Targeted expression of MYCN causes neuroblastoma in transgenic mice - Full text - MIT Libraries
WA Weiss, K Aldape, G Mohapatra, BG Feuerstein, JM … - The EMBO Journal, 1997 - embojournal.npgjournals.com
... penetrance of 40% at 10 months (Figure 4b). No neuroblastomas were seen in mice
heterozygous for deletions of RB1 or NF1, but not carrying the MYCN transgene. ...
Cited by 93 - Web Search - nature.com - emboj.org - ingentaconnect.com - all 11 versions »

Homozygous inactivation of NF 1 gene in a patient with familial NF 1 and disseminated neuroblastoma - Full text - MIT Libraries
P Origone, R Defferrari, K Mazzocco, CL Cunsolo, … - American Journal of Medical Genetics, 2003 - doi.wiley.com
... whose deathresultedfromdiseaseprogression.The mother had café-au-lait spots suggesting
a familial NF1. Neuroblastoma cells showed MYCN amplification and ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Molecular Cytogenetic Delineation of 17q Translocation Breakpoints in Neuroblastoma Cell Lines
ADJ Pearson, MS Jackson - GENES, CHROMOSOMES & CANCER, 1998 - doi.wiley.com
... A breakpoint between NF1 and ERRB2 was also present in SKNBE (2C), while a ... geneously
staining region (hsr) containing ampli- fied MYCN oncogene was inserted. ...
Cited by 16 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

B7. Clinical and Metabolic Investigations Offer New Insights into Pathophysiology of Succinic …
PL Pearl, MT Acosta, EJ Novotny, C Jakobs, KM … - doi.wiley.com
... bone development, and tumor suppression were regulated in NF1 blood samples ...
Amplification of the MYCN protooncogene is associated with advanced disease and ...
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Linkage Analysis in Families with Recurrent Neuroblastoma - Full text - MIT Libraries
P PERRI, L LONGO, C McCONVILLE, R CUSANO, SA REES, … - Annals of the New York Academy of Sciences, 2002 - annalsnyas.org
... Most prominent among these is the amplification of the MYCN oncogene and the ... analyzed
markers located close to several candidate genes (RET, NF1, GDNF, GFRA1 ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Loss of heterozygosity for chromosome 1p in familial neuroblastoma - Full text - MIT Libraries
GP Tonini, C Lo Cunsolo, R Cusano, A Iolascon, M … - Eur J Cancer, 1997 - ingentaconnect.com
... NF1). All patients of both families showed tumour cells with chromosome 1p deletion
(1pdel), but only the patient from family C also had MYCN gene amplification ...
Cited by 4 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Systematic multiplex polymerase chain reaction and reverse transcription-polymerase chain reaction … - Full text - MIT Libraries
SYU Clinic, J Sendai - Electrophoresis, 2004 - doi.wiley.com
... system: ABL1, ELK1, ERBB2, FOS1, HRAS, KIT, KRAS2, MYB, MYC, MYCN, NRAS, RAF1
proto-oncogenes and APC, BRCA1, BRCA2, CDKN2A, CDKN2B, NF1, PTEN, TP53, TP73, VHL ...
Web Search - ncbi.nlm.nih.gov

Familial Neuroblastoma: Report of a Kindred With Later Age at Diagnosis.
EG Lemire, BN Chodirker, GJ Williams, LE Seargeant … - J Pediatr Hematol Oncol, 1998 - jpho-online.com
... MYCN expression was also analyzed by immunohistochemistry to confirm the polymerase
chain ... D14S543 (14q32); and D17S1880, 53.0 (intron 38 of NF1 gene), D17S798 ...
Cited by 1 - Web Search - jpho-online.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Antioncogenes and human cancer - Full text - MIT Libraries
AG Knudson - Proc Natl Acad Sci USA, 1993 - pnas.org
Page 1. Proc. Natl. Acad. Sci. USA Vol. 90, pp. 10914-10921, December 1993
Review Antioncogenes and human cancer Alfred G. Knudson ...
Cited by 232 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Biology and genetics of human neuroblastomas
GM Brodeur, JM Maris, DJ Yamashiro, MD Hogarty, PS … - J Pediatr Hematol Oncol, 1997 - jpho-online.com
... deletions or mutations in the NF1 gene in neuroblastoma cell lines (57,58), but
it is unclear if this occurs commonly in primary tumors. MYCN Amplification and ...
Cited by 78 - Web Search - jpho-online.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

