TP53 mutations are frequent in malignant NF1 tumors
E Legius, H Dierick, R Wu, BK Hall, P Marynen, JJ … - Genes Chromosomes Cancer, 1994 - ncbi.nlm.nih.gov
TP53 mutations are frequent in malignant NF1 tumors. Legius E, Dierick H,
Wu R, Hall BK, Marynen P, Cassiman JJ, Glover TW. Center ...
Cited by 36 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Rb and TP53 pathway alterations in sporadic and NF1-related malignant peripheral nerve sheath tumors - Full text - MIT Libraries
S Birindelli, F Perrone, M Oggionni, C Lavarino, B … - Lab Invest, 2001 - nature.com
Nature.com
Cited by 17 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Molecular and cytogenetic analysis of tumors in von Recklinghausen neurofibromatosis
TW Glover, CK Stein, E Legius, LB Andersen, A … - Genes Chromosomes Cancer, 1991 - ncbi.nlm.nih.gov
... EVI2B; HRAS; NF1; TP53. Substances: DNA, Neoplasm; Genetic Markers. Grant Support:
NS23427/NS/NINDS. PMID: 1906341 [PubMed - indexed for MEDLINE]
Cited by 45 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genetic events in tumour initiation and progression in multiple endocrine neoplasia type 2
LM Mulligan, E Gardner, BA Smith, CG Mathew, BA … - Genes Chromosomes Cancer, 1993 - ncbi.nlm.nih.gov
... Thyroid Neoplasms/genetics*; Thyroid Neoplasms/pathology. Gene Symbols: APC; DCC;
MCC; MEN2; MYCL1; NF1; RB1; TP53; WT1. Substances: DNA Probes; Genetic Markers ...
Cited by 31 - Web Search - Get it from MIT Libraries

Genetic alterations in a malignant schwannoma from a patient with neurofibromatosis (NF1)
RA Lothe, G Saeter, HE Danielsen, AE Stenwig, B … - Pathol Res Pract, 1993 - ncbi.nlm.nih.gov
... gene may function as a tumour suppressor gene, and that, either by effect of dose
reduction or complete inactivation, both the NF1 gene and the TP53 gene may ...
Cited by 16 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Alterations at chromosome 17 loci in peripheral nerve sheath tumors
RA Lothe, A Slettan, G Saeter, A Brogger, AL … - J Neuropathol Exp Neurol, 1995 - ncbi.nlm.nih.gov
... during development of MPNST in patients with NF1. In contrast to other reports,
we did not find evidence for a homozygous mutated condition of the TP53 gene in ...
Cited by 30 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Cancer-related gene expression profiles in NF1-associated pilocytic astrocytomas - Full text - MIT Libraries
J Li, A Perry, CD James, DH Gutmann - Neurology, 2001 - neurology.org
... sporadic JPA 19,20 and the recent studies in which mice carrying a targeted disruption
of both the NF1 and TP53 genes developed high-grade astrocytomas, 21 we ...
Cited by 8 - Web Search - neurology.org - neurology.org - ncbi.nlm.nih.gov

Pathology of tumors of the peripheral nerve sheath in type 1 neurofibromatosis
JM Woodruff - AMERICAN JOURNAL OF MEDICAL GENETICS (SEMIN. MED. GENET.), 1999 - doi.wiley.com
... Struc- tural alterations involving the NF1 and TP53 loci of chromosome 17 [Jhanwar
et al., 1994] and point mutations in exon 4 of the TP53 gene [Menon et al ...
Cited by 27 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Biallelic inactivation of TP 53 rarely contributes to the development of malignant peripheral nerve …
RA Lothe, B Smith‐Soerensen, M Hektoen, AE … - Genes Chromosomes and Cancer, 2001 - doi.wiley.com
... Mutations in the NF1 and TP53 genes have been found in some MPNSTs, and recent data
from mouse models support a synergistic effect of these two genes in the ...
Cited by 9 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas
L Kluwe, C Hagel, M Tatagiba, S Thomas, D Stavrou, … - J Neuropathol Exp Neurol, 2001 - jneuropath.com
... markers, we examined losses of NF1 alleles on the long arm of chromosome 17 in 12
NF1-associated and 25 sporadic pilocytic astrocytomas. The TP53 gene region ...
Cited by 21 - Web Search - neur.allenpress.com - apt.allenpress.com - ncbi.nlm.nih.gov - all 7 versions » - Get it from MIT Libraries

