Mutation of the p53 gene in neuroblastoma and its relationship with N-myc amplification
J Imamura, CR Bartram, F Berthold, D Harms, H … - Cancer Res, 1993 - cancerres.aacrjournals.org
... with N-myc amplification. In the two individuals, p53 mutations appeared as their
disease became more progressive. The neurofibromatosis 1 (NF1) gene is ...
Cited by 26 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Regulatory domains within the P0 promoter of human c-myc
JC Lang, NM Wilkie, AM Clark, A Chudleigh, S … - Oncogene, 1991 - ncbi.nlm.nih.gov
... site for CBP, and it is likely that concomitant binding of NF1 and CBP ... has described
a negative regulatory domain within the 5' flanking region of c-myc. ...
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YY1 and NF1 both activate the human p53 promoter by alternatively binding to a composite element, … - Full text - MIT Libraries
EE Furlong, T Rein, F Martin - Mol Cell Biol, 1996 - mcb.asm.org
... tide while the NF1 AV oligonucleotide had no effect (lanes 5 to 7). With M4 as probe,
which can bind only NF1, competition with the YY1 Myc oligonucleotide had ...
Cited by 37 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Differential binding of NF1 transcription factor to P53 gene promoter and its depletion in human …
BK Nayak, BR Das - Molecular Biology Reports, 1999 - springerlink.com
... Moreover reports are also available indicating oncogenes like Ha-ras and myc repress
the NF1 ac- tivity [52, 53] which in turn leads to deregulation of the NF1 ...
Cited by 5 - Web Search - kluweronline.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

… MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc … - Full text - MIT Libraries
AT Hoang, B Lutterbach, BC Lewis, T Yano, TY Chou, … - Mol. Cell. Biol, 1995 - mcb.asm.org
... show relative reporter activities resulting from duplicate experiments with chimeric
GAL4 proteins containing Myc, acidic VP16, or proline-rich NF1 TADs in the ...
Cited by 55 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Myc represses the growth arrest gene gadd 45 - Full text - MIT Libraries
WW Marhin, S Chen, LM Facchini, AJF Jr, LZ Penn - Oncogene, 1997 - nature.com
Page 1. Myc represses the growth arrest gene gadd45 Wilson ... cells. Keywords:
gadd45; Myc; cell cycle; p53; growth arrest Introduction ...
Cited by 75 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

… the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc - Full text - MIT Libraries
RM Jones, J Branda, KA Johnston, M Polymenis, M … - Mol. Cell. Biol, 1996 - mcb.asm.org
... an oligonucleotide containing the 38 nucleotides immediately surrounding the proximal
myc site (Fig ... scription binding sites (AP1, AP2, SP1, and CTF/NF1) did not ...
Cited by 82 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

… of human damage-specific DNA-binding protein genes DDB 1 and DDB 2 by Sp 1, E 2 F, N-myc and NF 1 … - Full text - MIT Libraries
AF Nichols, T Itoh, F Zolezzi, S Hutsell, S Linn - Nucleic Acids Research, 2003 - nar.oupjournals.org
... Basal transcriptional regulation of human damage-specific DNA-binding protein
genes DDB1 and DDB2 by Sp1, E2F, N-myc and NF1 elements. ...
Cited by 3 - Web Search - pubmedcentral.nih.gov - nar.oxfordjournals.org - ehscenter.berkeley.edu - all 8 versions »

Epidemiology, cytogenetics, and molecular biology of brain tumors
AP Kyritsis, H Saya - Curr Opin Oncol, 1993 - ncbi.nlm.nih.gov
... Glioma/genetics*; Glioma/pathology; Human; Incidence. Gene Symbols: EGFR; H-ras;
MDM2; MDR1; NF1; c-myc; p53. PMID: 8494908 [PubMed - indexed for MEDLINE]
Cited by 5 - Web Search - Get it from MIT Libraries

A myc-associated zinc finger protein binding site is one of four important functional regions in the … - Full text - MIT Libraries
DD Duncan, A Stupakoff, SM Hedrick, KB Marcu, G … - Mol. Cell. Biol, 1995 - mcb.asm.org
... analysis revealed homology of site 2 to the ME1a1 site of the Myc promoter (2 ... database
revealed that site 3 is similar in sequence to an NF1/CTF recognition ...
Cited by 44 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Involvement of YY1 and its correlation with c-myc in NDEA induced hepatocarcinogenesis, its …
T Parija, BR Das - Molecular Biology Reports, 2003 - kluweronline.com
... c-myc in our model system, an attempt has been made here to know the role of ...
Deregulation of NF1 transcription factor has also been observed in the same system ...
Cited by 1 - Web Search - springerlink.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