The biologic basis for neuroblastoma heterogeneity and risk stratification.
JM Maris - Current Opinion in Pediatrics, 2005 - co-pediatrics.com
... with aggressive disease without the oncogenic influence of deregulated MycN
[36,38 ... While biallelic inactivation of CDKN2A (INK4A/p16) [43] and NF1 [48,49] have ...
Cited by 1 - Web Search - co-pediatrics.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Neuroblastoma: biological insights into a clinical enigma - Full text - MIT Libraries
GM Brodeur - Nature Reviews Cancer, 2003 - nature.com
... somatic cell hybrids and identification of PND/A12M2 on chromosome 1 and NF1/SCYA7
on ... Reports the cloning of the MYCN proto-oncogene as the gene amplified in ...
Cited by 95 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Identification of the homozygously deleted region at chromosome 1 p 36. 2 in human neuroblastoma
A Nakagawara, M Ohira, H Kageyama, M Mihara, S … - Medical and Pediatric Oncology, 2000 - doi.wiley.com
... Case number, stage, and status of MYCN amplification are shown on the left. ... ported
that the neurofibromatosis-1 (NF1) gene on chro- mosome 17 was homozygously ...
Cited by 2 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Localization of the 17q Breakpoint of a Constitutional 1; 17 Translocation in a Patient With …
F Speleman - GENES, CHROMOSOMES & CANCER, 2002 - doi.wiley.com
... be an even stronger independent prog- nostic parameter than MYCN amplification
(Bown ... us to locate the constitutional 17q breakpoint between the NF1 and SCYA7 ...
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Localization of a hereditary neuroblastoma predisposition gene to 16 p 12-p 13
MJ Weiss, C Guo, S Shusterman, G Hii, TL Mirensky, … - Medical and Pediatric Oncology, 2000 - doi.wiley.com
... 3, 3p21-pter, 4p15-pter, 11q23, and 14q32), or consistent gain (2p24 [MYCN] and
17q23-25 ... GDNF at 5p12, GFRA2 at 8p21, RET at 10q11, EDNRB at 31q22, NF1 at 17q11 ...
Cited by 12 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

From® sh to FISH: the comparative pathology of neuroblastomas in humans, mice and® sh - Full text - MIT Libraries
M Schwab - J Cancer Res Clin Oncol, 1999 - springerlink.com
... NF1/ SCYA7 on chromosome 17 as breakpoint ¯anking single copy markers. Oncogene
10:1087±1093 Lutz W, Fulda S, Jeremias I, Debatin KM, Schwab M (1998) MycN ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Evidence for a hereditary neuroblastoma predisposition locus at chromosome 16p12-13 - Full text - MIT Libraries
JM Maris, MJ Weiss, Y Mosse, G Hii, C Guo, PS … - Cancer Res, 2002 - intl-cancerres.aacrjournals.org
... mutations can predispose to human cancer syndromes, the MYCN oncogene and ... containing
candidate "neurocristopathy" genes (GDNF, GFRA2, RET, EDNRB, NF1, and EDN3 ...
Cited by 14 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Detailed deletion mapping of chromosome band 14 q 32 in human neuroblastoma defines a 1. 1-Mb region … - Full text - MIT Libraries
M Hoshi, N Otagiri, HO Shiwaku, S Asakawa, N … - British Journal of Cancer, 2000 - nature.com
... There was no statistical correlation between LOH and any clinicopathologic features,
including age, stage, amplification of MYCN and ploidy. ...
Cited by 10 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Pediatric Solid Tumors: Dose Intensity and Targeted Therapy
NKV Cheung - ishapd.org
... chromosomal aberrations (Table 1), cellular oncogenes (eg, MYCN in neuroblastoma),
(4) tumor suppressor genes ... PNET, glioma 17q11 NF1 327 kD stimulator of ras- ...
View as HTML - Web Search - haem.nus.edu.sg