Molecular analysis of astrocytomas presenting after age 10 in individuals with NF1 - Full text - MIT Libraries
DH Gutmann, CD James, M Poyhonen, DN Louis, R … - NEUROLOGY, 2003 - intl.neurology.org
... 15 The finding of a TP53 mutation provides the first evidence that mutational events
in NF1 and TP53 can occur in human NF1-associated brain tumors. ...
Cited by 3 - Web Search - neurology.org - intl.neurology.org - ncbi.nlm.nih.gov - all 5 versions »

Comparative FISH-mapping of six expressed gene loci to river buffalo and sheep chromosomes
SK Davis, JF Taylor - Cytogenet Cell Genet, 1999 - content.karger.com
... Four (NF1, CRYB1, TP53 and P4HB) of the six genes map- ped by the current authors,
were assigned for the first time to OAR 11, extending the sheep physical map ...
Cited by 7 - Web Search - content.karger.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Physical assignment of six type I anchor loci to bovine chromosome 19 by fluorescence in situ … - Full text - MIT Libraries
DS Gallagher, YP Yang, JD Burzlaff, JE Womack, DM … - Animal Genetics, 1998 - ingentaconnect.com
... chromosome 19 (BTA19). Six out of eight loci were identified in the BAC library
(NF1, CRYB1, CHRNB1, TP53, GH1 and P4HB). The BACs were ...
Cited by 14 - Web Search - animalgenomics.missouri.edu - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

[CITATION] Ranzani GN, Pierotti MA, Pilotti S. Rb and TP53 pathway alterations in sporadic and NF1-related … - Full text - MIT Libraries
S Birindelli, F Perrone, M Oggionni, C Lavarino, B … - Lab. Invest, 2001
Cited by 2 - Web Search

Topoisomerase-II Is Upregulated in Malignant Peripheral Nerve Sheath Tumors and Associated With … - Full text - MIT Libraries
RI Skotheim, A Kallioniemi, B Bjerkhagen, F … - Journal of Clinical Oncology, 2003 - folk.uio.no
... 11 Mice heterozygous for mutations in both Nf1 and Tp53 develop MPNSTs, suggesting
the contribution of an altered TP53 pathway also in development of human ...
Cited by 3 - View as HTML - Web Search - dx.doi.org - ncbi.nlm.nih.gov

Malignant Peripheral Nerve Sheath Tumor: A Comparison of Grade, Immunophenotype, and Cell Cycle/ …
H Zhou, CM Coffin, SL Perkins, SR Tripp, M Liew, … - Am J Surg Pathol, 2003 - ajsp.com
... This is in contrast to mouse tumor models where double inactivation of Nf1
and Tp53 in mice is sufficient to generate MPNSTs. 9,52. ...
Cited by 3 - Web Search - ajsp.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Kinetic profiles by topographic compartments in muscle-invasive transitional cell carcinomas of the …
A Blanes, J Rubio, A Martinez, HJ Wolfe, SJ Diaz- … - Am J Clin Pathol, 2002 - ncbi.nlm.nih.gov
Kinetic profiles by topographic compartments in muscle-invasive transitional
cell carcinomas of the bladder: role of TP53 and NF1 genes. ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Nf1; Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects - Full text - MIT Libraries
KM Reilly, DA Loisel, RT Bronson, ME McLaughlin, T … - Nat Genet, 2000 - nature.com
... Alterations of the TP53 gene in human gliomas. ... astrogliosis in brains of mice
heterozygous for mutations in the neurofibromatosis type 1 (Nf1) tumor suppressor ...
Cited by 60 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

tp 53 mutant zebrafish develop malignant peripheral nerve sheath tumors - Full text - MIT Libraries
S Berghmans, RD Murphey, E Wienholds, D Neuberg, … - Proceedings of the National Academy of Sciences, 2005 - pnas.org
... Nerve sheath sarcomas are uncommon in humans and mice with isolated TP53 deficiency;
however, mice with both Nf1 and Tp53 mutations have also been shown to ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - dartmouth.edu - dx.doi.org - all 6 versions »

Allelic Loss of the NF1 Gene in NF1-Associated Plexiform Neurofibromas-a review of the clinical … - Full text - MIT Libraries
L Kluwe… - Cancer Genetics and Cytogenetics, 1999 - ingentaconnect.com
... of the NF1 gene, is associated with the development of plexiform neurofibromas.
The 14 plexiform neufibromas were also examined for mutation in the TP53 gene ...
Cited by 30 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Genetic aberrations in the development and subsequent progression of myelodysplastic syndrome
S Misawa, S Horiike, H Kaneko, K Kashima - Leukemia, 1997 - ncbi.nlm.nih.gov
... We performed longitudinal analyses of chromosomes and studied the configuration
of NRAS, TP53, NF1, and cFMS genes in 70 patients with myelodysplastic syndrome ...
Cited by 8 - Web Search - Get it from MIT Libraries

Nervous system: Peripheral nerve sheath tumors
C Morphological, C Molecular - caroll.vjf.cnrs.fr
... in embryonic lethality. However, mice with heterozygous germline mutations
of both Nf1 and Tp53 develop MPNST. This animal model ...
Cached - Web Search

RAS, FLT3, and TP53 mutations in therapy-related myeloid malignancies with abnormalities of …
LE Side, NP Curtiss, K Teel, C Kratz, PW Wang, RA … - Genes Chromosomes Cancer, 2004 - doi.wiley.com
... lines was available from two of the remaining patients, both of which also showed
a single allele at each polymorphic NF1 locus. SSCP analysis of TP53 exons 5 ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis …
SA Rasmussen, J Overman, SAM Thomson, SD Colman, … - Genes Chromosomes and Cancer, 2000 - doi.wiley.com
... tumors. The losses in the plexiform tumors all included sequences distal
to NF1. No subtle TP53 mutations were found in any tumors. ...
Cited by 30 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Construction of a bovine Chromosome 19 linkage map with an interspecies hybrid backcross - Full text - MIT Libraries
YP Yang, JE Womack - Mammalian Genome, 1997 - springerlink.com
... This map includes eight previ- ously unmapped type I anchor loci, CHRNB1, CRYB1,
GH1, MYL4, NF1, P4HB, THRA1, TP53, and five microsatellite mark- ers, HEL10 ...
Cited by 13 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Benign neurofibromas in type 1 neurofibromatosis(NF 1) show somatic deletions of the NF 1 gene
SD Colman, CA Williams, MR Wallace - Nature Genetics, 1995 - nature.com
... The Mspl polymorphism in intron 6 of p53 (TP53) detected by digestion of PCR products.
Nucl. ... Refined physical map of the NF1 region on chromosome 17. Am. ...
Cited by 94 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Mini Review Pathogenesis of hereditary tumors: beyond the" two-hit" hypothesis - Full text - MIT Libraries
T Tucker, JM Friedman - Clinical Genetics, 2002 - blackwell-synergy.com
... The NF1 and TP53 loci are on the same chromosome in both humans and mice.
These mouse tumors demonstrate LOH for both Nf1 and Tp53 ...
Cited by 10 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Mouse Models of Human Familial Cancer Syndromes
J WARD, D DEVOR-HENNEMAN - Toxicologic Pathology, 2004 - dx.doi.org
... null for genes known or suspected of being involved in human cancer syndromes,
including APC, ATM, BLM, BRCA1, BRCA2, LKB1, MEN1, MLH, MSH, NF1, TP53, PTEN, RB1 ...
Web Search - taylorandfrancis.metapress.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecular profiling of malignant peripheral nerve sheath tumors associated with neurofibromatosis … - Full text - MIT Libraries
P Levy, D Vidaud, K Leroy, I Laurendeau, J … - Molecular Cancer, 2004 - dx.doi.org
... Consistent with the role of p53 in the progression of MPNSTs, mice that
harbor both NF1 and TP53 mutations develop MPNSTs [15]. ...
Web Search - pubmedcentral.nih.gov - bmc.ub.uni-potsdam.de - molecular-cancer.com - all 10 versions »

P53 mutations in sporadic and NF1 related malignant peripheral nerve sheath tumors (MPNST): from …
M Ferrone, S Pricl, MS Paneni, E Tamborini, S … - caslab.units.it
... B. Vergani, GN Ranzani, MA Pierotti and S. Pilotti, Rb and TP53 pathway alterations
in sporadic and NF1-related malignant peripheral nerve sheath tumors, Lab. ...
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Elevated risk for MPNST in NF1 microdeletion patients - Full text - MIT Libraries
T De Raedt, H Brems, P Wolkenstein, D Vidaud, S … - Am J Hum Genet, 2003 - journals.uchicago.edu
... F, Oggionni M, Lavarino C, Pasini B, Vergani B, Ranzani GN, Pierotti MA, Pilotti
S (2001) Rb and TP53 pathway alterations in sporadic and NF1-related malignant ...
Cited by 19 - Web Search - pubmedcentral.nih.gov - journals.uchicago.edu - ncbi.nlm.nih.gov - all 5 versions »

Familial neurofibromatosis microdeletion syndrome complicated by rhabdomyosarcoma - Full text - MIT Libraries
AK Lampe, G Seymour, PW Thompson, A Toutain, SA … - Archives of Disease in Childhood, 2002 - adc.bmjjournals.com
... NF1 neurocristopathy. Inactivation of both NF1 genes and/or TP53 has been
shown in NF1 associated malignancies. Several models of ...
Cited by 4 - Web Search - adc.bmjjournals.com - dx.doi.org - ncbi.nlm.nih.gov

Human chromosome 17 comparative anchor loci are conserved on bovine chromosome 19 - Full text - MIT Libraries
YP Yang, JE Womack - Genomics, 1995 - ncbi.nlm.nih.gov
... Support, US Gov't, Non-PHS. Gene Symbols: CHRNB1; CRYB1; MPO; MYL4; NF1; P4HB; THRA1;
TP53. Substances: Genetic Markers. PMID: 7557995 [PubMed - indexed for MEDLINE ...
Cited by 12 - Web Search - ncbi.nlm.nih.gov

Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate … - Full text - MIT Libraries
HA Kim, B Ling, N Ratner - Mol. Cell. Biol, 1997 - mcb.asm.org
... Nf1-Deficient Mouse Schwann Cells Are Angiogenic and ... We have developed a potential
model of Schwann cell tumor formation in neurofibromatosis type 1 (NF1). ...
Cited by 50 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Oligo GEArray® Human Neurotrophin and Receptors Microarray
S Conditions - search.cosmobio.co.jp
... Cell cycle: BAX, BCL2, F2, FGF2, FGF9, IL1B, MYC, NF1, PTN, STAT1, TGFA,
TGFB1, TP53. Cell proliferation: BCL2, CCKBR, ETS1, FGF2 ...
View as HTML - Web Search

Unusual clustering of brain tumors in a family with NF1 and variable expression of cutaneous … - Full text - MIT Libraries
F Faravelli, M Upadhyaya, M Osborn, SM Huson, R … - J Med Genet, 1999 - jmedgenet.com
... 23 In addition, an abnormal TP53 allele would be unlikely to cosegregate with the
abnormal NF1 allele in the numerous family members reported here. ...
Cited by 1 - Cached - Web Search - jmedgenet.com - jmg.bmjjournals.com - ncbi.nlm.nih.gov

Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but … - Full text - MIT Libraries
R Fahsold, S Hoffmeyer, C Mischung, C Gille, C … - Am J Hum Genet, 2000 - dx.doi.org
... 1995), 45% 50% of TP53 point mutations in colorectal cancer (Greenblatt et ... Likewise,
overlap between pseudogene sequence variants and NF1 germline mutations as ...
Cited by 62 - Web Search - journals.uchicago.edu - charite.de - ncbi.nlm.nih.gov - all 5 versions »

Genetic and molecular abnormalities in tumors of the bone and soft tissues - Full text - MIT Libraries
GD Letson, CA Muro-Cacho - Cancer Control, 2001 - moffitt.usf.edu
... It has been suggested that the NF1 gene may function as a tumor suppressor gene
and that both the NF1 and the TP53 genes may be critical for the pro- gression ...
Cited by 7 - View as HTML - Web Search - issoonline.com - issoonline.com - ncbi.nlm.nih.gov - all 5 versions »

Genetic modeling of glioma formation in mice - Full text - MIT Libraries
M Begemann, GN Fuller, EC Holland - Brain Pathol, 2002 - brainpath.medsch.ucla.edu
... locus (78, 97), TP53 (122,123), and RB (55,118). ... Activation of the Ras pathway
also includes the NF1 pathway (for review, see 19). ...
Cited by 5 - View as HTML - Web Search - brainpathology.com - ncbi.nlm.nih.gov

Plexiform neurofibromas in NF1 - Full text - MIT Libraries
RJ Packer, DH Gutmann, MD PhD, A Rubenstein, D … - Neurology, 2002 - neurology.org
... Birindelli S, Perrone F, Oggionni M, et al. Rb and TP53 pathway alterations in sporadic
and NF1-related malignant peripheral nerve sheath tumors. Lab Invest . ...
Cited by 13 - Web Search - intl.neurology.org - neurology.org - ncbi.nlm.nih.gov - all 5 versions »

Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral …
A Perry, SN Kunz, CE Fuller, R Banerjee, EF Marley … - J Neuropathol Exp Neurol, 2002 - jneuropath.com
... Birindelli S, Perrone F, Oggionni M, et al. Rb and TP53 pathway alterations in sporadic
and NF1-related malignant peripheral nerve sheath tumors. ...
Cited by 11 - Web Search - neur.allenpress.com - apt.allenpress.com - ncbi.nlm.nih.gov - all 7 versions » - Get it from MIT Libraries

Germline RET 634 mutation positive MEN 2A-related C-cell hyperplasias have genetic features … - Full text - MIT Libraries
SJ Diaz-Cano, M de Miguel, A Blanes, R Tashjian, … - J Clin Endocrinol Metab, 2001 - jcem.endojournals.org
... 3 ). No alterations were detected in NF1 locus. TP53 abnormalities were concordantly
detected in both lobes in all patients in at least one polymorphic region. ...
Cited by 9 - Web Search - dx.doi.org - intl-jcem.endojournals.org - ncbi.nlm.nih.gov

Screening 500 unselected neurofibromatosis 1 patients for deletions of the NF1 gene. - Full text - MIT Libraries
L Kluwe, R Siebert, S Gesk, RE Friedrich, S … - Hum Mutat, 2004 - doi.wiley.com
... mutations analysis, especially for large genes such as the NF1 gene with ... Screening
for TP53 rearrangements in families with the Li-Fraumeni syndrome reveals a ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

Tumor Suppressor Mutations and Growth Factor Signaling in the Pathogenesis of NF1-Associated …
SL Carroll, MS Stonecypher - Journal of Neuropathology and Experimental Neurology - jneuropath.com
... TP53 mutations are frequent in malignant NF1 tumors. ... Rb and TP53 pathway alterations
in sporadic and NF1-related malignant peripheral nerve sheath tumors. ...
Cited by 1 - Web Search - neur.allenpress.com - apt.allenpress.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Initiation of human astrocytoma by clonal evolution of cells with progressive loss of p53 functions … - Full text - MIT Libraries
G Fulci, N Ishii, D Maurici, KM Gernert, P Hainaut … - Cancer Res, 2002 - intl-cancerres.aacrjournals.org
... Initiation of Human Astrocytoma by Clonal Evolution of Cells with Progressive Loss
of p53 Functions in a Patient with a 283H TP53 Germ-line Mutation. ...
Cited by 6 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Subject Index Vol. 84, 1999
G PRKAR2B, TAC RELN, R EEF1AL11P, G GPAA, S SRD5B1 … - Cytogenet Cell Genet, 1999 - content.karger.com
... 186 Tlx2 115 tsg101, tsg101-ps1 87 Upk1b 37 pig 53 microsatellite markers rat Sult1a1,
Sult1c1 145 river buffalo CHRNB1, CRYB1, GH1, NF1, P4HB, TP53 161 sheep ...
Web Search - content.karger.com

Aberrant CpG island methylation in neurofibromas and neurofibrosarcomas - Full text - MIT Libraries
P Gonzalez-Gomez, MJ Bello, D Arjona, ME Alonso, J … - ONCOLOGY REPORTS, 2003 - 147.52.72.117
... 11. Legius E, Dierick H, Wu R, Hall BK, Marynen P, Cassiman JJ and Glover
TW: TP53 mutations are frequent in malignant NF1 tumours. ...
Cited by 5 - View as HTML - Web Search - virology.med.uoc.gr - biotools.net - ncbi.nlm.nih.gov

TP53, P14 ARF, P16 INK4A AND H-RAS GENE MOLECULAR ANALYSIS IN INTESTINAL-TYPE ADENOCARCINOMA OF THE … - Full text - MIT Libraries
I Milan - Int. J. Cancer, 2003 - doi.wiley.com
Page 1. TP53, P14 ARF , P16 INK4A AND H-RAS GENE MOLECULAR ANALYSIS IN
INTESTINAL-TYPE ADENOCARCINOMA OF THE NASAL CAVITY AND PARANASAL SINUSES ... III – TP53, ...
Web Search

A genetic, physical, and comparative map of rat Chromosome 10
RS Yeung, KH Buetow, T Scherpbier-Heddema, DW Bell … - Mammalian Genome, 1996 - springerlink.com
... this rat chromosome. Two of these (Nf1, Tp53) belong to one syntenic group
shared among RNO10, MMU11, and HSA17. To our knowledge ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Comparative FISH-mapping of six expressed gene loci to river buffalo and sheep chromosomes
F Alert - Cytogenetics and Cell Genetics, 1999 - dx.doi.org
... Six expressed gene loci (NF1, CRYB1, CHRNB1, TP53, P4HB and GH1), recently assigned
to cattle chromosome 19 by both radiation hybrid analysis and FISH-mapping ...
Web Search - content.karger.com - karger.com