A 40-kDa NF1-like protein, not YY1, binds to the rat p53 promoter for transactivation in various rat … - Full text - MIT Libraries
M Lee, H Song, S Yu, K Lee, JS Park - Biochem Cell Biol, 1999 - article.pubs.nrc-cnrc.gc.ca
... They include NF1 (nuclear factor 1), YY1 (yin yang 1), PF1 (p53 factor 1), PF2
(p53 factor 2), NF-kB (nuclear factor-kB), c-Myc, and USF (upstream stimulating ...
Cited by 6 - Web Search - article.pubs.nrc-cnrc.gc.ca - ncbi.nlm.nih.gov

Nucleosomal structure of active and inactive c-myc genes. - Full text - MIT Libraries
A Pullner, J Mautner, T Albert, D Eick - J Biol Chem, 1996 - jbc.org
... elements has been identified within the regulatory region of the c-myc promoters
with potential binding sites for the transcription factors NF1/CTF, SP1, E2F ...
Cited by 12 - Web Search - jbc.org - ncbi.nlm.nih.gov

In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells - Full text - MIT Libraries
N Mahgoub, BR Taylor, M Gratiot, NE Kohl, JB Gibbs … - Blood, 1999 - bloodjournal.org
... Ryder JW, Srour EF, Jacks T, Shannon K, Clapp DW: Nf1 regulates hematopoietic ...
HL-60 transforming sequence: A ras oncogene coexisting with altered myc genes in ...
Cited by 25 - Web Search - bloodjournal.org - bloodjournal.org - ncbi.nlm.nih.gov - all 5 versions »

Oligo GEArray® Human Neurotrophin and Receptors Microarray
S Conditions - search.cosmobio.co.jp
... Cell cycle: BAX, BCL2, F2, FGF2, FGF9, IL1B, MYC, NF1, PTN, STAT1, TGFA,
TGFB1, TP53. Cell proliferation: BCL2, CCKBR, ETS1, FGF2 ...
View as HTML - Web Search

Tumor suppressor genes
Y Kuchino - Nippon Rinsho, 1994 - ncbi.nlm.nih.gov
... In this review, recent topics on tumor suppressors such as Rb, p53, Wt1, APC, NF1,
s-Myc and H19 are included to discuss their significance and function. ...
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Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression - Full text - MIT Libraries
SK Oster, WW Marhin, C Asker, LM Facchini, PA Dion … - Mol. Cell. Biol, 2000 - mcb.asm.org
... such as GATA-1, SRF, AP1, NF1, AP2, and NF-Y, and it is possible that one or all
of these sites are required to mediate the repression of pdgf- r mRNA by Myc. ...
Cited by 23 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

… rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc … - Full text - MIT Libraries
KW Foster, S Ren, ID Louro, SM Lobo-Ruppert, P … - Cell Growth Differ, 1999 - cgd.aacrjournals.org
... For example, c-MYC expression is regulated by the APC colorectal tumor suppressor ...
GTPase activity is regulated by the familial neurofibromatosis gene NF1 (6, 7 ...
Cited by 19 - Web Search - cgd.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Analysis of Human Breast Cancer Nuclear Proteins Binding to the Promoter Elements of the c-myc Gene
M Winnipeg, OW Canada - doi.wiley.com
... like proteins were gen- erated by NF1 and CBP. Identification of Novel
Sequence-Specific DNA-Binding Proteins Associated With the DH Site 112 Region of ...
Web Search - doi.wiley.com

DNA ploidy and MYC DNA amplification in ovarian carcinomas
J Diebold, B Suchy, GB Baretton, S Blasenbreu, H … - Virchows Archiv, 1996 - springerlink.com
... Suchy • Gustavo Bruno Baretton • Sabine Blasenbreu • Werner Meier Michael Schmidt •
Hartmut Rabes • Udo Liihrs DNA ploidy and MYC DNA amplification ...
Cited by 13 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Frequent Disruption of the Nf1 Gene by a Novel Murine AIDS Virus-Related Provirus in BXH-2 Murine … - Full text - MIT Libraries
HG BEDIGIAN, AM BUCHBERG, NA JENKINS, NG COPELAND - Journal OF Virology, 1995 - jvi.asm.org
... Frequent Disruption of the Nf1 Gene by a Novel Murine AIDS ... Viral integration at
Evi-2 appears to induce disease by disrupting normal Nf1 expression. ...
Cited by 12 - Web Search - pubmedcentral.nih.gov - jvi.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Expression of a 74-kDa nuclear factor 1 (NF1) protein is induced in mouse mammary gland involution - Full text - MIT Libraries
EEM Furlong, NK Keon, FD Thornton, T Rein, F … - J. Biol. Chem, 1996 - jbc.org
... the involution-specific 74-kDa NF1 accounts for the enhanced NF1 footprint detected ...
Jun, and JunD (10); p53, transforming growth factor- , and c-Myc (11); and ...
Cited by 11 - Web Search - intl.jbc.org - jbc.org - ncbi.nlm.nih.gov

Retroviral integration at the Epi1 locus cooperates with Nf1 gene loss in the progression to acute … - Full text - MIT Libraries
SM Blaydes, SC Kogan, BT Truong, DJ Gilbert, NA … - J. Virol, 2001 - jvi.asm.org
... 6- or leukemia inhibitory factor-induced myeloid differentiation prior to c-myc:
role in ... Loss of the normal NF1 allele from the bone marrow of children with ...
Cited by 8 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

… -Type and Mutant SL3-3 Murine Leukemia Virus Insertions in the c-myc Promoter during Lymphomagenesis … - Full text - MIT Libraries
AA Nielsen, AB Soerensen, J Schmidt, FS Pedersen - J Virol, 2005 - jvi.asm.org
... an extra wild-type repeat in combination with the deletion of two NF1 (nuclear factor
1 ... of which 20 to 25% display clonal rearrangements in the c-myc locus due ...
Web Search - pubmedcentral.nih.gov - jvi.asm.org - ncbi.nlm.nih.gov

Malignant Blue Nevus: A Case Report and Molecular Analysis.
SM Ariyanayagam-Baksh, FK Baksh, SD Finkelstein, … - Am J Dermatopathol, 2003 - amjdermatopathology.com
... on microdissected samples from the spectrum of benign to malignant blue nevus, using
a panel of eight genes (MTS1, MXI1, CMM1, p53, NF1, L-myc, hOGG1, and MCC ...
Cited by 3 - Web Search - amjdermatopathology.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

In simple synthetic promoters YY 1-induced DNA bending is important in transcription activation and … - Full text - MIT Libraries
J Kim, DJ Shapiro - Nucleic Acids Research, 1996 - nar.oupjournals.org
... with cellular or viral regulatory proteins such as cyclophilin A, c- myc and viral ...
of YY1-induced DNA bending in the modulation of transcription by NF1 or AP1. ...
Cited by 23 - Web Search - nar.oupjournals.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Genetics of cancer predisposition and progression
K Schwechheimer, WK Cavenee - The Clinical Investigator, 1993 - ncbi.nlm.nih.gov
... Gene Symbols: APC; H-ras; K-ras; Ki-ras; L-myc; MEN 1; MEN2; N-myc; N-ras; NF1;
RB1; RCC; VHL; WT1; able; c-myc; dcc; erbB; fms; fos; jun; mos; myc; raf1; src. ...
Cited by 4 - Web Search - Get it from MIT Libraries

… in a cell line producing spliced and polyadenylated RNA polymerase I transcripts from an rDNA-myc … - Full text - MIT Libraries
C Chen, N Fossar, D Weil, M Guillaud-Bataille, G … - Nucleic Acids Research, 2005 - nar.oxfordjournals.org
... G. (1997) Emergence and scattering of multiple neurofibromatosis (NF1)-related
sequences ... of two enhancer elements downstream of the human c-myc gene Nucleic ...
Web Search - nar.oupjournals.org - pubmedcentral.nih.gov - ingentaconnect.com - all 6 versions »

… in a cell line producing spliced and polyadenylated RNA polymerase I transcripts from an rDNA-myc …
B Raynal, F Dautry, A Bernheim, O Brison - nar.oxfordjournals.org
... spliced and polyadenylated RNA polymerase I transcripts from an rDNA-myc chimeric
gene ... 2G1Myc- P2Tu1 cells produce MYC mRNAs and proteins of abnormal size. ...
Web Search

Mxi1 mutations in human neurofibrosarcomas - Full text - MIT Libraries
XJ Li, DY Wang, Y Zhu, RJ Guo, XD Wang, K Lubomir, … - Jpn. J. Cancer Res, 1999 - bcasj.or.jp
... pathogenesis of neurofibrosarcoma. Key words: Mxi1 -- Neurofibrosarcoma --
NF1 -- c-myc -- Mutation. 7 Present address: Department ...
Cited by 8 - Cached - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Neurofibromatosis type 1 gene mutations in neuroblastoma
N Genetics - Nature Genetics, 1993 - nature.com
... Complete human NF1 cDNA sequence: two alternatively spliced mRNAs and absence of ...
for chromosome 1p in human neuroblastomas: correlation with N-myc amplification ...
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Nuclear factor 1 activates the feline leukemia virus long terminal repeat but is … - Full text - MIT Libraries
M Plumb, R Fulton, L Breimer, M Stewart, K … - J. Virol, 1991 - pubmedcentral.nih.gov
... NM, Onions DE, Lees G, Jarrett O. Transduction and rearrangement of the myc gene
by ... Paonessa G, Gounari F, Frank R, Cortese R. Purification of a NF1-like DNA ...
Cited by 12 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

The high-risk human papillomavirus type 16 E6 counters the GAP function of E6TP1 toward small Rap G … - Full text - MIT Libraries
L Singh, Q Gao, A Kumar, T Gotoh, DE Wazer, H Band … - J. Virol, 2003 - jvi.asm.org
... alone (A) or 1 µg of pCMV-HA-Rap2A alone (B) or in combination with increasing amounts
(0.5, 1, 2.5, and 5 µg) of pCMV-myc-E6TP1 or 5 µg of NF1, SPA1, or ...
Cited by 6 - Web Search - pubmedcentral.nih.gov - jvi.asm.org - ncbi.nlm.nih.gov

Alterations in the PITSLRE protein kinase gene complex on chromosome 1 p 36 in childhood …
JM Lahti, M Valentine, J Xiang, B Jones, J Amann, … - Nature Genetics, 1994 - nature.com
... Fanidi, A., Harrington, EA & Evan, GI Cooperative interaction between c-myc and
bcl-2 ... AT, DeClue, JE, Valentine, MB & Lowy, DR Inactivatlon of the NF1 gene in ...
Cited by 45 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Context-dependent Transcriptional Regulation - Full text - MIT Libraries
CJ Fry, PJ Farnham - J Biol Chem, 1999 - dx.doi.org
... and S. Linn Basal transcriptional regulation of human damage-specific DNA-binding
protein genes DDB1 and DDB2 by Sp1, E2F, N-myc and NF1 elements Nucleic Acids ...
Cited by 76 - Web Search - jbc.org - ncbi.nlm.nih.gov

Activation of nuclear factor kappa B and oncogene expression by 12 (R)- hydroxyeicosatrienoic acid, … - Full text - MIT Libraries
M Laniado-Schwartzman, Y Lavrovsky, RA Stoltz, MS … - J Biol Chem, 1994 - ncbi.nlm.nih.gov
... AP-1, AP-2, SP1, TRE, NF kappa B, TFIID, OKT1, CREB, CTF/NF1, and GRE ... Since the
protooncogenes (c-fos, c-jun, and c-myc) are immediate early response genes ...
Cited by 13 - Web Search

Multiple tandemly repeated binding sites for cellular nuclear factor 1 that surround the major … - Full text - MIT Libraries
KT Jeang, DR Rawlins, PJ Rosenfeld, JH Shero, TJ … - J. Virol, 1987 - pubmedcentral.nih.gov
... strength, whereas the arrangement of further upstream tandemly repeated NF1-binding
sites may ... binding in the putative regulatory region of the c-myc gene in ...
Cited by 24 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Parsing the Heart: Genetic Minireview Modules for Organ Assembly - Full text - MIT Libraries
MC Fishman, EN Olson - Cell, 1997 - genetics.wisc.edu
... apart Concentric growth of myocardium Thin myocardium RXR santa RAR valentine
NF1 heart of glass n-myc TEF-1 “Segmentation” Ventricular ...
Cited by 77 - View as HTML - Web Search - ncbi.nlm.nih.gov

Tumour class prediction and discovery by microarray-based DNA methylation analysis - Full text - MIT Libraries
P Adorjan, J Distler, E Lipscher, F Model, J … - Nucleic Acids Research, 2002 - nar.oupjournals.org
... c-MOS, TSP, VEGF, EGFR, CDC25A, ERBB2, c-fos, c-myc, n-myc, l-myc, c-abl ... b, GP1BB,
DAPK1, DBCCR1, PR, WT1, CTLA4, DAD1, HSPA2, MC2R, AFP, TGFB1, NF1, TGFA, POMC ...
Cited by 63 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Networks of tumor suppressors - Full text - MIT Libraries
M Serrano, J Massague - EMBO Reports, 2000 - emboreports.npgjournals.com
... Interestingly, this downregulation of NF1 is transient, and this may help the cell
to ... to a number of oncogenes, notably oncogenic Ras and Myc, thus signaling ...
Cited by 1 - Web Search - nature.com

The Xenopus laevis ribosomal gene promoter contains a binding site for nuclear factor-1 - Full text - MIT Libraries
P Walker, RH Reeder - Nucleic Acids Res, 1988 - pubmedcentral.nih.gov
... We have found that there is also an NF1 binding site within the ribosomal gene ...
requirements for premature termination of transcription in the human c-myc gene. ...
Cited by 2 - Web Search - nar.oupjournals.org - ncbi.nlm.nih.gov

Epigenetic changes in pilocytic astrocytomas and medulloblastomas - Full text - MIT Libraries
P Gonzalez-Gomez, MJ Bello, J Lomas, D Arjona, ME … - Int J Mol Med, 2003 - 147.52.72.117
... NF1 alleles occurs in up to 92% (11 of 12) of informative NF1- associated cases ...
Amplification of the genes for MYC, MYCN and EGFR together is present in about 10 ...
Cited by 7 - View as HTML - Web Search - biotools.net - virology.med.uoc.gr - ncbi.nlm.nih.gov

The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis … - Full text - MIT Libraries
D Viskochil, R Cawthon, P O’Connell, GF Xu, J … - Mol Cell Biol, 1991 - pubmedcentral.nih.gov
... N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts. ... Precise
localization of NF1 to 17q11.2 by balanced translocation. ...
Cited by 23 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Networks of tumor suppressors
J Massague, M Serrano - nature.com
... Interestingly, this downregula- tion of NF1 is transient, and this may help the
cell to ... to a number of oncogenes, notably oncogenic Ras and Myc, thus signaling ...
Web Search - nature.com

A Look Inside
T Bullock - Neuron Glia Biology, 2004 - journals.cambridge.org
... in NF1. To finish the Special Feature section we move back into the CNS. In the
study by Lassman et al., it is shown that overexpression of c-Myc oncogene ...
Web Search - journals.cambridge.org

Recent advances in cancer research: mouse models of tumorigenesis
M Herzig, G Christofori - Biochim. Biophys. Acta, 2002 - inje.ac.kr
... T antigen [217] MT Growth hormone [218] MT, albumin TGFa, c-Myc [219] HBx ... Genetic
ablation of both tumor suppressors, NF1 and p53, in composite knockout mice ...
Cited by 18 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage … - Full text - MIT Libraries
S Keeney, APM Eker, T Brody, W Vermeulen, D … - Proceedings of the National Academy of Sciences - pnas.org
... and S. Linn Basal transcriptional regulation of human damage-specific DNA-binding
protein genes DDB1 and DDB2 by Sp1, E2F, N-myc and NF1 elements Nucleic Acids ...
Cited by 42 - Web Search - pubmedcentral.nih.gov - dspace.ubib.eur.nl - ep.eur.nl - all 7 versions »

Down-Regulation of c-myb Gene Expression is a Prerequisite for Erythropoietin-Induced Erythroid … - Full text - MIT Libraries
K Todokoro, RJ Watson, H Higo, H Amanuma, S … - Mol. Cell. Biol, 2003 - pnas.org
... Pathways Required for the Initiation and the Elongation of c-myc J. Biol. ... and CI
Brannan Retroviral Integration at the Epi1 Locus Cooperates with Nf1 Gene Loss ...
Cited by 55 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu

New genes involved in cancer identified by retroviral tagging - Full text - MIT Libraries
T Suzuki, H Shen, K Akagi, HC Morse, JD Malley, DQ … - Nature Genetics, 2002 - nature.com
... t(8;22) translocations map within a distance of 300 kb downstream of MYC. ... the
Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without ...
Cited by 58 - Web Search - nature.com - ncbi.nlm.nih.gov

Molecular genetics and cytogenetics of sarcomas
RP Kruzelock, MF Hansen - Hematol Oncol Clin North Am, 1995 - ncbi.nlm.nih.gov
... Syndrome. Gene Symbols: ERG; FKHR; FL1; NF1; PAX3; RB1; c-myc; mdm2; p53. Grant
Support: CA-53318/CA/NCI. PMID: 7649940 [PubMed - indexed for MEDLINE]
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