The neuroblastoma," enfant terrible" among pediatric tumors
G Laureys - Verh K Acad Geneeskd Belg, 2003 - ncbi.nlm.nih.gov
... with prognostic value (eg amplification of the oncogene MYCN, frequently associated ...
The 17q breakpoint was located between the NF1 (neurofibromatosis 1) gene ...
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High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
YP Mosse, J Greshock, A Margolin, T Naylor, K Cole … - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
... Even in the context of modern risk-based therapy, MYCN amplification remains a ... to
be exceedingly rare in this tumor, with CDKN2A or NF1 biallelic deletion ...
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Detailed molecular analysis of 1 p 36 in neuroblastoma
PS White, PM Thompson, BA Seifried, EP Sulman, SJ … - Medical and Pediatric Oncology, 2001 - doi.wiley.com
... No MYCN amplification was detected in the tumor. ... Establishment of somatic cell hybrids
and identification of PND/A12M2 on chromosome 1 and NF1/SCYA7 on ...
Cited by 18 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molekulare Ursachen der Tumorentstehung - Full text - MIT Libraries
Z Thema, M Onkologie - Der Onkologe - springerlink.com
... NF1 17q11 GTPase-aktivierendes Protein Neurale Tumoren ... MYC 8q24 Transkriptionsfaktor
Leukämien MYCN 2p24 Möglicher Transkriptionsfaktor Neuroblastom ...
Web Search

Molecular Cytogenetic Definition of 17q Translocation Breakpoints in Neuroblastoma
P Roberts, J Lunec, T Strachan, ADJ Pearson, MS … - Medical and Pediatric Oncology, 2001 - doi.wiley.com
... Amplification of MYCN [1], 1p deletion [2,3] and ploidy [4] are established genetic
abnormalities of prog- nostic significance in ... 2. c7G4 (NF1) q11.2 303.4 ...
Web Search - doi.wiley.com

Epigenetic changes in pilocytic astrocytomas and medulloblastomas - Full text - MIT Libraries
P Gonzalez-Gomez, MJ Bello, J Lomas, D Arjona, ME … - Int J Mol Med, 2003 - 147.52.72.117
... NF1 alleles occurs in up to 92% (11 of 12) of informative NF1- associated cases ...
Amplification of the genes for MYC, MYCN and EGFR together is present in about 10 ...
Cited by 7 - View as HTML - Web Search - biotools.net - virology.med.uoc.gr - ncbi.nlm.nih.gov

Testing of new agents in childhood cancer preclinical models: meeting summary - Full text - MIT Libraries
PJ Houghton, PC Adamson, S Blaney, HA Fine, R … - Clin. Cancer Res, 2002 - dimscan.com
... However, adoptive transfer of homozygous Nf1 mutant fetal liver hematopoietic cells
to ... model of neuroblastoma involving overexpres- sion of the MYCN gene has ...
Cited by 8 - View as HTML - Web Search - reprints.nant.org - nant.org - ncbi.nlm.nih.gov - all 5 versions »

Testing of New Agents in Childhood Cancer Preclinical Models - Full text - MIT Libraries
CE Biomarkers, PMC Therapeutics - Clinical Cancer Research, 2002 - clincancerres.aacrjournals.org
... in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic ...
G., Feuerstein BG, Bishop JM Targeted expression of MYCN causes neuroblastoma ...
Web Search - clincancerres.aacrjournals.org

Molecular pathogenesis of childhood brain tumors
T Pietsch, MD Taylor, JT Rutka - Journal of Neuro-Oncology, 2004 - springerlink.com
... Why this difference between NF1 and non-NFl pilocytic astrocytomas should exist
is ... L, Kepner JL, Friedman HS, McLendon RE: MYCC and MYCN oncogene amplification ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Malignant peripheral nerve sheath tumor cell invasion is facilitated by Src and aberrant CD 44 … - Full text - MIT Libraries
W Su, M Sin, A Darrow, LS Sherman - Glia, 2003 - doi.wiley.com
... NF1 tumor suppressor gene function: narrowing the GAP. ... 1997. Clinical relevance of
CD44 cell surface expression and MYCN gene amplification in neuroblas- toma. ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at other tumor suppressor … - Full text - MIT Libraries
PM Thompson, JM Maris, MD Hogarty, RC Seeger, CP … - Cancer Res, 2001 - cancerres.aacrjournals.org
... identifying correlations between 1p deletion size and the presence of MYCN
amplification (11 ... reported for neuroblastoma: HD of several exons of the NF1 gene ...
Cited by 15 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Nervous system: Astrocytic tumors
C Morphological - caroll.vjf.cnrs.fr
... tumor syndrome incuding the Li-Fraumeni syndrome, Turcot syndrome, and the NF1 syndrome. ...
in a few cases of astrocytomas : oncogenes Gli, MYC, MYCN, MET and N ...
Cached - Web Search

