PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1 interneurons … - Full text - MIT Libraries
JD Burrill, L Moran, MD Goulding, H Saueressig - Development, 1997 - dev.biologists.org
... Interestingly, the expression domains of PAX2, EN1 and EVX1 in postmitotic neurons
correlate closely with those of Pax6 and Pax7 in the ventricular zone, ...
Cited by 72 - Web Search - dev.biologists.org - wwwlib.bionet.nsc.ru - ncbi.nlm.nih.gov

Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2 - Full text - MIT Libraries
E Matsunaga, I Araki, H Nakamura - Development, 2000 - dev.biologists.org
... Company of Biologists. JOURNAL ARTICLES. Pax6 defines the di-mesencephalic
boundary by repressing En1 and Pax2. E Matsunaga, I Araki ...
Cited by 47 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Sequential roles for Fgf4, En1 and Fgf8 in specification and regionalisation of the midbrain - Full text - MIT Libraries
H Shamim, R Mahmood, C Logan, P Doherty, A Lumsden … - Development, 1999 - dev.biologists.org
... beads and examined its ability to maintain and/or induce the expression of genes
involved in specification of the posterior midbrain including Pax2 and En1 ...
Cited by 95 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

The mouse Pax2 (1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma … - Full text - MIT Libraries
J Favor, R Sandulache, A Neuhauser-Klaus, W … - Proc Natl Acad Sci USA, 1996 - dx.doi.org
... Home page, Development Home page E Matsunaga, I Araki, and H Nakamura Pax6 defines
the di-mesencephalic boundary by repressing En1 and Pax2 Development, January ...
Cited by 145 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain … - Full text - MIT Libraries
JP Martinez-Barbera, M Signore, PP Boyl, E Puelles … - Development, 2001 - dev.biologists.org
... hOtx1 2 ; Gbx2 –/– embryos exhibit broad co-expression of early forebrain, midbrain
and rostral hindbrain markers such as hOtx1, Gbx2, Pax2, En1 and Wnt1 ...
Cited by 19 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Neuroepithelial co-expression of Gbx2 and Otx2 precedes Fgf8 expression in the isthmic organizer - Full text - MIT Libraries
AL Garda, D Echevarria, S Martinez - Mech. Dev, 2001 - ncbi.nlm.nih.gov
... The inductive effect of the Gbx2/Otx2 limit keeps Fgf8 expression stable and thus
maintains its positive role in the expression of Pax2, En1,2 and Wnt1. ...
Cited by 31 - Web Search - ncbi.nlm.nih.gov

GATA2 is required for the generation of V2 interneurons - Full text - MIT Libraries
Y Zhou, M Yamamoto, JD Engel - Development, 2000 - dev.biologists.org
... Co-staining with other neuronal markers showed that V1 interneurons (which
co- express En1 and Pax2; Fig. ... 4K-N), V1 (Pax2 + En1 + ; Fig. ...
Cited by 22 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer - Full text - MIT Libraries
KA Adams, JM Maida, JA Golden, RD Riddle - Development, 2000 - dev.biologists.org
... Wnt1, Pax2 and En1 transcripts are all initiated in large domains within the
mesencephalic/metencephalic region (MMR) during the first phase of development. ...
Cited by 21 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression - Full text - MIT Libraries
JY Li, AL Joyner - Development, 2001 - dev.biologists.org
... hOtx1/hOtx1 embryos at the nine-somite stage, however, human OTX1 was found in a
broad anterior region, largely co-localized with Wnt1, Fgf8, Pax2 and En1 (Fig ...
Cited by 19 - Web Search - saturn.med.nyu.edu - dev.biologists.org - ncbi.nlm.nih.gov

Towards the comprehension of genetic mechanisms controlling brain morphogenesis - Full text - MIT Libraries
A Simeone - Trends Neurosci, 2002 - courses.bio.psu.edu
... Pax6 function might be involved in the definition of diencephalic–mesencephalic
boundary (DMB) by repressing anterior expression of Pax2 and En1 [17]. ...
Cited by 2 - View as HTML - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov

Regionalisation and acquisition of polarity in the optic tectum
H Nakamura - Prog. Neurobiol, 2001 - ncbi.nlm.nih.gov
... structure. It is proposed that the brain vesicle that expresses Otx2, Pax2,
and En1 may differentiate into the tectum. Publication ...
Cited by 6 - Web Search - Get it from MIT Libraries

Early subdivisions in the neural plate define distinct competence for inductive signals - Full text - MIT Libraries
D Kobayashi, M Kobayashi, K Matsumoto, T Ogura, M … - Development, 2002 - dev.biologists.org
... Broccoli et al., 1999; Millet et al., 1999; Katahira et al., 2000), and similar
interactions were demonstrated between Pax6 and Pax2 or En1 (Araki and Nakamura ...
Cited by 31 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

FGFR 1 is independently required in both developing mid- and hindbrain for sustained response to … - Full text - MIT Libraries
R Trokovic, N Trokovic, S Hernesniemi, U Pirvola, … - The EMBO Journal, 2003 - embojournal.npgjournals.com
... In the mouse embryo, Fgf8 expression is activated after Pax2 and En1 in the entire
rhombomere 1 of the hindbrain, and later restricted to a stripe in the most ...
Cited by 14 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 7 versions »

A series of no isthmus (noi) alleles of the zebrafish pax2. 1 gene reveals multiple signaling events … - Full text - MIT Libraries
K Lun, M Brand - Development, 1998 - dev.biologists.org
... Several transcription factors are required during development of the MHB, such as
En1 and En2 (Wurst et al., 1994; Millen et al., 1994), Pax2 (Torres et al ...
Cited by 85 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2 - Full text - MIT Libraries
P Pax - Development, 2000 - dev.biologists.org
... In the early stage of chick embryos, En1 and Pax2 are expressed in the entire
mesencephalon down to the isthmus (Gardner and Barald, 1992; Okafuji et al., 1999 ...
Web Search

Polarity and laminar formation of the optic tectum in relation to retinal projection - Full text - MIT Libraries
H Nakamura, S Sugiyama - Journal of Neurobiology, 2004 - doi.wiley.com
... Pax2 and En1 expression covers whole the mesencephalic region (Fig. ... These results
indicated that En1 and Pax2 are indispensable for tectum develop- ment. ...
Web Search - ncbi.nlm.nih.gov

Regulation and function of FGF8 in patterning of midbrain and anterior hindbrain - Full text - MIT Libraries
I Mason, D Chambers, H Shamim, J Walshe, C Irving - Biochem Cell Biol, 2000 - article.pubs.nrc-cnrc.gc.ca
... Temporal analysis of Fgf8 expression in the chick embryo showed that, while it was
normally expressed before En2 and Wnt1, both Pax2 and En1 were present in ...
Cited by 10 - Web Search - article.pubs.nrc-cnrc.gc.ca - ncbi.nlm.nih.gov

Cooperation of Pax2 and Pax5 in midbrain and cerebellum development - Full text - MIT Libraries
P Urbanek, I Fetka, MH Meisler, M Busslinger - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... Retinal pigmented epithelium determination requires the redundant activities of
Pax2 and Pax6 ... A Lumsden, and I Mason Sequential roles for Fgf4, En1 and Fgf8 in ...
Cited by 64 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Specification of midbrain territory - Full text - MIT Libraries
NPW Wurst - Cell Tissue Res, 2004 - springerlink.com
... Interest- ingly, in all these mutant mice, expression of the MHO genes Fgf8, Wnt1,
Pax2 and En1/2 is relocated at the newly created Otx2 expression boundary. ...
Web Search

Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the … - Full text - MIT Libraries
PL Pfeffer, M Bouchard, M Busslinger - Development, 2000 - dev.biologists.org
... organizer critically depends on the mhb-specific expression of secreted proteins
(Wnt1, Fgf8) and transcription factors (Otx2, Gbx2, En1, En2, Pax2, Pax5). ...
Cited by 21 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Two Pax2/5/8-binding sites in Engrailed2 are required for proper initiation of endogenous mid- … - Full text - MIT Libraries
DL Song, AL Joyner - Mech. Dev, 2000 - saturn.med.nyu.edu
... A growing number of genes, including those that encode the transcription factors
Engrailed1 and 2 (En1 and 2), Pax2, Pax5, Pax8, Otx2 and Gbx2, as well as the ...
Cited by 13 - View as HTML - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov

spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain … - Full text - MIT Libraries
HG Belting, G Hauptmann, D Meyer, S Abdelilah- … - Development, 2001 - dev.biologists.org
... Loss-of-function studies in mouse and zebrafish have demonstrated that Fgf8, Wnt1,
Pax2 and En1 are required for normal mid-/hindbrain development (McMahon and ...
Cited by 20 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Search for genes involved in Joubert syndrome: evidence that one or more major loci are yet to be … - Full text - MIT Libraries
IP Blair, RR Gibson, CL Bennett, PF Chance - Am J Med Genet, 2002 - doi.wiley.com
... PAX2, PAX5, PAX6, PAX8, OTX1, OTX2, GBX2, WNT5a, and NKX2.2, several of which encode
proteins that either act up- stream or regulate the expression of EN1, EN2 ...
Cited by 16 - Web Search - ncbi.nlm.nih.gov

Emx2 directs the development of diencephalon in cooperation with Otx2 - Full text - MIT Libraries
Y Suda, ZM Hossain, C Kobayashi, O Hatano, M … - Development, 2001 - dev.biologists.org
... and diencephalon has been proposed to occur around the ten-somite stage, at the
point where Pax6 expression segregates from that of Pax2 and En1 (Araki and ...
Cited by 15 - Web Search - cdb.riken.go.jp - cdb.riken.jp - ncbi.nlm.nih.gov - all 5 versions »

Directed Differentiation of Dopaminergic Neuronal Subtypes from Human Embryonic Stem Cells - Full text - MIT Libraries
Y Yan, D Yang, ED Zarnowska, Z Du, B Werbel, C … - Stem Cells, 2005 - stemcells.alphamedpress.org
... with Hoechst (blue in C, D). Bar = 50 µm. (G): Reverse transcription–polymerase
chain reaction showed a higher expression level of Pax2, En1, Wnt1, and Gbx2 ...
Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer
AL Joyner, A Liu, S Millet - Curr. Opin. Cell Biol, 2000 - saturn.med.nyu.edu
... Figure 1 Otx2 Wnt1,Otx2 Fgf8,Gbx2 En1/Pax2 r2-4 Otx2 Gbx2 Gbx2 Otx2 ... T D r2-4 E9.5
Mes Met Gbx2 Otx1/2 Wnt1 En1 Pax2 Fgf8 En2, Pax5 Gbx2 Otx1/2 Wnt1 En1, Pax2 ...
Cited by 53 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions » - Get it from MIT Libraries

The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by … - Full text - MIT Libraries
PL Pfeffer, B Payer, G Reim, MP di Magliano, M … - Development, 2002 - dev.biologists.org
... Subsequently, the transcription factors Pax2, Pax5 and Pax8, and En1 and En2 are
expressed across the Otx2-Gbx2 boundary in the mid-hindbrain region and ...
Cited by 12 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: … - Full text - MIT Libraries
M Schwarz, G Alvarez-Bolado, P Urbanek, M … - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... Home page, Development Home page E Matsunaga, I Araki, and H Nakamura Pax6 defines
the di-mesencephalic boundary by repressing En1 and Pax2 Development, January ...
Cited by 51 - Web Search - pnas.org - pubmedcentral.nih.gov - adsabs.harvard.edu - all 6 versions »

Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development - Full text - MIT Libraries
M Bouchard, P Pfeffer, M Busslinger - Development, 2000 - dev.biologists.org
... The vertebrate Pax2, Pax5 and Pax8 genes constitute one such subclass, which has
been even further diversified during zebrafish evolution by a recent Pax2 gene ...
Cited by 41 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

In vitro and in vivo analyses of human embryonic stem cell-derived dopamine neurons - Full text - MIT Libraries
CH Park, YK Minn, JY Lee, DH Choi, MY Chang, JW … - Journal of Neurochemistry, 2005 - blackwell-synergy.com
... efficiently generated DA neurons with concomitant expression of transcriptional
factors related to midbrain DA development, such as Pax2, En1 (Engrailed-1 ...
Cited by 1 - Web Search - ingentaconnect.com - biochem.northwestern.edu - med.umich.edu - all 5 versions »

