C620A,C629T before and 5 min after treatment with 400 µMH 2 O 2 were processed ...
Cached - Web Search - stke.org

Early Expression of Yeast Genes Affected by Chemical Stress {dagger}
A Lucau-Danila, G Lelandais, Z Kozovska, V Tanty, … - mcb.asm.org
... 8). After addition of benomyl to the growth medium, ChIP analyses were conducted
at different times (tChIP) to assess the variations of myc-Yap1 binding on ...
Web Search - mcb.asm.org

Activity of the Yap1 Transcription Factor in Saccharomyces cerevisiae Is Modulated by Methylglyoxal, … - Full text - MIT Libraries
K Maeta, S Izawa, S Okazaki, S Kuge, Y Inoue - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... yap1Δ glo1Δ mutants. We confirmed that Myc-tagged Yap1 is functional
in yap1Δ cells (data not shown). As shown in Fig. 2B, no ...
Cited by 3 - Web Search - mcb.asm.org - mcb.asm.org - ncbi.nlm.nih.gov

Ybp 1 Is Required for the Hydrogen Peroxide-induced Oxidation of the Yap 1 Transcription Factor - Full text - MIT Libraries
EA Veal, SJ Ross, P Malakasi, E Peacock, BA Morgan - J Biol Chem, 2003 - jbc.org
... The ability of Myc-tagged Yap1 protein to co-purify with His 6 FLAG-tagged Ybp1
was analyzed by SDS-PAGE and Western blotting using monoclonal anti-Myc ...
Cited by 9 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Yap 1 and Skn 7 Control Two Specialized Oxidative Stress Response Regulons in Yeast - Full text - MIT Libraries
J Lee, C Godon, G Lagniel, D Spector, J Garin, J … - J Biol Chem, 1999 - jbc.org
... When the EMSAs were performed with extracts expressing a Myc epitope-tagged version
of Yap1, adding the anti-Myc mAb to the binding reaction resulted in the ...
Cited by 105 - Web Search - jbc.org - ncbi.nlm.nih.gov

Stress-induced transcriptional activation mediated by YAP1 and YAP2 genes that encode the Jun family …
KY Dai Hirata, T Miyakawa - Mol Gen Genet, 1994 - springerlink.com
... by YAP1 and YAP2 genes that encode the Jun family ... The yap1 disruptant has been shown
to be sensitive to H202. In this study, we demonstrated that the yap1 dis- ...
Web Search - Get it from MIT Libraries

ROD 1, a novel gene conferring multiple resistance phenotypes in Saccharomyces cerevisiae. - Full text - MIT Libraries
AL Wu, TC Hallstrom, WS Moye-Rowley - J Biol Chem, 1996 - jbc.org
... yap1- 1::HIS3 double mutant strain (YAW15) was constructed by disruption of the
ROD1 gene in the SM10 ( yap1) (20) background. Addition of a c-Myc Epitope to ...
Cited by 8 - Web Search - jbc.org - ncbi.nlm.nih.gov

WW Domain–Containing Proteins, WWOX and YAP, Compete for Interaction with ErbB-4 and Modulate Its … - Full text - MIT Libraries
RI Aqeilan, V Donati, A Palamarchuk, F Trapasso, M … - Cancer Research, 2005 - cancerres.aacrjournals.org
... Myc-WWOX, Myc-WWOXY33R, and WWOX-GFP constructs were used to express WWOX protein. ...
YAP2 contains two WW domains compared with one WW domain in YAP1 but both ...
Web Search - cancerres.aacrjournals.org

Coupled and uncoupled induction of fos and jun transcription by different second messengers in cells … - Full text - MIT Libraries
J Auwerx, B Staels, P Sassone-Corsi - Nucleic Acids Res, 1990 - pubmedcentral.nih.gov
... region in the oligomerization and transforming activity of human c-myc protein. ... Yeast
YAP1 encodes a novel form of the jun family of transcriptional activator ...
Cited by 9 - Web Search - nar.oupjournals.org - ncbi.nlm.nih.gov

Proteomik: Proteine im (Hefe-) Kontext
CCBFC CtIP - imb-jena.de
... Myc-Mad-Max: Krebs- proteine … und Hefe? 56 (56) Abb. 2: Proteinnetzwerk in Hefe. ...
CSE4 LYS9 YMR322C YMR071C TSP1 YBR103W YAP1 TEF4 SPP41 YLR238W YKL155C SWI3 ...
View as HTML - Web Search - igtmv1.fzk.de - itgmv1.fzk.de - presse.fzk.de

The Yeast Nucleoporin Nup 2 p Is Involved in Nuclear Export of Importin alpha/Srp 1 p - Full text - MIT Libraries
JW Booth, KD Belanger, MI Sannella, LI Davis - J Biol Chem, 1999 - jbc.org
... EcoRI fragment from pLDB60 in pRS304 at EcoRI), and pLDB690 (NUP2 myc (1-546 ... B, pLDB461
(YAP1-GFP) was expressed in strains W303 (wild-type), LDY936 (crm1-1 ...
Cited by 26 - Web Search - jbc.org - ncbi.nlm.nih.gov

Untranslated regions of mRNAs - Full text - MIT Libraries
F Mignone, C Gissi, S Liuni, G Pesole - Genome Biology, 2002 - biomedcentral.com
... the mRNAs for the yeast transcription factors GCN4 and YAP1, which contain ... regulatory
proteins, such as proto-oncogene products like c-Myc, homeodomain proteins ...
Cited by 56 - View as HTML - Web Search - dx.doi.org - st-andrews.ac.uk - genomebiology.com - all 10 versions »

Responses to peroxynitrite in yeast: glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a sensitive …
DP Buchczyk, K Briviba, FU Hartl, H Sies - Biol. Chem, 2000 - degruyter.com
... tagged ubiquitin was then detected with antibodies specific to the c-myc-tag ... the
control of the redox sensitive AP-1-like transcription factor Yap1 (Stephen et ...
Cited by 15 - Web Search - extenza-eps.com - degruyter.de - ncbi.nlm.nih.gov - all 8 versions » - Get it from MIT Libraries

Forum Original Research Communication
M SHIBANUMA, K MORI, J KIM-KANEYAMA, K NOSE - dx.doi.org
... a functional overlap has not been reported for the NES of Yap1/Pap1. ... 12CA5) from
Boehringer Mannheim (Indianapolis, IN, USA), and anti-myc monoclonal antibody ...
Web Search - liebertonline.com - liebertonline.com

Nucleo-cytoplasmic transport of proteins as a target for therapeutic drugs.
Y Yashiroda, M Yoshida - Current Medicinal Chemistry, 2003 - ingentaconnect.com
... Like Pho4, the nuclear import of Yap1 is mediated by Pse1 [22]. ... in the nucleus, and
the consequent activation of transforming genes such as c- myc and cyclin D ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Discrimination between paralogs using microarray analysis: application to the Yap1p and Yap2p … - Full text - MIT Libraries
BA Cohen, Y Pilpel, RD Mitra, GM Church - Mol. Biol. Cell, 2002 - molbiolcell.org
... Gene-target recognition among members of the myc superfamily, and implications for ...
The PAR1 (YAP1/SNQ3) gene of Saccharomyces cerevisiae, a c-jun homologue, is ...
Cited by 13 - Web Search - longitude.weizmann.ac.il - bio.davidson.edu - genetics.med.harvard.edu - all 16 versions »

ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin - Full text - MIT Libraries
B Biteau, J Labarre, MB Toledano - Nature, 2003 - nature.com
... Western blot analysis of reduced (SH) and oxidized (SO2H) forms of Myc-Tsa1 in ... &
Toledano, MB H 2 O 2 sensing through oxidation of the Yap1 transcription factor ...
Cited by 40 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Trans-dominant negative mutants of Fos and Jun - Full text - MIT Libraries
LJ Ransone, J Visvader, P Wamsley, IM Verma - Proc Natl Acad Sci US A, 1990 - pubmedcentral.nih.gov
... activity of human c-myc protein. Nature 1989 Feb 16;337(6208):664–666. [PubMed]
[Full Text]; Moye-Rowley WS, Harshman KD, Parker CS. Yeast YAP1 encodes a ...
Cited by 16 - Web Search - ncbi.nlm.nih.gov - adsabs.harvard.edu

Chronological aging leads to apoptosis in yeast - Full text - MIT Libraries
E Herker, H Jungwirth, KA Lehmann, C Maldener, KU … - J. Cell Biol, 2004 - uni-frankfurt.de
... Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and ...
in the yeast Saccharomyces cerevi- siae reveals a link between YAP1 and the ...
Cited by 15 - View as HTML - Web Search - dx.doi.org - intl.jcb.org - ncbi.nlm.nih.gov - all 6 versions »

Transcriptional Activation of Metalloid Tolerance Genes in Saccharomyces cerevisiae Requires the AP- … - Full text - MIT Libraries
R Wysocki, PK Fortier, E Maciaszczyk, M Thorsen, A … - Mol Biol Cell, 2004 - molbiolcell.org
... previously described (Vongsamphanh et al., 2001). Anti-myc antibodies (Sc-40; Santa
Cruz ... RESULTS Cells lacking YAP1 and YAP8 display distinct phenotypes ...
Cited by 3 - Web Search - molbiolcell.org - pubmedcentral.nih.gov - intl.molbiolcell.org - all 8 versions »

Glutaredoxin Exerts an Antiapoptotic Effect by Regulating the Redox State of Akt - Full text - MIT Libraries
H Murata, Y Ihara, H Nakamura, J Yodoi, K Sumikawa … - J Biol Chem, 2003 - jbc.org
... M H 2 O 2 for 1 h. Redox states of Myc-tagged Akt were ... Yap1, a functional homologue
of the bacterial OxyR, regulates hydroperoxide homeostasis in Saccharomyces ...
Cited by 9 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Ask10p Mediates the Oxidative Stress-Induced Destruction of the Saccharomyces cerevisiae C-Type … - Full text - MIT Libraries
TJ Cohen, K Lee, LH Rutkowski, R Strich - Eukaryot. Cell, 2003 - intl-ec.asm.org
... The YAP1 deletion strains were constructed by an identical method utilizing pFA6a ...
extracts were prepared as previously described (6, 7). Srb11p-myc or Ask10p-HA ...
Cited by 2 - Cached - Web Search - pubmedcentral.nih.gov - ec.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Role of the ASK 1-SEK 1-JNK 1-HIPK 1 Signal in Daxx Trafficking and ASK 1 Oligomerization - Full text - MIT Libraries
JJ Song, YJ Lee - J Biol Chem, 2003 - jbc.org
... insertion of HA-ASK1 or myc-ASK1 or Flag-JBD or various Flag-Daxx or His-Daxx ...
transcription factor, Yap1, a sub-family of AP-1, which is a sensor of the redox ...
Cited by 10 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress … - Full text - MIT Libraries
T Zu, J Verna, R Ballester - Mol. Genet. Genomics, 2001 - springerlink.com
... The triple Myc epitope from the pMPY-3X-myc vector was then ligated intopSKII-PAR8 ...
YAP1 was deleted in the strain TZwt-1 (MATa leu2 his3 ura3 trp1 ade8, this ...
Cited by 14 - Web Search - ncbi.nlm.nih.gov

Supporting online material for: Transcriptional Regulatory Networks in Saccharomyces cerevisiae
GL Analysis - statgen.ncsu.edu
... epitope-tagged protein was confirmed by Western blotting using an anti-Myc antibody ...
PUT3 Mbp1 TMP1 Mcm1 SWI5, STE2, CLB1, CDC20, CLN3 Msn4 ROX1, YAP1, RPN4 Ndd1 ...
View as HTML - Web Search - statgen.ncsu.edu

Computational inference of transcriptional regulatory networks from expression profiling and … - Full text - MIT Libraries
S Material, P Haverty, U Hansen, Z Weng - Nucleic Acids Res, 2004 - pubmedcentral.nih.gov
... Figure 4 shows such a network inferred from the YAP1 deletion experiment. ... These data
were obtained upon over-expression of TF-myc fusion proteins using an anti ...
Cited by 9 - Web Search - bcgsc.ca - sullivan.bu.edu - nar.oxfordjournals.org - all 9 versions »

Overlapping Roles of the Cytoplasmic and Mitochondrial Redox Regulatory Systems in the Yeast … - Full text - MIT Libraries
EW Trotter, CM Grant - Eukaryot Cell, 2005 - ec.asm.org
... Mitochondrial Trx3 was detected using mouse anti-c-Myc antibody (Roche), and ... elevated
levels of reduced GSH, consistent with the known Yap1-mediated increase ...
Web Search - pubmedcentral.nih.gov - ec.asm.org - ncbi.nlm.nih.gov

Rck 1 and Rck 2 MAPKAP kinases and the HOG pathway are required for oxidative stress resistance - Full text - MIT Libraries
E Bilsland, C Molin, S Swaminathan, A Ramne, P … - Molecular Microbiology, 2004 - blackwell-synergy.com
... weak sensitivity to such compounds except in combination with yap1 (Wu et al ... 9A,
a band representing Zrc1-myc immunoprecipitated with -Rck2 antibodies is indeed ...
Cited by 5 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

The Skn7 response regulator of Saccharomyces cerevisiae interacts with Hsf1 in vivo and is required … - Full text - MIT Libraries
DC Raitt, AL Johnson, AM Erkine, K Makino, B … - Mol. Biol. Cell, 2000 - intl.molbiolcell.org
... shown to be regulated by SKN7 and the yeast AP-1 homologue YAP1, both of ... fragment
into the unique BamHI site of the integrating vector pRS306-Myc, which is ...
Cited by 24 - Web Search - pubmedcentral.nih.gov - molbiolcell.org - ncbi.nlm.nih.gov - all 5 versions »

Superoxide signalling required for multicellular development of Dictyostelium - Full text - MIT Libraries
G Bloomfield, C Pears - J Cell Sci, 2003 - jcs.biologists.org
... The Yap1 transcription factor of Saccharomyces cerevisiae (a homologue of mammalian
AP-1 ... in order to incorporate a 5' BglII restriction site and c-myc tag, and ...
Cited by 2 - Web Search - jcs.biologists.org - ncbi.nlm.nih.gov

Genetic and Biochemical Interactions Among Yar1, Ltv1 and RpS3 Define Novel Links Between … - Full text - MIT Libraries
JW Loar, RM Seiser, AE Sundberg, HJ Sagerson, N … - Genetics, 2004 - genetics.org
... individual proteins were detected using antibodies directed against the Myc and
HA ... with diamide, at least as sensitive as cells lacking YAP1, the major ...
Web Search - lclark.edu - genetics.org - ncbi.nlm.nih.gov

Identification of Saccharomyces cerevisiae genes conferring resistance to quinoline ring-containing … - Full text - MIT Libraries
U Delling, M Raymond, E Schurr - Antimicrob Agents Chemother, 1998 - aac.asm.org
... Overexpression of YAP1 confers multidrug resistance via trans-activation of the
YCF1 gene ... levels of transcription from the P1 promoter of human c-myc (42) and ...
Cited by 21 - Web Search - pubmedcentral.nih.gov - aac.asm.org - ncbi.nlm.nih.gov

Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer … - Full text - MIT Libraries
A Tsujimoto, H Nyunoya, T Morita, T Sato, K … - J. Virol, 1991 - pubmedcentral.nih.gov
... region in the oligomerization and transforming activity of human c-myc protein. ... Yeast
YAP1 encodes a novel form of the jun family of transcriptional activator ...
Cited by 31 - Web Search - ncbi.nlm.nih.gov

Genomic approaches for reconstructing gene networks
NH Lee - Pharmacogenomics, 2005 - futuremedicine.com
... was imple- mented to eliminate the possibility that MYC- induced proteins ... In yeast-
overexpressing transcription factor Yap1, about two-thirds of the most ...
Web Search - futuremedicine.com

Identification of Sumoylated Proteins by Systematic Immunoprecipitation of the Budding Yeast … - Full text - MIT Libraries
DD Wykoff, EK O’Shea, EK O’Shea - Molecular & Cellular Proteomics, 2004 - mcponline.org
... Criterion gels (26). Generation of myc-tagged ORFs ... codon so that the ORF was
in frame with thirteen myc epitopes. We ligated the myc tag ...
Cited by 3 - Web Search - mcponline.highwire.org - mcponline.org - ncbi.nlm.nih.gov - all 7 versions »

The NuA4 transcription activation/histone H4 acetyltransferase complex contains the essential Esa1 …
S Allard, RT Utley, J Savard, A Clarke, P Grant, … - Biochem. Cell Biol, 1999 - article.pubs.nrc-cnrc.gc.ca
... another subunit of the complex as the product of TRA1, an ATM-related essential
gene homologous to human TRRAP, an essential cofactor for c-Myc- and E2F ...
Web Search - article.pubs.nrc-cnrc.gc.ca - Get it from MIT Libraries

BIOINFORMATICS
SM Kiełbasa, JO Korbel, D Beule, J Schuchhardt, H … - BIOINFORMATICS, 2001 - bioinformatics.oupjournals.org
... similar to the expected element CACGTG was found in the promoters of genes regulated
via c-Myc. ... YAP 1 (16) TTACTAA 2 Yap1 MTTASK(1) 99/16 5.1 (6.5) CATTAC(2) ...
Web Search - bioinformatics.oupjournals.org - Get it from MIT Libraries

Control of eukaryotic protein synthesis by upstream open reading frames in the 5'-untranslated … - Full text - MIT Libraries
HA Meijer, AA Thomas - Biochem. J, 2002 - bj.portlandpress.com
... Apaf-1 Apoptosis [67] XIAP Apoptosis [68] c-myc Apoptosis, tissue specific
translation [64,66] Ubx Tissue specific translation [81] ...
Cited by 52 - View as HTML - Web Search - biochemj.org - ncbi.nlm.nih.gov - nutritionandmetabolism.com - all 6 versions »

Sut 1 p interaction with Cyc 8 p (Ssn 6 p) relieves hypoxic genes from Cyc 8 p-Tup 1 p repression in … - Full text - MIT Libraries
M Regnacq, P Alimardani, BE Moudni, T Berges - Molecular Microbiology, 2001 - ingentaconnect.com
... 5B clearly demon- strate that c-myc-Cyc8p was specifically and efficiently retained
on the column containing recombinant Sut1p but not MBP alone. ...
Cited by 7 - Web Search - ncbi.nlm.nih.gov

Methionine-containing zipper peptides
C Garcia-Echeverria - Letters in Peptide Science, 1997 - springerlink.com
... a positions of CREBA (CRE-binding protein), ATF6 (activating transcription factor),
and YAP1 (yeast AP1 ... of GCN4 [16] and in a d position of the l-Myc gene prod ...
Cited by 1 - Web Search - kluweronline.com

Number 1/numero
C Van Themsche, M Jacob, C Salesse, BJ Thatcher, … - proceedings.nrc.ca
... Spilsbury, and Piroska E. Rakoczy Addition of a c-myc epitope tag ... Bouganim, Jocelyn
David, Robert Wysocki, and Dindial Ramotar Yap1 overproduction restores ...
Web Search - pubs.nrc-cnrc.gc.ca - ingentaconnect.com - nrc.ca - all 5 versions »

Gene regulation during morphogenesis in Candida albicans
AJP Brown, CJ Barelle, S Budge, J Duncan, S Harris … - Contrib. Microbiol, 2000 - content.karger.com
... including c-Myc [45]. ... Also, since Cap1p complements S. cerevisiae yap1 mutants [47],
Cap1p presum- ably activates oxidative stress gene families in C. albicans ...
Cited by 8 - Web Search - content.karger.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Hic-5 Communicates between Focal Adhesions and the Nucleus through Oxidant-Sensitive Nuclear Export … - Full text - MIT Libraries
M Shibanuma, J Kim-Kaneyama, K Ishino, N Sakamoto, … - Mol. Biol. Cell, 2003 - molbiolcell.org
... was similarly visualized with the antibodies to the tags in HA-mHic and hHic-myc,
whose tags ... residues in the NES module of Hic-5 and the NESs of Yap1 and Pap1. ...
Cited by 9 - Web Search - pubmedcentral.nih.gov - dx.doi.org - all 10 versions »

Identification and Characterization of an SKN7 Homologue in Cryptococcus neoformans
FL Wormley Jr, G Heinrich, JL Miller, JR Perfect, … - iai.asm.org
... Domains of the SFL1 protein of yeasts are homologous to Myc oncoproteins or ... YAP1
dependent activation of TRX2 is essential for the response of Saccharomyces ...
Web Search - iai.asm.org

Statistical Applications in Genetics and Molecular Biology
M Experiments - bepress.com
... regions cross-linked to the transcription factor using an anti-Myc antibody. ... factors
are included, as well as three additional factors, Fkh2, Rgt1 and Yap1. ...
Web Search - bepress.com - sun01pt2-1523.statgen.ncsu.edu - statgen.ncsu.edu

Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection - Full text - MIT Libraries
C Li, WH Wong - Ann. NY Acad. Sci, 2004 - dx.doi.org
... of the Transcriptional Regulation of Glutathione Biosynthesis to the Availability
of Glutathione and Methionine via the Met4 and Yap1 Transcription Factors J ...
Cited by 657 - Web Search - pnas.org - icg.cpmc.columbia.edu - astor.som.jhmi.edu - all 38 versions »

MBC in Press, published on December 25, 2002 as 10.1091/mbc. 02-06-0099
OSNE Signal - proteins - molbiolcell.org
... for HA- or Myc-tagged wild-type mouse (m) or human (h) Hic-5, respectively, or ... (St.
Louis, MO) and anti-myc tag antibodies from Invitrogen (San Diego, ...
Web Search - Get it from MIT Libraries