Second Israeli-German Bi-National Conference Current Concepts in Pediatric Oncology and Hematology
O Session - Monatsschrift Kinderheilkunde, 2002 - springerlink.com
Page 1. Abstracts | Monatsschrift Kinderheilkunde 10•2002 1278 Topic 1:
Stem cell therapy in malignant and non-malignant diseases ...
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EXTENSIVE GENETIC HETEROGENEITY IN THE NEUROBLASTOMA CELL LINE NB (TU)
A Inoue, K Yokomori, H Tanabe, H Mizusawa, T … - Cancer, 1997 - doi.wiley.com
... TABLE I – KARYOTYPES OF NB(TU)1 CELLS 46, XX, hsr(2)(q31).ish ins(2)(q31p24.1p24.
1)(MYCN ), del(2)(p?24), hsr(4)(p12).ish ins(4;2)(p12;p24.1p24.1)(MYCN ), del ...
Cited by 1 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in …
N Van Roy, H Van Limbergen, J Vandesompele, M Van … - Genes Chromosomes and Cancer, 2001 - doi.wiley.com
... were detected, including a balanced t(2;4)(p24.3;q34.3) translocation in cell line
NBL-S, with the 2p24 breakpoint located at about 40 kb from MYCN. ...
Cited by 14 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Emerging issues in genotoxicology
BJ Barclay - currentdrugdiscovery.com
... NF1 Ras inhibitor Ras signal transduction Neurofibroma, glioma, pheochromocytoma ...
MYCN Transcription factor, Activates expression of Neuroblastoma, small-cell ...
View as HTML - Web Search - inpharm.com

WHO-Klassifikation der Tumoren des Nervensystems
GK der Hirntumoren - krebsinfo.de
... Page 8. J. Schlegel, A. Peraud, J. Herms 10 Genetik Typischer zentralnervöser Tumor
der Neurofib- romatose Typ I (von Recklinghausen, NF1, MIM-No. ...
View as HTML - Web Search - iontest.web.med.uni-muenchen.de - krebsinfo.de

De la cytogenetique a la cytogenomique oncologique
A Bernheim, J Couturier - medecine/sciences, 2000 - ist.inserm.fr
... Dans 2 % à 4 % des cas sont observées aussi des amplifications de MYCN, sous forme
de chromosomes double minutes (figure 5). Ces anoma- lies sont liées à ...
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Neuroblastoma tumour genetics: clinical and biological aspects - Full text - MIT Libraries
N Bown - J Clin Pathol, 2001 - jcp.bmjjournals.com
... plex combinations of acquired genetic aberrations, including ploidy changes, deletions
of chromosome arms 1p and 11q, amplification of the MYCN oncogene, and ...
Cited by 25 - Web Search - doccancers.info - doccancers.info - ncbi.nlm.nih.gov - all 6 versions »

Shedding Light on the Dark Side of the Genome: Overlapping Genes in Higher Eukaryotes
S Boi, G Solda, ML Tenchini - Current Genomics, 2004 - dx.doi.org
... MYCN v-myc myelocytomatosis viral related oncogene MYCNOS DNA-binding transcriptional
activator H ... NF1 neurofibromin 1 OMG oligodendrocyte myelin glycoprotein ...
Cited by 3 - Web Search - ingentaconnect.com