Motoneuron-derived neurotrophin-3 is a survival factor for PAX2-expressing spinal interneurons - Full text - MIT Libraries
C Bechade, C Mallecourt, F Sedel, S Vyas, A … - J. Neurosci, 2002 - jneurosci.org
... Ventral populations of PAX2-IR interneurons can be subdivided into three groups
based on the expression of the transcription factors Engrailed-1 (EN1) and EVX1 ...
Cited by 2 - Web Search - jneurosci.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Half a century of neural prepatterning: the story of a few bristles and many genes - Full text - MIT Libraries
JL Gomez-Skarmeta, S Campuzano, J Modolell - Nature Reviews Neuroscience, 2003 - nature.com
1. Stern, C. Two or three bristles. American Scientist 42, 213-247 (1954).
A seminal genetic study of the pattern of bristles on ...
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[CITATION] PAX2 is 708 expressed in multiple spinal cord interneurons, including a popula-709 tion of EN1+ … - Full text - MIT Libraries
JD Burrill, L Moran, MD Goulding, H Saueressig - Development, 1997
Cited by 1 - Web Search

An essential role for the Drosophila Pax2 homolog in the differentiation of adult sensory organs - Full text - MIT Libraries
J Kavaler, W Fu, H Duan, M Noll, JW Posakony - Development, 1999 - dev.biologists.org
... Here we show that D-Pax2, the Drosophila homolog of the vertebrate Pax2 gene,
has an essential role in the differentiation of the shaft cell. ...
Cited by 21 - Web Search - www-biology.ucsd.edu - unizh.ch - ncbi.nlm.nih.gov - all 6 versions »

Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the … - Full text - MIT Libraries
A Mansouri, P Gruss - Mech. Dev, 1998 - invivo.caltech.edu
... 3B,F; see also Fig. 3I,J). The En1-positive interneurons coexpress Lim1 and
Pax2 (Burill et al., 1997; Ericson et al., 1997). Accordingly ...
Cited by 41 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

A Distinct Preisthmic Histogenetic Domain Is Defined by Overlap of Otx2 and Pax2 Gene Expression in … - Full text - MIT Libraries
RM ALVARADO-MALLART, L PUELLES - THE JOURNAL OF COMPARATIVE NEUROLOGY, 2005 - doi.wiley.com
... Several relevant transcription factors, such as Otx2, Gbx2, En1/2 and Pax2/5, and
two signalling molecules, Fgf8 and Wnt1, are expressed in this region, among ...
Web Search

A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is … - Full text - MIT Libraries
A Picker, S Scholpp, H Bohli, H Takeda, M Brand - Development, 2002 - dev.biologists.org
... En1 protein did not bind. Consistent with these studies, analysis of the zebrafish
MHB mutant spiel-ohne-grenzen/pou2 showed that Pou2 is a regulator of pax2.1 ...
Cited by 11 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

The midbrain–hindbrain boundary organizer - Full text - MIT Libraries
M Rhinn, M Brand - Curr. Opin. Neurobiol, 2001 - cbs.montana.edu
... Otx2 Gbx2 Fgf8 Wnt1 En1 En2 Pax2 Pax5 Pax8 Otx2 Gbx2 Fgf8 Wnt1 En1 En2 Pax2 Pax5
Pax8 Current Opinion in Neurobiology Page 3. ... Wnt1 En1/2 Pax2 Fgf8 ...
Cited by 69 - View as HTML - Web Search - cbs.montana.edu - ncbi.nlm.nih.gov

FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate - Full text - MIT Libraries
W Ye, K Shimamura, JL Rubenstein, MA Hynes, A … - Cell, 1998 - uni-marburg.de
... mRNA for Fgf8, Wnt1, Pax2, Pax5, En1, and En2 were brain ... the ANR from v1 explants
(left side, n 6). En1, Pax2, and Pax5 (but not for En2) were initially in- ...
Cited by 210 - View as HTML - Web Search - ncbi.nlm.nih.gov

Integrity of the Midbrain Region Is Required to Maintain the Diencephalic–Mesencephalic Boundary … - Full text - MIT Libraries
S Scholpp, M Brand - Dev. Dyn, 2003 - doi.wiley.com
... transcription factors are required, eg, En1 and En2 (Wurst et al., 1994; Millen
et al., 1994; Scholpp and Brand, 2001), Pax2 (Brand et al., 1996; Favor et al ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Isthmus organizer and regionalization of the mesencephalon and metencephalon.
H Nakamura, Y Watanabe - ncbi.nlm.nih.gov
... Overlapping expression of Otx2, En1 and Pax2 may define the mesencephalic region
and additional expression of Pax3/7 may instruct the mesencephalic region to ...
Web Search - Get it from MIT Libraries

EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region - Full text - MIT Libraries
A Liu, AL Joyner - Development, 2001 - dev.biologists.org
... In addition to Fgf8, Wnt1, En1/2 and Pax2/5 are expressed early in the mes/met region,
with Wnt1 expressed in the mes in a band of cells anterior to Fgf8, and ...
Cited by 35 - Web Search - dev.biologists.org - saturn.med.nyu.edu - ncbi.nlm.nih.gov

A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b - Full text - MIT Libraries
MP Smidt, CH Asbreuk, JJ Cox, H Chen, RL Johnson, … - Nat. Neurosci, 2000 - nature.com
... Sequential roles for Fgf4, En1 and Fgf8 in specification and regionalisation of
the ... The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a ...
Cited by 82 - Web Search - nature.com - cellbio.wustl.edu - ncbi.nlm.nih.gov

An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila - Full text - MIT Libraries
F Hirth, L Kammermeier, E Frei, U Walldorf, M Noll … - Development, 2003 - dev.biologists.org
... Inactivation of Pax2, Pax5, En1 or Fgf8 results in the loss of the midbrain and
cerebellum because of a failure to maintain development of this brain region ...
Cited by 9 - Web Search - molbio.unizh.ch - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Inductive signal and tissue responsiveness defining the tectum and the cerebellum - Full text - MIT Libraries
T Sato, I Araki, H Nakamura - Development, 2001 - dev.biologists.org
... En1 and Pax2 are expressed both in the mesencephalon and the metencephalon,
and they may be involved in the initiation of Fgf8 expression. ...
Cited by 26 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Derivation of midbrain dopamine neurons from human embryonic stem cells - Full text - MIT Libraries
AL Perrier, V Tabar, T Barberi, ME Rubio, J Bruses … - J. Neurosci, 2005 - dx.doi.org
... dopamine (DA) neuron fate was monitored by the sequential expression of key
transcription factors, including Pax2, Pax5, and engrailed-1 (En1), measurements ...
Cited by 21 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Sonic Hedgehog-Mediated Ventralization Disrupts Formation of the Midbrain-Hindbrain Junction in the …
XJ Yang - Dev Neurosci, 2000 - content.karger.com
... Furthermore, the normally restricted expression of two genes (En1 and Pax2) in the
mid/hindbrain junction region are expanded, reflecting the morphological ...
Cited by 8 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms’ tumor - Full text - MIT Libraries
GR Dressler, EC Douglass - Proceedings of the National Academy of Sciences - pnas.org
... Home page S. Buttiglieri, MC Deregibus, S. Bravo, P. Cassoni, R. Chiarle, B. Bussolati,
and G. Camussi Role of Pax2 in Apoptosis Resistance and Proinvasive ...
Cited by 115 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Gene silencing in chick embryos with a vector-based small interfering RNA system - Full text - MIT Libraries
T Katahira, H Nakamura - Development Growth and Differentiation, 2003 - blackwell-synergy.com
... Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2.
Development 127, 2357-2365. MEDLINE Abstract ISI Abstract. ...
Cited by 16 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

EARLY ANTERIOR/POSTERIOR PATTERNING OF THE MIDBRAIN AND CEREBELLUM - Full text - MIT Libraries
A Liu, AL Joyner - Annual Review of Neuroscience, 2001 - neuro.annualreviews.org
... Fgf8 and Gbx2 are expressed broadly in the anterior hindbrain, and En1, En2,
Pax2 and Pax5 are expressed in the entire mes/met region. ...
Cited by 34 - Web Search - nutr.annualreviews.org - neuro.annualreviews.org - ncbi.nlm.nih.gov