Evi27 encodes a novel membrane protein with homology to the IL17 - Full text - MIT Libraries
J D Shaughnessy Jr - Oncogene, 2000 - nature.com
... Four of the genes are proven or suspected human disease genes: EVI1, NF1 and HOXA9
are causally associated with myeloid leukemia and EVI5 with stage 4S ...
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CBFA2 (AML1) translocations with novel partner chromosomes in myeloid leukemias: association with … - Full text - MIT Libraries
D Roulston, R Espinosa III, G Nucifora, RA Larson, … - Blood, 1998 - bloodjournal.org
... as the fusion genes formed by the t(3;21) (AML1/EAP, AML1/EVI1, and AML1 ... 27 The NF1
YAC was a gift from Douglas A. Marchuk, PhD (Duke University Medical Center ...
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Chromosome and molecular abnormalities in myelodysplastic syndromes
P Fenaux - Int J Hematol, 2001 - cardenjennings.metapress.com
... whose rearrangements appear to play a role in the pathogen- esis of some cases of
MDS.These genes include MDS1-EVI1 in t(3 ... 3.1.1. Mutations of RAS and NF1 genes ...
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Unbalanced t (3; 12) in a case of juvenile myelomonocytic leukemia(JMML) results in partial trisomy …
S Tosi, G Mosna, G Cazzaniga, G Giudici, L Kearney … - Leukemia, 1997 - nature.com
... Nf1 in the t(3;12)(q26;q22) causes blastic crisis in chronic myelocytic ... 1992; 6:
93–99. at 3q21 associated with the transcriptional activation of the EVI1 ...
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Molecular abnormalities and clonality in myelodysplastic syndromes
P Fenaux, C Preudhomme - Pathol Biol (Paris), 1997 - ncbi.nlm.nih.gov
... of the cFMS genes are less common, abnormalities of the NF1 genes seem ... been demonstrated,
and their study has provided evidence that the TEL, EVI1, MDS1, and ...
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Focus on myeloproliferative diseases and myelodysplastic syndromes - Full text - MIT Libraries
RA Van Etten, KM Shannon - Cancer Cell, 2004 - tufts-mori.org
... that hyperactive Ras initiates this MDS.This is support- ed by studies of Nf1, Kras,
and ... product of t(11;16) in t-MDS (Lavau et al., 2000), and of EVI1, a zinc ...
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Nuclear factor 1 is required for both hormone-dependent chromatin remodeling and transcriptional … - Full text - MIT Libraries
PB Hebbar, TK Archer - Mol. Cell. Biol, 2003 - mcb.asm.org
... an evaluation of the precise mechanism(s) by which NF1 contributes to ... EVI1 Promotes
Cell Proliferation by Interacting with BRG1 and Blocking the Repression of ...
Cited by 13 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

Molecular Mechanisms of Myelodysplastic Syndrome - Full text - MIT Libraries
H Hirai - Japanese Journal of Clinical Oncology, 2003 - jjco.oupjournals.org
... Homozygous inactivation of the NF1 gene in bone marrow cells from children with ... gene
at 3q21 associated with the transcriptional activation of the EVI1 gene in ...
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Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion …
AR von Bergh, PM Wijers, AJ Groot, S van Zelderen- … - Genes Chromosomes Cancer, 2004 - doi.wiley.com
... high homology with four RASGAP-related domains present in nGAP, NF1, and P120GAP ...
cryptic” exons have been described for the ABL, BCR, and EVI1 genes (Romero ...
Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - peo.cshl.org - Get it from MIT Libraries

Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, … - Full text - MIT Libraries
PJ Valk, Y Vankan, M Joosten, NA Jenkins, NG … - J Virol, 1999 - jvi.asm.org
... oncogenes (2, 22, 35, 36, 40) or inactivation of tumor suppressor genes (7). Multiple
human proto-oncogenes and tumor suppressors, eg, EVI1 (34), NF1 (47), and ...
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Rearrangements of Chromosome Band 3 q 21 in Myeloid Leukemia
R Wieser - Leukemia & Lymphoma, 2002 - dx.doi.org
... of the GATA family, stem cell leukemia gene, and EVI1 in leukemia ... P. and Upadhyaya,
M. (1996) “Molecular genetics of neurofibromatosis type 1 (NF1)”, J. Med ...
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Molecular pathogenesis of MDS
H Hirai - Int J Hematol, 2002 - haem.nus.edu.sg
... JMML is a pediatric myelodysplastic syndrome that is associated with
neurofibromatosis type 1 (NF1). The NF1 tumor suppressor gene ...
Cited by 3 - View as HTML - Web Search - ishapd.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Sox4 blocks cytokine-induced differentiation of 32Dcl3 cells and is a possible cooperating partner …
KE Boyd, A Poholek, O Mironenko, NG Copeland, NA … - yalepath.org
... and IL-3 3-5 ), growth factor receptors (c-fms 6 ), signaling molecules (Nf1 7 ),
and transcription factors including cMyb, Hoxa9, Hoxa7, Fli1, Meis1, and Evi1 ...
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A statistical analysis of the TRANSFAC database.
GB Fogel, DG Weekes, G Varga, ER Dow, AM Craven, … - Biosystems, 2005 - natural-selection.com
... B Muscle initiator sequence-20 MUSCLE INI B Muscle initiator NF1 Q6 Nuclear ... EVI1
06 Ectopic viral integration site 1 encoded factor Core should be ACAAGAT not ...
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Molecular Defects in Chronic Myeloproliferative Disorders - Full text - MIT Libraries
M Albitar, EJ Freireich, CM Leukemia - Molecular Medicine, 2000 - muse.jhu.edu
... As in adult CMML, there is in- creased incidence of RAS mutations (30%) (97) and
NF1 deletions (98). ... (1994) Generation of the AML1-EVI1 fusion gene in the t(3 ...
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Blood First Edition Paper, prepublished online August 1, 2002; DOI 10.1182/blood-2002-04-1244
W Count - bloodjournal.org
... established. Supporting this, a recent study suggested that BCR-ABL and
AML1/MDS1/EVI1 (AME) also genetically interact 34 . ... NG. Nf1 deficiency ...
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Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging … - Full text - MIT Libraries
N Mayotte, DC Roy, J Yao, E Kroon, G Sauvageau - Blood, 2002 - bloodjournal.org
... this, a recent study suggested that BCR-ABL and AML1/MDS1/EVI1 (AME) also ... Nf1 deficiency
causes Ras-mediated granulocyte/macrophage colony stimulating 7factor ...
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Large-scale identification of disease genes involved in acute myeloid leukemia - Full text - MIT Libraries
SJ Erkeland, M Valkhof, C Heijmans-Antonissen, A … - J. Virol, 2004 - pubmedcentral.nih.gov
... group comprises the previously reported virus targets Notch-1, NF1, PTPN1, Inpp4a ...
Phenotyping of Evi1, Evi11/Cb2, and Evi12 transformed leukemias isolated from ...
Cited by 4 - Web Search - jvi.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Cytogenetic and molecular heterogeneity of 7q36/12p13 rearrangements in childhood AML
NPG Contact - Leukemia, 2002 - nature.com
... D, Hagemeijer A, Van den Berghe H, Marynen P. Fusion of ETV6 to MDS1/EVI1 as a ... Tumour
predisposition in mice heterozygous for a targeted mutation in Nf1. ...
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Appearance of leukemia in peripheral blood
A Neutropenia, B Anemia, C Thrombocytopenia, C Mac - bloodjournal.org
... BXH-2 mice. Retroviral transduction with AML1-MDS1-EVI1 fusion. ... Myeloproliferative
disease. Nf1 +/- mice; Recipients of Nf1 -/- fetal liver cells. ...
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The molecular basis of myelodysplastic syndromes - Full text - MIT Libraries
A Gallagher, RL Darley, R Padua - Haematologica, 1997 - haematologica.it
Page 1. molecular basis of disease Haematologica 1997; 82:191-204 I neffective
hematopoiesis in the myelodysplastic syndromes is ...
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The Role of Cyclic-AMP Binding Protein(CREB) in Leukemia Cell Proliferation and Acute Leukemias
D SHANKAR, K SAKAMOTO - Leukemia & Lymphoma, 2004 - dx.doi.org
... Cognitive defects in neurofibro- matosis type 1 (NF1) mental retardation has recently ...
Nucifora, G. and Ren, R. (2000) ‘‘Human AML1/ MDS/EVI1 fusion protein ...
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Diagnosis, classification, and cytogenetics of myelodysplastic syndromes - Full text - MIT Libraries
T Vallespi, M Imbert, C Mecucci, C Preudhomme, P … - Haematologica, 1998 - haematologica.it
Page 1. Haematologica 1998; 83:258-275 review A BSTRACT Recent Advances
in Myelodysplastic Syndromes Guest Editors: Miguel Angel ...
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The gene encoding the transcriptional regulator Yin Yang 1 (YY1) is a myeloid transforming gene … - Full text - MIT Libraries
SJ Erkeland, M Valkhof, C Heijmans-Antonissen, R … - Blood, 2003 - bloodjournal.org
... in several genes previously demonstrated to be involved in MuLV-induced leukemias
(eg, Notch-1, Nf1, p53, Fli ... 8. Nucifora G. The EVI1 gene in myeloid leukemia. ...
Cited by 9 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Inaugural-Dissertation zur Erlangung des Doktorgrades der Naturwissenschaftlichen Fakultaet der …
U Fuchs - deposit.ddb.de
... Zelle ein, so zB als • GTPase-stimulierende Proteine, die in den RAS-
Signaltransduktionsweg eingreifen wie zB NF1 (I NGRAM et al., 2001); ...
Web Search - bibl7.hrz.uni-giessen.de - geb.uni-giessen.de - bibd.uni-giessen.de