Cytogenetics and molecular pathology in cancer diagnostics
S Knuutila - Annals of Medicine, 2004 - dx.doi.org
... HER-2) in breast cancer, EGFR in gliomas, and MYCN in neuroblastoma. ... Neuro®bromatosis
type 1 NF1 Neuro®brosarcoma, astrocytomas, melanoma, rhabdomyosarcoma ...
Cited by 1 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/ … - Full text - MIT Libraries
CJ Rorie, VD Thomas, P Chen, HH Pierce, JP O’ … - Cancer Res, 2004 - intl-cancerres.aacrjournals.org
... NBs generally show increased expression of sympathetic pathway enzymes tyrosine
hydroxylase and dopamine-ß-hydroxylase, MycN amplification, markers of adrenal ...
Cited by 4 - Web Search - intl-cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Molecular Analysis of Pediatric Brain Tumors - Full text - MIT Libraries
JA Biegel, IF Pollack - Current Science, 2004 - current-reports.com
Web Search - current-reports.com - ncbi.nlm.nih.gov

Childhood Cancer: Past Successes, Future Directions
A Leukemia - rimed.org
... Over the last 20 years, other bio- logic features have been found to be strong
predictors of outcome, espe- cially amplification of the mycN oncogene (which ...
View as HTML - Web Search - rimed.org

Mouse models of childhood cancer of the nervous system - Full text - MIT Libraries
MA Dyer - Journal of Clinical Pathology, 2004 - jclinpath.com
... In addition to MYCN amplification, a few other general chromosomal alterations have
been ... in adult tumours such as p53, p16, p18, p27, and NF1 are rarely ...
Cited by 1 - Cached - Web Search - jcp.bmjjournals.com - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Array-based comparative genomic hybridization for the detection of DNA sequence copy number changes … - Full text - MIT Libraries
B Albrecht, M Hausmann, H Zitzelsberger, H Stein, … - The Journal of Pathology, 2004 - doi.wiley.com
... 13414 LAMC2 PTGS2(C0X2) TGFB2 AKT3 SHGC-18290 10TEL10 U32389 2PTEL27 MYCN(N-mvc ...
D17S125,D17S61 D17S1296,D17S1523 LLGL1 FLI,TOP3A NF1 5' NF1 3' BRCA1 PPARBP(PBP ...
Cited by 2 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Genetics of Soft Tissue Tumors
J Lasota - elsevierinternational.com
Page 1. 99 Introduction Over the past several years, intensive studies on the human
cancer genome have identified numerous cancer-specific genetic alterations. ...
View as HTML - Web Search - harcourt-international.com - elsevier-international.com - intl.elsevierhealth.com - all 6 versions »

62. wissenschaftliche Halbjahres-tagung der Gesellschaft fuer Paediatrische Onkologie und …
NW eines postoperativen Dekubitus - Monatsschrift Kinderheilkunde, 2003 - springerlink.com
... study of the European SIOP Neuroblasto- ma group for children over the age of one
with stage 4 disease or stag- es 2 and 3 with MycN-amplified neuroblastoma ...
Web Search

Transcriptional Control of Hepatocanalicular Transporter Gene Expression - Full text - MIT Libraries
M MUeLLER - Seminars in Liver Disease, 2000 - humanabc.4t.com
Page 1. SEMINARS IN LIVER DISEASE—VOL. 20, NO. 3, 2000 323 From the Division
of Gastroenterology and Hepatology, University Hospital ...
Cited by 31 - View as HTML - Web Search - ncbi.nlm.nih.gov

Advanced Cancer Genetics in Neurosurgical Research.
M Taylor, C Raffel, J Bayani, PRT Marrano, TGMD … - Neurosurgery, 2003 - neurosurgery-online.com
... B, FISH analysis of a neuroblastoma metaphase spread showing amplification of MYCN
(in red ... identified to date are encoded by very large genes, ie, NF1, APC, and ...
Web Search - neurosurgery-online.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

NB 4 S, a member of the TBC 1 domain family of genes, is truncated as a result of a constitutional t … - Full text - MIT Libraries
T Roberts, O Chernova, JK Cowell - Human Molecular Genetics, 1998 - hmg.oupjournals.org
... G., Feuerstein, BG and Bishop, JM ( 1997 ) Targeted expression of MYCN causes
neuroblastoma in ... and identification of PND/A12M2 on chromosome 1 and NF1/SCA7 on ...
Cited by 23 - Web Search - hmg.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »