Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation - Full text - MIT Libraries
S Diehl, CW Chow, L Weiss, A Palmetshofer, T … - J. Exp. Med, 2002 - intl.jem.org
... factors (eg, GATA3, c-maf) are likely to be more important for further IL-4–driven
Th2 differentiation. IL-6 Selectively Induces the Expression of NFATc2 in ...
Cited by 18 - Web Search - dx.doi.org - jem.org - ncbi.nlm.nih.gov - all 5 versions »

Oligo GEArray® Mouse Th1-Th2-Th3 Microarray
S Conditions - search.cosmobio.co.jp
... Transcription factor activity: Ccl5, Cebpb, Fos, Gata3, Irf1, Irf4, Jun, Junb, Jund1,
Nfatc1, Nfatc2, Nfatc3, Nfatc4, Nfkb1, Stat1, Stat4, Stat6, Tbx21, Yy1 ...
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Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4 - Full text - MIT Libraries
M Lohoff, HW Mittrucker, S Prechtl, S Bischof, F … - Proceedings of the National Academy of Sciences - pnas.org
... Normal STAT6 Phosphorylation, but Dysregulated Expression of GATA3 in IL-4-Triggered ...
of an absence of the reported strong synergism between NFATc2 and IRF4 in ...
Cited by 15 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive … - Full text - MIT Libraries
L Guo, J Hu-Li, J Zhu, CJ Watson, MJ … - Proc. Natl. Acad. Sci. USA, 2002 - intl.pnas.org
... elements. Chromatin immunoprecipitation (CHIP) revealed that antibodies
to Gata3 and NFATc2 precipitated DNA spanning this region. ...
Cited by 12 - Web Search - pnas.org - pubmedcentral.nih.gov - dx.doi.org - all 7 versions »

NFATc 2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression - Full text - MIT Libraries
DS Mehta, AL Wurster, AS Weinmann, MJ Grusby - Proceedings of the National Academy of Sciences, 2005 - pnas.org
... factors with restricted expression, such as c-Maf or GATA3 (4, 24). In addition,
there is also evidence of subset-restricted binding of NFATc2 to cytokine ...
Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

GEArray S Series Human Immunology Signaling Pathways Gene Array: AR-SAHS-605
FG Grouping, A Molecules, I ICAM, CS Molecules, C … - eurogentec.com
... NFAT Family Members: NFATC1, NFATC2, NFATC3, NFATC4, NFAT5. ... ELK4, EP300, ETS1, ETS2,
FKBP1B, FLJ14639 (NIP45), FOS, FOSL1, FOXO1A, FOXO3A, GATA3, GATA4, GRLF1 ...
View as HTML - Web Search - eurogentec.be

Tumor necrosis factor receptor-associated factor (TRAF) 2 represses the T helper cell type 2 … - Full text - MIT Libraries
R Lieberson, KA Mowen, KD McBride, V Leautaud, X … - J. Exp. Med, 2001 - intl.jem.org
... It may be that GATA3, another Th2-specific factor, can serve this function ... is critical
in potentiating IL-4 gene transcription, mice lacking NFATc2 or doubly ...
Cited by 11 - Web Search - jem.org - ncbi.nlm.nih.gov

Decision making in the immune system: The lineage decisions of helper T cells - Full text - MIT Libraries
KM Murphy, SL Reiner - Nature Reviews Immunology, 2002 - nature.com
... Immunity 12, 27-37 (2000). This study showed that GATA3 might act independently
of STAT6 and that GATA3 induces chromatin remodelling of the IL-4 locus. ...
Cited by 8 - Web Search

A novel polymorphic GATA site in the human IL-12 Rbeta 2 promoter region affects transcriptional … - Full text - MIT Libraries
JGI van Rietschoten, R Westland, R van den Bogaard … - Tissue Antigens, 2004 - blackwell-synergy.com
... Transcription factors like NFATc2, SP1, and SP3 play a role in the ... experiments have
implicated the polarizing master-switch transcription factors GATA3 and T ...
Cited by 1 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

[BOOK] Cytokines and Autoimmune Diseases
V Kuchroo, N Sarvetnick, D Hafler, L Nicholson - 2002 - print.google.com
... 3.2.1. Tissue-Spec fic Regulation ofIL-4: c-mafand GATA3 The identification ... c-maf
strongly transactivates the iL-4 promoter in vitro and synergizes with NFATc2 ...
Cited by 5 - Web Search - Get it from MIT Libraries - Library Search

GEArray Q Series Mouse Th1-Th2-Th3 Gene Array: AR-SAMM-021
FG Grouping - eurogentec.be
... Gata3, Gfi1, Gpr2, Gpr44 (CRTH2), Icos, Il10, Il13, Il13ra1, Il13ra2, Il1rl1l
(T1/ST2), Il4, Il4ra, Il5, Il9, Jak1, Jak3, Junb, Maf, Nfatc1 (NFATc), Nfatc2 ( ...
View as HTML - Web Search - eurogentec.com

GEArray Q Series Human Th1-Th2-Th3 Gene Array: AR-SAHS-021.2
FG Grouping - eurogentec.com
... NIP45), GATA3, GFI1, GPR44 (CRTH2), ICOS, IL1R1, IL1R2, IL13, IL13RA1, IL13RA2,
IL4, IL4R, IL5, JAK1, JAK3, JUNB, MAF, MHC2TA (CIITA), NFATC1 (NFATc), NFATC2 ( ...
View as HTML - Web Search - eurogentec.be

GEArray Q Series Mouse Th1-Th2-Th3 Gene Array
FG Grouping - superarray.com
... Gata3, Gfi1, Gpr2, Gpr44 (CRTH2), Icos, Il10, Il13, Il13ra1, Il13ra2, Il1rl1l
(T1/ST2), Il4, Il4ra, Il5, Il9, Jak1, Jak3, Junb, Maf, Nfatc1 (NFATc), Nfatc2 ( ...
View as HTML - Web Search - superarray.com

GEArray Q Series Human Th1-Th2-Th3 Gene Array
FG Grouping - superarray.com
... FOG2, GATA3, GFI1, GPR44 (CRTH2), ICOS, IL1R1, IL1R2, IL13, IL13RA1, IL13RA2, IL4,
IL4R, IL5, JAK1, JAK3, JUNB, MAF, MHC2TA (CIITA), NFATC1 (NFATc), NFATC2 ( ...
View as HTML - Web Search - cosmobio.co.jp - cosmobio.co.jp

Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo - Full text - MIT Libraries
S Agarwal, O Avni, A Rao - Immunity, 2000 - cbr.med.harvard.edu
... The antigen-induced transcription factor NFAT and GATA3 in vivo but is not perceptibly
influenced by the ... Our re- (NFATp, NFATc2), NFAT2 (NFATc, NFATc1), NFAT3 ...
Cited by 100 - View as HTML - Web Search - ncbi.nlm.nih.gov

GEArray Q series Human Ca2+/NF-AT Signaling Pathway Gene Array: AR-SAHS-022
FG Grouping, RT Factors, C CEBPB, NA Receptors, … - eurogentec.be
... NFATC1, NFATC2, NFATC3, NFATC4, NFAT5 Related Transcription Factors: CEBPB, CREBBP,
EGR2, EGR3, EP300, FKBP1B, FLJ14639 (NIP45), FOS, FOSL1, GATA3, GATA4, GRLF1 ...
View as HTML - Web Search - eurogentec.com

GEArray S Series Mouse Autoimmune and Inflammatory Response Gene Array: AR-SAMM-602.3
FG Grouping, A Proteins, CS Receptors, ST Proteins … - eurogentec.com
... Elk1, Elk3, Fkbp1b, Fos, Fosb, Fosl1, Fosl2, Gata3, Gata4, Icos, Irf1, Jun, Junb,
Jund1, Maf, Max, Mef2b, Mef2d, Myc, Nfat5, Nfatc1, Nfatc2, Nfatc2ip, Nfatc3 ...
View as HTML - Web Search - eurogentec.be

GEArray S Series Human Autoimmune and Inflammatory Response Gene Array: AR-SAHS-602
FG Grouping, A Proteins, CS Receptors, ST Proteins … - eurogentec.be
... NIP45), FOS, FOSL1, FOSL2, FOXP3, GATA3, GATA4, GRLF1, ICOS, IRF1, JUN, JUNB, JUND,
MAF, MAX, MEF2A, MEF2B, MEF2D, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4 ...
View as HTML - Web Search - eurogentec.com

CTLA-4 regulates the requirement for cytokine-induced signals in TH2 lineage commitment - Full text - MIT Libraries
H Bour-Jordan, JL Grogan, Q Tang, JA Auger, RM … - Nature Immunology, 2003 - nature.com
... 24. Rengarajan, J., Tang, B. & Glimcher, LH NFATc2 and NFATc3 regulate T H 2 ... A critical
role for NF- B in Gata3 expression and Th2 differentiation in allergic ...
Cited by 13 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Regulation of IL 4 gene expression by T cells and therapeutic perspectives - Full text - MIT Libraries
M Li-Weber, PH Krammer - Nature Reviews Immunology, 2003 - nature.com
... 20. Diehl, S. et al. Induction of NFATc2 expression by interleukin 6 promotes
T helper type 2 differentiation. J. Exp. Med. 196, 39-49 (2002). ...
Cited by 11 - Web Search - nature.com - ncbi.nlm.nih.gov

An epigenetic view of helper T cell differentiation - Full text - MIT Libraries
KM Ansel, DU Lee, A Rao - Nature Immunology, 2003 - nature.com
... 41. Peng, SL, Gerth, AJ, Ranger, AM & Glimcher, LH NFATc1 and NFATc2 together
control both T and B cell activation and differentiation. ...
Cited by 38 - Web Search - nature.com - microbiology.emory.edu - ncbi.nlm.nih.gov

Modulation of Th1 and Th2 responses for immunotherapy
FJ Dumont - inflammation. - extenza-eps.com
... sequence of events is the induction and main- tained expression of subset-specific
transcription factors, prin- cipally T-bet in Th1 cells and GATA3 in Th2 ...
Cited by 5 - Web Search - ashley-pub.com - dx.doi.org - ingentaconnect.com - all 7 versions »

c-Maf and JunB Mediation of Th2 Differentiation Induced by the Type 2 G Protein-Coupled Receptor ( … - Full text - MIT Libraries
J Voice, S Donnelly, G Dorsam, G Dolganov, S Paul, … - The Journal of Immunology, 2004 - jimmunol.org
... In contrast to GATA3, the protooncogene, c-Maf, which has been shown to be ... the basic
leucine zipper factor AP-1 family, cooperates with NFAT1, NFATc2, and NIP ...
Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

The lineage decisions of helper T cells - Full text - MIT Libraries
KM Murphy, SL Reiner - Nat. Rev. Immunol, 2002 - nature.com
... mice havea selec- tive defect in IL-4 production 24 .A second,and perhaps further
upstream,T H 2-cell-specific transcription factor, GATA3,was identified ... GATA3 ...
Cited by 170 - Web Search - uiowa.edu - medicine.ucsd.edu - icb.ufmg.br - all 7 versions »

T helper type-2 cytokine responses: potential therapeutic targets - Full text - MIT Libraries
AG JARNICKI, PG FALLON - Curr. Opin. Pharmacol, 2003 - medicine1.bjmu.edu.cn
... 2. Some transcription factors are Th2-specific, whereas others such as GATA3, although
crucial ... Naıv T cells from mice deficient in both NFATc2 and NFATc3 are ...
Cited by 1 - View as HTML - Web Search - ncbi.nlm.nih.gov

The human IL-3 locus is regulated cooperatively by two NFAT-dependent enhancers that have distinct … - Full text - MIT Libraries
A Hawwari, J Burrows, MA Vadas, PN Cockerill - J. Immunol, 2002 - jimmunol.org
... cJun, and recombinant NFAT containing the DNA-binding domain of NFATC2 were also ...
a GATA-like element (AGATtA) that most closely matches the GATA3 consensus (Ref ...
Cited by 5 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 6 versions »

Transcriptional regulation of the IL-5 gene in peripheral T cells of asthmatic patients - Full text - MIT Libraries
K OGAWA, O KAMINUMA, H OKUDAIRA, H KIKKAWA, K … - Clinical and Experimental Immunology, 2002 - blackwell-synergy.com
... A (CsA) was from Sandoz Japan (Tokyo, Japan), recombinant human (rh) IL-2 was from
Peprotech (London, UK), mouse monoclonal anti-NFATc1 (7A6), -NFATc2 (4G6-G5 ...
Cited by 2 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

TEC-family kinases: regulators of T-helper-cell differentiation - Full text - MIT Libraries
PL Schwartzberg, LD Finkelstein, JA Readinger - Nature Reviews Immunology, 2005 - nature.com
... NFATc1 (nuclear factor of activated T cells,cytoplasmic, calcineurin-dependent 1)
and NFATc2 (REFS 9–11,15) (TABLE 1) .Impaired activation of the MAPKs ERK ...
Web Search - ncbi.nlm.nih.gov

The Potency of TCR Signaling Differentially Regulates NFATc/p Activity and Early IL-4 Transcription … - Full text - MIT Libraries
JL Brogdon, D Leitenberg, K Bottomly - The Journal of Immunology, 2002 - jimmunol.org
... have demonstrated a crucial role for NFATc (NFATc1 or NFAT2), NFATp (NFATc2 or NFAT1 ...
was a 460-bp HindIII-SacI fragment derived from pBS-GATA3 construct kindly ...
Cited by 21 - Web Search - jimmunol.org - uiowa.edu - ncbi.nlm.nih.gov - all 6 versions »

Transcription: tantalizing times for T cells - Full text - MIT Libraries
IC Ho, LH Glimcher, I Diseases - Cell, 2002 - uiowa.edu
... ities of GATA-3 can be modulated by physical interaction NFATc2 (NFATp, NFAT1),
and NFATc3 (NFAT4, NFATx) ... Thus, NFATc2-deficient (NFATc2 / ) ...
Cited by 77 - View as HTML - Web Search - ncbi.nlm.nih.gov - all 3 versions »

The Molecular Basis of Th2 Development
M Li-Weber - Current Immunology Reviews, 2005 - ingentaconnect.com
... NFATc1 and NFATc2 together control both T and B cell activation and differentiation. ...
Essential role of GATA3 for the maintenance of type 2 helper T (Th2 ...
Web Search

Partners in transcription: NFAT and AP-1 - Full text - MIT Libraries
F MaciaAn, C LoApez-RodroAguez, A Rao - Oncogene, 2001 - nature.com
... members of this family comprise NFAT1 (also known as NFATp or NFATc2) (McCaf- frey ...
distal enhancer in the IL-4 gene binds both NFAT1 and GATA3, and cooperation ...
Web Search

The role of Th1/Th2 polarization in mucosal immunity - Full text - MIT Libraries
MF Neurath, S Finotto, LH Glimcher - Nature Medicine, 2002 - nature.com
... Immunity 8, 125-134 (1998). | Article | PubMed | ISI | ChemPort |; Rengarajan, J.,
Tang, B. & Glimcher, LH NFATc2 and NFATc3 regulate TH2 differentiation and ...
Cited by 76 - Web Search - nature.com - jessig.mit.edu - ncbi.nlm.nih.gov

Role of NFATx (NFAT4/NFATc3) in Expression of Immunoregulatory Genes in Murine Peripheral CD4 T … - Full text - MIT Libraries
J Chen, Y Amasaki, Y Kamogawa, M Nagoya, N Arai, K … - The Journal of Immunology, 2003 - jimmunol.org
... the expression levels of master regulatory genes of Th subset differentiation, GATA3
and T ... NFATc1 and NFATc2 together control both T and B cell activation and ...
Cited by 6 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Transcriptional Regulation of the Human CD3 {gamma} Gene: The TATA-Less CD3 {gamma} Promoter … - Full text - MIT Libraries
BM Badran, K Kunstman, J Stanton, M Moschitta, A … - The Journal of Immunology, 2005 - jimmunol.org
... SC-644X), TFIID (SC-204X) (all from Santa Cruz Biotechnology), NFATc2 (67.1; kindly ...
The GATA family of transcription factors includes GATA3, which is expressed ...
Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Cytokines and transcription factors that regulate T helper cell differentiation: new players and new …
D Agnello, CS Lankford, J Bream, A Morinobu, M … - J Clin Immunol, 2003 - springerlink.com
Page 1. Journal of Clinical Immunology, Vol. 23, No. 3, May 2003 ( C 2003)
Cytokines and Transcription Factors That Regulate T Helper ...
Cited by 29 - Web Search - kluweronline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Modulation of T Cell Cytokine Production by Interferon Regulatory Factor-4 - Full text - MIT Libraries
CM Hu, SY Jang, JC Fanzo, AB Pernis - J Biol Chem, 2002 - jbc.org
... what has been reported for the association between murine IRF-4 and NFATc2 (45),
we ... reported to be associated with defects in the up-regulation of GATA3 in TH2 ...
Cited by 9 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

DNA methylation is a nonredundant repressor of the Th2 effector program - Full text - MIT Libraries
KW Makar, CB Wilson - The Journal of Immunology, 2004 - jimmunol.org
... Primer and probe sequences for Il4, Il5, IL13, Gata3, and Tbx21 (T-bet) were ... 4; we
have also shown previously that expression of NFATc1, NFATc2, NFATc3, STAT4 ...
Cited by 4 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

CD 28-mediated co-stimulation: a quantitative support for TCR signalling - Full text - MIT Libraries
O Acuto, F Michel - Nature Reviews Immunology, 2003 - nature.com
1. Goodnow, CC Pathways for self-tolerance and the treatment of autoimmune diseases.
Lancet 357, 2115–2121 (2001). | Article | PubMed | ISI | ChemPort |. 2. ...
Cited by 21 - Web Search - columbia.edu - mail.med.upenn.edu - ncbi.nlm.nih.gov - all 6 versions »

Lineage commitment in the immune system: the T helper lymphocyte grows up
LH Glimcher, KM Murphy - Immunology, 2000 - genesdev.org
... 1995b ). Each of these sites bind NFATc1 and NFATc2 (Timmerman et al. ... Mice lacking
NFATc2 display a moderate increase in Th2-type cytokines (Hodge et al. ...
Cited by 148 - Web Search - genesdev.org - cbr.med.harvard.edu - ncbi.nlm.nih.gov - Get it from MIT Libraries

University of California Postprints
SE Baranzini, P Mousavi, J Rio, SJ Caillier, A … - repositories.cdlib.org
... and a transcription factor with dual function (activator/repressor) that regulates
transcription of IL4 through physical interaction with NFATc2 [23]. ...
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Signaling pathways in Th2 development - Full text - MIT Libraries
KA Mowen, LH Glimcher - Immunological Reviews, 2004 - blackwell-synergy.com
... IL-6 promotes Th2 differentiation through upregulation of nuclear factor (NF) for
activated T cells c2 (NFATc2) and inhibits Th1 differentiation by inducing ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov

Heat-shock proteins induce T-cell regulation of chronic inflammation - Full text - MIT Libraries
W van Eden, R van der Zee, B Prakken - Nature Reviews Immunology, 2005 - noorderlicht.vpro.nl
Page 1. © 2005 Nature Publishing Group 318 | APRIL 2005 | VOLUME 5
www.nature.com/reviews/immunol REVIEWS The expression of heat ...
Cited by 1 - View as HTML - Web Search - pharm.uu.nl - ncbi.nlm.nih.gov - all 4 versions »

Roles of interferon-regulatory factors in T-helper-cell differentiation - Full text - MIT Libraries
M Lohoff, TW Mak - Nature Reviews Immunology, 2005 - nature.com
1. Miyamoto, M. et al. Regulated expression of a gene encoding a nuclear factor,
IRF-1, that specifically binds to IFN- gene regulatory elements. ...
Cited by 1 - Web Search - nature.com - ncbi.nlm.nih.gov

What it takes to become an effector T cell: The process, the cells involved, and the mechanisms - Full text - MIT Libraries
MA Santana, Y Rosenstein - Journal of Cellular Physiology, 2003 - doi.wiley.com
... signals directly induce the TH2 pathway in vivo and in vitro, through the up-regulation
of the specific TH2 transcrip- tion factor GATA3 (Rodriguez-Palmero et ...
Cited by 14 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Cellular inputs affecting NFAT - Full text - MIT Libraries
PG Hogan, L Chen, J Nardone, A Rao - GENES & DEVELOPMENT, 2003 - dx.doi.org
... the ability of NFAT1 to cooperate with AP-1 was as effective as or more effective
than wild-type NFAT1 in its ability to synergize functionally with GATA3 in a ...
Cited by 68 - Web Search - mcb.berkeley.edu - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Die Haematopoetische Progenitor Kinase (HPK) 1 und NFAT-Transkriptionsfaktoren unterstuetzen die …
J Schulze-Luehrmann - opus.bibliothek.uni-wuerzburg.de
Page 1. Die Hämatopoetische Progenitor Kinase (HPK) 1 und NFAT-
Transkriptionsfaktoren unterstützen die Apoptose von T-Lymphozyten ...
View as HTML - Web Search - deposit.ddb.de - opus.bibliothek.uni-wuerzburg.de

Protein kinase C theta is critical for the development of in vivo T helper (Th) 2 cell but not Th1 … - Full text - MIT Libraries
BJ Marsland, TJ Soos, G Spath, DR Littman, M Kopf - J. Exp. Med, 2004 - jem.org
... A critical role for NF- B in Gata3 expression and Th2 differentiation in ... NFATc2 and
NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of ...
Cited by 9 - Web Search - dx.doi.org - jem.org - ncbi.nlm.nih.gov

Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice - Full text - MIT Libraries
Y Tanaka, T So, S Lebedeva, M Croft, A Altman - Blood, 2005 - bloodjournal.org
... wild-type Th1 cells expressed very low amounts of cMaf or GATA3 mRNA (Figure ... promotes
Th2 differentiation and IL-4 expression, 27,28 whereas NFATc2 and NFATc3 ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

The Journal of Experimental Medicine
BJ Marsland, TJ Soos, G Spaeth, DR Littman, M Kopf - saturn.med.nyu.edu
Page 1. The Journal of Experimental Medicine J. Exp. Med. The Rockefeller
University Press • 0022-1007/2004/07/181/9 $8.00 ...
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