Epigenetic regulation of tumor suppressors in t (8: 21)-containing AML - Full text - MIT Libraries
G Yang, W Khalaf, L van de Locht, JH Jansen, BA … - Annals of Hematology, 2004 - springerlink.com
... Keywords NF1 · ETO · RUNX1 · MTG8 · Ras · 14ARF ... RUNX1-MTG8 also re- pressed the
expression of the endogenous NF1 gene (Yang et al., submitted). ...
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Regulation of the Murine D {delta} 2 Promoter by Upstream Stimulatory Factor 1, Runx1, and c-Myb - Full text - MIT Libraries
J Carabana, E Ortigoza, MS Krangel - The Journal of Immunology, 2005 - jimmunol.org
... of the indicated cold competitors (lanes 2–4), or in the presence of the indicated
Abs (lanes 5 and 6). Complexes containing Runx1 and NF1 are indicated. ...
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Transcriptional Repression of the Neurofibromatosis-1 Tumor Suppressor by the t (8; 21) Fusion …
G Yang, W Khalaf, L van de Locht, JH Jansen, M Gao … - mcb.asm.org
... (D) The synergistic transactivation of the NF1 promoter by RUNX1 and ETS2 requires
a RUNX1 binding site. ... 3C). Thus, NF1 is bound by both RUNX1 and RUNX1-MTG8. ...
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Mutated SHP and AML in leukemias - Full text - MIT Libraries
GS Feng - Blood, 2004 - bloodjournal.org
... Furthermore, both groups found that mutations in PTPN11, RAS, and NF1 are mutually
exclusive ... identification of a new type of mutation in the AML1/RUNX1 gene in ...
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Upstream and downstream targets of RUNX proteins - Full text - MIT Libraries
F Otto, M Luebbert, M Stock - Journal of Cellular Biochemistry, 2003 - doi.wiley.com
... activity of both, the proximal (P2) and distal (P1) promoters of the RUNX1 gene
[Ghozi et al ... While an NF1 site seems to bind NF1-A in non-osseous cells and ...
Cited by 16 - Web Search - ncbi.nlm.nih.gov

Cooperative activation of human papillomavirus type 8 gene expression by the E2 protein and the … - Full text - MIT Libraries
A Mueller, A Ritzkowsky, G Steger - J. Virol, 2002 - jvi.asm.org
... The NCR of HPV8 encodes binding sites for a variety of cellular transcription factors,
like AP1, NF1, YY1, RUNX1, and papillomavirus-binding factor (5, 14, 39 ...
Cited by 6 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

A New Cellular Factor Recognizes E2 Binding Sites of Papillomaviruses Which Mediate Transcriptional … - Full text - MIT Libraries
S Boeckle, H Pfister, G Steger - Virology, 2002 - milkpa.idv.tw
... BPV1 E2 BS-1; papillomavirus binding factor; transcriptional repression mediated
by E2; RUNX1. ... individual HPV types.However, the presence of AP1, NF1, and YY1 ...
Cited by 7 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

RAG-2-Deficient Blastocyst Complementation: An Assay of Gene Function in Lymphocyte Development - Full text - MIT Libraries
J Chen, R Lansford, V Stewart, F Young, FW Alt - Proceedings of the National Academy of Sciences - pnas.org
... VWRPY motif-dependent and -independent roles of AML1/Runx1 transcription factor ... of
neurofibromin: functional and biochemical consequences of Nf1 deficiency in T ...
Cited by 79 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu - all 5 versions »

Focus on myeloproliferative diseases and myelodysplastic syndromes - Full text - MIT Libraries
RA Van Etten, KM Shannon - Cancer Cell, 2004 - tufts-mori.org
... Ras initiates this MDS.This is support- ed by studies of Nf1, Kras, and Ptpn11 ... might
also con- tribute to MDS, as germline haploinsufficiency of RUNX1 is the ...
Cited by 1 - View as HTML - Web Search - ncbi.nlm.nih.gov

Molecular Mechanisms of Myelodysplastic Syndrome - Full text - MIT Libraries
H Hirai - Japanese Journal of Clinical Oncology, 2003 - jjco.oupjournals.org
... RAS gene mutations or inactivation of NF1 gene are thought to be ... AML1 gene The AML1
(Runx1) gene encoding the heterodimeric transcription factor, which binds ...
Cited by 5 - Web Search - jjco.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Molecular pathogenesis of MDS
H Hirai - Int J Hematol, 2002 - haem.nus.edu.sg
... RAS gene mutations or inactivation of NF1 gene are thought to be critical ... The AML1
(Runx1) gene encoding the heterodimeric transcription factor, which binds to ...
Cited by 3 - View as HTML - Web Search - ishapd.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Appearance of leukemia in peripheral blood
A Neutropenia, B Anemia, C Thrombocytopenia, C Mac - bloodjournal.org
... Granulocytic sarcoma. ENU treated Runx1-ETO knock-in mice. Histiocytic sarcoma. ...
Myeloproliferative disease. Nf1 +/- mice; Recipients of Nf1 -/- fetal liver cells ...
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Genomic structure of the PIK3CG gene on chromosome band 7q22 and evaluation as a candidate myeloid … - Full text - MIT Libraries
CP Kratz, BM Emerling, J Bonifas, W Wang, ED Green … - Blood, 2002 - bloodjournal.org
... to leukemogenesis, as has recently been reported for the human RUNX1 (AML1) gene ...
Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell ...
Cited by 8 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

High incidence of malformation syndromes in a series of 1, 073 children with cancer - Full text - MIT Libraries
JHM Merks, HN Caron, RCM Hennekam - American Journal of Medical Genetics Part A, 2005 - doi.wiley.com
... Chromosomal Rb Yes À Bunin e t a l. [1989] 302 N F I Germ cell tumor A D NF1 Pending
À Groot-Loonen et al. [ 1988] 1,073 NF I MPNST AD Deletion 17q11.2 Y es ...
Web Search - ncbi.nlm.nih.gov

Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated … - Full text - MIT Libraries
CP Kratz, BM Emerling, S Donovan, M Laig-Webster, … - Genomics, 2001 - warta.bio.psu.edu
... It is notable that NF1 inac- tivation in myeloid leukemias is not associated ... In addition,
haploinsufficiency of RUNX1 (also known as AML1 or CBFA2) causes a ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Control of RUNX 2 isoform expression: The role of promoters and enhancers - Full text - MIT Libraries
M Stock, F Otto - Journal of Cellular Biochemistry, 2005 - doi.wiley.com
... control has also been reported to be a crucial checkpoint in the expression of RUNX1
protein [Pozner et al ... It contains binding sites for AP1 and NF1 factors. ...
Web Search - ncbi.nlm.nih.gov

Expression of Galectin-3 in Skeletal Tissues Is Controlled by Runx 2 - Full text - MIT Libraries
M Stock, H Schaefer, S Stricker, G Gross, S … - J Biol Chem, 2003 - jbc.org
... other two members of the Runt family of transcription factors (Runx1 and Runx3 ... GATA
proteins, GFI1, HNF3b, Ikaros factors, Lmo2 complex, MyoD, MZF1, NF1, NF-AT ...
Cited by 4 - Web Search - jbc.org - ncbi.nlm.nih.gov

The Molecular Basis of Leukemia - Full text - MIT Libraries
DG Gilliland, CT Jordan, CA Felix, CT Jordan - Hematology, 2004 - asheducationbook.org
... When mutations such as RUNX1-ETO are expressed alone, they impair differentiation
and ... 6 Germline NF1 mutations and somatic RAS mutations are known to activate ...
Cited by 1 - Web Search - neuroscienzemolecolari.it - asheducationbook.org - ncbi.nlm.nih.gov

Array-based comparative genomic hybridization for the detection of DNA sequence copy number changes … - Full text - MIT Libraries
B Albrecht, M Hausmann, H Zitzelsberger, H Stein, … - The Journal of Pathology, 2004 - doi.wiley.com
... D17S125,D17S61 D17S1296,D17S1523 LLGL1 FLI,TOP3A NF1 5' NF1 3' BRCA1 PPARBP ...
ZNF217(ZABC1) CYP24 TNFRSF 6B (DCR3) TPD52L2,TOM 200TEL14 D21S378 RUNX1(AML1) DYRK1A ...
Cited by 2 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Abstracts presented at the Spring Conference 2003 of the Cancer Genetics Group, 12–13 May 2003, … - Full text - MIT Libraries
MRCHG Unit, UK Edinburgh - Familial Cancer, 2003 - kluweronline.com
... NF1 whole gene deletions: affected individuals have a distinct phenotype and may
have a greater risk of malignancy Lucy E. Side 1 , Bruce Castle 2 , Peter ...
Web Search - springerlink.com

RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in …
E Puxeddu, JA Knauf, MA Sartor, N Mitsutake, EP … - Endocrine-Related Cancer, 2005 - journals.endocrinology.org
... Gstt1), signal transduction (Socs3, Nf1, Jak2, Cpg21, Dusp6, Socs1, Stat1, Stat3,
Cish) and transcription (Nr4a1, Junb, Hfh1, Runx1, Foxe1). ...
View as HTML - Web Search - erc.endocrinology-journals.org - journals.endocrinology.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Mutation of All Runx (AML1/Core) Sites in the Enhancer of T-Lymphomagenic SL3-3 Murine Leukemia … - Full text - MIT Libraries
KD Soerensen, L Quintanilla-Martinez, S Kunder, J … - J Virol, 2004 - jvi.asm.org
... 3 enhancer is transiently activated by ectopic murine Runx1 (CBF2 -451 ... 5' UTR, 5'
untranslated region; GRE, glucocorticoid response element; NF1, nuclear factor ...
Web Search - jvi.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Type B Leukemogenic Virus Has a T-Cell-Specific Enhancer That Binds AML-1 - Full text - MIT Libraries
JA Mertz, F Mustafa, S Meyers, JP Dudley - J. Virol, 2001 - jvi.asm.org
... 5A). Several pieces of evidence confirm that AML-1 (recently renamed RUNX1 [36,
38 ... bind to the MuLV enhancer repeats, including Ets-1, Myb, GR, NF1, and basic ...
Cited by 3 - Web Search - pubmedcentral.nih.gov - jvi.asm.org - ncbi.nlm.nih.gov

Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell … - Full text - MIT Libraries
R Kim, A Trubetskoy, T Suzuki, NA Jenkins, NG … - J Virol, 2003 - jvi.asm.org
... One of its paralogs, Runx1/AML1, is important in human leukemias and was also ... Retroviral
integration at the Epi1 locus cooperates with Nf1 gene loss in the ...
Cited by 18 - Web Search - liv.med.utoronto.ca - mstp.nwu.edu - mstp.northwestern.edu - all 10 versions »

Cytogenetics and molecular pathology in cancer diagnostics
S Knuutila - Annals of Medicine, 2004 - dx.doi.org
... t(8;21)(q22;q22) CBFA2T1(ETO); RUNX2(CBFA1), RUNX1(AML1) AMLM2 ... Neuro®bromatosis type
1 NF1 Neuro®brosarcoma, astrocytomas, melanoma, rhabdomyosarcoma ...
Cited by 1 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Animal models of acute myelogenous leukaemia– development, application and future perspectives
E Mc Cormack, O Bruserud, BT Gjertsen - Leukemia, 2005 - nature.com
... Firstly, the AML1(Cbfa2, Runx1, Pebp2 B) 84 oncogene targeted by chromosomal ... 113
Finally, patients exhibiting mutations in the Nf1 45, 87, 114 tumour ...
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Treatment-related myelodysplastic syndrome/acute myeloid leukemia in survivors of childhood cancer …
DR BARNARD, WG WOODS - Leukemia & Lymphoma, 2005 - taylorandfrancis.metapress.com
... Children with NF1 are postulated to have decreased neurofibromin, thus less ... Bcl-2
or WT1 function, histone deacetylase inhibitors to alter RUNX1-ETO function ...
Web Search - ingentaconnect.com

A stable human-derived packaging cell line for production of high titer retrovirus/vesicular … - Full text - MIT Libraries
DS Ory, BA Neugeboren, RC Mulligan - J. Biol. Chem, 2004 - dx.doi.org
Vol. 93, Issue 21, 11400-11406, October 15, 1996. This paper was presented
at a colloquium entitled "Genetic Engineering of Viruses ...
Cited by 320 - Web Search - pnas.org - ncbi.nlm.nih.gov - adsabs.harvard.edu - all 6 versions »

Translocation and gross deletion breakpoints in human inherited disease and cancer I: Nucleotide … - Full text - MIT Libraries
SS Abeysinghe, N Chuzhanova, M Krawczak, EV Ball, … - Human Mutation, 2003 - doi.wiley.com
Page 1. RESEARCH ARTICLE Translocation and Gross Deletion Breakpoints in
Human Inherited Disease and Cancer I: Nucleotide Composition ...
Cited by 19 - Web Search - ncbi.nlm.nih.gov

Pathogenesis of acute myeloid leukaemia and inv (16)(p 13; q 22): a paradigm for understanding … - Full text - MIT Libraries
JT Reilly - British Journal of Haematology, 2005 - blackwell-synergy.com
... one of three CBF subunits, CBF 1, AML1 (also known as RUNX1 or CBF 2 ... mutual exclusivity
characterizes the proliferative mutations that involve RAS, NF1 and SHP1 ...
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Bibliography Current World Literature
L Benboubker, H Watier, A Carion, MT Georget, I … - Current Opinion in Hematology, 2002 - co-hematology.com
May 2002, 9:3 > Bibliography Current World Literature. < Previous | Next >.
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