YY1 and NF1 both activate the human p53 promoter by alternatively binding to a composite element, … - Full text - MIT Libraries
EE Furlong, T Rein, F Martin - Mol Cell Biol, 1996 - mcb.asm.org
... regulators occurs by posttranslational modification; eg, cdc2 kinase can phosphorylate
NF1 (26 ... elements have been described, eg, YY1/MGF (39), YY1/SRF (34), and ...
Cited by 37 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

… correlated crystal-field interaction through the B 0 0 term of Gd 3 in CaF 2, SrF 2, and BaF 2 - Full text - MIT Libraries
PP Yaney - Phys Rev B, 1974 - link.aps.org
... form [a-(b / R)] / R, where R is the anion-cation separation in CaF 2 , SrF 2 ,
and BaF 2 ... factors Mnf, a are given by oz A 4=1 1-2E XJAWn ra)SMj,,nf1 ra) +E AX ...
Cited by 1 - Web Search - adsabs.harvard.edu

SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability - Full text - MIT Libraries
N Ramanan, Y Shen, S Sarsfield, T Lemberger, G … - Nature Neuroscience, 2005 - neuroscience.jhu.edu
Page 1. SRF mediates activity-induced gene expression and ... SRF is a transcription
factor containing the highly conserved MADS domain ...
Web Search - nature.com - nature.com - ncbi.nlm.nih.gov

Context-dependent Transcriptional Regulation
TACB Achieved - cbr.med.harvard.edu
... protein; TCF, T cell factor; HMG, high mobility group; Rb, retinoblastoma; NF1,
nuclear factor ... 13-acetate; CDF-1, CDE-CHR binding factor-1; SRF, serum response ...
View as HTML - Web Search - genomecenter.ucdavis.edu - mcardle.oncology.wisc.edu - genomics.ucdavis.edu - all 6 versions »

Expression of the smooth muscle myosin heavy chain gene is regulated by a negative-acting GC-rich … - Full text - MIT Libraries
CS Madsen, JC Hershey, MB Hautmann, SL White, GK … - J Biol Chem, 1997 - jbc.org
... The Sp1, Sp3, SRF, and CTF/NF1 antibodies used for EMSA supershift experiments
were all purchased commercially (Santa Cruz). EMSA ...
Cited by 60 - Web Search - jbc.org - ncbi.nlm.nih.gov

Context-dependent Transcriptional Regulation - Full text - MIT Libraries
CJ Fry, PJ Farnham - J Biol Chem, 1999 - dx.doi.org
... protein; TCF, T cell factor; HMG, high mobility group; Rb, retinoblastoma; NF1,
nuclear factor ... 13-acetate; CDF-1, CDE-CHR binding factor-1; SRF, serum response ...
Cited by 76 - Web Search - jbc.org - ncbi.nlm.nih.gov

Computational analysis of composite regulatory elements - Full text - MIT Libraries
P Qiu, W Ding, Y Jiang, JR Greene, L Wang - Mammalian Genome, 2002 - springerlink.com
... 21.6 BRN2 TATA 257.1 HNF4 RORA1 80.4 CREB SRF 34.4 CHOP NF1 21.4 USF XBP1
256.3 EGR3 SP1 75.1 HNF1 TATA 33.9 HNF1 Oct-1 21.2 MZF1 ...
Cited by 10 - Web Search - ncbi.nlm.nih.gov

Myocyte Enhancer Factor-2 and Serum Response Factor Binding Elements Regulate Fast Myosin Heavy … - Full text - MIT Libraries
DL Allen, JN Weber, LK Sycuro, LA Leinwand - Journal of Biological Chemistry - jbc.org
... All antibodies used for supershifting assays (Oct-1, MEF-2, SRF, NF1, and lamin
A/C) were purchased from Santa Cruz Biotechnology. RESULTS. ...
Web Search - jbc.org - ncbi.nlm.nih.gov

Molecular and Cell Biology of TGF-ß
AB Roberts - Miner Electrolyte Metab, 1998 - content.karger.com
... and p15 Ink4b [22] by TGF-ß while an NF1 site mediates enhancement by TGF-ß of ... Two
of these, termed CarG elements, bind the serum response factor (SRF). ...
Cited by 90 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Molecular and cell biology of TGF-ß
AB Roberts - Miner Electrolyte Metab, 1998 - content.karger.com
... and p15 Ink4b [22] by TGF-ß while an NF1 site mediates enhancement by TGF-ß of ... Two
of these, termed CarG elements, bind the serum response factor (SRF). ...
Cited by 26 - Web Search - content.karger.com