Myelodysplastic syndromes: recent advances - Full text - MIT Libraries
EP Alessandrino, S Amadori, M Cazzola, F Locatelli … - Haematologica, 2001 - haematologica.it
... genetic predisposition to MDS Genetic and family mapping studies have clear- ly
demonstrated that mutations in a specific gene, such as AML1, NF1, or genes ...
Cited by 17 - View as HTML - Web Search - haematologica.org - haematologica.org - ncbi.nlm.nih.gov - all 9 versions »

Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice - Full text - MIT Libraries
JJ Moskow, F Bullrich, K Huebner, IO Daar, AM … - Mol. Cell. Biol, 1995 - mcb.asm.org
... involved in neoplastic disease in humans, as in the case of Evi1, making murine ... Omgp,
located within intron 27b of the neurofibromatosis type 1 (Nf1) gene (33 ...
Cited by 96 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Pathogenesis of acute myeloid leukaemia and inv (16)(p 13; q 22): a paradigm for understanding … - Full text - MIT Libraries
JT Reilly - British Journal of Haematology, 2005 - blackwell-synergy.com
... ETO (Ferro et al, 1992; Kojima et al, 1999), AML1-EVI1 (Cuenco & Ren ... mutual exclusivity
characterizes the proliferative mutations that involve RAS, NF1 and SHP1 ...
Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Targeted Therapy: For Kids, Too
S TRANSDUCTION - Pediatr Blood Cancer, 2005 - doi.wiley.com
... 4;11 MLL-AF4 TF ALL 8;21 AML1-ETO TF AML, M2 15;17 PML-RAR TF AML, M3 3;21
Evi1-ETO TF AML/MDS 11;22 EWS-FLI1 TF Ewing sarcoma 11;22 EWS-WT1 TF DSRCT ...
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Animal models of acute myelogenous leukaemia– development, application and future perspectives
E Mc Cormack, O Bruserud, BT Gjertsen - Leukemia, 2005 - nature.com
... 113 Finally, patients exhibiting mutations in the Nf1 45, 87, 114 tumour suppressor
gene with Ras ... the genesis of MLL/ELL t(11;19) 444 and to AML1/MDS1/EVI1 t(3 ...
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[CITATION] MEDICAL PROGRESS
C LEUKEMIAS, R Factors - THE NEW ENGLAND JOURNAL OF MEDICINE, 1995
... inv(3)(q21q26) or 1 EVI1 activation Thrombocytosis, abnormal platelets ... estingly,
it has been suggested that NF1, encoding one of the GTPase-activating proteins ...
Web Search - indianpediatrics.net - indianpediatrics.net - Get it from MIT Libraries

NB 4 S, a member of the TBC 1 domain family of genes, is truncated as a result of a constitutional t … - Full text - MIT Libraries
T Roberts, O Chernova, JK Cowell - Human Molecular Genetics, 1998 - hmg.oupjournals.org
... Huang, S. and Rowley, JD ( 1996 ) Intergenic splicing of MDS1 and Evi1 occurs in ...
cell hybrid and identification of PND/A12M2 on chromosome 1 and NF1/SCA7 on ...
Cited by 23 - Web Search - hmg.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified … - Full text - MIT Libraries
M Van Gele, JH Leonard, N Van Roy, H Van Limbergen … - International Journal of Cancer, 2002 - doi.wiley.com
... 22q11.2/22q13), LSI SRY/CEP X (Yp11.3/Xp11.1-q11.1; Vysis, Downers Grove, IL), BAC
clones RPCI-11 178P16 (16q23-24), RPCI-11 1094H24 (17q21), EVI1 BAC clones ...
Cited by 13 - Web Search - ncbi.nlm.nih.gov

Cytogenetics and molecular pathology in cancer diagnostics
S Knuutila - Annals of Medicine, 2004 - dx.doi.org
... inv(3)(q21q26)/ ROPN1;EVI1 AMLFrequent presence of thrombocytosis Resistant to ...
Neuro®bromatosis type 1 NF1 Neuro®brosarcoma, astrocytomas, melanoma ...
Cited by 1 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Cytogenetics and Physical Chromosome Maps
G Freising-Weihenstephan, L de Genetique - agri.ubu.ac.th
Page 1. R. Fries and P. Popescu Cytogenetics and Physical Chromosome Maps R.
Fries 1 and P. Popescu 2 1 Lehrstuhl für Tierzucht, Technische ...
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