Two YY-1-binding Proximal Elements Regulate the Promoter Strength of the TATA-less Mouse … - Full text - MIT Libraries
E Johansson, K Hjortsberg, L Thelander - J Biol Chem, 1998 - jbc.org
... YY1 can inhibit the binding of SRF (23, 24) but also facilitate the binding of SRF
(25). It has been shown that NF1 and YY1 both can activate the human p53 ...
Cited by 15 - Web Search - medchem.umu.se - jbc.org - ncbi.nlm.nih.gov

MEF-2 and Oct-1 Bind to Two Homologous Promoter Sequence Elements and Participate in the Expression … - Full text - MIT Libraries
MM Lakich, TT Diagana, DL North, RG Whalen - J Biol Chem, 1998 - jbc.org
... The proteins SRF and NF1 bind to adjacent sites centered at 100 bp on the IIB MyHC
promoter and induce a bend in the DNA (data not shown), which may in turn ...
Cited by 23 - Web Search - jbc.org - ncbi.nlm.nih.gov

Failure to Detect Differences in Proliferation Status of Nevi from CDKN 2 A Mutation Carriers and … - Full text - MIT Libraries
SR Florell, KM Boucher, JA Holden, LJ Meyer, WE … - Journal of Investigative Dermatology, 2002 - blackwell-synergy.com
... Foundation Leaders Society Dermatologist Investigator Research Fellowship (SRF),
Doris Duke ... Ota M, Stephens K, Viskochil D: Identification of NF1 mutations in ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

A Complex Tale of Serum Response Factor–Mediated Tissue Inhibitor of Metalloproteinase-3 … - Full text - MIT Libraries
VP Krymskaya, JM Shipley - American Journal of Respiratory Cell and Molecular Biology, 2003 - intl-ajrcmb.atsjournals.org
... 2001. NF1 tumor suppressor gene function: narrowing the GAP. ... The Rho family of GTPases
RhoA, Rac1, and Cdc42Hs regulate transcriptional activation by SRF. ...
Cited by 3 - Web Search - ajrcmb.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Multiple interdependent regulatory sites in the mouse c-fos promoter determine basal level … - Full text - MIT Libraries
FC Lucibello, F Ehlert, R Muller - Nucleic Acids Res, 1991 - pubmedcentral.nih.gov
... Other sites, including the SRE, a NF1 site around position -165, a novel ... R, Treisman
R. Isolation and properties of cDNA clones encoding SRF, a transcription ...
Cited by 4 - Web Search - nar.oupjournals.org - ncbi.nlm.nih.gov

GAPs in growth factor signalling
A BERNARDS, J SETTLEMAN - Growth Factors, 2005 - taylorandfrancis.metapress.com
... raising the interesting possibility that p190A regulates growth factor-dependent
gene expression both by inhibiting Rho-dependent SRF activity through its ... NF1 ...
Web Search - ingentaconnect.com

ESTRATEGIAS PARA EL DISENO DE NUEVOS
AEC CELULAS, MAPOR ONCOGENES - infomedonline.com.ve
... Tanto SRF como SIF están involucrados en la activación transcripcional de c-Fos
(el ... Rb), p53, los genes de la neurofibromatosis tipo 1 y 2 (NF1, NF2), el gen ...
Cached - Web Search - infomedonline.com.ve - infomedonline.com.ve

NF 1-L is the DNA-binding component of the protein complex at the peripherin negative regulatory … - Full text - MIT Libraries
AD Adams, DM Choate, MA Thompson - J Biol Chem, 1995 - jbc.org
... performed by preincubating nuclear extract with 1 µl of anti-NF1 antibody (partially ...
approach was successfully used by Treisman in the purification of SRF(31 ...
Cited by 37 - Web Search - jbc.org - ncbi.nlm.nih.gov

Increasing Complexity of the Ras Signaling Pathway - Full text - MIT Libraries
AB Vojtek, CJ Der - J Biol Chem, 1998 - dx.doi.org
... form of Ras (1). GTPase-activating proteins (GAPs; p120 GAP and NF1) accelerate
the ... trisphosphate; MEKK, MEK kinase; SEK, SAPK/JNK kinase; SRF, serum response ...
Cited by 158 - Web Search - jbc.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

Transactivation of the Moloney murine leukemia virus and T-cell receptor-chain enhancers by cbf and … - Full text - MIT Libraries
W Sun, BJ Graves, NA Speck - J. Virol, 1995 - jvi.asm.org
... do- main (eg, Elk-1, SAP-1 [30], and NET [21]) and can interact with SRF. ... receptor
and the bHLH protein SEF2 [10, 14]), the nuclear factor 1 (NF1) binding site ...
Cited by 89 - Web Search - jvi.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

GEArray Q series Mouse cAMP/Ca2+ PathwayFinder Gene Array: AR-SAMM-028
FG Grouping - eurogentec.com
... Hspa4 (hsp70), Junb, Nr4a2 (Nur77), Scg2 (secretogranin II), Srf, Thbs1 (TSP ... Ccna1
(CyclinA), Ccnd1 (CyclinD1), Cdk5, Cdkn2b (p15IND4b), Gem, Nf1, Pcna, Pmaip1 ...
View as HTML - Web Search - eurogentec.be

GEArray Q series Human cAMP/Ca2+ PathwayFinder Gene Array: AR-SAHS-028
FG Grouping - eurogentec.com
... JUNB, NR4A2 (Nur77), S100A6 (Calcyclin), SCG2 (secretogranin II), SRF, THBS1
(TSP-1 ... CyclinA), CCND1 (CyclinD1), CDK5, CDKN2B (p15IND4b), GEM, NF1, PCNA, PMAIP1 ...
View as HTML - Web Search - eurogentec.be

The Role of Cyclic-AMP Binding Protein(CREB) in Leukemia Cell Proliferation and Acute Leukemias
D SHANKAR, K SAKAMOTO - Leukemia & Lymphoma, 2004 - dx.doi.org
... response to growth factor stimulation [26,27] Since CREB and SRF are both ... Cognitive
defects in neurofibro- matosis type 1 (NF1) mental retardation has recently ...
Cited by 1 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Transcriptional regulation of cardiac development: implications for congenital heart disease and … - Full text - MIT Libraries
JA Epstein, CA Buck - Pediatr Res, 2000 - pedresearch.org
... factors such as Nkx2.5 and serum response factor (SRF) to activate ... in the ras-GAP
protein encoded by the Neurofibromatosis gene NF1 disrupt valvulogenesis (41 ...
Cited by 19 - Web Search - pedresearch.org - ncbi.nlm.nih.gov

Factors involved in cardiogenesis and the regulation of cardiac-specific gene expression - Full text - MIT Libraries
JD Mably, CC Liew - Circ Res, 1996 - circresaha.org
... The CArG motif is shaded, and the guanine residues implicated in SRF binding are ...
structure, not all activators have this ability, since both NF1 and heat shock ...
Cited by 22 - Cached - Web Search - circres.ahajournals.org - intl-circres.ahajournals.org - ncbi.nlm.nih.gov - all 6 versions »

A Comprehensive Screen for TWIST Mutations in Patients with Craniosynostosis Identifies a New … - Full text - MIT Libraries
… , DM Moloney, M Oldridge, SRF Twigg, S Walsh, M … - Am. J. Hum. Genet, 1998 - journals.uchicago.edu
... in article | Medline; Upadhyaya M, Ruggieri M, Maynard J, Osborn M, Hartog C, et
al (1998) Gross deletions of the neurofibromatosis type I (NF1) gene are ...
Cited by 52 - Web Search - ncbi.nlm.nih.gov

Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian … - Full text - MIT Libraries
DT Denhardt - Biochem J, 1996 - bj.portlandpress.com
... phosphotyrosine-binding domain; SH domain, Src homology domain; SRF, serum response ...
quite distinct and larger ("290 kDa) neurofibromin, NF1, whose expression ...
Cited by 192 - View as HTML - Web Search - biochemj.org - cmbi.bjmu.edu.cn - ncbi.nlm.nih.gov - all 6 versions »

Oto-facio-cervical (OFC) syndrome is a contiguous gene deletion syndrome involving EYA1: molecular … - Full text - MIT Libraries
I Russell-Eggitt, RM Winter, M Bitner-Glindzicz - Hum Genet, 2001 - springerlink.com
... NF1 and the renal abnormalities found in his sibling and mother are almost certainly ...
15–27 Johnson D, Horsley SW, Moloney DM, Oldridge M, Twigg SRF, Walsh S ...
Web Search

Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Induced Gene Regulation in …
E Valjent, J Caboche, P Vanhoutte - Molecular Neurobiology, 2001 - journals.humanapress.com
... Activation of the Ras-GTPases, SynGAP by CaMKII and NF1 by calmodulin, leads to ... a
ternary complex composed of a dimer of serum responsive factor (SRF) and one ...
Cited by 16 - Web Search - biomed.humanapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Positive and negative regulatory elements in the upstream region of the rat Cu/Zn-superoxide … - Full text - MIT Libraries
MS Chang, HY Yoo, HM Rho - Biochem. J, 1999 - biochemj.org
... 1; AP, activator protein; CP, CCAAT-box-binding protein; SRF, serum response ... four
possible putative transcription-factor-binding sites (for YY1, NF1, MyoD and ...
Cited by 7 - View as HTML - Web Search - biochemj.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Pak protein kinases as mediators of Ras signaling and cell transformation. A place for Pak on the …
Y Tang, A Chen, Y Zhuo, Q Wang, A Pahk, J Field - Gene Ther Mol Biol, 1999 - gtmb.org
... Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by
SRF. ... NF1-deficient mouse Schwann cells are angiogenic and invasive and can be ...
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Ras proteins: recent advances and new functions - Full text - MIT Libraries
A Rebollo, AC Martinez - Blood, 1999 - bloodjournal.org
... PLD, phospholipase D; PIP, phosphatidylinositol phosphate; SRF, serum response factor. ...
The RasGAP NF1 shares both sequence identity and substrate specificity ...
Cited by 52 - Web Search - cmbi.bjmu.edu.cn

Exocrine specific expression of Connexin32 is dependent on the basic helix-loop-helix transcription … - Full text - MIT Libraries
JM Rukstalis, A Kowalik, L Zhu, D Lidington, CL … - Journal of Cell Science, 2003 - jcs.biologists.org
... given that the 680 bp 5' flanking sequence contains protein binding sites for many
general transcription factors including Sp1, NF1, Stat5 and SRF (data not ...
Cited by 4 - Web Search - jcs.biologists.org - ncbi.nlm.nih.gov

Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer- … - Full text - MIT Libraries
H Kong, MJ Park, SH Hong, HJ Yu, YC Lee, YH Choi, … - Hepatology, 2003 - dx.doi.org
... driven by some of the same transcription factors, includ- ing AP-1, SRF, RXR, and ...
91 to 84) and is immediately adjacent to a nuclear factor 1 (NF1)-binding site ...
Cited by 2 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - all 4 versions »

Molecular cloning of the mouse gene coding for carbonic anhydrase IV
S Tamai, LB Cody, WS Sly - Biochem. Genet, 1996 - springerlink.com
... 368), AP1 (-364), GATA1 (-348, -374, -397), CF1 (-459, -856), and CTF/NF1 (-749,
-839 ... The binding motifs of CAAT, C/EBP, AP2, octamer, CREB, and SRF were not ...
Cited by 7 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

REVIEW ARTICLES Transcriptional Regulation of Cardiac Development: Implications for Congenital Heart …
JA EPSTEIN, CA BUCK - PEDIATRIC RESEARCH, 2000 - uphs.upenn.edu
... factors such as Nkx2.5 and serum response factor (SRF) to activate ... in the ras-GAP
protein encoded by the Neurofibromatosis gene NF1 disrupt valvulogenesis (41 ...
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Multiple basal promoter elements determine the level of human c-fos transcription - Full text - MIT Libraries
L Runkel, PE Shaw, RE Herrera, RA Hipskind, A … - Mol Cell Biol, 1991 - pubmedcentral.nih.gov
... Another spans an NF1-like site situated at -170. ... C, Runswick M, Pollock R, Treisman
R. Isolation and properties of cDNA clones encoding SRF, a transcription ...
Cited by 15 - Web Search - ncbi.nlm.nih.gov

TC21 causes transformation by Raf-independent signaling pathways - Full text - MIT Libraries
SM Graham, AB Vojtek, SY Huff, AD Cox, GJ Clark, … - Mol. Cell. Biol, 1996 - mcb.asm.org
... SOS1 and RasGRF/CDC25) synergistically enhanced wild-type TC21 activity in vivo
and that Ras GTPase-activating proteins (GAPs; p120-GAP and NF1-GAP) stimulated ...
Cited by 29 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage - Full text - MIT Libraries
RE Breitbart, CS Liang, LB Smoot, DA Laheru, V … - Development, 1993 - dev.biologists.org
... hMEF2D comprises several alternatively spliced products of a single gene, one of
which is the human homolog of the Xenopus SRF- related factor SL-1. Like its ...
Cited by 73 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Spl Phosphorylation Induced by Serum Stimulates the Human alpha 2 (I) Collagen Gene Expression - Full text - MIT Libraries
H Ihn, Y Ihn, M Trojanowska - Journal of Investigative Dermatology, 2001 - blackwell-synergy.com
... TCF), which can only bind the SRE via interaction with SRF (Shaw et al ... promoter,
in which cytokine treatment affected the interaction of CTF/NF1 with histone H3 ...
Cited by 8 - Web Search - jidonline.org - ncbi.nlm.nih.gov

TRANSCRIPTIONAL CONTROL OF MUSCLE DEVELOPMENT BY MYOCYTE ENHANCER FACTOR-2(MEF 2) PROTEINS - Full text - MIT Libraries
BL Black, EN Olson - Annual Review of Cell and Developmental Biology, 1998 - dx.doi.org
... type selection; Agamous and Deficiens, which act as homeotic factors that control
leaf identity in plants; and serum-response factor (SRF), which regulates ...
Cited by 244 - Web Search - cellbio.annualreviews.org - cvri-server2.ucsf.edu - ncbi.nlm.nih.gov - all 7 versions »

Identification and characterization of R-ras 3: a novel member of the RAS gene family with a non- … - Full text - MIT Libraries
A Kimmelman, T Tolkacheva, MV Lorenzi, M Osada, … - Oncogene, 1997 - nature.com
... in activating transcription responses by transcription factors: (a) SRF (SRF-LUC),
(b ... and GRF2 (Fam et al., 1997); GTPase activating proteins ± NF1 (Hattori et ...
Cited by 35 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Hepatitis B Virus X Protein: Structure, Function and Biology
S Murakami, S Murakami, FTC Alert - Intervirology, 1999 - content.karger.com
... PMA) (TPA)- responsive element (TRE)-like sequence, aC stretch and an NF1-binding
site [19 ... XRE, which include binding sites for AP-1, AP2, NF-ÎB, SRF, c/EBP ...
Cited by 42 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression - Full text - MIT Libraries
SK Oster, WW Marhin, C Asker, LM Facchini, PA Dion … - Mol. Cell. Biol, 2000 - mcb.asm.org
... The pdgf- r promoter contains several putative binding sites for transcription factors
such as GATA-1, SRF, AP1, NF1, AP2, and NF-Y, and it is possible that ...
Cited by 23 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

MULTIPLE VIRAL STRATEGIES OF HTLV-1 FOR DYSREGULATION OF CELL GROWTH CONTROL - Full text - MIT Libraries
M Yoshida - Annual Review of Immunology, 2001 - dx.doi.org
... The target molecules are CREB, CREM, NF- B, I B, SRF, and CBP/p300 for activation,
E47, p53, and CBP/p300 for repression, and p16INK4a, p15INK4b, p18INK4c, and ...
Cited by 98 - Web Search - immunol.annualreviews.org - phyto.annualreviews.org - ncbi.nlm.nih.gov - all 6 versions »

Role of single-stranded DNA regions and Y-box proteins in transcriptional regulation of viral and … - Full text - MIT Libraries
SK Swamynathan, A Nambiar, RV Guntaka - FASEB J, 1998 - fasebj.org
... cold shock domain; RSV LTR, Rous sarcoma virus long-terminal repeats; SRF,
serum-responsive ... Kuwano, M. (1994) Involvement of a DNA binding protein, MDR-NF1/ ...
Cited by 35 - Web Search - fasebj.org - ncbi.nlm.nih.gov

A concise promoter region of the heart fatty acid-binding protein gene dictates tissue-appropriate … - Full text - MIT Libraries
Q Qian, L Kuo, YT Yu, JN Rottman - Circ. Res, 1999 - circresaha.org
... The SRF/CArG-like element is discussed in the text. ... b, Cotransfection of 1
µg SRF expression plasmid with the same reporter construct. ...
Cited by 9 - Web Search - circres.ahajournals.org - intl-circres.ahajournals.org - ncbi.nlm.nih.gov - all 9 versions »

Genetica DEL Cancer
PCL Jimenez, DN Bosch, MLS Bravo, CC de la Salud - escancer.com
... c-jun. Algunos factores de transcripción son SRF, SIS y NF-kB, que están ... retinoblastoma
(RB), DCC, MCC, APC, NF1, NF2 y WT-1. 3.1 Gen del retinoblastoma ...
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Foxp1 regulates cardiac outflow tract and endocardial cushion morphogenesis and myocyte …
B Wang, J Weidenfeld, MM Lu, S Maika, WA Kuziel, … - bio.utexas.edu
... including GATA, MEF, SRF, and Nkx factors (reviewed in (Brand, 2003). ... (NF1 endo -/-)
results in a similar constellation of defects as observed in Foxp1 null ...
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Psychophysiological stress-regulated gene expression in mice. - Full text - MIT Libraries
S Murata, T Yoshiara, CR Lim, M Sugino, M Kogure, … - FEBS Lett, 2005 - dna-chip.co.jp
... factor 3 (ATF3) [20], serum response factor (SRF) [21] and neurofibromatosis
type 1 protein (NF1) [22]. However, their splicing ...
Web Search - ncbi.nlm.nih.gov